logo
CanyamAI summaries for academic research
language
MobileMobile
  • Phone FeatureWeChat Mini Program
EnglishEnglish
noticeNotice
BlogBlog
delete
arrow
Back
M

Mitsuhiko Ikura

university health network

94H-index
478Paper Count
3.7WCitation Count
Published Papers 133
Publication Date
logo
CD33 and clusterin interact biophysically and genetically to modulate Alzheimer risk
errNature Communications
IF15.7
err2026-07-17
err0
errOAAI
errRoger B. Dodd; Masahiro Enomoto; Ye Zhou; Kanayo Satoh; Yalun Zhang; Fusheng Chen; Beatrice Acheson; Deniz Ghaffari; Elizabeth Sayn-Wittgenstein; Jamie J. Manning; George V. Dukas; Ronak Patel; Alondra Schweizer Burguete; Mason J. Kralovec; Mamunur Rashid; Jennifer L. Hall; Kirstin A. Tamucci; Zena Chatila; Minghua Liu; Annie J. Lee; Badri N. Vardarajan; Mariko F. Taga; Sirkku Pollari; Alon Rabinovitch; Cory D. Rillahan; Andrey A. Bobkov; Eduard Sergienko; William Meadows; Seema Qamar; Suzanne J. Randle; Christopher M. Johnson; Jean Sevalle; Jennifer Griffin; Christopher Bohm; Mitsuhiko Ikura; Xunde Xian; Joachim Herz; Megan A. Kelly; Jennifer West; Sandeep Satapathy; Mark R. Wilson; Jonathan A. Javitch; Paul E. Fraser; David A. Bennett; Philip L. De Jager; Zvi Fishelson; Dan Frenkel; Wesley B. Asher; Elizabeth M. Bradshaw; Peter St George-Hyslop
errShare
errSave
Allosteric Targeting of the ACE2 Dimer Interface by a Medium-sized Compound Inhibits SARS-CoV-2 Entry
errJournal of Molecular Biology
IF4.5
err2026-06-22
err0
errOAAI
errMariko Yokogawa; Shunki Kaneichi; Mahoro Horiuchi; Taiga Otake; Tomoki Yonezawa; Yugo Shimizu; Kazuyoshi Ikeda; Yuichiro Yamamoto; Shota Sakai; Yoshimi Shimizu; Kohji Noguchi; Masayoshi Fukasawa; Mitsuhiko Ikura; Masanori Osawa
errShare
errSave
Erythrocytosis-inducing PHD2 mutations implicate biological role for N-terminal prolyl-hydroxylation in HIF1α oxygen-dependent degradation domain
errELIFE
IF0
err2025-10-20
err0
PREAI
errTaber, Cassandra C.; He, Wenguang; Gasmi-Seabrook, Genevieve M. C.; Hubert, Mia; Ferens, Fraser G.; Ikura, Mitsuhiko; Lee, Jeffrey E.; Ohh, Michael
errShare
errSave
DIRAS3-derived cyclic peptides disrupt KRAS-RAF interaction and KRAS nanoclustering, suppressing KRAS-driven pancreatic and ovarian tumors
erriScience
IF4.1
err2025-10-04
err0
errOAAI
errJoshua P. Gray; Gamze Bildik; Ha-Neul Kim; Margie N. Sutton; Jing Wang; Amarachi O. Osuji; Nefeli Batistatou; Hailing Yang; Weiqun Mao; Zhi Tan; Geneviève M.C. Gasmi-Seabrook; Junchen Liu; John F. Hancock; Christopher B. Marshall; Joshua A. Kritzer; Mitsuhiko Ikura; Robert C. Bast; Steven W. Millward; Zhen Lu
errShare
errSave
Switch II Pocket Inhibitor Allosterically Freezes KRASG12D Nucleotide-binding Site and Arrests the GTPase Cycle
errJOURNAL OF MOLECULAR BIOLOGY
IF4.5
err2025-07-01
err0
PREAI
errKim, Ha-Neul; Gasmi-Seabrook, Genevieve M. C.; Uchida, Arisa; Gebregiworgis, Teklab; Marshall, Christopher B.; Ikura, Mitsuhiko
errShare
errSave
Time- resolved NMR detection of prolyl- hydroxylation in intrinsically disordered region of HIF-1α
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2024-09-04
err0
errOAAI
errHe, Wenguang; Seabrook, Genevieve M. C. Gasmi; Ikura, Mitsuhiko; Lee, Jeffrey E.; Ohh, Michael
errShare
errSave
Aromatically stacking the odds in favour of increased ORAI1 activation
errCELL CALCIUM
IF4
err2024-01-01
err0
PREAI
errStathopulos, Peter B.; Ikura, Mitsuhiko
errShare
errSave
Hitting the hotspots
errNATURE CHEMICAL BIOLOGY
IF13.7
err2022-03-21
err2
PREAI
errMarshall, Christopher B.; Ikura, Mitsuhiko
errShare
errSave
Regulation of GTPase function by autophosphorylation
errMOLECULAR CELL
IF16.6
err2022-03-01
err11
errOAAI
errJohnson, Christian W.; Seo, Hyuk-Soo; Terrell, Elizabeth M.; Yang, Moon-Hee; KleinJan, Fenneke; Gebregiworgis, Teklab; Gasmi-Seabrook, Genevieve M. C.; Geffken, Ezekiel A.; Lakhani, Jimit; Song, Kijun; Bashyal, Puspalata; Popow, Olesja; Paulo, Joao A.; Liu, Andrea; Mattos, Carla; Marshall, Christopher B.; Ikura, Mitsuhiko; Morrison, Deborah K.; Dhe-Paganon, Sirano; Haigis, Kevin M.
errShare
errSave
Force-induced changes of α-catenin conformation stabilize vascular junctions independently of vinculin
errJOURNAL OF CELL SCIENCE
IF3.6
err2021-12-22
err10
errOAAI
errDuong, Cao Nguyen; Brueckner, Randy; Schmitt, Martina; Nottebaum, Astrid F.; Braun, Laura J.; Zu Brickwedde, Marika Meyer; Ipe, Ute; Vom Bruch, Hermann; Schoeler, Hans R.; Trapani, Giuseppe; Trappmann, Britta; Ebrahimkutty, Mirsana P.; Huveneers, Stephan; de Rooij, Johan; Ishiyama, Noboru; Ikura, Mitsuhiko; Vestweber, Dietmar
errShare
errSave
The Q61H mutation decouples KRAS from upstream regulation and renders cancer cells resistant to SHP2 inhibitors
errNATURE COMMUNICATIONS
IF15.7
err2021-11-01
err30
errOAAI
errGebregiworgis, Teklab; Kano, Yoshihito; St-Germain, Jonathan; Radulovich, Nikolina; Udaskin, Molly L.; Mentes, Ahmet; Huang, Richard; Poon, Betty P. K.; He, Wenguang; Valencia-Sama, Ivette; Robinson, Claire M.; Huestis, Melissa; Miao, Jinmin; Yeh, Jen Jen; Zhang, Zhong-Yin; Irwin, Meredith S.; Lee, Jeffrey E.; Tsao, Ming-Sound; Raught, Brian; Marshall, Christopher B.; Ohh, Michael; Ikura, Mitsuhiko
errShare
errSave
KRAS Q61H mutation evades the regulation of tyrosyl phosphorylation and renders cancer cells resistant to SHP2 inhibitor
errANNALS OF ONCOLOGY
IF65.4
err2021-07-01
err0
errOAAI
errKano, Yoshihito; Gebregiworgis, Teklab; Marshall, Christopher; Ikura, Mitsuhiko; Miyake, Satoshi; Ohh, Michael
errShare
errSave
Tankyrase regulates epithelial lumen formation via suppression of Rab11 GEFs
errJOURNAL OF CELL BIOLOGY
IF6.4
err2021-06-15
err8
errOAAI
errChandrakumar, Arun A.; Coyaud, Etienne; Marshall, Christopher B.; Ikura, Mitsuhiko; Raught, Brian; Rottapel, Robert
errShare
errSave
The p.E152K-STIM1 mutation deregulates Ca2+ signaling contributing to chronic pancreatitis
errJOURNAL OF CELL SCIENCE
IF3.6
err2021-02-10
err4
errOAAI
errBurgos, Miguel; Philippe, Reginald; Antigny, Fabrice; Buscaglia, Paul; Masson, Emmanuelle; Mukherjee, Sreya; Dubar, Pauline; Le Marechal, Cedric; Campeotto, Florence; Lebonvallet, Nicolas; Frieden, Maud; Llopis, Juan; Domingo, Beatriz; Stathopulos, Peter B.; Ikura, Mitsuhiko; Brooks, Wesley; Guida, Wayne; Chen, Jian-Min; Ferec, Claude; Capiod, Thierry; Mignen, Olivier
errShare
errSave
Oncogenic KRAS G12D mutation promotes dimerization through a second, phosphatidylserine-dependent interface: a model for KRAS oligomerization
errCHEMICAL SCIENCE
IF7.4
err2021-01-01
err19
errOAAI
errLee, Ki-Young; Enomoto, Masahiro; Gebregiworgis, Teklab; Gasmi-Seabrook, Genevieve M. C.; Ikura, Mitsuhiko; Marshall, Christopher B.
errShare
errSave
Real-Time In-Cell NMR Reveals the Intracellular Modulation of GTP-Bound Levels of RAS
errCELL REPORTS
IF6.9
err2020-08-01
err21
errOAAI
errZhao, Qingci; Fujimiya, Ryu; Kubo, Satoshi; Marshall, Christopher B.; Ikura, Mitsuhiko; Shimada, Ichio; Nishida, Noritaka
errShare
errSave
Multivalent assembly of KRAS with the RAS-binding and cysteine-rich domains of CRAF on the membrane
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2020-05-15
err47
errOAAI
errFang, Zhenhao; Lee, Ki-Young; Huo, Ku-Geng; Gasmi-Seabrook, Genevieve; Zheng, Le; Moghal, Nadeem; Tsao, Ming-Sound; Ikura, Mitsuhiko; Marshall, Christopher B.
errShare
errSave
Calmodulin disrupts plasma membrane localization of farnesylated KRAS4b by sequestering its lipid moiety
errSCIENCE SIGNALING
IF6.6
err2020-03-31
err26
PREAI
errGrant, Benjamin M. M.; Enomoto, Masahiro; Back, Sung-In; Lee, Ki-Young; Gebregiworgis, Teklab; Ishiyama, Noboru; Ikura, Mitsuhiko; Marshall, Christopher B.
errShare
errSave
Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation
errNATURE COMMUNICATIONS
IF15.7
err2019-01-15
err82
errOAAI
errKano, Yoshihito; Gebregiworgis, Teklab; Marshall, Christopher B.; Radulovich, Nikolina; Poon, Betty P. K.; St-Germain, Jonathan; Cook, Jonathan D.; Valencia-Sama, Ivette; Grant, Benjamin M. M.; Herrera, Silvia Gabriela; Miao, Jinmin; Raught, Brian; Irwin, Meredith S.; Lee, Jeffrey E.; Yeh, Jen Jen; Zhang, Zhong-Yin; Tsao, Ming-Sound; Ikura, Mitsuhiko; Ohh, Michael
errShare
errSave
Does stromal interaction molecule-1 have five senses?
errCELL CALCIUM
IF4
err2019-01-01
err6
PREAI
errStathopulos, Peter B.; Ikura, Mitsuhiko
errShare
errSave

Research Directions

No research directions
Co-authors
Cooperation Journals
T
Tak W. Mak
H-index: 181 · Papers: 1.6K
N
Nahum Sonenberg
H-index: 178 · Papers: 957
R
Robert G. Roeder
H-index: 162 · Papers: 679
T
Tony Pawson
H-index: 157 · Papers: 751
M
Ming‐Sound Tsao
H-index: 151 · Papers: 1.6K
View more