Manuel Serrano - Publications, H-index & Citations

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Manuel Serrano

Altos Labs

98H-index

539Paper Count

7.6WCitation Count

Published Papers 224

Publication Date

Immune surveillance and immune evasion of senescent cells

Nature Reviews Immunology

IF60.9

2026-08-11

PREAI

Pau Garcia-Baucells; Manuel Serrano; Corina Amor

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Author Correction: The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2

Nature Cancer

IF28.5

2026-05-29

OAAI

Selim Chaib; José Alberto López-Domínguez; Marta Lalinde-Gutiérrez; Neus Prats; Ines Marin; Olga Boix; Andrea García-Garijo; Kathleen Meyer; María Isabel Muñoz; Mònica Aguilera; Lidia Mateo; Camille Stephan-Otto Attolini; Susana Llanos; Sandra Pérez-Ramos; Marta Escorihuela; Fatima Al-Shahrour; Timothy P. Cash; Tamara Tchkonia; James L. Kirkland; María Abad; Alena Gros; Joaquín Arribas; Manuel Serrano

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Senotoxins target senescence via lipid binding specificity, ion imbalance and lipidome remodeling

Nature Aging

IF19.4

2026-01-12

OAAI

Javier Moral-Sanz; Isabel Fernández-Carrasco; Valentina Ramponi; Amanda Garrido; Izhar Karbat; Pablo Cabezas-Sainz; Esperanza Rivera-de-Torre; Osama Elsallabi; Roberto Martín-Hernández; José L. López-Aceituno; Nathan L. Price; Laura Sanchez; Gonzalo Colmenarejo; Álvaro Martínez-del-Pozo; Irina Vetter; Angel Cogolludo; Francisco Perez-Vizcaino; Jorge Del-Pozo; Eitan Reuveny; Manuel A. Fernández-Rojo; Paul D. Robbins; Rafael de Cabo; Manuel Serrano; Maria P. Ikonomopoulou

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Author Correction: ImAge quantitates aging and rejuvenation

Nature Aging

IF19.4

2025-08-05

PREAI

Martin Alvarez-Kuglen; Kenta Ninomiya; Haodong Qin; Delany Rodriguez; Lorenzo Fiengo; Chen Farhy; Wei-Mien Hsu; Brian Kirk; Aaron Havas; Collin Kaufman; Gen-Sheng Feng; Amanda J. Roberts; Rozalyn M. Anderson; Manuel Serrano; Peter D. Adams; Tatyana O. Sharpee; Alexey V. Terskikh

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A TFEB–TGFβ axis systemically regulates diapause, stem cell resilience and protects against a senescence-like state

Nature Aging

IF19.4

2025-06-30

OAAI

Tim J. Nonninger; Jennifer Mak; Birgit Gerisch; Valentina Ramponi; Kazuto Kawamura; Roberto Ripa; Klara Schilling; Christian Latza; Jonathan Kölschbach; Manuel Serrano; Adam Antebi

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HRK downregulation and augmented BCL-xL binding to BAK confer apoptotic protection to therapy-induced senescent melanoma cells

CELL DEATH AND DIFFERENTIATION

IF15.4

2024-12-03

OAAI

Alcon, Clara; Kovatcheva, Marta; Morales-Sanchez, Paula; Lopez-Polo, Vanessa; Torres, Teresa; Puig, Susana; Lu, Albert; Samitier, Josep; Enrich, Carlos; Serrano, Manuel; Montero, Joan

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Expansion of the neocortex and protection from neurodegeneration by in vivo transient reprogramming

CELL STEM CELL

IF20.4

2024-12-01

OAAI

Shen, Yi-Ru; Zaballa, Sofia; Bech, Xavier; Sancho-Balsells, Anna; Rodrguez-Navarro, Irene; Cifuentes-Diaz, Carmen; Seyit-Bremer, Gonul; Chun, Seung Hee; Straub, Tobias; Abante, Jordi; Merino-Valverde, Inaki; Richart, Laia; Gupta, Vipul; Li, Hao-Yi; Ballasch, Ivan; Alcazar, Noelia; Alberch, Jordi; Canals, Josep M.; Abad, Maria; Serrano, Manuel; Klein, Rudiger; Giralt, Albert; del Toro, Daniel

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Leonard Hayflick (1928-2024) - obituary

NPJ AGING

IF6

2024-10-31

OAAI

Serrano, Manuel

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Co-expression of matrix metalloproteinase-7 and cellular senescence markers in fibrosing interstitial lung diseases

EUROPEAN RESPIRATORY JOURNAL

IF21

2024-10-30

PREAI

Gonzalez, Fernanda Ines Hernandez; Martinez, Daniel; Cruz, Tamara; Mendoza, Nuria; Casas-Recasens, Sandra; Frino-Garcia, Alejandro; Perez-Rodas, Nancy; Alsina-Restoy, Xavier; Lopez-Saiz, Gemma; Medina, Ana Maria; Pietrocola, Federico; Agusti, Alvar; Rojas, Mauricio; Serrano, Manuel; Faner, Rosa; Sellares, Jacobo

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Cyclophilin D plays a critical role in the survival of senescent cells

EMBO JOURNAL

IF8.3

2024-10-24

PREAI

Protasoni, Margherita; Lopez-Polo, Vanessa; Attolini, Camille Stephan-Otto; Brandariz, Julian; Herranz, Nicolas; Mateo, Joaquin; Ruiz, Sergio; Fernandez-Capetillo, Oscar; Kovatcheva, Marta; Serrano, Manuel

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Iron chelation as a new therapeutic approach to prevent senescence and liver fibrosis progression

CELL DEATH & DISEASE

IF9.6

2024-09-17

OAAI

Amengual, Josep; Alay, Ania; Vaquero, Javier; Gonzalez-Sanchez, Ester; Bertran, Esther; Sanchez, Aranzazu; Herrera, Blanca; Meyer, Kathleen; Maus, Mate; Serrano, Manuel; Martinez-Chantar, Maria Luz; Fabregat, Isabel

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ImAge quantitates aging and rejuvenation

NATURE AGING

IF19.4

2024-08-29

PREAI

Alvarez-Kuglen, Martin; Ninomiya, Kenta; Qin, Haodong; Rodriguez, Delany; Fiengo, Lorenzo; Farhy, Chen; Hsu, Wei-Mien; Kirk, Brian; Havas, Aaron; Feng, Gen-Sheng; Roberts, Amanda J.; Anderson, Rozalyn M.; Serrano, Manuel; Adams, Peter D.; Sharpee, Tatyana O.; Terskikh, Alexey V.

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Release of mitochondrial dsRNA into the cytosol is a key driver of the inflammatory phenotype of senescent cells

NATURE COMMUNICATIONS

IF15.7

2024-08-27

OAAI

Lopez-Polo, Vanessa; Maus, Mate; Zacharioudakis, Emmanouil; Lafarga, Miguel; Attolini, Camille Stephan-Otto; Marques, Francisco D. M.; Kovatcheva, Marta; Gavathiotis, Evripidis; Serrano, Manuel

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A pattern emerges in chromatin aging: AP-1 steals the show

CELL METABOLISM

IF30.9

2024-08-01

PREAI

Lynch, Cian J.; Richart, Laia; Serrano, Manuel

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Flexible structural arrangement and DNA-binding properties of protein p6 from Bacillus subtillis phage φ29

NUCLEIC ACIDS RESEARCH

IF13.1

2024-01-28

OAAI

Alcorlo, Martin; Luque-Ortega, Juan Roman; Gago, Federico; Ortega, Alvaro; Castellanos, Milagros; Chacon, Pablo; de Vega, Miguel; Blanco, Luis; Hermoso, Jose M.; Serrano, Manuel; Rivas, German; Hermoso, Juan A.

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The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2

NATURE CANCER

IF28.5

2024-01-24

OAAI

Chaib, Selim; Lopez-Dominguez, Jose Alberto; Lalinde-Gutierrez, Marta; Prats, Neus; Marin, Ines; Boix, Olga; Garcia-Garijo, Andrea; Meyer, Kathleen; Munoz, Maria Isabel; Aguilera, Monica; Mateo, Lidia; Attolini, Camille Stephan-Otto; Llanos, Susana; Perez-Ramos, Sandra; Escorihuela, Marta; Al-Shahrour, Fatima; Cash, Timothy P.; Tchkonia, Tamara; Kirkland, James L.; Abad, Maria; Gros, Alena; Arribas, Joaquin; Serrano, Manuel

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Mucosal TLR5 activation controls healthspan and longevity

NATURE COMMUNICATIONS

IF15.7

2024-01-02

OAAI

Lim, Jae Sung; Jeon, Eun Jae; Go, Hye Sun; Kim, Hyung-Jin; Kim, Kye Young; Nguyen, Thi Quynh Trang; Lee, Da Young; Kim, Kyu Suk; Pietrocola, Federico; Hong, Seol Hee; Lee, Shee Eun; Kim, Kyoung-Shim; Park, Tae-Shin; Choi, Dong-Hee; Jeong, Yu-Jin; Park, Jong-Hwan; Kim, Hyeon Sik; Min, Jung-Joon; Kim, Yong Sook; Park, Joon Tae; Cho, Jae-Ho; Lee, Gil-Woo; Lee, Ji Hyeon; Choy, Hyon E.; Park, Sang Chul; Lee, Chul-Ho; Rhee, Joon Haeng; Serrano, Manuel; Cho, Kyung A.

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Iron accumulation drives fibrosis, senescence and the senescence-associated secretory phenotype

NATURE METABOLISM

IF20.8

2023-12-14

OAAI

Maus, Mate; Lopez-Polo, Vanessa; Mateo, Lidia; Lafarga, Miguel; Aguilera, Monica; De Lama, Eugenia; Meyer, Kathleen; Sola, Anna; Lopez-Martinez, Cecilia; Lopez-Alonso, Ines; Guasch-Piqueras, Marc; Hernandez-Gonzalez, Fernanda; Chaib, Selim; Rovira, Miguel; Sanchez, Mayka; Faner, Rosa; Agusti, Alvar; Dieguez-Hurtado, Rodrigo; Ortega, Sagrario; Manonelles, Anna; Engelhardt, Stefan; Monteiro, Freddy; Attolini, Camille Stephan-Otto; Prats, Neus; Albaiceta, Guillermo; Cruzado, Josep M.; Serrano, Manuel

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COPI vesicle formation and N-myristoylation are targetable vulnerabilities of senescent cells

NATURE CELL BIOLOGY

IF19.1

2023-11-27

OAAI

McHugh, Domhnall; Sun, Bin; Gutierrez-Munoz, Carmen; Hernandez-Gonzalez, Fernanda; Mellone, Massimiliano; Guiho, Romain; Duran, Imanol; Pombo, Joaquim; Pietrocola, Federico; Birch, Jodie; Kallemeijn, Wouter W.; Khadayate, Sanjay; Dharmalingam, Gopuraja; Vernia, Santiago; Tate, Edward W.; Martinez-Barbera, Juan Pedro; Withers, Dominic J.; Thomas, Gareth J.; Serrano, Manuel; Gil, Jesus

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A fluorophore-conjugated reagent enabling rapid detection, isolation and live tracking of senescent cells

MOLECULAR CELL

IF16.6

2023-10-01

OAAI

Magkouta, Sophia; Veroutis, Dimitris; Pousias, Athanasios; Papaspyropoulos, Angelos; Pippa, Natassa; Lougiakis, Nikolaos; Kambas, Konstantinos; Lagopati, Nefeli; Polyzou, Aikaterini; Georgiou, Maria; Chountoulesi, Maria; Pispas, Stergios; Foutadakis, Spyros; Pouli, Nicole; Marakos, Panagiotis; Kotsinas, Athanassios; Verginis, Panayotis; Valakos, Dimitrios; Mizi, Athanasia; Papantonis, Argyris; Vatsellas, Giannis; Galanos, Panagiotis; Bartek, Jiri; Petty, Russell; Serrano, Manuel; Thanos, Dimitris; Roussos, Charis; Demaria, Marco; Evangelou, Konstantinos; Gorgoulis, Vassilis G.

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Research Directions