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M

Manuel I. Osorio

university diego portales

8H-index
29Paper Count
221Citation Count
Published Papers 13
Publication Date
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Drug Repurposing Uncovers New Chemical Scaffolds as Potent Urease Inhibitors: A Comprehensive Computational Study
errInternational Journal of Molecular Sciences
IF4.9
err2026-04-17
err0
errOAAI
errSofía E. Ríos-Rozas; Elizabeth Valdés-Muñoz; Vicente Rojas-Santander; Javier Farías-Abarca; Erix W. Hernández-Rodríguez; Héctor R. Contreras; Jonathan M. Palma; Reynier Suardíaz; Manuel I. Osorio; Osvaldo Yáñez; Luis Morales-Quintana; Daniel Bustos
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Unveiling the TP5 dual binding mechanism and structure-based search for potential dual inhibitors of tubulin and PD-L1
errPhysical Chemistry Chemical Physics
IF2.9
err2026-02-01
err0
PREAI
errGalaz-Araya, Constanza; Yanez, Osvaldo; Osorio, Manuel; Saldivar-Gonzalez, Fernanda I.; Zuniga-Bustos, Matias
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Chemical Profiling and Cheminformatic Insights into Piper Essential Oils as Sustainable Antimicrobial Agents Against Pathogens of Cocoa Crops
errMolecules
IF4.6
err2026-01-17
err0
errOAAI
errDiannefair Duarte; Marcial Fuentes-Estrada; Yorladys Martínez Aroca; Paloma Sendoya-Gutiérrez; Manuel I. Osorio; Osvaldo Yáñez; Carlos Areche; Elena Stashenko; Olimpo García-Beltrán
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Integrative Computational Approaches for the Discovery of Triazole-Based Urease Inhibitors: A Machine Learning, Virtual Screening, and Meta-Dynamics Framework
errInternational Journal of Molecular Sciences
IF4.9
err2025-11-28
err0
errOAAI
errSofía E. Ríos-Rozas; Natalia Morales; Elizabeth Valdés-Muñoz; Gabriela Urra; Camila A. Flores-Morales; Javier Farías-Abarca; Erix W. Hernández-Rodríguez; Jonathan M. Palma; Manuel I. Osorio; Osvaldo Yáñez-Osses
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Iron dextran nanoparticles interacting with micrometric crosslinked protein scaffolds: Theoretical, computational and experimental results to design formulations for iron deficiency
errInternational Journal of Biological Macromolecules
IF8.5
err2025-10-24
err0
PREAI
errEmerson Durán; Osvaldo Yañez; Patricio Romero-Hasler; Eduardo Soto; Manuel I. Osorio; Andrónico Neira-Carrillo; Ignacio Moreno-Villoslada; Diego Gaete-Sanhueza; Gonzalo Álvarez-Acevedo; Juan M. Ruso; Diane J. Burgess; Carolina Valenzuela; Felipe Oyarzun-Ampuero
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Inhibitor-induced dimerization mediates lufotrelvir resistance in mutants of SARS-CoV-2 3C-like protease
errProtein Science
IF5.2
err2025-08-25
err0
errOAAI
errGuanyu Wang; Felipe Venegas; Andres Rueda; Osvaldo Yañez; Manuel I. Osorio; Sibei Qin; José Manuel Pérez-Donoso; Christopher J. Thibodeaux; Nicolas Moitessier; Anthony K. Mittermaier
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Chemical composition, antioxidant, antimicrobial and antiproliferative activity of Laureliopsis philippiana essential oil of Chile, study in vitro and in silico
errARABIAN JOURNAL OF CHEMISTRY
IF5.2
err2022-12-01
err12
errOAAI
errBruna, Flavia; Fernandez, Katia; Urrejola, Felipe; Touma, Jorge; Navarro, Myriam; Sepulveda, Betsabet; Larrazabal-Fuentes, Maria; Paredes, Adrian; Neira, Ivan; Ferrando, Matias; Osorio, Manuel; Yanez, Osvaldo; Bravo, Jessica
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Search for Novel Potent Inhibitors of the SARS-CoV-2 Papain-like Enzyme: A Computational Biochemistry Approach
errPHARMACEUTICALS
IF4.8
err2022-08-11
err5
errOAAI
errOsorio, Manuel, I; Yanez, Osvaldo; Gallardo, Mauricio; Zuniga-Bustos, Matias; Mulia-Rodriguez, Jorge; Lopez-Rendon, Roberto; Garcia-Beltran, Olimpo; Gonzalez-Nilo, Fernando; Perez-Donoso, Jose M.
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Theobroma cacao L. compounds: Theoretical study and molecular modeling as inhibitors of main SARS-CoV-2 protease
errBIOMEDICINE & PHARMACOTHERAPY
IF7.5
err2021-08-01
err16
errOAAI
errYanez, Osvaldo; Osorio, Manuel Isaias; Areche, Carlos; Vasquez-Espinal, Alejandro; Bravo, Jessica; Sandoval-Aldana, Angelica; Perez-Donoso, Jose M.; Gonzalez-Nilo, Fernando; Matos, Maria Joao; Osorio, Edison; Garcia-Beltran, Olimpo; Tiznado, William
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In Silico Study of Coumarins and Quinolines Derivatives as Potent Inhibitors of SARS-CoV-2 Main Protease
errFRONTIERS IN CHEMISTRY
IF4.2
err2021-02-08
err33
errOAAI
errYanez, Osvaldo; Osorio, Manuel Isaias; Uriarte, Eugenio; Areche, Carlos; Tiznado, William; Perez-Donoso, Jose M.; Garcia-Beltran, Olimpo; Gonzalez-Nilo, Fernando
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Biotransformation of 2,4,6-Trinitrotoluene by Pseudomonas sp. TNT3 isolated from Deception Island, Antarctica
errENVIRONMENTAL POLLUTION
IF7.3
err2020-07-01
err24
PREAI
errAngeles Cabrera, Ma; Marquez, Sebastian L.; Quezada, Carolina P.; Osorio, Manuel, I; Castro-Nallar, Eduardo; Gonzalez-Nilo, Fernando D.; Perez-Donoso, Jose M.
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Odd Loop Regions of XenA and XenB Enzymes Modulate Their Interaction with Nitro-explosives Compounds and Provide Structural Support for Their Regioselectivity
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2019-08-27
err4
PREAI
errOsorio, Manuel, I; Angeles Cabrera, Ma; Gonzalez-Nilo, Fernando; Perez-Donoso, Jose M.
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errSave
Modulation of glucan-enzyme interactions by domain V in GTF-SI from Streptococcus mutans
errPROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
IF2.8
err2018-11-18
err8
PREAI
errOsorio, Manuel I.; Zuniga, Matias A.; Mendoza, Fernanda; Jana, Gonzalo A.; Jimenez, Veronica A.
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Research Directions

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Co-authors
Cooperation Journals
D
Diane J. Burgess
H-index: 71 · Papers: 329
E
Eugenio Uriarte
H-index: 61 · Papers: 503
E
Elena E. Stashenko
H-index: 47 · Papers: 403
M
María João Matos
H-index: 43 · Papers: 260
N
Nicolas Moitessier
H-index: 39 · Papers: 205
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