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D

David Sinclair

Harvard University

114H-index
653Paper Count
8.3WCitation Count
Published Papers 187
Publication Date
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Past, present and future perspectives on the science of aging
errNature Aging
IF19.4
err2026-01-21
err0
PREAI
errFabrisia Ambrosio; Maxim N. Artyomov; Steven N. Austad; Nir Barzilai; Juan Carlos Izpisua Belmonte; Daniel W. Belsky; Bérénice A. Benayoun; Anne Brunet; Handan Melike Dönertaş; Dena B. Dubal; Evandro F. Fang; Jerome N. Feige; Linda P. Fried; David Furman; Xu Gao; Vadim N. Gladyshev; Vera Gorbunova; Myriam Gorospe; Jing-Dong J. Han; Oskar Hansson; Eiji Hara; Steve Horvath; Nancy Y. Ip; George A. Kuchel; Matt Kaeberlein; Dudley W. Lamming; Becca R. Levy; Guang-Hui Liu; Jinkook Lee; Terrie E. Moffitt; Tohru Minamino; Linda Partridge; Parminder Raina; Thomas A. Rando; John W. Rowe; Michal Schwartz; Andrew J. Scott; Felipe Sierra; David A. Sinclair; Charlotte E. Teunissen; Bruno Vellas; Eric Verdin; Keenan A. Walker; Ashley E. Webb; Tony Wyss-Coray; Ming Xu; Jin-Tai Yu; Alex Zhavoronkov; Yahyah Aman; Anna Kriebs; Qingzhong Ren; Hannah Walters; Sebastien Thuault
errShare
errSave
Epigenetic Reprogramming for Ocular Aging and Disease: Mechanisms, Biomarkers, and the Road to the Clinic
errProgress in Retinal and Eye Research
IF14.7
err2026-01-21
err0
PREAI
errJunwon Lee; Minseok Han; Kaixiang Wang; L.Rainer Butler; David A. Sinclair
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errSave
Oculomics and AI: The eye as a biomarker for health span
errAsia-Pacific Journal of Ophthalmology
IF4.5
err2026-01-01
err1
errOAAI
errWong, Joy Le Yi; Cheng, Haoran; Peh, Wen Jun; Ho, Dean; Wong, Tien Y.; Hui, Celene Yan Yan; Ting, Darren S. J.; Bee, Yong Mong; Goh, Su Yen; Apte, Rajendra S.; Mahajan, Vinit B.; Goldberg, Jeffrey L.; Bischof, Evelyne; Sinclair, David A.; Cheung, Carol C.; Chan, Hiok Hong; Fukutsu, Kanae; Tan, Ting Fang; Quek, Chrystie Wan Ning; Hong, Ashley Shuen Ying; Jin, Li Yuan; Wagner, Siegfried Karl; Keane, Pearse; Ferrara, Daniela; Eydelman, Malvina; Lam, Dennis S. C.; Wang, Xiaomeng; Ting, Daniel S. W.
errShare
errSave
Multiomic clocks to predict phenotypic age in mice
errJOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
IF3.8
err2025-11-01
err0
errOAAI
errVera, Daniel L.; Griffin, Patrick T.; Leigh, David; Kras, Jason; Ramos, Enrique; Bishof, Isaac; Butler, Anderson; Chwalek, Karolina; Vogel, David S.; Kane, Alice E.; Sinclair, David A.
errShare
errSave
Metabolomics biomarkers of frailty: a longitudinal study of aging female and male mice
errNPJ AGING
IF6
err2025-05-23
err0
errOAAI
errZhu, Dantong; Wu, Judy Z.; Griffin, Patrick T.; Samuelson, Brady A.; Sinclair, David A.; Kane, Alice E.
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errSave
Sex dimorphism and tissue specificity of gene expression changes in aging mice
errBIOLOGY OF SEX DIFFERENCES
IF5.1
err2024-10-31
err0
errOAAI
errZhu, Dantong; Arnold, Matt; Samuelson, Brady A.; Wu, Judy Z.; Mueller, Amber; Sinclair, David A.; Kane, Alice E.
errShare
errSave
A Single-Short Partial Reprogramming of the Endothelial Cells Decreases Blood Pressure Via Attenuation of Endothelial-to-Mesenchymal Transition in Hypertensive Mice
errHYPERTENSION
IF8.2
err2024-09-01
err0
PREAI
errPernomian, Laena; Waigi, Emily; Vi Nguyen; Mohammed, Ahmed; Costa, Tiago JanuarioDa; Fontes, Milene; Kubinack, Jason; Aitken, Andrew; Biancardi, Vinicia; Sinclair, David; McCarthy, Cam; Tan, Wenbin; Wenceslau, Camilla
errShare
errSave
Fertility protection during chemotherapy treatment by boosting the NAD(P)+ metabolome
errEMBO MOLECULAR MEDICINE
IF8.3
err2024-08-21
err1
errOAAI
errHo, Wing-Hong Jonathan; Marinova, Maria B.; Listijono, Dave R.; Bertoldo, Michael J.; Richani, Dulama; Kim, Lynn-Jee; Brown, Amelia; Riepsamen, Angelique H.; Cabot, Safaa; Frost, Emily R.; Bustamante, Sonia; Zhong, Ling; Selesniemi, Kaisa; Wong, Derek; Madawala, Romanthi; Marchante, Maria; Goss, Dale M.; Li, Catherine; Araki, Toshiyuki; Livingston, David J.; Turner, Nigel; Sinclair, David A.; Walters, Kirsty A.; Homer, Hayden A.; Gilchrist, Robert B.; Wu, Lindsay E.
errShare
errSave
Extracellular matrix abnormalities in the hippocampus of subjects with substance use disorder
errTRANSLATIONAL PSYCHIATRY
IF6.2
err2024-02-24
err8
errOAAI
errValeri, Jake; Stiplosek, Charlotte; O'Donovan, Sinead M.; Sinclair, David; Grant, Kathleen A.; Bollavarapu, Ratna; Platt, Donna M.; Stockmeier, Craig A.; Gisabella, Barbara; Pantazopoulos, Harry
errShare
errSave
Human trials exploring anti-aging medicines
errCELL METABOLISM
IF30.9
err2024-02-01
err30
errOAAI
errGuarente, Leonard; Sinclair, David A.; Kroemer, Guido
errShare
errSave
TIME-seq reduces time and cost of DNA methylation measurement for epigenetic clock construction
errNATURE AGING
IF19.4
err2024-01-10
err5
errOAAI
errGriffin, Patrick T.; Kane, Alice E.; Trapp, Alexandre; Li, Jien; Arnold, Matthew; Poganik, Jesse R.; Conway, Ryan J.; McNamara, Maeve S.; Meer, Margarita V.; Hoffman, Noah; Amorim, Joao A.; Tian, Xiao; MacArthur, Michael R.; Mitchell, Sarah J.; Mueller, Amber L.; Carmody, Colleen; Vera, Daniel L.; Kerepesi, Csaba; Ying, Kejun; Hooten, Nicole Noren; Mitchell, James R.; Evans, Michele K.; Gladyshev, Vadim N.; Sinclair, David A.
errShare
errSave
Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming (vol 4, 14, 2024)
errNATURE AGING
IF19.4
err2024-01-04
err0
errOAAI
errCipriano, Andrea; Moqri, Mahdi; Maybury-Lewis, Sun Y.; Rogers-Hammond, Ryan; de Jong, Tineke Anna; Parker, Alexander; Rasouli, Sajede; Scholer, Hans Robert; Sinclair, David A.; Sebastiano, Vittorio
errShare
errSave
Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming
errNATURE AGING
IF19.4
err2023-12-15
err9
errOAAI
errCipriano, Andrea; Moqri, Mahdi; Maybury-Lewis, Sun Y.; Rogers-Hammond, Ryan; de Jong, Tineke Anna; Parker, Alexander; Rasouli, Sajede; Schoeler, Hans Robert; Sinclair, David A.; Sebastiano, Vittorio
errShare
errSave
The Information Theory of Aging
errNATURE AGING
IF19.4
err2023-12-15
err21
PREAI
errLu, Yuancheng Ryan; Tian, Xiao; Sinclair, David A.
errShare
errSave
SIRT2 transgenic over-expression does not impact lifespan in mice
errAGING CELL
IF7.1
err2023-11-27
err1
errOAAI
errWu, Lindsay E.; Fiveash, Corrine E.; Bentley, Nicholas L.; Kang, Myung-Jin; Govindaraju, Hemna; Barbour, Jayne A.; Wilkins, Brendan P.; Hancock, Sarah E.; Madawala, Romanthi; Das, Abhijit; Massudi, Hassina; Li, Catherine; Kim, Lynn-Jee; Wong, Ashley S. A.; Marinova, Maria B.; Sultani, Ghazal; Das, Abhirup; Youngson, Neil A.; Le Couteur, David G.; Sinclair, David A.; Turner, Nigel
errShare
errSave
Restricting mealtime ameliorates neurodegeneration
errCELL METABOLISM
IF30.9
err2023-10-01
err1
errOAAI
errTian, Xiao; Sinclair, David A.
errShare
errSave
Host-microbiome interactions in nicotinamide mononucleotide (NMN) deamidation
errFEBS LETTERS
IF3
err2023-08-09
err10
errOAAI
errKim, Lynn-Jee; Chalmers, Timothy J. J.; Madawala, Romanthi; Smith, Greg C. C.; Li, Catherine; Das, Abhirup; Poon, Eric Wing Keung; Wang, Jun; Tucker, Simon P. P.; Sinclair, David A. A.; Quek, Lake-Ee; Wu, Lindsay E. E.
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errSave
The multifactorial nature of healthy brain ageing: Brain changes, functional decline and protective factors
errAGEING RESEARCH REVIEWS
IF12.4
err2023-07-01
err21
errOAAI
errTurrini, Sonia; Wong, Bonnie; Eldaief, Mark; Press, Daniel Z.; Sinclair, David A.; Koch, Giacomo; Avenanti, Alessio; Santarnecchi, Emiliano
errShare
errSave
Defining a longevity biotechnology company
errNATURE BIOTECHNOLOGY
IF41.7
err2023-06-26
err0
PREAI
errBoekstein, Nicola; Barzilai, Nir; Bertram, Andre; Betts-LaCroix, Joe; Fortney, Kristen; Helliwell, Stephen B.; Hufford, Michael; Mannick, Joan; McLaughlin, Jerry; Mellon, Jim; Morgen, Eric; Regge, Nils; Robinton, Daisy A.; Sinclair, David A.; Young, Sergey; Starr, Risa; Zhavoronkov, Alex; Peyer, James
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errSave
SIRT3 overexpression in rat muscle does not ameliorate peripheral insulin resistance
errJOURNAL OF ENDOCRINOLOGY
IF3.9
err2023-06-19
err0
PREAI
errOsborne, Brenna; Wright, Lauren E.; Brandon, Amanda E.; Stuart, Ella; Small, Lewin; Hoeks, Joris; Schrauwen, Patrick; Sinclair, David A.; Montgomery, Magdalene K.; Cooney, Gregory J.; Turner, Nigel
errShare
errSave

Research Directions

No research directions
Co-authors
Cooperation Journals
L
Luigi Ferrucci
H-index: 237 · Papers: 2.6K
M
Mark P. Mattson
H-index: 217 · Papers: 1.3K
S
Steven P. Gygi
H-index: 195 · Papers: 1.0K
J
Johan Auwerx
H-index: 183 · Papers: 913
H
Holger J. Schünemann
H-index: 174 · Papers: 1.2K
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