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F

Fred S. Apple

University System of Ohio

98H-index
587Paper Count
4.3WCitation Count
Published Papers 210
Publication Date
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Analytical Error of Cardiac Troponin and Impact on the Performance of Accelerated Diagnostic Protocols in Patients with Acute Chest Pain
errCLINICAL CHEMISTRY
IF6.3
err2025-10-01
err0
PREAI
errSaeed, Nasir; Restan, Ingar Z.; Steiro, Ole-Thomas; Tjora, Hilde L.; Langorgen, Jorund; Skadberg, Oyvind; Mjelva, Oistein R.; Bonarjee, Vernon V. S.; Bjorneklett, Rune O.; Steinsvik, Trude; Vikenes, Kjell; Omland, Torbjorn; Apple, Fred S.; Jaffe, Allan S.; Mills, Nicholas L.; Collinson, Paul O.; Kavsak, Peter A.; Aakre, Kristin M.
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Evaluation of a newly developed Access anti-HAV immunoassay on the DxI 9000 Immunoassay Analyzer
errCLINICAL CHEMISTRY
IF6.3
err2025-10-01
err0
errOAAI
errKalamatas, Jennifer; Jortani, Saeed; Apple, Fred; Christenson, Robert; Bord-Romeu, Stephanie; Robin, Thomas
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errSave
Clinical Performance of a Novel Point-of-Care High-Sensitivity Cardiac Troponin I Assay
errJOURNAL OF APPLIED LABORATORY MEDICINE
IF1.9
err2025-10-01
err0
errOAAI
errWu, Alan H. B.; Mahler, Simon A.; House, Stacey L.; Jortani, Saeed A.; Creer, Michael H.; Rising, Kristin L.; Bischof, Jason J.; Crystal, Chad; Headden, Gary F.; Apple, Fred S.; Harrison, Nicholas E.; Meltzer, Andrew C.; Baca, Justin T.; Tiffany, Brian; Sochor, Mark; Pentecostes, Grace U.; Di Tullio, Katrina P.; Gupta, Manish S.; Singer, Adam J.; Januzzi, James L.
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A Multicenter Evaluation of the Access Syphilis Assay on the DxI 9000 and Access 2 Immunoassay Analyzers
errCLINICAL CHEMISTRY
IF6.3
err2025-10-01
err0
errOAAI
errMaher, Danielle; Jortani, Saeed; Apple, Fred; Christenson, Robert; Schulz, Karen; Rouvier, Eric; Mathison, Bridget; Ciczora, Yann; Milhem, Clara
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errSave
Diagnostic Accuracy of a Novel 0/1-H Algorithm Using Point-of-Care High-Sensitivity Troponin in the Emergency Department
errClinical Chemistry
IF6.3
err2025-09-03
err0
PREAI
errViola I L Thulin; Gard M S Myrmel; Paul O Collinson; Fred S Apple; Kjell Vikenes; Rune O Bjørneklett; Torbjørn Omland; Kristin M Aakre
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errSave
Cardiovascular biomarkers for risk stratification in primary prevention
errEUROPEAN HEART JOURNAL
IF35.6
err2025-08-01
err3
PREAI
errNeumann, Johannes T.; de Lemos, James A.; Apple, Fred S.; Leong, Darryl P.
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Cardiac Biomarkers for the Prediction, Discrimination, and Risk-Stratification of Type 2 Myocardial Infarction: A Critical Appraisal
errThe American Journal of Medicine
IF0
err2025-04-26
err0
PREAI
errDaniel L. Pollmann; Jonathan D. Knott; Pedro E.P. Carvalho; Fred S. Apple; Allan S. Jaffe; Yader Sandoval
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errSave
Effectiveness of Point-of-Care High-Sensitivity Troponin Testing in the Emergency Department: A Randomized Controlled Trial
errAnnals of Emergency Medicine
IF5
err2025-04-09
err0
errOAAI
errViola I.L. Thulin; Silje M.F. Jordalen; Gard M.S. Myrmel; Ole Christian Lekven; Jeyaseelan Krishnapillai; Ole Thomas Steiro; Richard Body; Paul Collinson; Fred S. Apple; Louise Cullen; Tone M. Norekvål; Torbjørn Wisløff; Kjell Vikenes; Rune O. Bjørneklett; Torbjørn Omland; Kristin M. Aakre
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errSave
Novel Mindray high sensitivity cardiac troponin I assay for single sample and 0/2-hour rule out of myocardial infarction: MERITnI study
errCLINICAL CHEMISTRY AND LABORATORY MEDICINE
IF3.7
err2025-03-01
err0
PREAI
errBuda, Kevin G.; Sandoval, Yader; Smith, Stephen W.; Wagner, Barrett; Schulz, Karen; Sexter, Anne; Apple, Fred S.
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errSave
Diagnostic performance of Mindray CL1200i high sensitivity cardiac troponin I assay compared to Abbott Alinity cardiac troponin I assay for the diagnosis of type 1 and 2 acute myocardial infarction in females and males: MERITnI study
errCLINICAL CHEMISTRY AND LABORATORY MEDICINE
IF3.7
err2025-02-10
err1
PREAI
errApple, Fred S.; Buda, Kevin G.; Wagner, Barrett P.; Sexter, Anne; Sandoval, Yader; Smith, Stephen W.; Meyer, Kylie; Ladd, Alanna; Worrell, Kathryn; Brown, Hannah M.; Schulz, Karen M.
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errSave
Design and Analytical Evaluation of Novel Cardiac Troponin Assays Targeting Multiple Forms of the Cardiac Troponin I-Cardiac Troponin T-Troponin C Complex and Fragmentation Forms
errCLINICAL CHEMISTRY
IF6.3
err2024-12-19
err1
PREAI
errLi, Ling; Liu, Yuqing; Katrukha, Ivan A.; Zhang, Litao; Shu, Xin; Xu, Ao; Yang, Juan; Wu, Yu; Jing, Yisha; Wang, Hui; Ni, Tongxin; Schulz, Karen; Bereznikova, Anastasia, V; Katrukha, Alexey G.; Apple, Fred S.; Zhang, Yi; Zhang, Zhenlu
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errSave
Characterization of Cardiac Troponin Fragment Composition Reveals Potential for Differentiating Etiologies of Myocardial Injury
errCLINICAL CHEMISTRY
IF6.3
err2024-12-17
err0
PREAI
errLi, Ling; Liu, Yuqing; Katrukha, Ivan A.; Zhang, Litao; Shu, Xin; Xu, Ao; Yang, Juan; Wu, Yu; Jing, Yisha; Wang, Hui; Ni, Tongxin; Schulz, Karen; Bereznikova, Anastasia, V; Katrukha, Alexey G.; Apple, Fred S.; Zhang, Yi; Zhang, Zhenlu
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errSave
Comparison of multiple high sensitivity cardiac troponin assays for early low risk rule out of myocardial infarction: SCORECARD
errEUROPEAN HEART JOURNAL
IF35.6
err2024-10-28
err0
PREAI
errApple, F.; Mills, N. L.; Vasile, V. C.; Schulz, K.; Sexter, A.; Jaffe, A. S.
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errSave
Diagnostic accuracy of a machine learning algorithm using point-of-care high-sensitivity cardiac troponin I for rapid rule-out of myocardial infarction: a retrospective study
errLANCET DIGITAL HEALTH
IF24.1
err2024-10-01
err0
errOAAI
errToprak, Betuel; Solleder, Hugo; Di Carluccio, Eleonora; Greenslade, Jaimi H.; Parsonage, William A.; Schulz, Karen; Cullen, Louise; Apple, Fred S.; Ziegler, Andreas; Blankenberg, Stefan
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errSave
Impact of high-sensitivity cardiac troponin I assay imprecision on the safety of a single-sample rule-out approach for myocardial infarction
errCLINICAL CHEMISTRY AND LABORATORY MEDICINE
IF3.7
err2024-09-20
err2
PREAI
errLi, Ziwen; Tew, Yong Yong; Kavsak, Peter A.; Aakre, Kristin M.; Jaffe, Allan S.; Apple, Fred S.; Collinson, Paul O.; Mills, Nicholas L.
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errSave
Point-of-care high-sensitivity cardiac troponin in suspected acute myocardial infarction assessed at baseline and 2 h
errEUROPEAN HEART JOURNAL
IF35.6
err2024-06-06
err3
PREAI
errCullen, Louise; Greenslade, Jaimi; Parsonage, William; Stephensen, Laura; Smith, Stephen W.; Sandoval, Yader; Ranasinghe, Isuru; Gaikwad, Niranjan; Bayat, Maryam Khorramshahi; Mahmoodi, Ehsan; Schulz, Karen; Than, Martin; Apple, Fred S.
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errSave
Analytical validation of the Mindray CL1200i analyzer high sensitivity cardiac troponin I assay: MERITnI study
errCLINICAL CHEMISTRY AND LABORATORY MEDICINE
IF3.7
err2024-05-28
err4
PREAI
errFabre-Estremera, Blanca; Schulz, Karen; Ladd, Alanna; Sexter, Anne; Apple, Fred S.
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errSave
Performance of Three Anti-SARS-CoV-2 Anti-S and One Anti-N Immunoassays for the Monitoring of Immune Status and Vaccine Response
errVIRUSES-BASEL
IF3.5
err2024-02-14
err1
errOAAI
errZhang, Y. Victoria; Kumanovics, Attila; Wiencek, Joesph; Melanson, Stacy E. F.; Love, Tanzy; Wu, Alan H. B.; Zhao, Zhen; Meng, Qing H.; Koch, David D.; Apple, Fred S.; Ondracek, Caitlin R.; Christenson, Robert H.
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errSave
Navigating the Observation Zone: Do Risk Scores Help Stratify Patients With Indeterminate High-Sensitivity Cardiac Troponins?
errCIRCULATION
IF38.6
err2024-01-02
err1
errOAAI
errAshburn, Nicklaus P.; McCord, James K.; Snavely, Anna C.; Christenson, Robert H.; Apple, Fred S.; Nowak, Richard M.; Peacock, William F.; deFilippi, Christopher R.; Mahler, Simon A.
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errSave
Lower Limits for Reporting High-Sensitivity Cardiac Troponin Assays and Impact of Analytical Performance on Patient Misclassification
errCLINICAL CHEMISTRY
IF6.3
err2023-12-15
err11
errOAAI
errAakre, Kristin M.; Apple, Fred S.; Mills, Nicolas L.; Meex, Steven J. R.; Collinson, Paul O.
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errSave

Research Directions

No research directions
Co-authors
Cooperation Journals
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Daniel Levy
H-index: 230 · Papers: 1.6K
P
Paul M. Thompson
H-index: 222 · Papers: 4.3K
G
Gregg C. Fonarow
H-index: 198 · Papers: 3.0K
B
Børge G. Nordestgaard
H-index: 192 · Papers: 1.8K
J
Jeroen J. Bax
H-index: 189 · Papers: 3.1K
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