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K

Kristian Helin

University of Copenhagen

119H-index
447Paper Count
5.1WCitation Count
Published Papers 178
Publication Date
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Addressing the specific roles of histone modifications in transcriptional repression
errNature Communications
IF15.7
err2025-11-22
err0
errOAAI
errLin Hedehus; Aina M. Mas; Aktan Alpsoy; Robin L. Armstrong; Richard Koche; Tülin Tatar; Hua Wang; Kristian Helin
errShare
errSave
Functional dissection of H3K4 methyltransferases reveals distinct catalytic and non-catalytic roles in C. elegans development
errDEVELOPMENT
IF3.6
err2025-11-01
err0
errOAAI
errAttianese, Benedetta; Wang, Hua; Madsen, Katrine; Zeijdner, Mandoh; Helin, Kristian; Abay-Norgaard, Steffen; Salcini, Anna Elisabetta
errShare
errSave
A needed nomenclature for nucleosomes
errMolecular Cell
IF16.6
err2025-10-02
err0
PREAI
errMichael-Christopher Keogh; Genevieve Almouzni; Andrew J. Andrews; Karim-Jean Armache; Cheryl H. Arrowsmith; Sung Hee Baek; Mark T. Bedford; Emily Bernstein; Jacques Côté; Yael David; John M. Denu; Beat Fierz; Benjamin A. Garcia; Karen C. Glass; Or Gozani; Kristian Helin; Steven Henikoff; Ole N. Jensen; Steven Z. Josefowicz; Neil L. Kelleher; Tatiana G. Kutateladze; Herbert H. Lindner; Chao Lu; Karolin Luger; Parag Mallick; Catherine A. Musselman; Tom W. Muir; Ljiljana Paša-Tolić; Robert Schneider; Xiaobing Shi; Yang Shi; Simone Sidoli; Lloyd M. Smith; Jessica K. Tyler; Cynthia Wolberger; Jerry L. Workman; Brian D. Strahl; Nicolas L. Young
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errSave
ETV2/ER71 regulates hematovascular lineage generation and vascularization through an H3K9 demethylase, KDM4A
errISCIENCE
IF4.1
err2025-01-01
err0
PREAI
errKim, Min Seong; Lee, Raham; Lee, Dong Hun; Song, Heesang; Ha, Taekyung; Kim, Joo Kyung; Kang, Bum-Yong; Agger, Karl; Helin, Kristian; Shin, Donghyun; Kang, Yunhee; Park, Changwon
errShare
errSave
Inhibition of TOPORS ubiquitin ligase augments the efficacy of DNA hypomethylating agents through DNMT1 stabilization
errNATURE COMMUNICATIONS
IF15.7
err2024-08-28
err0
errOAAI
errKaito, Satoshi; Aoyama, Kazumasa; Oshima, Motohiko; Tsuchiya, Akiho; Miyota, Makiko; Yamashita, Masayuki; Koide, Shuhei; Nakajima-Takagi, Yaeko; Kozuka-Hata, Hiroko; Oyama, Masaaki; Yogo, Takao; Yabushita, Tomohiro; Ito, Ryoji; Ueno, Masaya; Hirao, Atsushi; Tohyama, Kaoru; Li, Chao; Kawabata, Kimihito Cojin; Yamaguchi, Kiyoshi; Furukawa, Yoichi; Kosako, Hidetaka; Yoshimi, Akihide; Goyama, Susumu; Nannya, Yasuhito; Ogawa, Seishi; Agger, Karl; Helin, Kristian; Yamazaki, Satoshi; Koseki, Haruhiko; Doki, Noriko; Harada, Yuka; Harada, Hironori; Nishiyama, Atsuya; Nakanishi, Makoto; Iwama, Atsushi
errShare
errSave
Epigenetic and Oncogenic Inhibitors Cooperatively Drive Differentiation and Kill KRAS-Mutant Colorectal Cancers
errCANCER DISCOVERY
IF33.3
err2024-08-12
err0
errOAAI
errLoi, Patrick; Schade, Amy E.; Rodriguez, Carrie L.; Krishnan, Anjana; Perurena, Naiara; Nguyen, Van T. M.; Xu, Yilin; Watanabe, Marina; Davis, Rachel A.; Gardner, Alycia; Pilla, Natalie F.; Mattioli, Kaia; Popow, Olesja; Gunduz, Nuray; Lannagan, Tamsin R. M.; Fitzgerald, Samantha; Sicinska, Ewa T.; Lin, Jia-Ren; Tan, William; Brais, Lauren K.; Haigis, Kevin M.; Giannakis, Marios; Ng, Kimmie; Santagata, Sandro; Helin, Kristian; Sansom, Owen J.; Cichowski, Karen
errShare
errSave
E2F1 is crucial for E2F-dependent apoptosis (vol 6, 661, 2005)
errEMBO REPORTS
IF6.2
err2024-06-14
err0
errOAAI
errDenchi, Eros Lazzerini; Helin, Kristian
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errSave
A novel oncogenic BTK isoform is overexpressed in colon cancers and required for RAS-mediated transformation ( vol 35 ,pg 4368, 2016)
errONCOGENE
IF7.3
err2024-04-18
err0
errOAAI
errGrassilli, E.; Pisano, F.; Cialdella, A.; Bonomo, S.; Missaglia, C.; Cerrito, M. G.; Masiero, L.; Ianzano, L.; Giordano, F.; Cicirelli, V.; Narloch, R.; D'Amato, F.; Noli, B.; Ferri, G. L.; Leone, B. E.; Stanta, G.; Bonin, S.; Helin, K.; Giovannoni, R.; Lavitrano, M.
errShare
errSave
TAK1 inhibition leads to RIPK1-dependent apoptosis in immune-activated cancers
errCELL DEATH & DISEASE
IF9.6
err2024-04-17
err3
errOAAI
errDamhofer, Helene; Tatar, Tulin; Southgate, Benjamin; Scarneo, Scott; Agger, Karl; Shlyueva, Daria; Uhrbom, Lene; Morrison, Gillian M.; Hughes, Philip F.; Haystead, Timothy; Pollard, Steven M.; Helin, Kristian
errShare
errSave
EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer (vol 22, pg 5323, 2003)
errEMBO JOURNAL
IF8.3
err2024-02-12
err0
errOAAI
errBracken, Adrian P.; Pasini, Diego; Capra, Maria; Prosperini, Elena; Colli, Elena; Helin, Kristian
errShare
errSave
Keep quiet: the HUSH complex in transcriptional silencing and disease
errNATURE STRUCTURAL & MOLECULAR BIOLOGY
IF10.1
err2024-01-12
err2
PREAI
errMuller, Iris; Helin, Kristian
errShare
errSave
An alternative NURF complex sustains acute myeloid leukemia by regulating the accessibility of insulator regions
errEMBO JOURNAL
IF8.3
err2023-11-21
err3
errOAAI
errRadzisheuskaya, Aliaksandra; Pena-Romer, Isabel; Lorenzini, Eugenia; Koche, Richard; Zhan, Yingqian; Shliaha, Pavel, V; Cooper, Alexandra J.; Fan, Zheng; Shlyueva, Daria; Johansen, Jens, V; Hendrickson, Ronald C.; Helin, Kristian
errShare
errSave
Vitamin C activates young LINE-1 elements in mouse embryonic stem cells via H3K9me3 demethylation
errEPIGENETICS & CHROMATIN
IF3.5
err2023-10-16
err1
errOAAI
errCheng, Kevin C. L.; Frost, Jennifer M.; Sanchez-Luque, Francisco J.; Garcia-Canadas, Marta; Taylor, Darren; Yang, Wan R.; Irayanar, Branavy; Sampath, Swetha; Patani, Hemalvi; Agger, Karl; Helin, Kristian; Ficz, Gabriella; Burns, Kathleen H.; Ewing, Adam; Garcia-Perez, Jose L.; Branco, Miguel R.
errShare
errSave
An organoid-based CRISPR-Cas9 screen for regulators of intestinal epithelial maturation and cell fate
errSCIENCE ADVANCES
IF12.5
err2023-07-14
err13
errOAAI
errHansen, Stine L.; Larsen, Hjalte L.; Pikkupeura, Laura M.; Maciag, Grzegorz; Guiu, Jordi; Muller, Iris; Clement, Ditte L.; Mueller, Christina; Johansen, Jens Vilstrup; Helin, Kristian; Lerdrup, Mads; Jensen, Kim B.
errShare
errSave
Chromatin regulation of transcriptional enhancers and cell fate by the Sotos syndrome gene NSD1
errMOLECULAR CELL
IF16.6
err2023-07-01
err9
errOAAI
errSun, Zhen; Lin, Yuan; Islam, Mohammed T.; Koche, Richard; Hedehus, Lin; Liu, Dingyu; Huang, Chang; Vierbuchen, Thomas; Sawyers, Charles L.; Helin, Kristian
errShare
errSave
EZH2i unlocks PDAC immune surveillance
errNATURE CANCER
IF28.5
err2023-06-27
err1
PREAI
errDamhofer, Helene; Helin, Kristian
errShare
errSave
Panorama of complex structural variants in primary localized prostate cancer
errCANCER RESEARCH
IF16.6
err2023-06-02
err0
PREAI
errOlsen, Andre; Favero, Francesco; Li, Yilong; Girma, Etsehiwot; Feran, Breon; Papenfuss, Tony; Helin, Kristian; Reimand, Juri; Weischenfeldt, Joachim
errShare
errSave
Catching active enhancers via H2B N-terminal acetylation
errNATURE GENETICS
IF31.8
err2023-04-06
err3
PREAI
errHuang, Chang; Helin, Kristian
errShare
errSave
p27(KIP1) blocks cyclin E-dependent transactivation of cyclin A gene expression
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-29
err119
errOAAI
errZerfassThome, K; Schulze, A; Zwerschke, W; Vogt, B; Helin, K; Bartek, J; Henglein, B; JansenDurr, P
errShare
errSave
Cell cycle regulated expression of mammalian CDC6 is dependent on E2F
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-28
err173
errOAAI
errHateboer, G; Wobst, A; Petersen, BO; Le Cam, L; Vigo, E; Sardet, C; Helin, K
errShare
errSave

Research Directions

No research directions
Co-authors
Cooperation Journals
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Marc W. Kirschner
H-index: 169 · Papers: 526
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Paul Flicek
H-index: 167 · Papers: 522
M
Manel Esteller
H-index: 165 · Papers: 1.6K
R
Ross L. Levine
H-index: 147 · Papers: 1.5K
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