Joost C. M. Holthuis - Publications, H-index & Citations

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Joost C. M. Holthuis

osnabrück university

46H-index

124Paper Count

7.9KCitation Count

Published Papers 64

Publication Date

Challenging a role for ceramide channels and microdomains in apoptosis induction using a bottom-up approach

Scientific Reports

IF3.9

2026-10-15

OAAI

Milena Wessing; Pia Webersinn; Sophie Klaßen; Britta Fiedler; Katia Cosentino; Joost C. M. Holthuis

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Mitochondria-specific photorelease of ceramide induces apoptosis

Journal of Lipid Research

IF4.1

2025-09-19

OAAI

Christian Schröer; Matthijs Kol; Anna Koch; Emely Döffinger; Murali Annamalai; Joost C.M. Holthuis

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Characterization of Caenorhabditis elegans sphingomyelin synthases through heterologous expression

Journal of Biological Chemistry

IF3.9

2025-07-01

OAAI

Gaelen Guzman; Helene Jahn; Scotland E. Farley; Jennifer E. Kyle; Lisa M. Bramer; Sandra Hoetzl; Joep van den Dikkenberg; Martin Hermansson; Joost C.M. Holthuis; Fikadu G. Tafesse

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Hexokinase-I directly binds to a charged membrane-buried glutamate of mitochondrial VDAC1 and VDAC2

COMMUNICATIONS BIOLOGY

IF5.1

2025-02-10

OAAI

Bieker, Sebastian; Timme, Michael; Woge, Nils; Hassan, Dina G.; Brown, Chelsea M.; Marrink, Siewert J.; Melo, Manuel N.; Holthuis, Joost C. M.

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Optical control of sphingolipid biosynthesis using photoswitchable sphingosines

JOURNAL OF LIPID RESEARCH

IF4.1

2025-01-01

PREAI

Kol, Matthijs; Novak, Alexander J. E.; Morstein, Johannes; Schroeer, Christian; Sokoya, Tolulope; Mensing, Svenja; Korneev, Sergei M.; Trauner, Dirk; Holthuis, Joost C. M.

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Phospholipids are imported into mitochondria by VDAC, a dimeric beta barrel scramblase

NATURE COMMUNICATIONS

IF15.7

2023-12-08

OAAI

Jahn, Helene; Bartos, Ladislav; Dearden, Grace I.; Dittman, Jeremy S.; Holthuis, Joost C. M.; Vacha, Robert; Menon, Anant K.

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Toxoplasma ceramide synthases: Gene duplication, functional divergence, and roles in parasite fitness

FASEB JOURNAL

IF4.2

2023-10-05

OAAI

Koutsogiannis, Zisis; Mina, John G.; Albus, Christin A.; Kol, Matthijs A.; Holthuis, Joost C. M.; Pohl, Ehmke; Denny, Paul W.

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Biofunctional Nanodot Arrays in Living Cells Uncover Synergistic Co-Condensation of Wnt Signalodroplets

SMALL

IF12.1

2022-10-20

OAAI

Philippi, Michael; Richter, Christian P.; Kappen, Marie; Watrinet, Isabelle; Miao, Yi; Runge, Mercedes; Jorde, Lara; Korneev, Sergej; Holtmannspoetter, Michael; Kurre, Rainer; Holthuis, Joost C. M.; Garcia, K. Christopher; Plueckthun, Andreas; Steinhart, Martin; Piehler, Jacob; You, Changjiang

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Pathogenic variants of sphingomyelin synthase SMS2 disrupt lipid landscapes in the secretory pathway

ELIFE

IF0

2022-09-14

OAAI

Sokoya, Tolulope; Parolek, Jan; Foged, Mads Moller; Danylchuk, Dmytro, I; Bozan, Manuel; Sarkar, Bingshati; Hilderink, Angelika; Philippi, Michael; Botto, Lorenzo D.; Terhal, Paulien A.; Makitie, Outi; Piehler, Jacob; Kim, Yeongho; Burd, Christopher G.; Klymchenko, Andrey S.; Maeda, Kenji; Holthuis, Joost C. M.

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Ca2+-activated Sphingomyelin Scrambling and Turnover Mediate ESCRT-independent Lysosomal Repair

FASEB JOURNAL

IF4.2

2022-05-13

PREAI

Holthuis, Joost; Niekamp, Patrick

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Sphingolipids: A double-edged sword in the defense against Mycobacterium tuberculosis

JOURNAL OF IMMUNOLOGY

IF3.4

2022-05-01

PREAI

Guzman, Gaelen D.; Leier, Hans; Niekamp, Patrick; Holthuis, Joost; Tafesse, Fikadu G.

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Ca2+-activated sphingomyelin scrambling and turnover mediate ESCRT-independent lysosomal repair

NATURE COMMUNICATIONS

IF15.7

2022-04-06

OAAI

Niekamp, Patrick; Scharte, Felix; Sokoya, Tolulope; Vittadello, Laura; Kim, Yeongho; Deng, Yongqiang; Sudhoff, Elisabeth; Hilderink, Angelika; Imlau, Mirco; Clarke, Christopher J.; Hensel, Michael; Burd, Christopher G.; Holthuis, Joost C. M.

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Sphingomyelin Biosynthesis Is Essential for Phagocytic Signaling during Mycobacterium tuberculosis Host Cell Entry

MBIO

IF4.7

2021-02-23

OAAI

Niekamp, Patrick; Guzman, Gaelen; Leier, Hans C.; Rashidfarrokhi, Ali; Richina, Veronica; Pott, Fabian; Barisch, Caroline; Holthuis, Joost C. M.; Tafesse, Fikadu G.

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Short Photoswitchable Ceramides Enable Optical Control of Apoptosis

ACS CHEMICAL BIOLOGY

IF3.8

2021-02-15

PREAI

Morstein, Johannes; Kol, Matthijs; Novak, Alexander J. E.; Feng, Suihan; Khayyo, Shadi; Hinnah, Konstantin; Li-Purcell, Nasi; Pan, Grace; Williams, Benjamin M.; Riezman, Howard; Atilla-Gokcumen, G. Ekin; Holthuis, Joost C. M.; Trauner, Dirk

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A switchable ceramide transfer protein for dissecting the mechanism of ceramide-induced mitochondrial apoptosis

FEBS LETTERS

IF3

2020-10-26

OAAI

Jain, Amrita; Dadsena, Shashank; Holthuis, Joost C. M.

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Ceramides bind VDAC2 to trigger mitochondrial apoptosis

NATURE COMMUNICATIONS

IF15.7

2019-04-23

154

OAAI

Dadsena, Shashank; Bockelmann, Svenja; Mina, John G. M.; Hassan, Dina G.; Korneev, Sergei; Razzera, Guilherme; Jahn, Helene; Niekamp, Patrick; Mueller, Dagmar; Schneider, Markus; Tafesse, Fikadu G.; Marrink, Siewert J.; Melo, Manuel N.; Holthuis, Joost C. M.

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Osteoporosis and skeletal dysplasia caused by pathogenic variants in SGMS2

JCI INSIGHT

IF6.1

2019-04-04

OAAI

Pekkinen, Minna; Terhal, Paulien A.; Botto, Lorenzo D.; Henning, Petra; Makitie, Riikka E.; Roschger, Paul; Jain, Amrita; Kol, Matthijs; Kjellberg, Matti A.; Paschalis, Eleftherios P.; van Lassen, Koen; Murray, Mary; Bayrak-Toydemir, Pinar; Magnusson, Maria K.; Jans, Judith; Kausar, Mehran; Carey, John C.; Somerharju, Pentti; Lerner, Ulf H.; Olkkonen, Vesa M.; Klaushofer, Klaus; Holthuis, Joost C. M.; Makitie, Outi

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Optical manipulation of sphingolipid biosynthesis using photoswitchable ceramides

ELIFE

IF0

2019-02-05

OAAI

Kol, Matthijs; Williams, Ben; Toombs-Ruane, Henry; Franquelim, Henri G.; Korneev, Sergei; Schroeer, Christian; Schwille, Petra; Trauner, Dirk; Holthuis, Joost C. M.; Frank, James A.

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Defective cortex glia plasma membrane structure underlies light-induced epilepsy in cpes mutants

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2018-09-05

OAAI

Kunduri, Govind; Turner-Evans, Daniel; Konya, Yutaka; Izumi, Yoshihiro; Nagashima, Kunio; Lockett, Stephen; Holthuis, Joost; Bamba, Takeshi; Acharya, Usha; Acharya, Jairaj K.

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A search for ceramide binding proteins using bifunctional lipid analogs yields CERT-related protein StarD7

JOURNAL OF LIPID RESEARCH

IF4.1

2018-03-01

OAAI

Bockelmann, Svenja; Mina, John G. M.; Korneev, Sergei; Hassan, Dina G.; Mueller, Dagmar; Hilderink, Angelika; Vlieg, Hedwich C.; Raijmakers, Reinout; Heck, Albert J. R.; Haberkant, Per; Holthuis, Joost C. M.

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Research Directions