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Exome sequencing and analysis of 44,028 British South Asians enriched for high autozygosity Kim, Hye In; Deboever, Christopher; Walter, Klaudia; Kalantzis, Georgios; Li, Chen; Mozaffari, Sahar V.; Kundu, Kousik; Jacobs, Benjamin M.; Mohammadi-Shemirani, Pedrum; Musolf, Anthony M.; Davitte, Jonathan M.; Aksit, Melis A.; Gafton, Joseph; Catalano, Katrina A.; Dawed, Adem Y.; Graham, Robert R.; Guo, Bin; Gupta, Namrata; Heng, Teng Hiang; Hunt, Karen A.; Iyer, Vivek; Langenberg, Claudia; Lassen, Frederik H.; MacArthur, Daniel G.; Maher, Eamonn R.; Maroteau, Cyrielle; Newman, William G.; O'rahilly, Stephen; Palmer, Duncan S.; Popov, Iaroslav; Siddiqui, Moneeza K.; Simpson, Michael A.; Spreckley, Marie; Wright, John; Del Angel, Guillermo; Petrovski, Slave; Holzinger, Emily R.; Maranville, Joseph C.; Addis, Laura; Turner, Richard M.; Estrada, Karol; Longerich, Simone; Howson, Joanna M. M.; Jamshidi, Yalda; Fauman, Eric B.; Miller, Melissa R.; Diogo, Dorothee; Trembath, Richard C.; Finer, Sarah; Martin, Hilary C.; van Heel, David A. Share Save
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Effects of Rare Coding Variants in Severe Early-Onset Obesity Genes in the Population-Based UK Biobank Study Jia, Raina Y.; Lockhart, Sam; Lam, Brian Y. H.; Zhao, Yajie; Kentistou, Katherine A.; Gardner, Eugene J.; Farooqi, I. Sadaf; O'Rahilly, Stephen; Day, Felix R.; Ong, Ken K.; Perry, John R. B. Share Save
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Protein-truncating variants in BSN are associated with severe adult-onset obesity, type 2 diabetes and fatty liver disease Zhao, Yajie; Chukanova, Maria; Kentistou, Katherine A.; Fairhurst-Hunter, Zammy; Siegert, Anna Maria; Jia, Raina Y.; Dowsett, Georgina K. C.; Gardner, Eugene J.; Lawler, Katherine; Day, Felix R.; Kaisinger, Lena R.; Tung, Yi-Chun Loraine; Lam, Brian Yee Hong; Chen, Hsiao-Jou Cortina; Wang, Quanli; Berumen-Campos, Jaime; Kuri-Morales, Pablo; Tapia-Conyer, Roberto; Alegre-Diaz, Jesus; Barroso, Ines; Emberson, Jonathan; Torres, Jason M.; Collins, Rory; Saleheen, Danish; Smith, Katherine R.; Paul, Dirk S.; Merkle, Florian; Farooqi, I. Sadaf; Wareham, Nick J.; Petrovski, Slave; O'Rahilly, Stephen; Ong, Ken K.; Yeo, Giles S. H.; Perry, John R. B. Share Save
Low resting metabolic rate and increased hunger due to β-MSH and β-endorphin deletion in a canine model Dittmann, Marie T.; Lakatos, Gabriella; Wainwright, Jodie F.; Mokrosinski, Jacek; Cross, Eloise; Farooqi, I. Sadaf; Wallis, Natalie J.; Halsey, Lewis G.; Wilson, Rory; O'Rahilly, Stephen; Yeo, Giles S. H.; Raffan, Eleanor Share Save
The gastrointestinal tract is a major source of the acute metformin-stimulated rise in GDF15 Kincaid, John W. R.; Rimmington, Debra; Tadross, John A.; Cimino, Irene; Zvetkova, Ilona; Kaser, Arthur; Richards, Paul; Patel, Satish; O'Rahilly, Stephen; Coll, Anthony P. Share Save
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High morbidity and mortality in children with untreated congenital deficiency of leptin or its receptor Saeed, Sadia; Khanam, Roohia; Janjua, Qasim M.; Manzoor, Jaida; Ning, Lijiao; Hanook, Sharoon; Canouil, Mickael; Ali, Muhammad; Ayesha, Hina; Khan, Waqas I.; Farooqi, I. Sadaf; Yeo, Giles S. H.; O'Rahilly, Stephen; Bonnefond, Amelie; Butt, Taeed A.; Arslan, Muhammad; Froguel, Philippe Share Save
Large-scale exome sequence analysis identifies sex- and age-specific determinants of obesity Kaisinger, Lena R.; Kentistou, Katherine A.; Stankovic, Stasa; Gardner, Eugene J.; Day, Felix R.; Zhao, Yajie; Morseburg, Alexander; Carnie, Christopher J.; Zagnoli-Vieira, Guido; Puddu, Fabio; Jackson, Stephen P.; O'Rahilly, Stephen; Farooqi, I. Sadaf; Dearden, Laura; Pantaleao, Lucas C.; Ozanne, Susan E.; Ong, Ken K.; Perry, John R. B. Share Save
Prevalence of Deleterious Variants in MC3R in Patients With Constitutional Delay of Growth and Puberty Duckett, Katie; Williamson, Alice; Kincaid, John W. R.; Rainbow, Kara; Corbin, Laura J.; Martin, Hilary C.; Eberhardt, Ruth Y.; Huang, Qin Qin; Hurles, Matthew E.; He, Wen; Brauner, Raja; Delaney, Angela; Dunkel, Leo; Grinspon, Romina P.; Hall, Janet E.; Hirschhorn, Joel N.; Howard, Sasha R.; Latronico, Ana C.; Jorge, Alexander A. L.; McElreavey, Ken; Mericq, Veronica; Merino, Paulina M.; Palmert, Mark R.; Plummer, Lacey; Rey, Rodolfo A.; Rezende, Raissa C.; Seminara, Stephanie B.; Salnikov, Kathryn; Banerjee, Indraneel; Lam, Brian Y. H.; Perry, John R. B.; Timpson, Nicholas J.; Clayton, Peter; Chan, Yee-Ming; Ong, Ken K.; O'Rahilly, Stephen Share Save
Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake Williamson, Alice; Norris, Dougall M.; Yin, Xianyong; Broadaway, K. Alaine; Moxley, Anne H.; Vadlamudi, Swarooparani; Wilson, Emma P.; Jackson, Anne U.; Ahuja, Vasudha; Andersen, Mette K.; Arzumanyan, Zorayr; Bonnycastle, Lori L.; Bornstein, Stefan R.; Bretschneider, Maxi P.; Buchanan, Thomas A.; Chang, Yi-Cheng; Chuang, Lee-Ming; Chung, Ren-Hua; Clausen, Tine D.; Damm, Peter; Delgado, Graciela E.; de Mello, Vanessa D.; Dupuis, Josee; Dwivedi, Om P.; Erdos, Michael R.; Silva, Lilian Fernandes; Frayling, Timothy M.; Gieger, Christian; Goodarzi, Mark O.; Guo, Xiuqing; Gustafsson, Stefan; Hakaste, Liisa; Hammar, Ulf; Hatem, Gad; Herrmann, Sandra; Hojlund, Kurt; Horn, Katrin; Hsueh, Willa A.; Hung, Yi-Jen; Hwu, Chii-Min; Jonsson, Anna; Karhus, Line L.; Kleber, Marcus E.; Kovacs, Peter; Lakka, Timo A.; Lauzon, Marie; Lee, I-Te; Lindgren, Cecilia M.; Lindstrom, Jaana; Linneberg, Allan; Liu, Ching-Ti; Luan, Jian'an; Aly, Dina Mansour; Mathiesen, Elisabeth; Moissl, Angela P.; Morris, Andrew P.; Narisu, Narisu; Perakakis, Nikolaos; Peters, Annette; Prasad, Rashmi B.; Rodionov, Roman N.; Roll, Kathryn; Rundsten, Carsten F.; Sarnowski, Chloe; Savonen, Kai; Scholz, Markus; Sharma, Sapna; Stinson, Sara E.; Suleman, Sufyan; Tan, Jingyi; Taylor, Kent D.; Uusitupa, Matti; Vistisen, Dorte; Witte, Daniel R.; Walther, Romy; Wu, Peitao; Xiang, Anny H.; Zethelius, Bjorn; Ahlqvist, Emma; Bergman, Richard N.; Chen, Yii-Der Ida; Collins, Francis S.; Fall, Tove; Florez, Jose C.; Fritsche, Andreas; Grallert, Harald; Groop, Leif; Hansen, Torben; Koistinen, Heikki A.; Komulainen, Pirjo; Laakso, Markku; Lind, Lars; Loeffler, Markus; Maerz, Winfried; Meigs, James B.; Raffel, Leslie J.; Rauramaa, Rainer; Rotter, Jerome I.; Schwarz, Peter E. H.; Stumvoll, Michael; Sundstrom, Johan; Toenjes, Anke; Tuomi, Tiinamaija; Tuomilehto, Jaakko; Wagner, Robert; Barroso, Ines; Walker, Mark; Grarup, Niels; Boehnke, Michael; Wareham, Nicholas J.; Mohlke, Karen L.; Wheeler, Eleanor; O'Rahilly, Stephen; Fazakerley, Daniel J.; Langenberg, Claudia Share Save
Body composition and lung cancer-associated cachexia in TRACERx Al-Sawaf, Othman; Weiss, Jakob; Skrzypski, Marcin; Lam, Jie Min; Karasaki, Takahiro; Zambrana, Francisco; Kidd, Andrew C.; Frankell, Alexander M.; Watkins, Thomas B. K.; Martinez-Ruiz, Carlos; Puttick, Clare; Black, James R. M.; Huebner, Ariana; Al Bakir, Maise; Sokac, Mateo; Collins, Susie; Veeriah, Selvaraju; Magno, Neil; Naceur-Lombardelli, Cristina; Prymas, Paulina; Toncheva, Antonia; Ward, Sophia; Jayanth, Nick; Salgado, Roberto; Bridge, Christopher P.; Christiani, David C.; Mak, Raymond H.; Bay, Camden; Rosenthal, Michael; Sattar, Naveed; Welsh, Paul; Liu, Ying; Perrimon, Norbert; Popuri, Karteek; Beg, Mirza Faisal; McGranahan, Nicholas; Hackshaw, Allan; Breen, Danna M.; O'Rahilly, Stephen; Birkbak, Nicolai J.; Aerts, Hugo J. W. L.; Jamal-Hanjani, Mariam; Swanton, Charles; Lester, Jason F.; Bajaj, Amrita; Nakas, Apostolos; Sodha-Ramdeen, Azmina; Ang, Keng; Tufail, Mohamad; Chowdhry, Mohammed Fiyaz; Scotland, Molly; Boyles, Rebecca; Rathinam, Sridhar; Wilson, Claire; Marrone, Domenic; Dulloo, Sean; Fennell, Dean A.; Matharu, Gurdeep; Shaw, Jacqui A.; Riley, Joan; Primrose, Lindsay; Boleti, Ekaterini; Cheyne, Heather; Khalil, Mohammed; Richardson, Shirley; Cruickshank, Tracey; Price, Gillian; Kerr, Keith M.; Benafif, Sarah; Gilbert, Kayleigh; Naidu, Babu; Patel, Akshay J.; Osman, Aya; Lacson, Christer; Langman, Gerald; Shackleford, Helen; Djearaman, Madava; Kadiri, Salma; Middleton, Gary; Leek, Angela; Hodgkinson, Jack Davies; Totten, Nicola; Montero, Angeles; Smith, Elaine; Fontaine, Eustace; Granato, Felice; Doran, Helen; Novasio, Juliette; Rammohan, Kendadai; Joseph, Leena; Bishop, Paul; Shah, Rajesh; Moss, Stuart; Joshi, Vijay; Crosbie, Philip; Gomes, Fabio; Brown, Kate; Carter, Mathew; Chaturvedi, Anshuman; Priest, Lynsey; Oliveira, Pedro; Lindsay, Colin R.; Blackhall, Fiona H.; Krebs, Matthew G.; Summers, Yvonne; Clipson, Alexandra; Tugwood, Jonathan; Kerr, Alastair; Rothwell, Dominic G.; Kilgour, Elaine; Dive, Caroline; Schwarz, Roland F.; Kaufmann, Tom L.; Wilson, Gareth A.; Rosenthal, Rachel; Van Loo, Peter; Szallasi, Zoltan; Kisistok, Judit; Sokac, Mateo; Diossy, Miklos; Demeulemeester, Jonas; Bunkum, Abigail; Stewart, Aengus; Magness, Alastair; Rowan, Andrew; Karamani, Angeliki; Chain, Benny; Campbell, Brittany B.; Castignani, Carla; Bailey, Chris; Abbosh, Christopher; Weeden, Clare E.; Lee, Claudia; Richard, Corentin; Hiley, Crispin T.; Moore, David A.; Pearce, David R.; Karagianni, Despoina; Biswas, Dhruva; Levi, Dina; Hoxha, Elena; Cadieux, Elizabeth Larose; Lim, Emilia L.; Colliver, Emma; Nye, Emma; Gronroos, Eva; Galvez-Cancino, Felip; Athanasopoulou, Foteini; Gimeno-Valiente, Francisco; Kassiotis, George; Stavrou, Georgia; Mastrokalos, Gerasimos; Zhai, Haoran; Lowe, Helen L.; Matos, Ignacio Garcia; Goldman, Jacki; Reading, James L.; Herrero, Javier; Rane, Jayant K.; Nicod, Jerome; Hartley, John A.; Peggs, Karl S.; Enfield, Katey S. S.; Selvaraju, Kayalvizhi; Thol, Kerstin; Litchfield, Kevin; Ng, Kevin W.; Chen, Kezhong; Dijkstra, Krijn; Grigoriadis, Kristiana; Thakkar, Krupa; Ensell, Leah; Shah, Mansi; Duran, Marcos Vasquez; Litovchenko, Maria; Sunderland, Mariana Werner; Hill, Mark S.; Dietzen, Michelle; Leung, Michelle; Escudero, Mickael; Angelova, Mihaela; Tanic, Miljana; Sivakumar, Monica; Kanu, Nnennaya; Chervova, Olga; Lucas, Olivia; Pich, Oriol; Hobson, Philip; Pawlik, Piotr; Stone, Richard Kevin; Bentham, Robert; Hynds, Robert E.; Vendramin, Roberto; Saghafinia, Sadegh; Lopez, Saioa; Gamble, Samuel; Ung, Seng Kuong Anakin; Quezada, Sergio A.; Vanloo, Sharon; Zaccaria, Simone; Hessey, Sonya; Boeing, Stefan; Beck, Stephan; Bola, Supreet Kaur; Denner, Tamara; Marafioti, Teresa; Mourikis, Thanos P.; Spanswick, Victoria; Barbe, Vittorio; Lu, Wei-Ting; Hill, William; Liu, Wing Kin; Wu, Yin; Naito, Yutaka; Ramsden, Zoe; Veiga, Catarina; Royle, Gary; Collins-Fekete, Charles-Antoine; Fraioli, Francesco; Ashford, Paul; Clark, Tristan; Forster, Martin D.; Lee, Siow Ming; Borg, Elaine; Falzon, Mary; Papadatos-Pastos, Dionysis; Wilson, James; Ahmad, Tanya; Procter, Alexander James; Ahmed, Asia; Taylor, Magali N.; Nair, Arjun; Lawrence, David; Patrini, Davide; Navani, Neal; Thakrar, Ricky M.; Janes, Sam M.; Hoogenboom, Emilie Martinoni; Monk, Fleur; Holding, James W.; Choudhary, Junaid; Bhakhri, Kunal; Scarci, Marco; Hayward, Martin; Panagiotopoulos, Nikolaos; Gorman, Pat; Khiroya, Reena; Stephens, Robert C. M.; Wong, Yien Ning Sophia; Bandula, Steve; Sharp, Abigail; Smith, Sean; Gower, Nicole; Dhanda, Harjot Kaur; Chan, Kitty; Pilotti, Camilla; Leslie, Rachel; Grapa, Anca; Zhang, Hanyun; AbdulJabbar, Khalid; Pan, Xiaoxi; Yuan, Yinyin; Chuter, David; MacKenzie, Mairead; Chee, Serena; Alzetani, Aiman; Cave, Judith; Scarlett, Lydia; Richards, Jennifer; Ingram, Papawadee; Austin, Silvia; Lim, Eric; De Sousa, Paulo; Jordan, Simon; Rice, Alexandra; Raubenheimer, Hilgardt; Bhayani, Harshil; Ambrose, Lyn; Devaraj, Anand; Chavan, Hema; Begum, Sofina; Buderi, Silviu, I; Kaniu, Daniel; Malima, Mpho; Booth, Sarah; Nicholson, Andrew G.; Fernandes, Nadia; Shah, Pratibha; Proli, Chiara; Hewish, Madeleine; Danson, Sarah; Shackcloth, Michael J.; Robinson, Lily; Russell, Peter; Blyth, Kevin G.; Dick, Craig; Le Quesne, John; Kirk, Alan; Asif, Mo; Bilancia, Rocco; Kostoulas, Nikos; Thomas, Mathew Share Save
ETO/MTG8 is an inhibitor of C/EBPβ activity and a regulator of early adipogenesis Rochford, JJ; Semple, RK; Laudes, M; Boyle, KB; Christodoulides, C; Mulligan, C; Lelliott, CJ; Schinner, S; Hadaschik, D; Mahadevan, M; Sethi, JK; Vidal-Puig, A; O'Rahilly, S Share Save
Association of GDF15 levels with body mass index and endocrine status in β-thalassaemia Karusheva, Yanislava; Petry, Clive J.; Yasara, Nirmani; Kottahachchi, Dulani; Premawardhena, Anuja; Barker, Peter; Burling, Keith; Sattar, Naveed; Welsh, Paul; Mettananda, Sachith; O'Rahilly, Stephen Share Save
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