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J

Juan Carlos Izpisúa Belmonte

Salk Institute for Biological Studies

124H-index
586Paper Count
5.3WCitation Count
Published Papers 309
Publication Date
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ZNF512B safeguards genome integrity at regulatory regions to repress the SASP and inflammation
errCell Stem Cell
IF20.4
err2026-06-16
err0
PREAI
errSanjeeb Kumar Sahu; Sebastian Memczak; Sudhir Thakurela; Jinlong Lu; Priya Gupta; Naresh Mutukula; Alex Hirano; Yingzi Zhang; Tomoaki Hishida; Masakazu Kurita; Chao Wang; Yanjiao Shao; April Williams; Max Shokhirev; Vijay K. Tiwari; Concepcion Rodriguez Esteban; Pradeep Reddy; Alexander Meissner; Mo Li; Juan Carlos Izpisua Belmonte
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Single-nucleus interrogation of primate small intestinal aging reveals NCoR1 decline as a conserved feature that is reversed by metformin
errNature Aging
IF19.4
err2026-06-09
err0
PREAI
errJingyi Li; Xiaoyong Lu; Tianhong Tong; Xin Zhou; Baohu Zhang; Xiaoyan Sun; Bing Zhao; Gang Xu; Jinjiang Yang; Yanling Fan; Jianli Hu; Haoteng Yan; Zhejun Ji; Mingheng Li; Shanshan Che; Yuanhan Yang; Yingjie Ding; Qiaoran Wang; Shuhui Sun; Shuai Ma; Si Wang; Juan Carlos Izpisua Belmonte; Jing Qu; Weiqi Zhang; Guang-Hui Liu
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Mesenchymal drift: A convergent framework for the hallmarks of aging
errCell
IF42.5
err2026-05-28
err0
PREAI
errJinlong Y. Lu; William B. Tu; Shuai Ma; Zaijun Ma; Ivan Imaz-Rosshandler; Mingxi Weng; Jing Qu; Concepcion Rodriguez Esteban; Pradeep Reddy; Guang-Hui Liu; Juan Carlos Izpisua Belmonte
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Stable bioreactor control reveals acidic pH–driven metabolic reprogramming and mitochondrial dysfunction in human lymphoblastoid cells
errCommunications Biology
IF5.1
err2026-04-15
err0
errOAAI
errSamhan Alsolami; Yingzi Zhang; Upendra Singh; Yiqing Jin; Nadia Steiner; Kacper Szczepski; Shannon G. Klein; Baolei Yuan; Chongwei Bi; Mengge Wang; Siyi Fu; Juan Carlos Izpisua Belmonte; Pierre J. Magistretti; Carlos M. Duarte; Lukasz Jaremko; Mo Li
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A single small molecule-based human embryo model reveals V-ATPase requirement in mammalian blastocyst cavitation
errCell Research
IF25.9
err2026-04-06
err0
errOAAI
errSamhan Alsolami; Arun Pandian Chandrasekaran; Yiqing Jin; Yibo Wang; Ling Zhang; Ismail M. Shakir; Yingzi Zhang; Aisha Siddique; Gerardo Ramos-Mandujano; Baolei Yuan; Maya Ayach; Alfonso Saera-Vila; Zejun Fan; Siyi Fu; Huoming Zhang; Saige Xin; Kholoud Khalid AlDakhil; Juan Carlos Izpisua Belmonte; Jin Zhang; Yang Yu; Mo Li
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errSave
Anti-aging strategies and ex vivo organ rejuvenation
errCell Stem Cell
IF20.4
err2026-01-08
err0
PREAI
errMonika Haoui; Pradeep Reddy; Juan Carlos Izpisua Belmonte
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Vascular organoid model of Hutchinson-Gilford progeria syndrome uncovers repression of the SRF pathway in premature aging
errDevelopmental Cell
IF8.7
err2025-11-27
err0
PREAI
errXiaoyan Sun; Shanshan Che; Hengchao Wang; Yanling Fan; Yingjie Ding; Ansheng Tan; Kuan Yang; Jianli Hu; Yixin Zhang; Miyang Ma; Jinghao Hu; Shuhui Sun; Shuai Ma; Si Wang; Juan Carlos Izpisua Belmonte; Jing Qu; Weiqi Zhang; Guang-Hui Liu
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Nuclear-lamin-guided plastic positioning and folding of the human genome
errCell Reports
IF6.9
err2025-11-07
err0
errOAAI
errZehua Wang; Qianzhao Ji; Zunpeng Liu; Chunyu Jiao; Yiyuan Zhang; Feifei Liu; Shuhui Sun; Qun Chu; Zeming Wu; Jingyi Li; Hao Li; Jianli Hu; Yizhou Gao; Gang Cao; Juan Carlos Izpisua Belmonte; Weiqi Zhang; Guang-Hui Liu; Jing Qu
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errSave
Vitamin C conveys geroprotection on primate ovaries
errCell Stem Cell
IF20.4
err2025-10-14
err0
PREAI
errYing Jing; Huifen Lu; Jingyi Li; Zan He; Liyun Zhao; Chen Zhang; Ziqi Huang; Lixiao Liu; Shuhui Sun; Shuai Ma; Concepcion Rodriguez Esteban; Xiaobing Fu; Guoguang Zhao; Juan Carlos Izpisua Belmonte; Weiqi Zhang; Jing Qu; Si Wang; Guang-Hui Liu
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errSave
Prevalent mesenchymal drift in aging and disease is reversed by partial reprogramming
errCell
IF42.5
err2025-08-14
err0
PREAI
errJinlong Y. Lu; William B. Tu; Ronghui Li; Mingxi Weng; Bhargav D. Sanketi; Baolei Yuan; Pradeep Reddy; Concepcion Rodriguez Esteban; Juan Carlos Izpisua Belmonte
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EnsembleAge: enhancing epigenetic age assessment with a multi-clock framework
errGeroScience
IF5.4
err2025-08-06
err0
errOAAI
errAmin Haghani; Ake T. Lu; Qi Yan; Juan Carlos Izpisua Belmonte; Pradeep Reddy; Victor Cheng; X. William Yang; Nan Wang; Khyobeni Mozhui; Kevin Murach; Alejandro Ocampo; Robert W. Williams; Mathias Jucker; Carina Bergmann; Jesse R. Poganik; Bohan Zhang; Vadim N. Gladyshev; Steve Horvath
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errSave
Escaping ageing through Cell Annealing—a phenomenological model
errCell Research
IF25.9
err2025-07-08
err0
errOAAI
errSebastian Memczak; Juan Carlos Izpisua Belmonte; Thore Graepel
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errSave
Single-cell profiling identifies hair cell SLC35F1 deficiency as a signature of primate cochlear aging
errNature Aging
IF19.4
err2025-06-20
err0
PREAI
errGuoqiang Sun; Xiaolong Fu; Yandong Zheng; Guodong Hong; Ziyi Liu; Bilan Luo; Jinghui Lei; Dongliang Lv; Miao Chang; Yu Xiao; Siwei Guo; Shuai Ma; Ling Lu; Weiqi Zhang; Juan Carlos Izpisua Belmonte; Jing Qu; Si Wang; Renjie Chai; Guang-Hui Liu
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errSave
Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome (Apr, 10.1038/s41586-025-08924-0, 2025)
errNATURE
IF48.5
err2025-04-07
err0
PREAI
errLiu, Guang-Hui; Barkho, Basam Z.; Ruiz, Sergio; Diep, Dinh; Qu, Jing; Yang, Sheng-Lian; Panopoulos, Athanasia D.; Suzuki, Keiichiro; Kurian, Leo; Walsh, Christopher; Thompson, James; Boue, Stephanie; Fung, Ho Lim; Sancho-Martinez, Ignacio; Zhang, Kun; Yates Iii, John; Belmonte, Juan Carlos Izpisua
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Reactivation of retrotransposable elements is associated with environmental stress and ageing
errNATURE REVIEWS GENETICS
IF52
err2025-04-02
err1
PREAI
errDella Valle, Francesco; Reddy, Pradeep; Vazquez, Alain Aguirre; Belmonte, Juan Carlos Izpisua
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Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation (vol 30, pg 1452,2023)
errCELL STEM CELL
IF20.4
err2025-02-01
err0
PREAI
errJing, Yaobin; Jiang, Xiaoyu; Ji, Qianzhao; Wu, Zeming; Wang, Wei; Liu, Zunpeng; Guillen-Garcia, Pedro; Esteban, Concepcion Rodriguez; Reddy, Pradeep; Horvath, Steve; Li, Jingyi; Geng, Lingling; Hu, Qinchao; Wang, Si; Belmonte, Juan Carlos Izpisua; Ren, Jie; Zhang, Weiqi; Qu, Jing; Liu, Guang-Hui
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A single-cell transcriptomic atlas of exercise-induced anti-inflammatory and geroprotective effects across the body (vol 6, 100806, 2025)
errINNOVATION
IF25.7
err2025-02-01
err0
errOAAI
errSun, Shuhui; Ma, Shuai; Cai, Yusheng; Wang, Si; Ren, Jie; Yang, Yuanhan; Ping, Jiale; Wang, Xuebao; Zhang, Yiyuan; Yan, Haoteng; Li, Wei; Esteban, Concepcion Rodriguez; Yu, Yan; Liu, Feifei; Belmonte, Juan Carlos Izpisua; Zhang, Weiqi; Qu, Jing; Liu, Guang-Hui
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errSave
CELL REJUVENATION AND DISEASE
errINNOVATION IN AGING
IF4.3
err2024-12-31
err0
errOAAI
errBelmonte, Juan Carlos Izpisua
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Optimization of HITI-Mediated Gene Insertion for Rhodopsin and Peripherin-2 in Mouse Rod Photoreceptors: Targeting Dominant Retinitis Pigmentosa
errINVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
IF4.7
err2024-11-18
err0
errOAAI
errOnishi, Akishi; Tsunekawa, Yuji; Mandai, Michiko; Ishimaru, Aiko; Ohigashi, Yoko; Sho, Junki; Yasuda, Kazushi; Suzuki, Keiichiro; Belmonte, Juan Carlos Izpisua; Matsuzaki, Fumio; Takahashi, Masayo
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LINE-1 RNA triggers matrix formation in bone cells via a PKR-mediated inflammatory response (vol 43, pg 3587, 2024)
errEMBO JOURNAL
IF8.3
err2024-09-20
err0
errOAAI
errMangiavacchi, Arianna; Morelli, Gabriele; Reppe, Sjur; Saera-Vila, Alfonso; Liu, Peng; Eggerschwiler, Benjamin; Zhang, Huoming; Bensaddek, Dalila; Casanova, Elisa A.; Gomez, Carolina Medina; Prijatelj, Vid; Della Valle, Francesco; Atinbayeva, Nazerke; Belmonte, Juan Carlos Izpisua; Rivadeneira, Fernando; Cinelli, Paolo; Gautvik, Kaare Morten; Orlando, Valerio
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Research Directions

No research directions
Co-authors
Cooperation Journals
R
Ronald M. Evans
H-index: 211 · Papers: 924
D
David Baltimore
H-index: 209 · Papers: 1.1K
M
Michael G. Rosenfeld
H-index: 169 · Papers: 491
M
Manel Esteller
H-index: 165 · Papers: 1.6K
F
Fernando Rivadeneira
H-index: 165 · Papers: 923
View more