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J

Joan S. Brugge

Harvard Medical School

126H-index
597Paper Count
5.5WCitation Count
Published Papers 171
Publication Date
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Defining breast epithelial cell types in the single-cell era
errDevelopmental Cell
IF8.7
err2025-09-08
err0
errOAAI
errG. Kenneth Gray; Eric G. Carlson; Tatyana Lev; Bailey Marshall; Austin D. Reed; Alex P. Sánchez-Covarrubias; Alecia-Jane Twigger; Aleix Puig-Barbe; Aatish Thennavan; Ayodele Omotoso; Lyndsay M. Murrow; Deeptiman Chatterjee; Siyuan He; Sara Pensa; Brian Aevermann; Norbert K. Tavares; Natalie Chen; Jason A. Hilton; Kerrigan Blake; Yunlong Liu; Kiet Phong; Zev J. Gartner; Devon A. Lawson; Alexander Swarbrick; Camila O. dos Santos; Sophia H.L. George; Joan S. Brugge; Mark A. LaBarge; Harikrishna Nakshatri; Nicholas Navin; Kai Kessenbrock; Walid T. Khaled
errShare
errSave
The RAS-MEK-ERK pathway in low-grade serous ovarian cancer
errgynecologic oncology
IF4.1
err2025-07-17
err0
PREAI
errElizabeth H. Stover; Elizabeth K. Lee; Geoffrey I. Shapiro; Joan S. Brugge; Ursula A. Matulonis; Joyce F. Liu
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errSave
Breast organoid suspension cultures maintain long-term estrogen receptor expression and responsiveness
errNPJ BREAST CANCER
IF7.6
err2024-12-19
err0
errOAAI
errChang, Kung-Chi; Silvestri, Francesca; Oliphant, Michael U. J.; Martinez-Gakidis, M. Angie; Orgill, Dennis P.; Garber, Judy E.; Dillon, Deborah D.; Brugge, Joan S.
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errSave
Luminal breast epithelial cells of BRCA1 or BRCA2 mutation carriers and noncarriers harbor common breast cancer copy number alterations
errNATURE GENETICS
IF31.8
err2024-11-20
err0
errOAAI
errWilliams, Marc J.; Oliphant, Michael U. J.; Au, Vinci; Liu, Cathy; Baril, Caroline; O'Flanagan, Ciara; Lai, Daniel; Beatty, Sean; Van Vliet, Michael; Yiu, Jacky C. H.; O'Connor, Lauren; Goh, Walter L.; Pollaci, Alicia; Weiner, Adam C.; Grewal, Diljot; Mcpherson, Andrew; Norton, Klarisa; Moore, Mckenna; Prabhakar, Vikas; Agarwal, Shailesh; Garber, Judy E.; Dillon, Deborah A.; Shah, Sohrab P.; Brugge, Joan S.; Aparicio, Samuel
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errSave
Brca1 haploinsufficiency promotes early tumor onset and epigenetic alterations in a mouse model of hereditary breast cancer (11 Nov, 10.1038/s41588-024-01958-6, 2024)
errNATURE GENETICS
IF31.8
err2024-11-20
err0
errOAAI
errLi, Carman Man-Chung; Cordes, Alyssa; Oliphant, Michael U. J.; Quinn, S. Aidan; Thomas, Mayura; Selfors, Laura M.; Silvestri, Francesca; Girnius, Nomeda; Rinaldi, Gianmarco; Zoeller, Jason J.; Shapiro, Hana; Tsiobikas, Christina; Gupta, Kushali P.; Pathania, Shailja; Regev, Aviv; Kadoch, Cigall; Muthuswamy, Senthil K.; Brugge, Joan S.
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errSave
Brca1 haploinsufficiency promotes early tumor onset and epigenetic alterations in a mouse model of hereditary breast cancer
errNATURE GENETICS
IF31.8
err2024-11-11
err2
PREAI
errLi, Carman Man-Chung; Cordes, Alyssa; Oliphant, Michael U. J.; Quinn, S. Aidan; Thomas, Mayura; Selfors, Laura M.; Silvestri, Francesca; Girnius, Nomeda; Rinaldi, Gianmarco; Zoeller, Jason J.; Shapiro, Hana; Tsiobikas, Christina; Gupta, Kushali P.; Pathania, Shailja; Regev, Aviv; Kadoch, S. Cigall; Muthuswamy, Senthil K.; Brugge, Joan S.
errShare
errSave
Identifying compounds to promote apoptotic cell death in clear cell ovarian cancer
errCANCER RESEARCH
IF16.6
err2024-03-04
err0
PREAI
errShay, Brendan; Handly-Santana, Abram; Qin, Xingping; Choniere, Jonathan; Sarosiek, Kristopher; Brugge, Joan S.; Stover, Elizabeth H.
errShare
errSave
An analysis of the contribution of the glutathione and thioredoxin antioxidant pathways to triple negative breast cancer development
errCANCER RESEARCH
IF16.6
err2024-02-01
err0
PREAI
errGirnius, Nomeda; Henstridge, Aylin Z.; Silvestri, Francesca; Li, Carman Man Chung; Brugge, Joan S.
errShare
errSave
Single cell transcriptomics reveals putative tumor promoting subpopulation in Brca1 mutant breast cancer mouse model
errCANCER RESEARCH
IF16.6
err2024-02-01
err0
PREAI
errPathania, Shailja; Rivera, Joshua; Tran, Stevension; Li, Carman Man Chung; Brugge, Joan; Zarringhalam, Kourosh
errShare
errSave
Organoid Cultures for the Study of Mammary Biology and Breast Cancer: The Promise and Challenges
errCOLD SPRING HARBOR PERSPECTIVES IN MEDICINE
IF10.1
err2023-12-18
err3
PREAI
errMuthuswamy, Senthil K.; Brugge, Joan S.
errShare
errSave
Single-cell transcriptomics identifies a WNT7A-FZD5 signaling axis that maintains fallopian tube stem cells in patient-derived organoids
errCELL REPORTS
IF6.9
err2023-11-01
err2
errOAAI
errAlsaadi, Abdulkhaliq; Artibani, Mara; Hu, Zhiyuan; Wietek, Nina; Morotti, Matteo; Gonzalez, Laura Santana; Alazzam, Moiad; Jiang, Jason; Abdul, Beena; Majd, Hooman Soleymani; Blazer, Levi L.; Adams, Jarret; Silvestri, Francesca; Sidhu, Sachdev S.; Brugge, Joan S.; Ahmed, Ahmed Ashour
errShare
errSave
Single-cell and spatial analyses reveal a tradeoff between murine mammary proliferation and lineage programs associated with endocrine cues
errCELL REPORTS
IF6.9
err2023-10-01
err2
errOAAI
errGray, G. Kenneth; Girnius, Nomeda; Kuiken, Hendrik J.; Henstridge, Aylin Z.; Brugge, Joan S.
errShare
errSave
Final results of a phase I/II study of combined BCL-xL and MEK inhibition with navitoclax and trametinib in KRAS or NRAS mutant advanced solid tumors
errANNALS OF ONCOLOGY
IF65.4
err2023-10-01
err0
errOAAI
errCorcoran, R. B.; Do, K. T.; Cleary, J.; Parikh, A.; Yeku, O.; Weekes, C. D.; Ahronian, L.; Mauri, G.; Tian, J.; Brugge, J.; Juric, D.; Flaherty, K. T.; Sullivan, R. J.; Clark, J.; Heist, R.; Matulonis, U. A.; Liu, J. F.; Shapiro, G. I.
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errSave
A transcriptional response to replication stress selectively expands a subset of Brca2-mutant mammary epithelial cells
errNATURE COMMUNICATIONS
IF15.7
err2023-08-25
err1
errOAAI
errNajafabadi, Maryam Ghaderi; Gray, G. Kenneth; Kong, Li Ren; Gupta, Komal; Perera, David; Naylor, Huw; Brugge, Joan S.; Venkitaraman, Ashok R.; Shehata, Mona
errShare
errSave
TALAVE: Induction talazoparib (tala) followed by combined tala and avelumab in patients (pts) with advanced breast cancer (ABC)
errCANCER RESEARCH
IF16.6
err2023-04-14
err2
PREAI
errLynce, Filipa; Shimada, Kenichi; Geng, Xue; Richardson, Edward T.; Mainor, Candace; Wei, Mei; Collins, Julie M.; Pohlmann, Paula P.; Heeke, Arielle L.; Zheng, Kelly F.; Townsend, Madeline; Staunton, Jane; Schnitt, Stuart J.; Brugge, Joan S.; Wang, Hongkun; Isaacs, Claudine; Shapiro, Geoffrey I.; Guerriero, Jennifer L.
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errSave
Drug persistence pathways in ovarian cancer identified by single-cell analysis of patient samples and cell line models
errCANCER RESEARCH
IF16.6
err2023-04-04
err0
PREAI
errLeshchiner, Elizaveta; Panayiotou, Richard; Gupta, Anay; Zhang, Thomas; Neil, Kayli; Girnius, Nomeda; Henstridge, Aylin; Danysh, Brian P.; Leshchiner, Ignaty; Hill, Sarah J.; Parida, Laxmi; Matulonis, Ursula A.; Brugge, Joan S.; Getz, Gad
errShare
errSave
Phosphatidylinositol 3-kinase is required for integlrin-stimulated AKT and Raf-1/mitogen-activated protein kinase pathway activation
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-29
err417
errOAAI
errKing, WG; Mattaliano, MD; Chan, TO; Tsichlis, PN; Brugge, JS
errShare
errSave
Vav family proteins couple to diverse cell surface receptors
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-28
err150
errOAAI
errMoores, SL; Selfors, LM; Fredericks, J; Breit, T; Fujikawa, K; Alt, FW; Brugge, JS; Swat, W
errShare
errSave
Epidermal growth factor receptor-dependent regulation of integrin-mediated signaling and cell cycle entry in epithelial cells
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err167
errOAAI
errBill, HM; Knudsen, B; Moores, SL; Muthuswamy, SK; Rao, VR; Brugge, JS; Miranti, CK
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errSave
G1/S cell cycle arrest provides anoikis resistance through Erk-mediated Bim suppression
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err127
errOAAI
errCollins, NL; Reginato, MJ; Paulus, JK; Sgroi, DC; LaBaer, J; Brugge, JS
errShare
errSave

Research Directions

No research directions
Co-authors
Cooperation Journals
G
Gad Getz
H-index: 248 · Papers: 1.8K
G
Graham A. Colditz
H-index: 247 · Papers: 2.4K
H
Hans Clevers
H-index: 236 · Papers: 1.3K
G
Gordon B. Mills
H-index: 231 · Papers: 3.5K
M
Matthew Meyerson
H-index: 223 · Papers: 1.9K
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