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Valerian E. Kagan

School of Public Health

118H-index
829Paper Count
7.1WCitation Count
Published Papers 337
Publication Date
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15-LOX-catalytic bias towards ether-(alkenyl)-ETE-PEs oxidation bestows selectivity of PRO-ferroptotic cell death signaling
errNature Communications
IF15.7
err2026-06-17
err0
errOAAI
errYulia Y. Tyurina; Karolina Mikulska-Ruminska; Vladimir A. Tyurin; Brian A. Kleiboeker; Alexander A. Kapralov; Ayumi Hashimoto; Louis J. Sparvero; Haider H. Dar; Mert Akdogan; Kazuhiro Yamada; Jinming Zhao; Taha Kelestemur; Ecem Saritas; Sviatlana N. Samovich; Theodore R. Holman; Yuri L. Bunimovich; Yulia Nefedova; Dmitry I. Gabrilovich; Sally E. Wenzel; Ivet Bahar; Valerian E. Kagan; Hülya Bayır
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errSave
A GPX1-OSBPL8 axis mediates noncanonical in vivo ferroptosis and cancer growth suppression
errCell
IF42.5
err2026-02-19
err0
PREAI
errZhangchuan Xia; Xin Yang; Sviatlana N. Samovich; Yulia Y. Tyurina; Vladimir A. Tyurin; Ning Kon; Jiankang Zhang; Xuejun Jiang; Brent R. Stockwell; Jian Jin; Hülya Bayir; Valerian E. Kagan; Wei Gu
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Targeting PRDX6-dependent localization and function of GPX4 enhances ferroptosis-mediated tumor suppression
errMolecular Cell
IF16.6
err2025-12-18
err0
PREAI
errYameng Hu; Ziwen Li; Man Li; Xingui Wu; Shuxia Zhang; Miaoling Tang; Ruyuan Yu; Meisongzhu Yang; Xin Chen; Libing Song; Guido Kroemer; Valerian E. Kagan; Hülya Bayir; Rui Kang; Jinbao Liu; Daolin Tang; Jun Li
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Antiferroptotic Drugs Reduce sFlt-1 Release and Placenta Damage in Preeclampsia
errHYPERTENSION
IF8.2
err2025-10-01
err0
PREAI
errLianski, Sapir; Mizrachi, Tehila; Barak, Oren; Tsaitlin-Mor, Lilah; Elhaik-Goldman, Shirin; Yagel, Simcha; Goldman-Wohl, Debra; Cohen, Sarah M.; Medina, Ruth Hefetz; Rachmilewitz, Jacob; Barr, Haim Michael; Plotnikov, Alexander; Tyurina, Yulia Y.; Tyurin, Vladimir A.; Samovich, Svetlana N.; Kapralov, Alexander A.; Karumanchi, S. Ananth; Kagan, Valerian E.; Bayir, Hulya; Sadovsky, Yoel; Beharier, Ofer
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Emerging Roles of Ferroptosis in Skin Pathophysiology
errJournal of Investigative Dermatology
IF5.7
err2025-08-05
err0
errOAAI
errAlex S. Reznik; Kavita Vats; Kunal Singh; Alicia Mizes; Erik Jaklitsch; Hülya Bayır; Valerian E. Kagan; Yuri L. Bunimovich
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Author Correction: Endoplasmic reticulum–mitochondria contacts are prime hotspots of phospholipid peroxidation driving ferroptosis
errNature Cell Biology
IF19.1
err2025-08-04
err0
errOAAI
errMaria Livia Sassano; Yulia Y. Tyurina; Antigoni Diokmetzidou; Ellen Vervoort; Vladimir A. Tyurin; Sanket More; Rita La Rovere; Francesca Giordano; Geert Bultynck; Benjamin Pavie; Johan V. Swinnen; Hülya Bayir; Valerian E. Kagan; Luca Scorrano; Patrizia Agostinis
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15-Lipoxygenase-Dependent Radiomitigation by NO●-Donors Suppresses Ferroptosis in Intestinal Epithelium: Multiomics MS Imaging and LC-MS Evidence
errRedox Biology
IF11.9
err2025-07-21
err0
errOAAI
errYulia Y. Tyurina; Hua Tian; Haider H. Dar; Mert Akdogan; Ecem Saritas; Vladimir A. Tyurin; Louis J. Sparvero; Alexander A. Kapralov; Galina Shurin; Renee Fisher; Michael W. Epperly; Kunal Singh; Yuri L. Bunimovich; Joel S. Greenberger; Valerian E. Kagan; Hülya Bayir
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errSave
Endoplasmic reticulum–mitochondria contacts are prime hotspots of phospholipid peroxidation driving ferroptosis
errNature Cell Biology
IF19.1
err2025-06-13
err0
errOAAI
errMaria Livia Sassano; Yulia Y. Tyurina; Antigoni Diometzidou; Ellen Vervoort; Vladimir A. Tyurin; Sanket More; Rita La Rovere; Francesca Giordano; Geert Bultynck; Benjamin Pavie; Johan V. Swinnen; Hülya Bayir; Valerian E. Kagan; Luca Scorrano; Patrizia Agostinis
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errSave
The presence of substrate warrants oxygen access tunnels toward the catalytic site of lipoxygenases
errREDOX BIOLOGY
IF11.9
err2025-06-01
err0
errOAAI
errManivarma, Thiliban; Nowak, Wieslaw; Tyurina, Yulia Y.; Tyurin, Vladimir A.; Bayir, Huelya; Kagan, Valerian E.
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Oxidized phospholipid and transcriptomic signatures of THC-related vaping associated lung injury
errSCIENTIFIC REPORTS
IF3.9
err2024-12-30
err0
errOAAI
errSuber, Tomeka L.; Tabary, Mohammadreza; Bain, William; Olonisakin, Tolani; Lockwood, Karina; Xiong, Zeyu; Zhang, Yingze; Kohli, Naina; Furguiele, Lauren; Penaloza, Hernan; Mcverry, Bryan J.; Rose, Jason J.; Shah, Faraaz; Methe, Barbara; Li, Kelvin; Mallampalli, Rama K.; Chen, Kong; Fan, Li; Morris, Alison; Tyurin, Vladimir A.; Samovich, Svetlana N.; Bayir, Hulya; Tyurina, Yulia Y.; Kagan, Valerian; Lee, Janet S.
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The CoQ-reductase CYB5R1 functions in parallel to FSP1 to suppress ferroptosis
errFREE RADICAL BIOLOGY AND MEDICINE
IF8.2
err2024-11-01
err0
PREAI
errHall, Robert; Samovich, Svetlana; Taiclet, Stefanie; Katona, Mate; Bayir, Hulya; Kagan, Valerian; Straub, Adam
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errSave
A New Function of PUFA-Plasmalogens in Ferroptosis
errFREE RADICAL BIOLOGY AND MEDICINE
IF8.2
err2024-11-01
err0
PREAI
errKleiboeker, Brian; Tyurin, Vladimir; Mikulska-Ruminska, Karolina; Kapralov, Oleksandr; Tyurina, Yulia; Bunimovich, Yuri; Nefedova, Yulia; Bayir, Hulya; Kagan, Valerian
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Mitochondrial bioenergetics and cardiolipin remodeling abnormalities in mitochondrial trifunctional protein deficiency
errJCI INSIGHT
IF6.1
err2024-09-10
err0
errOAAI
errVieira Neto, Eduardo; Wang, Meicheng; Szuminsky, Austin J.; Ferraro, Lethicia; Koppes, Erik; Wang, Yudong; Land, Clinton Van't; Mohsen, Al-Walid; Zanatta, Geancarlo; El-Gharbawy, Areeg H.; Anthonymuthu, Tamil S.; Tyurina, Yulia Y.; Tyurin, Vladimir A.; Kagan, Valerian; Bayir, Hulya; Vockley, Jerry
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Targeted degradation of extracellular mitochondrial aspartyl-tRNA synthetase modulates immune responses
errNATURE COMMUNICATIONS
IF15.7
err2024-07-22
err0
errOAAI
errJohnson, Benjamin S.; Farkas, Daniela; El-Mergawy, Rabab; Adair, Jessica A.; Elhance, Ajit; Eltobgy, Moemen; Coan, Francesca M.; Chafin, Lexie; Joseph, Jessica A.; Cornwell, Alex; Johns, Finny J.; Rosas, Lorena; Rojas, Mauricio; Farkas, Laszlo; Bednash, Joseph S.; Londino, James D.; Ray, Prabir; Ray, Anuradha; Kagan, Valerian; Lee, Janet S.; Chen, Bill B.; Mallampalli, Rama K.
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Compartmentalized mitochondrial ferroptosis converges with optineurin-mediated mitophagy to impact airway epithelial cell phenotypes and asthma outcomes
errNATURE COMMUNICATIONS
IF15.7
err2024-07-10
err4
errOAAI
errYamada, Kazuhiro; St. Croix, Claudette; Stolz, Donna B.; Tyurina, Yulia Y.; Tyurin, Vladimir A.; Bradley, Laura R.; Kapralov, Alexander A.; Deng, Yanhan; Zhou, Xiuxia; Wei, Qi; Liao, Bo; Fukuda, Nobuhiko; Sullivan, Mara; Trudeau, John; Ray, Anuradha; Kagan, Valerian E.; Zhao, Jinming; Wenzel, Sally E.
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errSave
Neutrophils and galectin-3 defend mice from lethal bacterial infection and humans from acute respiratory failure
errNATURE COMMUNICATIONS
IF15.7
err2024-06-03
err3
errOAAI
errDas, Sudipta; Kaminski, Tomasz W.; Schlegel, Brent T.; Bain, William; Hu, Sanmei; Patel, Akruti; Kale, Sagar L.; Chen, Kong; Lee, Janet S.; Mallampalli, Rama K.; Kagan, Valerian E.; Rajasundaram, Dhivyaa; McVerry, Bryan J.; Sundd, Prithu; Kitsios, Georgios D.; Ray, Anuradha; Ray, Prabir
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PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression
errCELL METABOLISM
IF30.9
err2024-04-01
err12
errOAAI
errYang, Xin; Wang, Zhe; Samovich, Svetlana N.; Kapralov, Alexander A.; Amoscato, Andrew A.; Tyurin, Vladimir A.; Dar, Haider H.; Li, Zhiming; Duan, Shoufu; Kon, Ning; Chen, Delin; Tycko, Benjamin; Zhang, Zhiguo; Jiang, Xuejun; Bayir, Hulya; Stockwell, Brent R.; Kagan, Valerian E.; Gu, Wei
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International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis
errAUTOPHAGY
IF14.3
err2024-03-24
err31
errOAAI
errChen, Xin; Tsvetkov, Andrey S.; Shen, Han-Ming; Isidoro, Ciro; Ktistakis, Nicholas T.; Linkermann, Andreas; Koopman, Werner J. H.; Simon, Hans-Uwe; Galluzzi, Lorenzo; Luo, Shouqing; Xu, Daqian; Gu, Wei; Peulen, Olivier; Cai, Qian; Rubinsztein, David C.; Chi, Jen-Tsan; Zhang, Donna D.; Li, Changfeng; Toyokuni, Shinya; Liu, Jinbao; Roh, Jong-Lyel; Dai, Enyong; Juhasz, Gabor; Liu, Wei; Zhang, Jianhua; Yang, Minghua; Liu, Jiao; Zhu, Ling-Qiang; Zou, Weiping; Piacentini, Mauro; Ding, Wen-Xing; Yue, Zhenyu; Xie, Yangchun; Petersen, Morten; Gewirtz, David A.; Mandell, Michael A.; Chu, Charleen T.; Sinha, Debasish; Eftekharpour, Eftekhar; Zhivotovsky, Boris; Besteiro, Sebastien; Gabrilovich, Dmitry I.; Kim, Do-Hyung; Kagan, Valerian E.; Bayir, Hulya; Chen, Guang-Chao; Ayton, Scott; Luenemann, Jan D.; Komatsu, Masaaki; Krautwald, Stefan; Loos, Ben; Baehrecke, Eric H.; Wang, Jiayi; Lane, Jon D.; Sadoshima, Junichi; Yang, Wan Seok; Gao, Minghui; Munz, Christian; Thumm, Michael; Kampmann, Martin; Yu, Di; Lipinski, Marta M.; Jones, Jace W.; Jiang, Xuejun; Zeh, Herbert J.; Kang, Rui; Klionsky, Daniel J.; Kroemer, Guido; Tang, Daolin
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A guideline on the molecular ecosystem regulating ferroptosis
errNATURE CELL BIOLOGY
IF19.1
err2024-02-29
err53
PREAI
errDai, Enyong; Chen, Xin; Linkermann, Andreas; Jiang, Xuejun; Kang, Rui; Kagan, Valerian E.; Bayir, Huelya; Yang, Wan Seok; Garcia-Saez, Ana J.; Ioannou, Maria S.; Janowitz, Tobias; Ran, Qitao; Gu, Wei; Gan, Boyi; Krysko, Dmitri V.; Zhu, Xiaofeng; Wang, Jiayi; Krautwald, Stefan; Toyokuni, Shinya; Xie, Yangchun; Greten, Florian R.; Yi, Qing; Schick, Joel; Liu, Jiao; Gabrilovich, Dmitry I.; Liu, Jinbao; Zeh, Herbert J.; Zhang, Donna D.; Yang, Minghua; Iovanna, Juan; Kopf, Manfred; Adolph, Timon E.; Chi, Jen-Tsan; Li, Changfeng; Ichijo, Hidenori; Karin, Michael; Sankaran, Vijay G.; Zou, Weiping; Galluzzi, Lorenzo; Bush, Ashley I.; Li, Binghui; Melino, Gerry; Baehrecke, Eric H.; Lotze, Michael T.; Klionsky, Daniel J.; Stockwell, Brent R.; Kroemer, Guido; Tang, Daolin
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Vitamin E/Coenzyme Q-Dependent Free Radical Reductases: Redox Regulators in Ferroptosis
errANTIOXIDANTS & REDOX SIGNALING
IF6.1
err2024-02-01
err6
PREAI
errKagan, Valerian E.; Straub, Adam C.; Tyurina, Yulia Y.; Kapralov, Alexandr A.; Hall, Robert; Wenzel, Sally E.; Mallampalli, Rama K.; Bayir, Huelya
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Research Directions

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Co-authors
Cooperation Journals
G
Guido Kroemer
H-index: 283 · Papers: 2.3K
M
Michael Karin
H-index: 254 · Papers: 902
D
Daniel J. Klionsky
H-index: 156 · Papers: 885
P
Peter Vandenabeele
H-index: 154 · Papers: 669
L
Lorenzo Galluzzi
H-index: 153 · Papers: 988
View more