Marcos Hikari Toyama - Publications, H-index & Citations

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Marcos Hikari Toyama

Universidade de Coimbra

43H-index

268Paper Count

6.3KCitation Count

Published Papers 42

Publication Date

Linoleic Hydroperoxides Are Potent Hyperoxidative Agents of Sensitive and Robust Typical 2-Cys Peroxiredoxins

Antioxidants 2025, Vol. 14, Page 1422

IF6.6

2025-11-28

OAAI

Vitória Isabela Montanhero Cabrera; Sabrina Vargas; Nathália Miranda de Medeiros; Gabrielle Nascimento Sividanes; Laura Fernandes da Silva; Larissa Regina Diniz; Thiago Geronimo Pires Alegria; João Henrique Ghilardi Lago; Marcos Hikari Toyama; Sayuri Miyamoto; Daniela Ramos Truzzi; Luis Eduardo Soares Netto; Marcos Antonio de Oliveira

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NSAIDs beyond COX: In Silico and In Vitro Insights into Acetylcholinesterase Modulation

ACS OMEGA

IF4.3

2025-11-01

PREAI

Roggero, Airam; Loyola, Pedro Mathias; Ramos da Cruz, Caroline; Santos, Willian Haniel Bezerra de Carvalho; Borges, Paloma Peixoto; Dos Santos Junior, Adeilso Bispo; Martins, Fabio; Oliveira, Marcos A.; Sousa, Sergio F.; Toyama, Marcos H.

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Lands' Cycle at the Crossroads: Phospholipid Remodelling, Oxidative Stress, Cellular Toxicity, and Therapeutic Targeting

ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE

IF3.7

2025-11-01

PREAI

Roggero, Airam; Toyama, Marcos H.; Sousa, Sergio F.

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The First Anti-Snakebite and Hepatoprotective Characterization of a Trypsin Kunitz-like Inhibitor (EcTI) from the Plant Enterolobium contortisiliquum; A Case of Two Soul Mates Meeting

PHARMACEUTICALS

IF4.8

2023-04-21

OAAI

Costa, Caroline R. C.; Belchor, Mariana N.; Roggero, Airam; Moraes, Laila L. L.; Samelo, Ricardo; Annunciato, Isabelly; Bonturi, Camila R. R.; Oliva, Maria L. V.; Sousa, Sergio F. F.; de Oliveira, Marcos A. A.; Toyama, Marcos H. H.

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In Silico Evaluation of Quercetin Methylated Derivatives on the Interaction with Secretory Phospholipases A2 from Crotalus durissus terrificus and Bothrops jararacussu

PHARMACEUTICALS

IF4.8

2023-04-15

OAAI

Belchor, Mariana Novo; Costa, Caroline Ramos da Cruz; Roggero, Airam; Moraes, Laila L. F.; Samelo, Ricardo; Annunciato, Isabelly; de Oliveira, Marcos Antonio; Sousa, Sergio F.; Toyama, Marcos Hikari

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Adenanthin Is an Efficient Inhibitor of Peroxiredoxins from Pathogens, Inhibits Bacterial Growth, and Potentiates Antibiotic Activities

CHEMICAL RESEARCH IN TOXICOLOGY

IF3.8

2022-05-10

PREAI

dos Santos, Melina Cardoso; Tairum, Carlos Abrunhosa; Montanhero Cabrera, Vitoria Isabela; Guimaraes Cauz, Ana Carolina; Ribeiro, Luiz Fernando; Toledo Junior, Jose Carlos; Toyama, Marcos Hikari; Ghilardi Lago, Joao Henrique; Brocchi, Marcelo; Soares Netto, Luis Eduardo; de Oliveira, Marcos Antonio

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Gallic Acid as a Non-Selective Inhibitor of α/β-Hydrolase Fold Enzymes Involved in the Inflammatory Process: The Two Sides of the Same Coin

PHARMACEUTICS

IF5.5

2022-02-06

OAAI

Toyama, Marcos Hikari; Rogero, Airam; de Moraes, Laila Lucyane Ferreira; Fernandes, Gustavo Antonio; da Cruz Costa, Caroline Ramos; Belchor, Mariana Novo; De Carli, Agatha Manzi; de Oliveira, Marcos Antonio

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Effects of Serine or Threonine in the Active Site of Typical 2-Cys Prx on Hyperoxidation Susceptibility and on Chaperone Activity

ANTIOXIDANTS

IF6.6

2021-06-25

OAAI

Tairum, Carlos A.; Santos, Melina Cardoso; Breyer, Carlos Alexandre; Pires de Oliveira, Ana Laura; Montanhero Cabrera, Vitoria Isabela; Toledo-Silva, Guilherme; Mori, Gustavo Maruyama; Toyama, Marcos Hikari; Soares Netto, Luis Eduardo; de Oliveira, Marcos Antonio

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Influence of lysosomal protease sensitivity in the immunogenicity of the antitumor biopharmaceutical asparaginase

BIOCHEMICAL PHARMACOLOGY

IF5.6

2020-12-01

OAAI

Rodrigues, Mariane A. D.; Pimenta, Marcela V.; Costa, Iris M.; Zenatti, Priscila P.; Migita, Natacha A.; Yunes, Jose A.; Rangel-Yagui, Carlota O.; de Sa, Matheus M.; Pessoa, Adalberto; Costa-Silva, Tales A.; Toyama, Marcos H.; Breyer, Carlos A.; de Oliveira, Marcos A.; Santiago, Veronica F.; Palmisano, Giuseppe; Barbosa, Christiano M. V.; Hebeda, Cristina B.; Farsky, Sandra H. P.; Monteiro, Gisele

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Yeast Tsa1 as a Prototype Enzyme for the Screening of Fungal Typical 2-Cys Prx Inhibitors

FREE RADICAL BIOLOGY AND MEDICINE

IF8.2

2020-11-01

PREAI

Pires de Oliveira, Ana Laura; Santos, Melina; Tairum, Carlos; Sessa, Debora; Toyama, Marcos Hikari; Cunha, Rodrigo Luiz; Lago, Joao Henrique; Netto, Luis; Oliveira, Marcos

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Presence of Ser instead of Thr in the Catalytic Triad of Typical 2-Cys Prx Increases their Resistance to Hyperoxidation and Inactivation

FREE RADICAL BIOLOGY AND MEDICINE

IF8.2

2020-11-01

PREAI

Santos, Melina; Breyer, Carlos; Tairum, Carlos; Pires de Oliveira, Ana Laura; Montanhero, Vitoria Isabela; Toledo-Silva, Guilherme; Mori, Gustavo Maruyama; Toyama, Marcos Hikari; Augusto, Ohara; Netto, Luis; Oliveira, Marcos

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A Natural Compound as an Inhibitor of the Peroxidase Activity of Bacterial AhpCs

FREE RADICAL BIOLOGY AND MEDICINE

IF8.2

2020-11-01

PREAI

Montanhero, Vitoria Isabela; Ribeiro, Luiz Fernando; dos Santos, Melina Cardoso; Sessa, Debora; Toyama, Marcos Hikari; Cunha, Rodrigo Luiz; Lago, Joao Henrique; Netto, Luis; Oliveira, Marcos

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Glutaredoxin-like protein (GLP)-a novel bacteria sulfurtransferase that protects cells against cyanide and oxidative stresses

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

IF4.3

2020-04-19

PREAI

de Paula, Carla Peres; dos Santos, Melina Cardoso; Tairum, Carlos A.; Breyer, Carlos Alexandre; Toledo-Silva, Guilherme; Toyama, Marcos Hikari; Mori, Gustavo Maruyama; de Oliveira, Marcos Antonio

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Bioaffinity Fishing Procedure Using Secretory Phospholipase A2 for Screening for Bioactive Components: Modulation of Pharmacological Effect Induced by sPLA2 from Crotalus durissus terrificus by Hispidulin from Moquiniastrum floribundum

MOLECULES

IF4.6

2020-01-09

OAAI

dos Santos Junior, Adeilso Bispo; Tamayose, Cinthia I.; Ferreira, Marcelo J. P.; Belchor, Mariana N.; Costa, Caroline R. C.; de Oliveira, Marcos Antonio; Toyama, Marcos Hikari

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Evaluation of the Inhibitory Potential of Casuarictin, an Ellagitannin Isolated from White Mangrove (Laguncularia racemosa) Leaves, on Snake Venom Secretory Phospholipase A2

MARINE DRUGS

IF5.4

2019-07-08

OAAI

Bittencourt Rodrigues, Caroline Fabri; Pena Ferreira, Marcelo Jose; Belchor, Mariana Novo; Costa, Caroline R. C.; Novaes, Danielle P.; dos Santos Junior, Adeilso Bispo; Tamayose, Cinthia I.; Terashima Pinho, Marcus Vinicius; de Oliveira, Marcos Antonio; Toyama, Marcos Hikari

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Evaluation of Rhamnetin as an Inhibitor of the Pharmacological Effect of Secretory Phospholipase A2

MOLECULES

IF4.6

2017-08-31

OAAI

Belchor, Mariana Novo; Gaeta, Henrique Hessel; Bittencourt Rodrigues, Caroline Fabri; da Cruz Costa, Caroline Ramos; Toyama, Daniela de Oliveira; Domingues Passero, Luiz Felipe; Laurenti, Marcia Dalastra; Toyama, Marcos Hikari

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Tsa1 and Tsa2 Are Two Highly Similar 2-Cys Prx from Yeast That Display Remarkable Differences in Their Structural Switches

FREE RADICAL BIOLOGY AND MEDICINE

IF8.2

2016-11-01

PREAI

Tairum, Carlos A.; Santos, Melina Cardoso; Breyer, Carlos Alexandre; Geyer, Robert Ryan; Nieves, Cecilia J.; Portillo-Ledesma, Stephanie; Ferrer-Sueta, Gerardo; Toledo-, Jose Carlos, Jr.; Toyama, Marcos Hikari; Augusto, Ohara; Soares Netto, Luis Eduardo; de Oliveira, Marcos Antonio

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Catalytic Thr or Ser Residue Modulates Structural Switches in 2-Cys Peroxiredoxin by Distinct Mechanisms

SCIENTIFIC REPORTS

IF3.9

2016-09-15

OAAI

Tairum, Carlos A.; Santos, Melina Cardoso; Breyer, Carlos A.; Ryan Geyer, R.; Nieves, Cecilia J.; Portillo-Ledesma, Stephanie; Ferrer-Sueta, Gerardo; Toledo, Jose Carlos, Jr.; Toyama, Marcos H.; Augusto, Ohara; Netto, Luis E. S.; de Oliveira, Marcos A.

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Evaluation of Potential Thrombin Inhibitors from the White Mangrove (Laguncularia racemosa (L.) C.F. Gaertn.)

MARINE DRUGS

IF5.4

2015-07-21

OAAI

Bittencourt Rodrigues, Caroline Fabri; Gaeta, Henrique Hessel; Belchor, Mariana Novo; Pena Ferreira, Marcelo Jose; Terashima Pinho, Marcus Vinicius; Toyama, Daniela de Oliveira; Toyama, Marcos Hikari

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Solanidane and iminosolanidane alkaloids from Solanum campaniforme

PHYTOCHEMISTRY

IF3.4

2013-12-01

OAAI

Torres, Maria Conceicao M.; Jorge, Roberta Jeane B.; Ximenes, Rafael M.; Alves, Natacha Teresa Q.; Santos, Joao Victor de A.; Marinho, Aline D.; Monteiro, Helena S. A.; Toyama, Marcos H.; Braz-Filho, Raimundo; Silveira, Edilberto R.; Pessoa, Otilia Deusdenia L.

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Research Directions