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The host protein cyclophilin A restricts nuclear entry of HIV-1 mutants by reducing the elasticity of the viral capsid Hong, Jun; Deshpande, Akshay; Thakare, Yatish; Simonovsky, Lora; Douglas, Aidandarian W.; Mc Guinness, Conall; Rotem-Dai, Noa; Kortyna, Michelle L.; Klarhof, J. Ole; Shi, Jiong; James, Leo C.; Boecking, Till; Francis, Ashwanth C.; Rousso, Itay; Aiken, Christopher Share Save
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Antibodies targeting the Crimean-Congo Hemorrhagic Fever Virus nucleoprotein protect via TRIM21 Leventhal, Shanna S.; Bisom, Thomas; Clift, Dean; Rao, Deepashri; Meade-White, Kimberly; Shaia, Carl; Murray, Justin; Mihalakakos, Evan A.; Hinkley, Troy; Reynolds, Steven J.; Best, Sonja M.; Erasmus, Jesse H.; James, Leo C.; Feldmann, Heinz; Hawman, David W. Share Save
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Human coronaviruses activate and hijack the host transcription factor HSF1 to enhance viral replication Pauciullo, Silvia; Riccio, Anna; Santopolo, Silvia; Albecka, Anna; Papa, Guido; James, Leo C.; Piacentini, Sara; Lanzilli, Giulia; Rossi, Antonio; Santoro, M. Gabriella Share Save
Pharmacologic hyperstabilisation of the HIV-1 capsid lattice induces capsid failure Faysal, K. M. Rifat; Walsh, James C.; Renner, Nadine; Marquez, Chantal L.; Shah, Vaibhav B.; Tuckwell, Andrew J.; Christie, Michelle P.; Parker, Michael W.; Turville, Stuart G.; Towers, Greg J.; James, Leo C.; Jacques, David A.; Bocking, Till Share Save
A pan-SARS-CoV-2-specific soluble angiotensin-converting enzyme 2-albumin fusion engineered for enhanced plasma half-life and needle-free mucosal delivery Benjakul, Sopisa; Anthi, Aina Karen; Kolderup, Anette; Vaysburd, Marina; Lode, Heidrun Elisabeth; Mallery, Donna; Fossum, Even; Vikse, Elisabeth Lea; Albecka, Anna; Ianevski, Aleksandr; Kainov, Denis; Karlsen, Karine Flem; Sakya, Siri Aastedatter; Nyquist-Andersen, Mari; Gjolberg, Torleif Tollefsrud; Moe, Morten C.; Bjoras, Magnar; Sandlie, Inger; James, Leo C.; Andersen, Jan Terje Share Save
A TRIM21-based bioPROTAC highlights the therapeutic benefit of HuR degradation Fletcher, Alice; Clift, Dean; de Vries, Emma; Martinez Cuesta, Sergio; Malcolm, Timothy; Meghini, Francesco; Chaerkady, Raghothama; Wang, Junmin; Chiang, Abby; Weng, Shao Huan Samuel; Tart, Jonathan; Wong, Edmond; Donohoe, Gerard; Rawlins, Philip; Gordon, Euan; Taylor, Jonathan D.; James, Leo; Hunt, James Share Save
The type-I interferon response potentiates seeded tau aggregation and exacerbates tau pathology Sanford, Sophie A. I.; Miller, Lauren V. C.; Vaysburd, Marina; Keeling, Sophie; Tuck, Benjamin J.; Clark, Jessica; Neumann, Michal; Syanda, Victoria; James, Leo C.; McEwan, William A. Share Save
SLN124, a GalNAc conjugated 19-mer siRNA targeting tmprss6, reduces plasma iron and increases hepcidin levels of healthy volunteers Porter, John B.; Scrimgeour, Alison; Martinez, Alberto; James, Leo; Aleku, Manuela; Wilson, Rosamund; Muckenthaler, Martina; Boyce, Malcolm; Wilkes, Denise; Schaeper, Ute; Campion, Giles V. Share Save
Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit SARS-CoV-2 Gaynor, Katherine U. U.; Vaysburd, Marina; Harman, Maximilian A. J.; Albecka, Anna; Jeffrey, Phillip; Beswick, Paul; Papa, Guido; Chen, Liuhong; Mallery, Donna; McGuinness, Brian; Van Rietschoten, Katerine; Stanway, Steven; Brear, Paul; Lulla, Aleksei; Ciazynska, Katarzyna; Chang, Veronica T. T.; Sharp, Jo; Neary, Megan; Box, Helen; Herriott, Jo; Kijak, Edyta; Tatham, Lee; Bentley, Eleanor G. G.; Sharma, Parul; Kirby, Adam; Han, Ximeng; Stewart, James P. P.; Owen, Andrew; Briggs, John A. G.; Hyvonen, Marko; Skynner, Michael J. J.; James, Leo C. C. Share Save
Trim-Away ubiquitinates and degrades lysine-less and N-terminally acetylated substrates Kiss, Leo; Rhinesmith, Tyler; Luptak, Jakub; Dickson, Claire F.; Weidenhausen, Jonas; Smyly, Shannon; Yang, Ji-Chun; Maslen, Sarah L.; Sinning, Irmgard; Neuhaus, David; Clift, Dean; James, Leo C. Share Save
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