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SaveOpen Targets Platform: facilitating therapeutic hypotheses building in drug discovery
Buniello, Annalisa; Suveges, Daniel; Cruz-Castillo, Carlos; Llinares, Manuel Bernal; Cornu, Helena; Lopez, Irene; Tsukanov, Kirill; Roldan-Romero, Juan Maria; Mehta, Chintan; Fumis, Luca; Mcneill, Graham; Hayhurst, James D.; Osorio, Ricardo Esteban Martinez; Barkhordari, Ehsan; Ferrer, Javier; Carmona, Miguel; Uniyal, Prashant; Falaguera, Maria J.; Rusina, Polina; Smit, Ines; Schwartzentruber, Jeremy; Alegbe, Tobi; Ho, Vivien W.; Considine, Daniel; Ge, Xiangyu; Szyszkowski, Szymon; Tsepilov, Yakov; Ghoussaini, Maya; Dunham, Ian; Hulcoop, David G.; Mcdonagh, Ellen M.; Ochoa, David Share Save Human Genetics and Genomics for Drug Target Identification and Prioritization: Open Targets' PerspectiveMcdonagh, Ellen M.; Trynka, Gosia; Mccarthy, Mark; Holzinger, Emily Rose; Khader, Shameer; Nakic, Nikolina; Hu, Xinli; Cornu, Helena; Dunham, Ian; Hulcoop, David Share Save Share Save FORGEdb: a tool for identifying candidate functional variants and uncovering target genes and mechanisms for complex diseasesBreeze, Charles E.; Haugen, Eric; Gutierrez-Arcelus, Maria; Yao, Xiaozheng; Teschendorff, Andrew; Beck, Stephan; Dunham, Ian; Stamatoyannopoulos, John; Franceschini, Nora; Machiela, Mitchell J.; Berndt, Sonja I. Share Save Share Save Democratizing knowledge representation with BioCypherLobentanzer, Sebastian; Aloy, Patrick; Baumbach, Jan; Bohar, Balazs; Carey, Vincent J.; Charoentong, Pornpimol; Danhauser, Katharina; Dogan, Tunca; Dreo, Johann; Dunham, Ian; Farr, Elias; Fernandez-Torras, Adria; Gyori, Benjamin M.; Hartung, Michael; Hoyt, Charles Tapley; Klein, Christoph; Korcsmaros, Tamas; Maier, Andreas; Mann, Matthias; Ochoa, David; Pareja-Lorente, Elena; Popp, Ferdinand; Preusse, Martin; Probul, Niklas; Schwikowski, Benno; Sen, Buenyamin; Strauss, Maximilian T.; Turei, Denes; Ulusoy, Erva; Waltemath, Dagmar; Wodke, Judith A. H.; Saez-Rodriguez, Julio Share Save Share Save Share Save The next-generation Open Targets Platform: reimagined, redesigned, rebuiltOchoa, David; Hercules, Andrew; Carmona, Miguel; Suveges, Daniel; Baker, Jarrod; Malangone, Cinzia; Lopez, Irene; Miranda, Alfredo; Cruz-Castillo, Carlos; Fumis, Luca; Bernal-Llinares, Manuel; Tsukanov, Kirill; Cornu, Helena; Tsirigos, Konstantinos; Razuvayevskaya, Olesya; Buniello, Annalisa; Schwartzentruber, Jeremy; Karim, Mohd; Ariano, Bruno; Osorio, Ricardo Esteban Martinez; Ferrer, Javier; Ge, Xiangyu; Machlitt-Northen, Sandra; Gonzalez-Uriarte, Asier; Saha, Shyamasree; Tirunagari, Santosh; Mehta, Chintan; Roldan-Romero, Juan Maria; Horswell, Stuart; Young, Sarah; Ghoussaini, Maya; Hulcoop, DavidG; Dunham, Ian; McDonagh, EllenM Share Save Share Save Multi-ancestry Mendelian randomization of omics traits revealing drug targets of COVID-19 severityZheng, Jie; Zhang, Yuemiao; Zhao, Huiling; Liu, Yi; Baird, Denis; Karim, Mohd Anisul; Ghoussaini, Maya; Schwartzentruber, Jeremy; Dunham, Ian; Elsworth, Benjamin; Roberts, Katherine; Compton, Hannah; Miller-Molloy, Felix; Liu, Xingzi; Wang, Lin; Zhang, Hong; Smith, George Davey; Gaunt, Tom R. Share Save Whole-exome sequencing identifies rare genetic variants associated with human plasma metabolitesBomba, Lorenzo; Walter, Klaudia; Guo, Qi; Surendran, Praveen; Kundu, Kousik; Nongmaithem, Suraj; Karim, Mohd Anisul; Stewart, Isobel D.; Langenberg, Claudia; Danesh, John; Di Angelantonio, Emanuele; Roberts, David J.; Ouwehand, Willem H.; Dunham, Ian; Butterworth, Adam S.; Soranzo, Nicole Share Save Immune disease variants modulate gene expression in regulatory CD4+ T cellsBossini-Castillo, Lara; Glinos, Dafni A.; Kunowska, Natalia; Golda, Gosia; Lamikanra, Abigail A.; Spitzer, Michaela; Soskic, Blagoje; Cano-Gamez, Eddie; Smyth, Deborah J.; Cattermole, Claire; Alasoo, Kaur; Mann, Alice; Kundu, Kousik; Lorenc, Anna; Soranzo, Nicole; Dunham, Ian; Roberts, David J.; Trynka, Gosia Share Save CACHE (Critical Assessment of Computational Hit-finding Experiments): A public-private partnership benchmarking initiative to enable the development of computational methods for hit-findingAckloo, Suzanne; Al-awar, Rima; Amaro, Rommie E.; Arrowsmith, Cheryl H.; Azevedo, Hatylas; Batey, Robert A.; Bengio, Yoshua; Betz, Ulrich A. K.; Bologa, Cristian G.; Chodera, John D.; Cornell, Wendy D.; Dunham, Ian; Ecker, Gerhard F.; Edfeldt, Kristina; Edwards, Aled M.; Gilson, Michael K.; Gordijo, Claudia R.; Hessler, Gerhard; Hillisch, Alexander; Hogner, Anders; Irwin, John J.; Jansen, Johanna M.; Kuhn, Daniel; Leach, Andrew R.; Lee, Alpha A.; Lessel, Uta; Morgan, Maxwell R.; Moult, John; Muegge, Ingo; Oprea, Tudor, I; Perry, Benjamin G.; Riley, Patrick; Rousseaux, Sophie A. L.; Saikatendu, Kumar Singh; Santhakumar, Vijayaratnam; Schapira, Matthieu; Scholten, Cora; Todd, Matthew H.; Vedadi, Masoud; Volkamer, Andrea; Willson, Timothy M. Share Save Integrative analysis of 3604 GWAS reveals multiple novel cell type-specific regulatory associationsBreeze, Charles E.; Haugen, Eric; Reynolds, Alex; Teschendorff, Andrew; van Dongen, Jenny; Lan, Qing; Rothman, Nathaniel; Bourque, Guillaume; Dunham, Ian; Beck, Stephan; Stamatoyannopoulos, John; Franceschini, Nora; Berndt, Sonja, I Share Save The PROTACtable genomeSchneider, Melanie; Radoux, Chris J.; Hercules, Andrew; Ochoa, David; Dunham, Ian; Zalmas, Lykourgos-Panagiotis; Hessler, Gerhard; Ruf, Sven; Shanmugasundaram, Veerabahu; Hann, Michael M.; Thomas, Pam J.; Queisser, Markus A.; Benowitz, Andrew B.; Brown, Kris; Leach, Andrew R. Share Save Share Save Open Targets Platform: supporting systematic drug-target identification and prioritisationOchoa, David; Hercules, Andrew; Carmona, Miguel; Suveges, Daniel; Gonzalez-Uriarte, Asier; Malangone, Cinzia; Miranda, Alfredo; Fumis, Luca; Carvalho-Silva, Denise; Spitzer, Michaela; Baker, Jarrod; Ferrer, Javier; Raies, Arwa; Razuvayevskaya, Olesya; Faulconbridge, Adam; Petsalaki, Eirini; Mutowo, Prudence; Machlitt-Northen, Sandra; Peat, Gareth; McAuley, Elaine; Ong, Chuang Kee; Mountjoy, Edward; Ghoussaini, Maya; Pierleoni, Andrea; Papa, Eliseo; Pignatelli, Miguel; Koscielny, Gautier; Karim, Mohd; Schwartzentruber, Jeremy; Hulcoop, David G.; Dunham, Ian; McDonagh, Ellen M. Share Save Open Targets Genetics: systematic identification of trait-associated genes using large-scale genetics and functional genomicsGhoussaini, Maya; Mountjoy, Edward; Carmona, Miguel; Peat, Gareth; Schmidt, Ellen M.; Hercules, Andrew; Fumis, Luca; Miranda, Alfredo; Carvalho-Silva, Denise; Buniello, Annalisa; Burdett, Tony; Hayhurst, James; Baker, Jarrod; Ferrer, Javier; Gonzalez-Uriarte, Asier; Jupp, Simon; Karim, Mohd Anisul; Koscielny, Gautier; Machlitt-Northen, Sandra; Malangone, Cinzia; Pendlington, Zoe May; Roncaglia, Paola; Suveges, Daniel; Wright, Daniel; Vrousgou, Olga; Papa, Eliseo; Parkinson, Helen; MacArthur, Jacqueline A. L.; Todd, John A.; Barrett, Jeffrey C.; Schwartzentruber, Jeremy; Hulcoop, David G.; Ochoa, David; McDonagh, Ellen M.; Dunham, Ian Share Save 
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