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Stephen E. Girardin

university of toronto

85H-index
253Paper Count
3.3WCitation Count
Published Papers 133
Publication Date
Endothelial cell-intrinsic NOD2 signaling regulates the intestinal immune response through the generation of effector and memory T cells
err2026-07-20
err0
PREAI
errBoyan K. Tsankov; Madison Denney; Jennifer S. Y. Ahn; Charles Carr; Nayanan Nathan; Derek K. L. Tsang; Giuliano Bayer; Lauren Baerg; Alexander Luchak; Tapas Mukherjee; Elaine Tam; Bana Samman; Jennifer L. Gommerman; Stephen E. Girardin; Dana J. Philpott
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Bacterial ADP-heptose triggers stem cell regeneration in the intestinal epithelium following injury
err2025-07-11
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PREAI
errShawn Goyal; Cynthia X. Guo; Ojas Singh; Adrienne Ranger; Caitlin F. Harrigan; Justin Meade; Alexander Luchak; Derek K. Tsang; Herbert Y. Gaisano; Nan Gao; Scott A. Yuzwa; Jeffrey L. Wrana; Dana J. Philpott; Scott D. Gray-Owen; Stephen E. Girardin
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The innate immune receptor NLRX1 is a novel required modulator for mPTP opening: implications for cardioprotection
err2025-06-19
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errOAAI
errY. Xiao; X. Hu; C. F. Rudolphi; E. E. Nollet; R. Nederlof; Q. Wang; D. Bakker; Panagiota Efstathia Nikolaou; J. C. Knol; R. R. Goeij-de Haas; A. A. Henneman; T. V. Pham; C. R. Jimenez; A. E. Grootemaat; N. N. van der Wel; S. E. Girardin; N. Kaludercic; J. van der Velden; Z. Onódi; P. Leszek; Z. V. Varga; P. Ferdinandy; B. Preckel; N. C. Weber; M. W. Hollmann; F. Di Lisa; C. J. Zuurbier
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Gasdermin-D pores induce an inactivating caspase-4 cleavage that limits IL-18 production in the intestinal epithelium
err2025-05-13
err0
errOAAI
errBruce, J. K.; Li, L. Y.; Tang, Y.; Forster, E. G.; Winsor, N. J.; Bi, P. Y.; Krustev, C.; Keely, S.; Lee, J. E.; Rohde, J. R.; Gaisano, H. Y.; Philpott, D. J.; Girardin, S. E.
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Cross-kingdom-mediated detection of intestinal protozoa through NLRP6
err2025-03-01
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PREAI
errWinsor, Nathaniel J.; Bayer, Giuliano; Singh, Ojas; Chan, Jeremy K.; Li, Lu Yi; Lieng, Brandon Y.; Foerster, Elisabeth; Popovic, Ana; Tsankov, Boyan K.; Maughan, Heather; Lemire, Paul; Tam, Elaine; Streutker, Catherine; Chen, Lina; Heaver, Stacey L.; Ley, Ruth E.; Parkinson, John; Montenegro-Burke, J. Rafael; Birchenough, George M. H.; Philpott, Dana J.; Girardin, Stephen E.
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Activation of the NLRP1B inflammasome by caspase-8
err2024-09-17
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errOAAI
errMeade, Justin J.; Stuart, Sarah; Neiman-Zenevich, Jana; Krustev, Christian; Girardin, Stephen E.; Mogridge, Jeremy
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The conceptual foundations of innate immunity: Taking stock 30 years later
errIMMUNITY
IF26.3
err2024-04-01
err10
errOAAI
errPradeu, Thomas; Thomma, Bart P. H. J.; Girardin, Stephen E.; Lemaitre, Bruno
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Cytosolic retention of HtrA2 during mitochondrial protein import stress triggers the DELE1-HRI pathway
err2024-03-30
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errOAAI
errBi, Paul Y.; Killackey, Samuel A.; Schweizer, Linus; Arnoult, Damien; Philpott, Dana J.; Girardin, Stephen E.
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NLRX1: Versatile functions of a mitochondrial NLR protein that controls mitophagy
err2024-02-01
err11
errOAAI
errSchweizer, Linus; Bi, Paul Y.; Killackey, Samuel A.; Girardin, Stephen E.
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NLRX1 Prevents M2 Macrophage Polarization and Excessive Renal Fibrosis in Chronic Obstructive Nephropathy
errCELLS
IF5.2
err2023-12-21
err2
errOAAI
errLiu, Ye; Kors, Lotte; Butter, Loes M.; Stokman, Geurt; Claessen, Nike; Zuurbier, Coert J.; Girardin, Stephen E.; Leemans, Jaklien C.; Florquin, Sandrine; Tammaro, Alessandra
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ATG16L1 protects from interferon-γ-induced cell death in the small intestinal crypt
err2023-04-01
err4
errOAAI
errFoerster, Elisabeth G.; Tsang, Derek K. L.; Goyal, Shawn; Robertson, Susan J.; Robert, Lukian M.; Maughan, Heather; Streutker, Catherine J.; Girardin, Stephen E.; Philpott, Dana J.
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Isoginkgetin, a Natural Biflavonoid Proteasome Inhibitor, Sensitizes Cancer Cells to Apoptosis via Disruption of Lysosomal Homeostasis and Impaired Protein Clearance
err2023-03-03
err25
errOAAI
errTsalikis, Jessica; Abdel-Nour, Mena; Farahvash, Armin; Sorbara, Matthew T.; Poon, Stephanie; Philpott, Dana J.; Girardin, Stephen E.
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Invading Bacterial Pathogens Activate Transcription Factor EB in Epithelial Cells through the Amino Acid Starvation Pathway of mTORC1 Inhibition
err2023-02-27
err5
errOAAI
errCabral-Fernandes, Liliane; Goyal, Shawn; Farahvash, Armin; Tsalikis, Jessica; Philpott, Dana J.; Girardin, Stephen E.
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The innate immune receptor NLRX1 protects against cardiac ischemia/reperfusion injury through RISK signaling, mPTP regulation and inhibition of mitochondrial activity
err2022-12-01
err0
PREAI
errXiao, Yang; Rudolphi, Crissy; Nollet, Edgar; Bakker, Diane; Nederlof, Rianne; Wang, Qian; Grootemaat, Anita; Girardin, Stephen; Van der Velden, Jolanda; Wel, Nicole; Varga, Zoltan; Ferdinandy, Peter; Hollmann, Markus; Weber, Nina; Zuurbier, Coert
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Mitochondria-ER cooperation: NLRX1 detects mitochondrial protein import stress and promotes mitophagy through the ER protein RRBP1
errAUTOPHAGY
IF14.3
err2022-10-04
err6
errOAAI
errKillackey, Samuel A.; Bi, Yuntian; Philpott, Dana J.; Arnoult, Damien; Girardin, Stephen E.
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Bone marrow adipocytes drive the development of tissue invasive Ly6Chigh monocytes during obesity
err2022-09-20
err17
errOAAI
errBoroumand, Parastoo; Prescott, David C.; Mukherjee, Tapas; Bilan, Philip J.; Wong, Michael; Shen, Jeff; Tattoli, Ivan; Zhou, Yuhuan; Li, Angela; Sivasubramaniyam, Tharini; Shi, Nancy; Zhu, Lucie Y.; Liu, Zhi; Robbins, Clinton; Philpott, Dana J.; Girardin, Stephen E.; Klip, Amira
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A single cell survey of the microbial impacts on the mouse small intestinal epithelium
err2022-08-08
err13
errOAAI
errTsang, Derek K. L.; Wang, Ryan J.; De Sa, Oliver; Ayyaz, Arshad; Foerster, Elisabeth G.; Bayer, Giuliano; Goyal, Shawn; Trcka, Daniel; Ghoshal, Bibaswan; Wrana, Jeffrey L.; Girardin, Stephen E.; Philpott, Dana J.
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Mitochondrial protein import stress regulates the LC3 lipidation step of mitophagy through NLRX1 and RRBP1
err2022-08-01
err30
errOAAI
errKillackey, Samuel A.; Bi, Yuntian; Soares, Fraser; Hammi, Ikram; Winsor, Nathaniel J.; Abdul-Sater, Ali A.; Philpott, Dana J.; Arnoult, Damien; Girardin, Stephen E.
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Intestinal epithelial autophagy protects from cytokine-driven mortality and IFNγ-dependent cell death in acute small intestinal injury
err2022-05-01
err0
PREAI
errFoerster, Elisabeth G.; Streutker, Catherine J.; Maughan, Heather; Tsang, Derek Kl; Robert, Lukian M.; De Sa, Oliver; Girardin, Stephen E.; Philpott, Dana J.
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Defects in NLRP6, autophagy and goblet cell homeostasis are associated with reduced duodenal CRH receptor 2 expression in patients with functional dyspepsia
err2022-03-01
err17
PREAI
errBruce, Jessica K.; Burns, Grace L.; Soh, Wai Sinn; Nair, Prema M.; Sherwin, Simonne; Fan, KeNing; Dowling, Laura R.; Goggins, Bridie J.; Koloski, Natasha; Potter, Michael; Bollipo, Steven; Foster, Robert; Gan, Lay T.; Veysey, Martin; Philpott, Dana J.; Girardin, Stephen E.; Holtmann, Gerald; Kaiko, Gerard E.; Walker, Marjorie M.; Talley, Nicholas J.; Keely, Simon
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