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Stephen Neidle

pharmacy

101H-index
791Paper Count
3.9WCitation Count
Published Papers 187
Publication Date
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DNA damaging properties of G-quadruplex ligand QN-302 are potentiated by the DNA repair inhibitor Olaparib and mitigated by the molecular helicase PhpC
errGenome Biology
IF9.4
err2026-04-11
err0
errOAAI
errGarance Psalmon; Angélique Pipier; Manon Barbotte; Robert H. E. Hudson; Stephen Neidle; David Monchaud
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Cellular adaptations impact the biological activity of naphthalene diimide G-quadruplex ligands in ALT-positive osteosarcoma cells
errCell Death & Disease
IF9.6
err2025-08-01
err0
errOAAI
errJoanna Bidzinska; Lorenzo Di Pietro; Eisa Naghshineh; Cecilia Pandini; Filippo Doria; Nadia Zaffaroni; Paolo Gandellini; Stephen Neidle; Marco Folini
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Alternative Approach to Sequence-Specific Recognition of DNA: Cooperative Stacking of Dication Dimers-Sensitivity to Compound Curvature, Aromatic Structure, and DNA Sequence
errACS CHEMICAL BIOLOGY
IF3.8
err2025-02-07
err0
PREAI
errPaul, Ananya; Terrell, J. Ross; Farahat, Abdelbasset A.; Ogbonna, Edwin N.; Kumar, Arvind; Boykin, David W.; Neidle, Stephen; Wilson, W. David
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Interaction of N-methylmesoporphyrin IX with a hybrid left-/right-handed G-quadruplex motif from the promoter of the SLC2A1 gene
errNUCLEIC ACIDS RESEARCH
IF13.1
err2024-12-19
err0
errOAAI
errSeth, Paul; Xing, Eric; Hendrickson, Andrew D.; Li, Kevin; Monsen, Robert; Chaires, Jonathan B.; Neidle, Stephen; Yatsunyk, Liliya A.
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A Phenotypic Approach to the Discovery of Potent G-Quadruplex Targeted Drugs
errMOLECULES
IF4.6
err2024-08-01
err10
errOAAI
errNeidle, Stephen
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Structural basis of water-mediated cis Watson-Crick/Hoogsteen base-pair formation in non-CpG methylation
errNUCLEIC ACIDS RESEARCH
IF13.1
err2024-07-11
err0
errOAAI
errLin, Shan-Meng; Huang, Hsiang-Ti; Fang, Pei-Ju; Chang, Chi-Fon; Satange, Roshan; Chang, Chung-ke; Chou, Shan-Ho; Neidle, Stephen; Hou, Ming-Hon
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Early clinical experience with a novel first-in-class G-quadruplex experimental anti-cancer drug
errCANCER RESEARCH
IF16.6
err2024-04-05
err1
PREAI
errArshad, Tariq; Neidle, Stephen; Chandana, Sreenivasa; Borazanci, Erkut
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The pan-quadruplex drug QN-302 selectively down-regulates key pathway targets in pancreatic cancer cells that are up- regulated in human pancreatic cancer
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errNeidle, Stephen; Ahmed, Ahmed A.; Arshad, Tariq
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The pan-quadruplex drug QN-302 targets up-regulated genes in pancreatic cancer and in other cancer types and correlate with poor patient prognosis
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errNeidle, Stephen; Ahmed, Ahmed A.; Arshad, Tariq
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Characterization of the biological effects of a quadruplex-interacting molecule in dedifferentiated liposarcoma cells
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errNaghshineh, Eisa; Tosoni, Beatrice; Di Pietro, Lorenzo; Pasquali, Sandro; Zaffaroni, Nadia; Neidle, Stephen; Richter, Sara N.; Folini, Marco
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errSave
Structure-activity relationships for the pan-quadruplex experimental drug QN-302 and two analogs probed with comparative transcriptome profiling and molecular modeling
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errAhmed, Ahmed A.; Haider, Shozeb; Arshad, Tariq; Neidle, Stephen
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errSave
Structure-activity relationships for the G-quadruplex-targeting experimental drug QN-302 and two analogues probed with comparative transcriptome profiling and molecular modeling
errSCIENTIFIC REPORTS
IF3.9
err2024-02-11
err19
errOAAI
errAhmed, Ahmed Abdullah; Chen, Shuang; Roman-Escorza, Maria; Angell, Richard; Oxenford, Sally; McConville, Matthew; Barton, Naomi; Sunose, Mihiro; Neidle, Dan; Haider, Shozeb; Arshad, Tariq; Neidle, Stephen
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On Water Arrangements in Right- and Left-Handed DNA Structures
errMOLECULES
IF4.6
err2024-01-19
err4
errOAAI
errYatsunyk, Liliya A.; Neidle, Stephen
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The pan-quadruplex experimental drug QN-302 in pancreatic ductal adenocarcinoma (PDAC): Potential biomarkers for clinical studies
errCANCER RESEARCH
IF16.6
err2024-01-16
err0
PREAI
errAhmed, Ahmed; Arshad, Tariq; Neidle, Stephen
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Target genes in pancreatic cancer cells of the pan-quadruplex clinical candidate compound QN-302 revealed by comparative transcriptome profiling
errCANCER RESEARCH
IF16.6
err2024-01-16
err0
PREAI
errAhmed, Ahmed; Arshad, Tariq; Roman-Escorza, Maria; Neidle, Dan M.; Neidle, Stephen
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On the origins of the conflict between Rosalind Franklin and Maurice Wilkins
errNATURE REVIEWS CHEMISTRY
IF51.7
err2023-10-12
err0
PREAI
errNeidle, Stephen
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errSave
A comparison of the activity of the quadruplex-targeting experimental drugs QN-302 and CX-5461 (pidnarulex) in wild-type and gemcitabine-resistant pancreatic cancer cell lines
errCANCER RESEARCH
IF16.6
err2023-04-04
err1
PREAI
errAhmed, Ahmed; Arshad, Tariq; Neidle, Stephen
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Structure-based design rules for potent quadruplex-binding compounds based on the naphthalene diimide core
errCANCER RESEARCH
IF16.6
err2023-04-04
err0
PREAI
errNeidle, Stephen
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The potent quadruplex-binding compound QN302 shows anti-tumor activity as a monotherapy in an orthotopic in vivo model of pancreatic cancer
errCANCER RESEARCH
IF16.6
err2023-04-04
err0
PREAI
errWilliams, Nicole; Santos, Danielle; Worthington, Jenny; Ahmed, Ahmed; Arshad, Tariq; Neidle, Stephen
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errSave
The potent quadruplex-binding compound QN-302 down-regulates the S100P gene in in vitro and in vivo models of pancreatic cancer: a potential therapeutic target and biomarker for PDAC
errCANCER RESEARCH
IF16.6
err2023-04-04
err0
PREAI
errWilliams, Nicole; Worthington, Jenny; Ahmed, Ahmed; Arshad, Tariq; Neidle, Stephen
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errSave

Research Directions

No research directions
Co-authors
Cooperation Journals
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Henrik Zetterberg
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D
Dinshaw J. Patel
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Linda Partridge
H-index: 134 · Papers: 857
H
Henry Houlden
H-index: 120 · Papers: 1.5K
S
Shankar Balasubramanian
H-index: 118 · Papers: 521
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