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SaveThe PLK1 inhibitor, onvansertib, is active as monotherapy and in combination with cetuximab in RAS wild-type colorectal cancer patient-derived xenografts
Ridinger, Maya; Marie, Preeti Kanikarla; Gao, Fengqin; Liu, Zhensheng; Maddalena, Giulia; Menter, David; Sorokin, Alexey; Smeal, Tod; Kopetz, Scott Share Save ASCL2+tumor cells modulate the response of colorectal cancer to MAPK targeting therapyVillarreal, Oscar E.; Lee, Hey Min; Ha Tran; Machado, Annette; Alshenaifi, Jumanah; Wong, Chi Wut; Coker, Olu; Minelli, Rosalba; Peoples, Michael; Martinez, Alejandro Hernandez; Fowlkes, Natalie; Kanikarla, Preeti; Lin, Kangyu; Bristow, Christopher; Viale, Andrea; Marszalek, Joseph R.; Shen, John Paul; Kopetz, Scott Share Save Elevated H3K27 trimethylation mediates adaptation to DNA demethylation in BRAFV600E-mutated colorectal cancerLee, Hey Min; Saw, Ajay Kumar; Morris, Van Karlyle; Singh, Anand Kamal; Napolitano, Stefania; Sorokin, Alexey; Marie, Preeti Kanikarla; Coker, Oluwadara; Villarreal, Oscar Eduardo; Anvar, Nazanin Esmaeili; Rai, Kunal; Kopetz, Scott Share Save YAP-TAZ-TEAD transcriptional program is a prominent driver of acquired resistance to KRASG12C-based therapies in patients with metastatic colorectal cancerCoker, Oluwadara; Sorokin, Alexey; Akhave, Neal; Pan, Kelsey; Gao, Fengqin; Liu, Zhensheng; Kanikarla, Preeti; Lee, HeyMin; Villarreal, Oscar; Alshenaifi, Jumanah; Maddalena, Giulia; Mohamed, Alaa; Prescod, Dionne; Menter, David; Chowdury, Saikat; Corcoran, Ryan; Rai, Kunal; Hong, David; Kopetz, Scott Share Save Share Save Combining bromodomain and extraterminal (BET) protein inhibitor treatment with standard MAPK inhibitors improved MAPK signaling inhibition in colorectal cancerLee, Hey Min; Sorokin, Alexey; Marie, Preeti Kanikarla; Chowdhury, Saikat; Singh, Anand; Anderson, Amanda; Alshenaifi, Jumanah Yousef; Meric-Bernstam, Funda; Rai, Kunal; Kopetz, Scott Share Save Evaluating targeted therapy combination for refractory colorectal cancer using MicroOrganoSpheres (MOS)Ding, Shengli; Marie, Preeti Kanikarla; Zhang, Ray; Bohn, Alan; Moseley, Robert Moseley; Baro, Nicholas; Brown, Dan; Pittman, Kelly; Paduch, Marcin; Hsu, David; Kopetz, Scott; Shen, Xiling Share Save Autologous humanized mouse models to study combination and single-agent immunotherapy for colorectal cancer patient-derived xenograftsKanikarla Marie, Preeti; Sorokin, Alexey V.; Bitner, Lea A.; Aden, Rebecca; Lam, Michael; Manyam, Ganiraju; Woods, Melanie N.; Anderson, Amanda; Capasso, Anna; Fowlkes, Natalie; Overman, Michael J.; Menter, David G.; Kopetz, Scott Share Save Targeting RAS Mutant Colorectal Cancer with Dual Inhibition of MEK and CDK4/6Sorokin, Alexey V.; Marie, Preeti Kanikarla; Bitner, Lea; Syed, Muddassir; Woods, Melanie; Manyam, Ganiraju; Kwong, Lawrence N.; Johnson, Benny; Morris, Van K.; Jones, Philip; Menter, David G.; Lee, Michael S.; Kopetz, Scott Share Save KRASG12C-independent feedback activation of wild-type RAS constrains KRASG12C inhibitor efficacyRyan, Meagan B.; Coker, Oluwadara; Sorokin, Alexey; Fella, Katerina; Barnes, Haley; Wong, Edmond; Kanikarla, Preeti; Gao, Fengqin; Zhang, Youyan; Zhou, Lian; Kopetz, Scott; Corcoran, Ryan B. Share Save The Provocative Roles of Platelets in Liver Disease and CancerKanikarla Marie, Preeti; Fowlkes, Natalie W.; Afshar-Kharghan, Vahid; Martch, Stephanie L.; Sorokin, Alexey; Shen, John Paul; Morris, Van K.; Dasari, Arvind; You, Nancy; Sood, Anil K.; Overman, Michael J.; Kopetz, Scott; Menter, David George Share Save Sulindac plus a phospholipid is effective for polyp reduction and safer than sulindac alone in a mouse model of colorectal cancer developmentDavis, Jennifer S.; Kanikarla-Marie, Preeti; Gagea, Mihai; Yu, Patrick L.; Fang, Dexing; Sebastian, Manu; Yang, Peiying; Hawk, Ernest; Dashwood, Roderick; Lichtenberger, Lenard M.; Menter, David; Kopetz, Scott Share Save Sulindac plus phospholipid is effective for polyp reduction and safer than sulindac aloneDavis, Jennifer Sarah; Kanikarla, Preeti; Yu, Patrick L.; Gagea, Mihai; Fang, Dexing; Sebastian, Manu; Yang, Peiying; Hawk, Ernest; Dashwood, Roderick; Lichtenberger, Lenard M.; Menter, David; Kopetz, Scott Share Save Share Save Share Save Share Save Share Save Share Save Share Save 
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