Not logged inHarnessing transcriptional regulation of alternative end-joining to predict cancer treatment
Espin, Roderic; Medina-Jover, Ferran; Siguenza-Andrade, Javier; Farran-Matas, Sonia; Mateo, Francesca; Figueras, Agnes; Sanz, Rosario T.; Vicent, Guillermo Pablo; Shabbir, Arzoo; Ruiz-Auladell, Lara; Racionero-Andres, Emilio; Garcia, Irene; Baiges, Alexandra; Franco-Luzon, Lidia; Martinez-Tebar, Adrian; Pardo-Cea, Miguel Angel; Martinez-Iniesta, Maria; Wang, Xieng Chen; Cuyas, Elisabet; Menendez, Javier A.; Lopez-Cerda, Marta; Munoz, Purificacion; Richaud, Ivonne; Raya, Angel; Fabregat, Isabel; Villanueva, Alberto; Serrat, Xenia; Ceron, Julian; Alemany, Montserrat; Guix, Ines; Herencia-Ropero, Andrea; Serra, Violeta; Krishnan, Rehna; Mekhail, Karim; Hakem, Razqallah; Bruna, Jordi; Barcellos-Hoff, Mary Helen; Vinals, Francesc; Aytes, Alvaro; Pujana, Miquel Angel .png)
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SaveDNA double-strand break-capturing nuclear envelope tubules drive DNA repairShokrollahi, Mitra; Stanic, Mia; Hundal, Anisha; Chan, Janet N. Y.; Urman, Defne; Jordan, Chris A.; Hakem, Anne; Espin, Roderic; Hao, Jun; Krishnan, Rehna; Maass, Philipp G.; Dickson, Brendan C.; Hande, Manoor P.; Pujana, Miquel A.; Hakem, Razqallah; Mekhail, Karim Share Save SARS-CoV-2 targets ribosomal RNA biogenesisYerlici, V. Talya; Astori, Audrey; Kejiou, Nevraj S.; Jordan, Chris A.; Khosraviani, Negin; Chan, Janet N. Y.; Hakem, Razqallah; Raught, Brian; Palazzo, Alexander F.; Mekhail, Karim Share Save RNF8 ubiquitylation of XRN2 facilitates R-loop resolution and restrains genomic instability in BRCA1 mutant cellsKrishnan, Rehna; Lapierre, Mariah; Gautreau, Brandon; Nixon, Kevin C. J.; El Ghamrasni, Samah; Patel, Parasvi S.; Hao, Jun; Yerlici, V. Talya; Guturi, Kiran Kumar Naidu; St-Germain, Jonathan; Mateo, Francesca; Saad, Amine; Algouneh, Arash; Earnshaw, Rebecca; Shili, Duan; Seitova, Alma; Miller, Joshua; Khosraviani, Negin; Penn, Adam; Ho, Brandon; Sanchez, Otto; Hande, M. Prakash; Masson, Jean-Yves; Brown, Grant W.; Alaoui-Jamali, Moulay; Reynolds, John J.; Arrowsmith, Cheryl; Raught, Brian; Pujana, Miguel A.; Mekhail, Karim; Stewart, Grant S.; Hakem, Anne; Hakem, Razqallah Share Save Share Save Excessive transcription-replication conflicts are a vulnerability of BRCA1-mutant cancersPatel, Parasvi S.; Algouneh, Arash; Krishnan, Rehna; Reynolds, John J.; Nixon, Kevin C. J.; Hao, Jun; Lee, Jihoon; Feng, Yue; Fozil, Chehronai; Stanic, Mia; Yerlici, Talya; Su, Peiran; Soares, Fraser; Liedtke, Elisabeth; Prive, Gil; Baider, Gary D.; Pujana, Miquel Angel; Mekhail, Karim; He, Housheng Hansen; Hakem, Anne; Stewart, Grant S.; Hakem, Razqallah Share Save A small molecule antagonist of SMN disrupts the interaction between SMN and RNAP IILiu, Yanli; Iqbal, Aman; Li, Weiguo; Ni, Zuyao; Wang, Yalong; Ramprasad, Jurupula; Abraham, Karan Joshua; Zhang, Mengmeng; Zhao, Dorothy Yanling; Qin, Su; Loppnau, Peter; Guo, Xinghua; Zhou, Mengqi; Brown, Peter J.; Zhen, Xuechu; Xu, Guoqiang; Mekhail, Karim; Ji, Xingyue; Bedford, Mark T.; Greenblatt, Jack F.; Min, Jinrong Share Save Share Save Share Save RNF168 regulates R-loop resolution and genomic stability in BRCA1/2-deficient tumorsPatel, Parasvi S.; Abraham, Karan Joshua; Guturi, Kiran Kumar Naidu; Halaby, Marie-Jo; Khan, Zahra; Palomero, Luis; Ho, Brandon; Duan, Shili; St-Germain, Jonathan; Algouneh, Arash; Mateo, Francesca; El Ghamrasni, Samah; Barbour, Haithem; Barnes, Daniel R.; Beesley, Jonathan; Sanchez, Otto; Berman, Hal K.; Brown, Grant W.; Affar, El Bachir; Chenevix-Trench, Georgia; Antoniou, Antonis C.; Arrowsmith, Cheryl H.; Raught, Brian; Pujana, Miquel Angel; Mekhail, Karim; Hakem, Anne; Hakem, Razqallah Share Save Share Save Share Save Share Save Share Save Share Save Conserved Pbp1/Ataxin-2 regulates retrotransposon activity and connects polyglutamine expansion-driven protein aggregation to lifespan-controlling rDNA repeatsOstrowski, Lauren A.; Hall, Amanda C.; Szafranski, Kirk J.; Oshidari, Roxanne; Abraham, Karan J.; Chan, Janet N. Y.; Krustev, Christian; Zhang, Kevin; Wang, Ashley; Liu, Yupeng; Guo, Ru; Mekhail, Karim Share Save Share Save Share Save Intersection of calorie restriction and magnesium in the suppression of genome-destabilizing RNA-DNA hybridsAbraham, Karan J.; Chan, Janet N. Y.; Salvi, Jayesh S.; Ho, Brandon; Hall, Amanda; Vidya, Elva; Guo, Ru; Killackey, Samuel A.; Liu, Nancy; Lee, Jeffrey E.; Brown, Grant W.; Mekhail, Karim Share Save Share Save 
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