Gordon J. Freeman - Publications, H-index & Citations

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Gordon J. Freeman

harvard medical school

174H-index

1.1KPaper Count

13.0WCitation Count

Published Papers 277

Publication Date

IDH1-R132H enhances oncolytic HSV-1 therapy by facilitating viral entry and immune activation in glioma

Nature Communications

IF15.7

2026-06-17

OAAI

Eleni Panagioti; Hunter J. Kelley; Alexander L. Ling; Leinal Sejour; Shikha Saini; William F. Goins; Daniel Roberts; Sotiris Sotiriou; J. Bryan Iorgulescu; Karen O. Dixon; Michael B. Yaffe; Ioannis S. Vlachos; Maria G. Castro; Sean E. Lawler; Gordon J. Freeman; Vijay K. Kuchroo; E. Antonio Chiocca; Charles H. Cook

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Targeting FGFR signaling overcomes therapeutic resistance and immune evasion in oncogenic PIK3CA-driven serous-like endometrial cancer

Nature Communications

IF15.7

2026-05-04

OAAI

Xin Cheng; Yadong Zhang; Changli Qian; Erica Holdridge; Guruprasad Ananda; Tao Jiang; Jing Ni; Shaozhen Xie; Hao Gu; Renlei Ji; Elena V. Ivanova; Marisa R. Nucci; Zhe Wang; Kaifu Chen; Bose Kochupurakkal; Gordon J. Freeman; Geoffrey I. Shapiro; Joyce Liu; Panagiotis A. Konstantinopoulos; Ursula Matulonis; Jean J. Zhao

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Exposed phosphatidylserine is an inhibitory molecule in T cell exhaustion

Nature

IF48.5

2026-03-25

PREAI

Christopher B. Medina; Ewelina Sobierajska; Minghao Gong; Daniel T. McManus; Maheshwor Thapa; Judong Lee; Se Jin Im; Jason E. Toombs; Joshua M. Mitchell; Yating Wang; Jennifer W. Carlisle; Gordon J. Freeman; Viraj A. Master; Suresh S. Ramalingam; Haydn T. Kissick; Shuzhao Li; Rolf A. Brekken; Rafi Ahmed

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Destruction of VISTA by TRIM25 ablation in T cells potentiates cancer immunotherapy

Cell Research

IF25.9

2025-11-13

PREAI

Yishuang Sun; Zijian Zhang; Haiou Li; Xia Bu; Li Chen; Xiyong Wang; Lifang Fan; Baoxiang Chen; Lijun Kong; Panpan Dai; Wenjing Song; Xiangling Xiao; Jie Shi; Bolin Xiang; Chuan He; Yingmeng Yao; Wenjun Xiong; Haisheng Yu; Congqing Jiang; Qun Qian; Hudan Liu; Sufang Tian; Guoliang Qing; Zhiyong Yang; Wenyi Wei; Gordon J. Freeman; Haichuan Zhu; Jinfang Zhang

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Targeted destruction of VISTA boosts anti-tumor immunotherapy

Cell Research

IF25.9

2025-11-13

PREAI

Li Chen; Xia Bu; Yishuang Sun; Daoyuan Huang; Yong Chen; Tao Hou; Xiaoping Hu; Jingchao Wang; Peiqiang Yan; Yihang Qi; Weiwei Jiang; Yan Xiong; Jing Liu; Yang Gao; Mengxi Huan; Bin Wang; Qianjia Liu; Xiaoming Dai; Fabin Dang; John M. Asara; Masanori Fujimoto; Hiroyuki Inuzuka; Jian Jin; Jinfang Zhang; Gordon J. Freeman; Wenyi Wei

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Exposed phosphatidylserine is a non-classical inhibitory molecule during CD8 T cell exhaustion

JOURNAL OF IMMUNOLOGY

IF3.4

2025-11-01

PREAI

Medina, Christopher B.; Sobierajska, Ewelina; Gong, Minghao; McManus, Daniel Thomas; Thapa, Maheshwor; Lee, Judong; Im, Sejin; Toombs, Jason; Mitchell, Joshua; Carlisle, Jennifer; Freeman, Gordon J.; Master, Viraj; Ramalingam, Suresh; Kissick, Haydn; Li, Shuzhao; Brekken, Rolf; Ahmed, Rafi

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Overcoming microbiome-dependent resistance to cancer immunotherapy

JOURNAL OF IMMUNOLOGY

IF3.4

2025-11-01

PREAI

Park, Joon Seok; Gazzaniga, Francesca S.; Wu, Meng; Luthens, Amalia K.; Gillis, Jacob; Zheng, Wen; LaFleur, Martin W.; Johnson, Sarah B.; Morad, Golnaz; Park, Elizabeth M.; Zhou, Yifan; Watowich, Stephanie S.; Wargo, Jennifer A.; Freeman, Gordon J.; Kasper, Dennis L.; Sharpe, Arlene H.

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CD163+Tumor-Associated macrophages and clinical outcomes to First-Line nivolumab therapy in patients with metastatic clear cel renal cell carcinoma: insights from the HCRN GU16-260 trial

ONCOLOGIST

IF4.2

2025-10-01

OAAI

Simsek, Berkay; Paul, Morgan A.; Xie, Wanling; El Ahmar, Nourhan; Matar, Sayed; Laimon, Yasmin Nabil; RobertiDe Oliveira, Gabriel; Mohanna, Razan; Delcea, Andrew; Choueri, Toni; Braun, David; Sun, Maxine; Haas, Naomi B.; Hammers, Hans J.; Bilen, Mehmet; Stein, Mark N.; Sosman, Jeffrey A.; Freeman, Gordon J.; Wu, Catherine; Mcdermott, David; Atkins, Michael B.; Signoretti, Sabina

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PD-1 is requisite for skin TRM cell formation and specification by TGFβ

Nature Immunology

IF27.6

2025-07-29

OAAI

K. Sanjana P. Devi; Eric Wang; Abhinav Jaiswal; Piotr Konieczny; Tae-Gyun Kim; Christopher J. Nirschl; Akanksha Verma; Yong Liu; Julia Milczanowski; Susan N. Christo; Luke C. Gandolfo; Karyn Haitz; Trupti D. Vardam; Pinru Wu; Sandra L. King; Sze-Wah Tse; Komal Pradhan; Xiaodong Jiang; Tian Tian; Robert C. Fuhlbrigge; Chrysalyne D. Schmults; Rachael A. Clark; Thomas S. Kupper; Gordon J. Freeman; Laura K. Mackay; Shruti Naik; Evan W. Newell; Olivier Elemento; Mayte Suarez-Farinas; Niroshana Anandasabapathy

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RGMb drives macrophage infiltration to aggravate kidney disease

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2025-03-13

OAAI

Kong, Yonglun; Yue, Ming; Xu, Chunhua; Zhang, Jing; Hong, Huiling; Lu, Jiahuan; Wang, Yang; Zhang, Xiaoyi; Chen, Qiuju; Yang, Chen; Liu, Hua - Feng; Qin, Jinzhong; Zhou, Jingying; Lee, Nam Y.; Lin, Bin; Tian, Xiaoyu; Freeman, Gordon J.; Xia, Yin

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Tertiary Lymphoid Structures Predict Response to First-Line Nivolumab Therapy in Advanced Renal Cell Carcinoma: Findings from the HCRN GU16-260 Clinical Trial

LABORATORY INVESTIGATION

IF4.2

2025-03-01

PREAI

El Ahmar, Nourhan; Simsek, Berkay; Jegede, Opeyemi; Matar, Sayed; Savla, Varunika; Laimon, Yasmin; Mohanna, Razan; De Oliveira, Gabriel Roberti; Sheshdeh, Aseman Baghari; Delcea, Andrew; Paul, Morgan; Choueiri, Toni; Xie, Wanling; Freeman, Gordon; Braun, David; Haas, Naomi Balzer; Hammers, Hans; Bilen, Mehmet; Stein, Mark; Sosman, Jeffrey; Wu, Catherine; Mcdermott, David; Atkins, Michael; Signoretti, Sabina

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Targeting RGMb interactions: Discovery and preclinical characterization of potent anti-RGMb antibodies blocking multiple ligand bindings

MABS

IF7.3

2024-11-26

OAAI

Meira, Maria; Frey, Aurore; Chekkat, Neila; Rybczynska, Magda; Sellam, Zaki; Park, Joon Seok; Gazzaniga, Francesca Smylie; Parmentier, Alexia; Le Gall, Marianne; Freeman, Gordon James; Kasper, Dennis Lee; Sharpe, Arlene Helen; Rambeaux, Eric; Shamshiev, Abdijapar

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Targeting METTL3 reprograms the tumor microenvironment to improve cancer immunotherapy

CELL CHEMICAL BIOLOGY

IF7.2

2024-04-01

OAAI

Yu, Haisheng; Liu, Jing; Bu, Xia; Ma, Zhiqiang; Yao, Yingmeng; Li, Jinfeng; Zhang, Tiantian; Song, Wenjing; Xiao, Xiangling; Sun, Yishuang; Xiong, Wenjun; Shi, Jie; Dai, Panpan; Xiang, Bolin; Duan, Hongtao; Yan, Xiaolong; Wu, Fei; Zhang, Wen Cai; Lin, Dandan; Hu, Hankun; Zhang, Haojian; Slack, Frank J.; He, Housheng Hansen; Freeman, Gordon J.; Wei, Wenyi; Zhang, Jinfang

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Deciphering the effects of age on T cell immunity and immunotherapy

CANCER RESEARCH

IF16.6

2024-03-22

PREAI

Han, SeongJun; Georgiev, Peter; Schneider, Jaime; Huang, Amy; Nugmanova, Zhanel; Nguyen, Thao H.; Yao, Conghui; Johnson, Sheila; Joshi, Shakchhi; Dhiman, Ishita; Drijvers, Jefte M.; Fung, Megan; Rowe, Jared H.; Miller, Brian C.; Freeman, Gordon J.; Ringel, Alison E.; Haigis, Marcia C.; Sharpe, Arlene H.

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Affinity fine-tuning anti-CAIX CAR-T cells mitigate on-target off-tumor side effects

MOLECULAR CANCER

IF33.9

2024-03-16

OAAI

Wang, Yufei; Buck, Alicia; Piel, Brandon; Zerefa, Luann; Murugan, Nithyassree; Coherd, Christian D.; Miklosi, Andras G.; Johal, Haraman; Bastos, Ricardo Nunes; Huang, Kun; Ficial, Miriam; Laimon, Yasmin Nabil; Signoretti, Sabina; Zhong, Zhou; Hoang, Song-My; Kastrunes, Gabriella M.; Grimaud, Marion; Fayed, Atef; Yuan, Hsien-Chi; Nguyen, Quang-De; Thai, Tran; Ivanova, Elena V.; Paweletz, Cloud P.; Wu, Ming-Ru; Choueiri, Toni K.; Wee, Jon O.; Freeman, Gordon J.; Barbie, David A.; Marasco, Wayne A.

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The B7:CD28 family and friends Unraveling coinhibitory interactions

IMMUNITY

IF26.3

2024-02-01

OAAI

Burke, Kelly P.; Chaudhri, Apoorvi; Freeman, Gordon J.; Sharpe, Arlene H.

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Antigen presentation deficiency, mesenchymal differentiation, and resistance to immunotherapy in the murine syngeneic CT2A tumor model

FRONTIERS IN IMMUNOLOGY

IF5.9

2023-12-28

OAAI

Iorgulescu, J. Bryan; Ruthen, Neil; Ahn, Ryuhjin; Panagioti, Eleni; Gokhale, Prafulla C.; Neagu, Martha; Speranza, Maria C.; Eschle, Benjamin K.; Soroko, Kara M.; Piranlioglu, Raziye; Datta, Meenal; Krishnan, Shanmugarajan; Yates, Kathleen B.; Baker, Gregory J.; Jain, Rakesh K.; Suva, Mario L.; Neuberg, Donna; White, Forest M.; Chiocca, E. Antonio; Freeman, Gordon J.; Sharpe, Arlene H.; Wu, Catherine J.; Reardon, David A.

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Regulation of HHLA2 expression in kidney cancer and myeloid cells

BMC CANCER

IF3.4

2023-10-27

OAAI

Shigemura, Tomonari; Perrot, Nahuel; Huang, Zimo; Bhatt, Rupal S.; Sheshdeh, Aseman Bagheri; Ahmar, Nourhan El; Ghandour, Fatme; Signoretti, Sabina; Mcdermott, David F.; Freeman, Gordon J.; Mahoney, Kathleen M.

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Formate Supplementation Enhances Antitumor CD8+ T-cell Fitness and Efficacy of PD-1 Blockade

CANCER DISCOVERY

IF33.3

2023-09-20

OAAI

Rowe, Jared H.; Elia, Ilaria; Shahid, Osmaan; Gaudiano, Emily F.; Sifnugel, Natalia E.; Johnson, Sheila; Reynolds, Amy G.; Fung, Megan E.; Joshi, Shakchhi; LaFleur, Martin W.; Park, Joon Seok; Pauken, Kristen E.; Rabinowitz, Joshua D.; Freeman, Gordon J.; Haigis, Marcia C.; Sharpe, Arlene H.

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The CX3CL1-CX3CR1 chemokine axis can contribute to tumor immune evasion and blockade with a novel CX3CR1 monoclonal antibody enhances response to anti-PD-1 immunotherapy

FRONTIERS IN IMMUNOLOGY

IF5.9

2023-09-13

OAAI

Chaudhri, Apoorvi; Bu, Xia; Wang, Yunfei; Gomez, Michael; Torchia, James A.; Hua, Ping; Hung, Shao-Hsi; Davies, Michael A.; Lizee, Gregory A.; von Andrian, Ulrich; Hwu, Patrick; Freeman, Gordon J.

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Research Directions