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Phillip A. Sharp

Massachusetts Institute of Technology

173H-index
638Paper Count
12.6WCitation Count
Published Papers 124
Publication Date
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Engineered prime editors with minimal genomic errors
errNature
IF48.5
err2025-09-17
err0
errOAAI
errVikash P. Chauhan; Phillip A. Sharp; Robert Langer
errShare
errSave
Mutant p53 exploits enhancers to elevate immunosuppressive chemokine expression and impair immune checkpoint inhibitors in pancreatic cancer
errImmunity
IF26.3
err2025-06-30
err0
errOAAI
errDig B. Mahat; Heena Kumra; Sarah A. Castro; Emily Metcalf; Kim Nguyen; Ryo Morisue; William W. Ho; Ivy Chen; Brandon Sullivan; Leon H. Yim; Arundeep Singh; Jiayu Fu; Sean K. Waterton; Yu-Chi Cheng; Enrico Moiso; Vikash P. Chauhan; Hernandez Moura Silva; Stefani Spranger; Rakesh K. Jain; Phillip A. Sharp
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errSave
Mutant-p53 amplifies Cxcl1 expression from distal enhancers blunting immune checkpoint inhibition efficacy in pancreatic cancer
errCANCER RESEARCH
IF16.6
err2024-01-16
err0
PREAI
errMahat, Dig B.; Kumra, Heena; Metcalf, Emily; Castro, Sarah; Nguyen, Kim; Singh, Arundeep; Ho, William W.; Chen, Ivy; Sullivan, Brandon; Yim, Leon; Moiso, Enrico; Chauhan, Vikash; Silva, Hernandez Moura; Spranger, Stefani; Jain, Rakesh; Sharp, Phillip A.
errShare
errSave
Improved modeling of RNA-binding protein motifs in an interpretable neural model of RNA splicing
errGENOME BIOLOGY
IF9.4
err2024-01-16
err3
errOAAI
errGupta, Kavi; Yang, Chenxi; Mccue, Kayla; Bastani, Osbert; Sharp, Phillip A.; Burge, Christopher B.; Solar-Lezama, Armando
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errSave
Sustained Small Interfering RNA-Mediated Human Immunodeficiency Virus Type 1 Inhibition in Primary Macrophages (vol 77, pg 7174, 2003)
errJOURNAL OF VIROLOGY
IF3.8
err2023-10-31
err0
errOAAI
errSong, Erwei; Lee, Sang-Kyung; Dykxhoorn, Derek M.; Novina, Carl; Zhang, Dong; Crawford, Keith; Cerny, Jan; Sharp, Phillip A.; Lieberman, Judy; Manjunath, N.; Shankar, Premlata
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errSave
A minimal spliceosomal complex a recognizes the branch site and polypyrimidine tract
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-29
err41
errOAAI
errQuery, CC; McCaw, PS; Sharp, PA
errShare
errSave
Alternative splicing of the fibronectin EIIIB exon depends on specific TGCATG repeats
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-28
err109
errOAAI
errLim, LP; Sharp, PA
errShare
errSave
Mouse lymphoid cell line selected to have high immunoglobulin promoter activity
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-28
err8
errOAAI
errTantin, D; Sharp, PA
errShare
errSave
RNA polymerase II accumulation in the promoter-proximal region of the dihydrofolate reductase and γ-actin genes
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err72
errOAAI
errCheng, CH; Sharp, PA
errShare
errSave
A novel 50-kilodalton fragment of host cell factor 1 (C1) in Go cells
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err9
errOAAI
errScarr, RB; Smith, MR; Beddall, M; Sharp, PA
errShare
errSave
Embryonic lethality, decreased erythropoiesis, and defective octamer-dependent promoter activation in Oct-1-deficient mice
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err85
errOAAI
errWang, VEH; Schmidt, T; Chen, JZ; Sharp, PA; Tantin, D
errShare
errSave
Regulation of CD44 alternative splicing by SRm160 and its potential role in tumor cell invasion
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err191
errOAAI
errCheng, CH; Sharp, PA
errShare
errSave
Altered DNA repair pathway engagement by engineered CRISPR-Cas9 nucleases
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2023-03-07
err6
errOAAI
errChauhan, Vikash P.; Sharp, Phillip A.; Langer, Robert
errShare
errSave
Transcription factor antagonism regulates heterogeneity in embryonic stem cell states
errMOLECULAR CELL
IF16.6
err2022-12-01
err11
errOAAI
errHu, Sofia; Metcalf, Emily; Mahat, Dig Bijay; Chan, Lynette; Sohal, Noor; Chakraborty, Meenakshi; Hamilton, Maxwell; Singh, Arundeep; Singh, Abhyudai; Lees, Jacqueline A.; Sharp, Phillip A.; Garg, Salil
errShare
errSave
RNA in formation and regulation of transcriptional condensates
errRNA
IF5
err2021-11-12
err69
errOAAI
errSharp, Phillip A.; Chakraborty, Arup K.; Henninger, Jonathan E.; Young, Richard A.
errShare
errSave
Clarity on the crackdown
errSCIENCE
IF45.8
err2021-02-26
err0
PREAI
errLodish, Harvey; Chen, Jianzhu; Sharp, Phillip
errShare
errSave
Imprinted Maternally Expressed microRNAs Antagonize Paternally Driven Gene Programs in Neurons
errMOLECULAR CELL
IF16.6
err2020-04-01
err32
errOAAI
errWhipple, Amanda J.; Breton-Provencher, Vincent; Jacobs, Hannah N.; Chitta, Udbhav K.; Sur, Mriganka; Sharp, Phillip A.
errShare
errSave
MicroRNAs organize intrinsic variation into stem cell states
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2020-03-05
err21
errOAAI
errChakraborty, Meenakshi; Hu, Sofia; Visness, Erica; Del Giudice, Marco; De Martino, Andrea; Bosia, Carla; Sharp, Phillip A.; Garg, Salil
errShare
errSave
Enhancer Features that Drive Formation of Transcriptional Condensates
errMOLECULAR CELL
IF16.6
err2019-08-01
err282
errOAAI
errShrinivas, Krishna; Sabari, Benjamin R.; Coffey, Eliot L.; Klein, Isaac A.; Boija, Ann; Zamudio, Alicia, V; Schuijers, Jurian; Hannett, Nancy M.; Sharp, Phillip A.; Young, Richard A.; Chakraborty, Arup K.
errShare
errSave
Sequestration of microRNA-mediated target repression by the Ago2-associated RNA-binding protein FAM120A
errRNA
IF5
err2019-07-09
err24
errOAAI
errKelly, Timothy J.; Suzuki, Hiroshi, I; Zamudio, Jesse R.; Suzuki, Megumu; Sharp, Phillip A.
errShare
errSave

Research Directions

No research directions
Co-authors
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王小岗 (Xiaogang Wang)
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