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Characterization of the Immunogenomic Landscape of Ovarian Cancer Uncovers a Distinct Subset of Endometroid Tumors Associated with High CST2 Expression and a Favorable Prognosis Boyle, James; Zaucha, Jan; Ng, Felicia; Spitzmuller, Andreas; Vuko, Miljenka; Segerer, Felix J.; Azqueta-Gavaldon, Monica; Testori, Marco; Raymond, Amelia; Nuttall, Barrett R. B.; Storti, Andrea Ennio; Gulati, Sakshi; Gill, Shaan; Surace, Michael; Marco-Casanova, Paola; Jones, Emma V.; Sidders, Ben S.; Reis-Filho, Jorge S.; Scaltriti, Maurizio; Semertzidou, Anita; Angell, Helen K. Share Save
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A novel strategy for single-nucleus RNA-seq of frozen PAXgene blood: A clinical alternative to single-cell RNA-seq of cryopreserved PBMCs Rotem, A.; Chaudhary, O.; Duclos, G.; Gathungu, P.; Rao, M.; Aguilar, R.; Amir-Zilberstein, L.; Shankarappa, V.; Rands, C.; Chen, X.; Harbolick, E. Galery; Halpin, R.; Steinberg, M.; Boland, J.; Scaltriti, M.; Dougherty, B. Share Save
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Metaplastic Breast Cancer: Whole Genome Sequencing Analysis and Emerging Therapeutic Targets Pareja, Fresia; Gazzo, Andrea; Dopeso, Higinio; Brown, David; Selenica, Pier; Zhu, Yingjie; Blanco-Heredia, Juan; Gusain, Laxmi; Pei, Xin; Montagna, Giacomo; Abuhadra, Nour; Wen, Hanna Y.; Brogi, Edi; Riaz, Nadeem; Chandarlapaty, Sarat; Scaltriti, Maurizio; Norton, Larry; Powell, Simon; Reis-Filho, Jorge; Weigelt, Britta Share Save
Methylation of the chromatin modifier KMT2D by SMYD2 contributes to therapeutic response in hormone-dependent breast cancer Blawski, Ryan; Vokshi, Bujamin H.; Guo, Xinyu; Kittane, Srushti; Sallaku, Mirna; Chen, Wanlu; Gjyzari, Martina; Cheung, Tony; Zhang, Yuhan; Simpkins, Christopher; Zhou, Weiqiang; Kulick, Amanda; Zhao, Peihua; Wei, Meihan; Shivashankar, Pranavkrishna; Prioleau, Tatiana; Razavi, Pedram; Koche, Richard; Rebecca, Vito W.; de Stanchina, Elisa; Castel, Pau; Chan, Ho Man; Scaltriti, Maurizio; Cocco, Emiliano; Ji, Hongkai; Luo, Minkui; Toska, Eneda Share Save
Breast cancer multi-omic single cell profiling identifies key progressive disease markers Russell, Hugh; Rao, Manisha; Duclos, Grant; Aguilar, Rogelio; Barkas, Nick; Callahan, Megan; Chaudhary, Ojasvi; Gathungu, Peter; Rands, Chris; Shankarappa, Varsha; Stetson, Daniel; Rotem, Asaf; Scaltriti, Maurizio; Dougherty, Brian Share Save
The histone methyltransferase KMT2D mediates subtype-specific transcriptional regulation and therapeutic response in prostate cancer Kittane, Srushti; Ladewig, Erik; Li, Taibo; Love, Jillian; Arruabarrena-Aristorena, Amaia; Guo, Xinyu; Sallaku, Mirna; Garcia-Martinez, Liliana; Blawski, Ryan; Sanz, Javier Carmona; Simpkins, Christopher; Chen, Wanlu; Vokshi, Bujamin; Zhao, Peihua; Kelkar, Nachiket; Baldino, Laura; Kalemi, Ingrid; Castel, Pau; Cocco, Emiliano; Morey, Lluis; Sawyers, Charles; Ji, Hongkai; Scaltriti, Maurizio; Battle, Alexis; Leslie, Christina; Eneda, Wouter Karthaus Share Save
Novel therapeutic opportunities in metaplastic breast cancer Pareja, F.; Gazzo, A.; Dopeso, H.; Brown, D.; Selenica, P.; Zhu, Y.; Heredia, J. Blanco; Gusain, L.; Pei, X.; Marra, A.; Montagna, G.; Abuhadra, N.; Wen, H.; Brogi, E.; Riaz, N.; Chandarlapaty, S.; Scaltriti, M.; Powell, S.; Weigelt, B.; Reis-Filho, J. S. Share Save
Combination of T-DXd with the irreversible pan-HER TKI afatinib drives combination benefit in HER2-low gastric and lung tumors Bhavsar, Deepa; Kazlauskas, Laura; Michelini, Flavia; Griffin, Matt; Wilson, Matt; Cecchi, Fabiola; Croydon, Liz; Maratea, Kim; de Stanchina, Elisa; Janjigian, Yelena Y.; Scaltriti, Maurizio; Proia, Theresa; Mettetal, Jerome Share Save
A Naturally Occurring HER2 Carboxy-Terminal Fragment Promotes Mammary Tumor Growth and Metastasis Pedersen, Kim; Angelini, Pier-Davide; Laos, Sirle; Bach-Faig, Alba; Cunningham, Matthew P.; Ferrer-Ramon, Cristina; Luque-Garcia, Antonio; Garcia-Castillo, Jesus; Lluis Parra-Palau, Josep; Scaltriti, Maurizio; Ramon y Cajal, Santiago; Baselga, Jose; Arribas, Joaquin Share Save
Antitumor activity of the PI3K δ-sparing inhibitor MEN1611 in PIK3CA mutated, trastuzumab-resistant HER2+breast cancer Fiascarelli, Alessio; Merlino, Giuseppe; Capano, Stefania; Talucci, Simone; Bisignano, Diego; Bressan, Alessandro; Bellarosa, Daniela; Carrisi, Corrado; Paoli, Alessandro; Bigioni, Mario; Tunici, Patrizia; Irrissuto, Clelia; Salerno, Massimiliano; Arribas, Joaquin; de Stanchina, Elisa; Scaltriti, Maurizio; Binaschi, Monica Share Save
Genetic Heterogeneity and Tissue-specific Patterns of Tumors with Multiple PIK3CA Mutations Sivakumar, Smruthy; Jin, Dexter X.; Rathod, Ruchita; Ross, Jeffrey; Cantley, Lewis C.; Scaltriti, Maurizio; Chen, Jessica W.; Hutchinson, Katherine E.; Wilson, Timothy R.; Sokol, Ethan S.; Vasan, Neil Share Save
High p16 expression and heterozygous RB1 loss are biomarkers for CDK4/6 inhibitor resistance in ER+ breast cancer (September, 10.1038/s41467-022-32828-6, 2022) Palafox, Marta; Monserrat, Laia; Bellet, Meritxell; Villacampa, Guillermo; Gonzalez-Perez, Abel; Oliveira, Mafalda; Braso-Maristany, Fara; Ibrahimi, Nusaibah; Kannan, Srinivasaraghavan; Mina, Leonardo; Herrera-Abreu, Maria Teresa; Odena, Andreu; Sanchez-Guixe, Monica; Capelan, Marta; Azaro, Analia; Bruna, Alejandra; Rodriguez, Olga; Guzman, Marta; Grueso, Judit; Viaplana, Cristina; Hernandez, Javier; Su, Faye; Lin, Kui; Clarke, Robert B.; Caldas, Carlos; Arribas, Joaquin; Michiels, Stefan; Garcia-Sanz, Alicia; Turner, Nicholas C.; Prat, Aleix; Nuciforo, Paolo; Dienstmann, Rodrigo; Verma, Chandra S.; Lopez-Bigas, Nuria; Scaltriti, Maurizio; Arnedos, Monica; Saura, Cristina; Serra, Violeta Share Save
High p16 expression and heterozygous RB1 loss are biomarkers for CDK4/6 inhibitor resistance in ER+ breast cancer Palafox, Marta; Monserrat, Laia; Bellet, Meritxell; Villacampa, Guillermo; Gonzalez-Perez, Abel; Oliveira, Mafalda; Braso-Maristany, Fara; Ibrahimi, Nusaibah; Kannan, Srinivasaraghavan; Mina, Leonardo; Herrera-Abreu, Maria Teresa; Odena, Andreu; Sanchez-Guixe, Monica; Capelan, Marta; Azaro, Analia; Bruna, Alejandra; Rodriguez, Olga; Guzman, Marta; Grueso, Judit; Viaplana, Cristina; Hernandez, Javier; Su, Faye; Lin, Kui; Clarke, Robert B.; Caldas, Carlos; Arribas, Joaquin; Michiels, Stefan; Garcia-Sanz, Alicia; Turner, Nicholas C.; Prat, Aleix; Nuciforo, Paolo; Dienstmann, Rodrigo; Verma, Chandra S.; Lopez-Bigas, Nuria; Scaltriti, Maurizio; Arnedos, Monica; Saura, Cristina; Serra, Violeta Share Save
Pancreatoblastomas and mixed and pure acinar cell carcinomas share epigenetic signatures distinct from other neoplasms of the pancreas Benhamida, Jamal K.; Vyas, Monika; Tanaka, Atsushi; Wang, Lu; Bahrami, Armita; Ozcan, Kerem; Basturk, Olca; Villafania, Liliana; Mata, Douglas A.; El Jabbour, Tony; Selenica, Pier; Roehrl, Michael H. A.; Weigelt, Britta; Reis-Filho, J. S.; Maurizio, Scaltriti; Klimstra, David S. Share Save
Validation of a Novel Three-Dimensional (3D Fusion) Gross Sampling Protocol for Clear Cell Renal Cell Carcinoma to Overcome Intratumoral Heterogeneity: The Meet-Uro 18 Study Brunelli, Matteo; Martignoni, Guido; Malpeli, Giorgio; Volpe, Alessandro; Cima, Luca; Raspollini, Maria Rosaria; Barbareschi, Mattia; Tafuri, Alessandro; Masi, Giulia; Barzon, Luisa; Ammendola, Serena; Villanova, Manuela; Cerruto, Maria Angela; Milella, Michele; Buti, Sebastiano; Bersanelli, Melissa; Fornarini, Giuseppe; Rebuzzi, Sara Elena; Vellone, Valerio Gaetano; Gaggero, Gabriele; Procopio, Giuseppe; Verzoni, Elena; Bracarda, Sergio; Fanelli, Martina; Sabbatini, Roberto; Passalacqua, Rodolfo; Perrucci, Bruno; Giganti, Maria Olga; Donini, Maddalena; Panni, Stefano; Tucci, Marcello; Prati, Veronica; Ortega, Cinzia; Calio, Anna; Eccher, Albino; Alongi, Filippo; Pappagallo, Giovanni; Iacovelli, Roberto; Mosca, Alessandra; Umari, Paolo; Montagnani, Ilaria; Gobbo, Stefano; Atzori, Francesco; Munari, Enrico; Maruzzo, Marco; Basso, Umberto; Pierconti, Francesco; Patriarca, Carlo; Colombo, Piergiuseppe; Lapini, Alberto; Conti, Giario; Salvioni, Roberto; Bollito, Enrico; Cossarizza, Andrea; Massari, Francesco; Rizzo, Mimma; Franco, Renato; Zito-Marino, Federica; Plata, Yoseba Aberasturi; Galuppini, Francesca; Sbaraglia, Marta; Fassan, Matteo; Dei Tos, Angelo Paolo; Colecchia, Maurizio; Moch, Holger; Scaltriti, Maurizio; Porta, Camillo; Delahunt, Brett; Giannarini, Gianluca; Bortolus, Roberto; Rescigno, Pasquale; Banna, Giuseppe Luigi; Signori, Alessio; Obispo, Miguel Angel Llaja; Perris, Roberto; Antonelli, Alessandro Share Save
The Oncogenic PI3K-Induced Transcriptomic Landscape Reveals Key Functions in Splicing and Gene Expression Regulation Ladewig, Erik; Michelini, Flavia; Jhaveri, Komal; Castel, Pau; Carmona, Javier; Fairchild, Lauren; Zuniga, Adler G.; Arruabarrena-Aristorena, Amaia; Cocco, Emiliano; Blawski, Ryan; Kittane, Srushti; Zhang, Yuhan; Sallaku, Mirna; Baldino, Laura; Hristidis, Vasilis; Chandarlapaty, Sarat; Abdel-Wahab, Omar; Leslie, Christina; Scaltriti, Maurizio; Toska, Eneda Share Save
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