Robert J. Lee - Publications, H-index & Citations

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Robert J. Lee

pennsylvania medicine

54H-index

282Paper Count

1.2WCitation Count

Published Papers 86

Publication Date

Cigarette Smoke Exposure Attenuates T2R-Mediated Apoptosis in Head and Neck Squamous Cell Carcinoma

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck

IF2.2

2026-01-01

PREAI

Polen, Kyle; Sywanycz, Sarah; Turner, Gavin; Hill, Brianna L.; Huang, Lily; Miller, Zoey A.; Hanna, Casey; Raghav, Lovely; Basu, Devraj; Lee, Robert J.; Carey, Ryan M.

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A dual-responsive metal-polyphenol nanomedicine based on targeting LAT1 via levodopa and ROS amplification for precise treatment of breast cancer

Free Radical Biology and Medicine

IF8.2

2025-12-16

PREAI

Xiao He; Zhongmin Wang; Huayang Bai; Yaqin Tang; Daimeng Feng; Shuyu Zhang; Robert J. Lee; Jing Xie; Yansun Sun

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Mechanisms of Mitochondrial Toxicity and Cytotoxicity Caused by Pseudomonas aeruginosa Pyocyanin in Human Nasal Epithelial Cells

INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY

IF6.8

2025-12-01

OAAI

Thompson, Joel C.; Park, April; Kouakou, Yobouet Ines; Miller, Zoey A.; Darwich, Nabil F.; Adappa, Nithin D.; Palmer, James N.; Carey, Ryan M.; Lee, Robert J.

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Quercetin as a Bitter Taste Receptor Agonist with Anticancer Effects in Head and Neck Cancer Cells

Nutrients 2025, Vol. 17, Page 3224

IF0

2025-10-14

OAAI

Gavin Turner; Sarah M. Sywanycz; Brianna L. Buchler; Robert D. Wardlow II; Robert J. Lee; Ryan M. Carey

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Targeted treatment for neuroblastoma using methoxyestradiol (2-ME)-loaded mitochondria-targeting immunoliposomes modified by datuximab (anti-GD2) and (L-cyclohexyl alanine-D-arginine)3 ((Fx,r)3) peptide

Cancer Nanotechnology

IF4.8

2025-06-23

OAAI

Mingyu Wan; Zhili Chen; Yueyi Deng; Robert J. Lee; Chengyun Yan

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A deadly taste: linking bitter taste receptors and apoptosis

APOPTOSIS

IF8.1

2025-02-20

OAAI

Miller, Zoey A.; Carey, Ryan M.; Lee, Robert J.

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Hops bitter β-acids have antibacterial effects against sinonasal Staphylococcus aureus but also induce sinonasal cilia and mitochondrial dysfunction

INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY

IF6.8

2024-11-13

OAAI

Kouakou, Yobouet Ines; Thompson, Joel C.; Tan, Li Hui; Miller, Zoey A.; Ma, Ray Z.; Adappa, Nithin D.; Palmer, James N.; Cohen, Noam A.; Lee, Robert J.

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GLUT1 inhibitor BAY-876 induces apoptosis and enhances anti-cancer effects of bitter receptor agonists in head and neck squamous carcinoma cells

CELL DEATH DISCOVERY

IF7

2024-07-25

OAAI

Miller, Zoey A.; Muthuswami, Sahil; Mueller, Arielle; Ma, Ray Z.; Sywanycz, Sarah M.; Naik, Anusha; Huang, Lily; Brody, Robert M.; Diab, Ahmed; Carey, Ryan M.; Lee, Robert J.

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Microglia-targeted inhibition of miR-17 via mannose-coated lipid nanoparticles improves pathology and behavior in a mouse model of Alzheimer 's disease

BRAIN BEHAVIOR AND IMMUNITY

IF7.6

2024-07-01

OAAI

Badr, Asmaa; Daily, Kylene P.; Eltobgy, Mostafa; Estfanous, Shady; Tan, Michelle H.; Kuo, Jimmy Chun-Tien; Whitham, Owen; Carafice, Cierra; Gupta, Gauruv; Amer, Heba M.; Shamseldin, Mohamed M.; Yousif, Amir; Deems, Nicholas P.; Fitzgerald, Julie; Yan, Pearlly; Webb, Amy; Zhang, Xiaoli; Pietrzak, Maciej; Ghoneim, Hazem E.; Dubey, Purnima; Barrientos, Ruth M.; Lee, Robert J.; Kokiko-Cochran, Olga N.; Amer, Amal O.

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Effects of Akt Activator SC79 on Human M0 Macrophage Phagocytosis and Cytokine Production

CELLS

IF5.2

2024-05-24

OAAI

Lee, Robert J.; Adappa, Nithin D.; Palmer, James N.

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QTOLIMOD: A specific TLR9 agonist nanomedicine with high anti-solid tumor activity

CANCER RESEARCH

IF16.6

2024-03-22

PREAI

Su, Fei; Bai, Jun; Li, Chen; Wu, Yujing; Li, Jing; Zhao, Xiaobin; Yang, Yongsheng; Lee, Robert J.

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Akt activator SC79 stimulates antibacterial nitric oxide generation in human nasal epithelial cells in vitro

INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY

IF6.8

2024-01-10

PREAI

Lee, Robert J.; Adappa, Nithin D.; Palmer, James N.

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Lidocaine induces apoptosis in head and neck squamous cell carcinoma through activation of bitter taste receptor T2R14

CELL REPORTS

IF6.9

2023-12-01

OAAI

Miller, Zoey A.; Mueller, Arielle; Kim, Taebeom; Jolivert, Jennifer F.; Ma, Ray Z.; Muthuswami, Sahil; Park, April; Mcmahon, Derek B.; Nead, Kevin T.; Carey, Ryan M.; Lee, Robert J.

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Coronary Atherosclerotic Plaque Activity and Future Coronary Events

JAMA CARDIOLOGY

IF14.1

2023-08-01

OAAI

Moss, Alastair; Daghem, Marwa; Tzolos, Evangelos; Meah, Mohammed N.; Wang, Kang-Ling; Bularga, Anda; Adamson, Philip D.; Kwiecinski, Jacek; Fletcher, Alison; Dawson, Dana; Arumugam, Parthiban; Sabharwal, Nikant; Greenwood, John P.; Townend, Jon N.; Calvert, Patrick A.; Rudd, James H. F.; Berman, Dan; Verjans, Johan; Slomka, Piotr; Dey, Damini; Forsyth, Laura; Murdoch, Lauren; Lee, Robert J.; Lewis, Steff; Mills, Nicholas L.; van Beek, Edwin J. R.; Williams, Michelle C.; Dweck, Marc R.; Newby, David E.

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Interkingdom Detection of Bacterial Quorum-Sensing Molecules by Mammalian Taste Receptors

MICROORGANISMS

IF4.2

2023-05-16

OAAI

Kouakou, Yobouet Ines; Lee, Robert J.

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The ion channel CALHM6 controls bacterial infection-induced cellular cross-talk at the immunological synapse

EMBO JOURNAL

IF8.3

2023-03-02

OAAI

Danielli, Sara; Ma, Zhongming; Pantazi, Eirini; Kumar, Amrendra; Demarco, Benjamin; Fischer, Fabian A.; Paudel, Usha; Weissenrieder, Jillian; Lee, Robert J.; Joyce, Sebastian; Foskett, J. Kevin; Bezbradica, Jelena S.

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Utilizing the Off-Target Effects of T1R3 Antagonist Lactisole to Enhance Nitric Oxide Production in Basal Airway Epithelial Cells

NUTRIENTS

IF5

2023-01-19

OAAI

McMahon, Derek B.; Jolivert, Jennifer F.; Kuek, Li Eon; Adappa, Nithin D.; Palmer, James N.; Lee, Robert J.

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Loss of CFTR function is associated with reduced bitter taste receptor-stimulated nitric oxide innate immune responses in nasal epithelial cells and macrophages

FRONTIERS IN IMMUNOLOGY

IF5.9

2023-01-18

OAAI

Carey, Ryan M. M.; Palmer, James N. N.; Adappa, Nithin D. D.; Lee, Robert J. J.

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Savory Signaling: T1R Umami Receptor Modulates Endoplasmic Reticulum Calcium Store Content and Release Dynamics in Airway Epithelial Cells

NUTRIENTS

IF5

2023-01-18

OAAI

McMahon, Derek B. B.; Jolivert, Jennifer F. F.; Kuek, Li Eon; Adappa, Nithin D. D.; Palmer, James N. N.; Lee, Robert J. J.

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Microbial metabolite succinate activates solitary chemosensory cells in the human sinonasal epithelium

INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY

IF6.8

2023-01-10

PREAI

Sell, Elizabeth A.; Tan, Li Hui; Lin, Cailu; Bosso, John V.; Palmer, James N.; Adappa, Nithin D.; Lee, Robert J.; Kohanski, Michael A.; Reed, Danielle R.; Cohen, Noam A.

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Research Directions