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Complete preclinical evaluation of the novel antibody mimetic Nanofitin-IRDye800CW for diverse non-invasive diagnostic applications in the management of HER-2 positive tumors Iaboni, Margherita; Crivellin, Federico; Arena, Francesca; La Cava, Francesca; Cordaro, Alessia; Stummo, Francesco; Faletto, Daniele; Huet, Simon; Candela, Leo; Pedrault, Jessy; Zanella, Eugenia R.; Bertotti, Andrea; Blasi, Francesco; Maiocchi, Alessandro; Poggi, Luisa; Reitano, Erika Share Save
Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer (Vol 56, pg 458, 2024) Malla, Sudhir B.; Byrne, Ryan M.; Lafarge, Maxime W.; Corry, Shania M.; Fisher, Natalie C.; Tsantoulis, Petros K.; Mills, Megan L.; Ridgway, Rachel A.; Lannagan, Tamsin R. M.; Najumudeen, Arafath K.; Gilroy, Kathryn L.; Amirkhah, Raheleh; Maguire, Sarah L.; Mulholland, Eoghan J.; Belnoue-Davis, Hayley L.; Grassi, Elena; Viviani, Marco; Rogan, Emily; Redmond, Keara L.; Sakhnevych, Svetlana; McCooey, Aoife J.; Bull, Courtney; Hoey, Emily; Sinevici, Nicoleta; Hall, Holly; Ahmaderaghi, Baharak; Domingo, Enric; Blake, Andrew; Richman, Susan D.; Isella, Claudio; Miller, Crispin; Bertotti, Andrea; Trusolino, Livio; Loughrey, Maurice B.; Kerr, Emma M.; Tejpar, Sabine; Maughan, Timothy S.; Lawler, Mark; Campbell, Andrew D.; Leedham, Simon J.; Koelzer, Viktor H.; Sansom, Owen J.; Dunne, Philip D. Share Save
Preclinical efficacy of a synthetic Notch-based combinatorial immunotherapy against colorectal cancer with HER2 amplification Cortese, Marco; Torchiaro, Erica; D'Andrea, Alice; Petti, Consalvo; Invrea, Federica; Franco, Letizia; Donini, Chiara; Leuci, Valeria; Leto, Simonetta M.; Vurchio, Valentina; Cottino, Francesca; Isella, Claudio; Arena, Sabrina; Vigna, Elisa; Bertotti, Andrea; Trusolino, Livio; Sangiolo, Dario; Medico, Enzo Share Save
Molecular and therapeutic characterization of a large-scale collection of metastatic colorectal cancer patient-derived xenografts and matched organoids for translational oncology Leto, Simonetta M.; Grassi, Elena; Avolio, Marco; Vurchio, Valentina; Cottino, Francesca; Ferri, Martina; Zanella, Eugenia R.; Di Blasio, Laura; Puliafito, Alberto; Primo, Luca; Bertotti, Andrea; Trusolino, Livio Share Save
Unravelling intra-tumor phenotypic heterogeneity in colorectal cancer organoids Fletcher, Sabrina J.; Catalano, Irene; Grassi, Elena; Borgato, Sofia; Peracino, Barbara; Piretto, Elena; Alessandri, Luca; Calogero, Raffaele; Primo, Luca; Trusolino, Livio; Bertotti, Andrea; Puliafito, Alberto Share Save
Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer Malla, Sudhir B.; Byrne, Ryan M.; Lafarge, Maxime W.; Corry, Shania M.; Fisher, Natalie C.; Tsantoulis, Petros K.; Mills, Megan L.; Ridgway, Rachel A.; Lannagan, Tamsin R. M.; Najumudeen, Arafath K.; Gilroy, Kathryn L.; Amirkhah, Raheleh; Maguire, Sarah L.; Mulholland, Eoghan J.; Belnoue-Davis, Hayley L.; Grassi, Elena; Viviani, Marco; Rogan, Emily; Redmond, Keara L.; Sakhnevych, Svetlana; Mccooey, Aoife J.; Bull, Courtney; Hoey, Emily; Sinevici, Nicoleta; Hall, Holly; Ahmaderaghi, Baharak; Domingo, Enric; Blake, Andrew; Richman, Susan D.; Isella, Claudio; Miller, Crispin; Bertotti, Andrea; Trusolino, Livio; Loughrey, Maurice B.; Kerr, Emma M.; Tejpar, Sabine; Maughan, Timothy S.; Lawler, Mark; Campbell, Andrew D.; Leedham, Simon J.; Koelzer, Viktor H.; Sansom, Owen J.; Dunne, Philip D. Share Save
Phosphoproteomics of patient-derived xenografts identifies targets and markers associated with sensitivity and resistance to EGFR blockade in colorectal cancer Beekhof, Robin; Bertotti, Andrea; Boettger, Franziska; Vurchio, Valentina; Cottino, Francesca; Zanella, Eugenia R.; Migliardi, Giorgia; Viviani, Marco; Grassi, Elena; Lupo, Barbara; Henneman, Alex A.; Knol, Jaco C.; Pham, Thang V.; de Goeij-de Haas, Richard; Piersma, Sander R.; Labots, Mariette; Verheul, Henk M. W.; Trusolino, Livio; Jimenez, Connie R. Share Save
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MSI cancer associated DNA (TA)n-dinucleotide repeat expansions and implications for Werner synthetic lethality Picco, Gabriele; Bhosle, Shriram; Kalyva, Maria; Grassi, Elena; Gibson, Freddy; Al Saedi, Angham; Vieira, Sara; Sanders, Mathijs; Trusolino, Livio; Bertotti, Andrea; Mathew, Isidro Cortes-Ciriano Share Save
MicroRNA 483-3p overexpression unleashes invasive growth of metastatic colorectal cancer via NDRG1 downregulation and ensuing activation of the ERBB3/AKT axis Candiello, Ermes; Reato, Gigliola; Verginelli, Federica; Gambardella, Gennaro; D'Ambrosio, Antonio; Calandra, Noemi; Orzan, Francesca; Iuliano, Antonella; Albano, Raffaella; Sassi, Francesco; Luraghi, Paolo; Comoglio, Paolo M.; Bertotti, Andrea; Trusolino, Livio; Boccaccio, Carla Share Save
Colorectal cancer patient-derived organoids and cell lines harboring ATRX and/or DAXX mutations lack Alternative Lengthening of Telomeres (ALT) Falcinelli, Marta; Dell'Omo, Giulia; Grassi, Elena; Mariella, Elisa; Leto, Simonetta Maria; Scardellato, Sharon; Lorenzato, Annalisa; Arena, Sabrina; Bertotti, Andrea; Trusolino, Livio; Bardelli, Alberto; di Fagagna, Fabrizio d'Adda Share Save
A modified fluctuation-test framework characterizes the population dynamics and mutation rate of colorectal cancer persister cells Russo, Mariangela; Pompei, Simone; Sogari, Alberto; Corigliano, Mattia; Crisafulli, Giovanni; Puliafito, Alberto; Lamba, Simona; Erriquez, Jessica; Bertotti, Andrea; Gherardi, Marco; Di Nicolantonio, Federica; Bardelli, Alberto; Lagomarsino, Marco Cosentino Share Save
The EurOPDX Data Portal: an open platform for patient-derived cancer xenograft data sharing and visualization Dudova, Zdenka; Conte, Nathalie; Mason, Jeremy; Stuchlik, Dalibor; Pesa, Radim; Halmagyi, Csaba; Perova, Zinaida; Mosaku, Abayomi; Thorne, Ross; Follette, Alex; Pivarc, Luboslav; Sasinka, Radim; Usman, Muhammad; Neuhauser, Steven; Begley, Dale A.; Krupke, Debra M.; Frassa, Massimiliano; Fiori, Alessandro; Corsi, Riccardo; Vezzadini, Luca; Isella, Claudio; Bertotti, Andrea; Bult, Carol; Parkinson, Helen; Medico, Enzo; Meehan, Terrence; Krenek, Ales Share Save
Chromatin Velocity reveals epigenetic dynamics by single-cell profiling of heterochromatin and euchromatin Tedesco, Martina; Giannese, Francesca; Lazarevic, Dejan; Giansanti, Valentina; Rosano, Dalia; Monzanis, Silvia; Catalano, Irene; Grassi, Elena; Zanella, Eugenia R.; Botrugno, Oronza A.; Morelli, Leonardo; Bordignon, Paola Panina; Caravagna, Giulio; Bertotti, Andrea; Martino, Gianvito; Aldrighetti, Luca; Pasqualato, Sebastiano; Trusolino, Livio; Cittaro, Davide; Tonon, Giovanni Share Save
MEN1611 in combination with cetuximab: Targeting PIK3CA mutations in RAS-wild-type patient-derived colorectal cancer xenografts Capano, S.; Merlino, G.; Bigioni, M.; Tunici, P.; Cottino, F.; Zanella, E.; Vurchio, V.; Bertotti, A.; Trusolino, L.; Laurent, D. O.; Pellacani, A.; Binaschi, M. Share Save
Molecular Subtyping Combined with Biological Pathway Analyses to Study Regorafenib Response in Clinically Relevant Mouse Models of Colorectal Cancer Lafferty, Adam; O'Farrell, Alice C.; Migliardi, Giorgia; Khemka, Niraj; Lindner, Andreas U.; Sassi, Francesco; Zanella, Eugenia R.; Salvucci, Manuela; Vanderheyden, Evy; Modave, Elodie; Boeckx, Bram; Halang, Luise; Betge, Johannes; Ebert, Matthias P. A.; Dicker, Patrick; Argiles, Guillem; Tabernero, Josep; Dienstmann, Rodrigo; Medico, Enzo; Lambrechts, Diether; Bertotti, Andrea; Isella, Claudio; Trusolino, Livio; Prehn, Jochen H. M.; Byrne, Annette T. Share Save
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