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Hyun O. Lee

university of toronto

26H-index
58Paper Count
1.6WCitation Count
Published Papers 30
Publication Date
Long-read proteogenomic atlas of human neuronal differentiation reveals isoform diversity informing neurodevelopmental risk mechanisms
err2026-08-19
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errOAAI
errNuo Xu; Katherine M. Rynard; Elizabeth Radley; Ai Tian; Maahil Arshad; Chaoying Long; Jimmy Ly; Hua Luo; Ellie Hogan; Maria Eleni Fafouti; Melanie Davie; Fatima Naimi; Yun Li; John A. Calarco; Brett Trost; Julien Muffat; Hyun O. Lee; Howard D. Lipshitz; Craig A. Smibert; Shreejoy J. Tripathy
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Human J-domain proteins promote stress granule disassembly and suppress neurodegeneration-linked protein aggregation
err2026-06-08
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errOAAI
errGiovanni J. Mastromarco; Rebecca Earnshaw; Gaelen Moore; X.Y. Sherwin Xu; Nour H. Sadek; Fiona Cui; Natalie Lo; Hyun O. Lee
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RNA polymerase II drives FUS and EWSR1 exclusion from damaged chromatin
err2026-04-08
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errOAAI
errSylvia Varhoshkova; Christopher Chin Sang; Liana Antonova; Sonya Uzunova; Dilyana Kirova; Radoslav Aleksandrov; Masato T. Kanemaki; Hyun O. Lee; Stoyno Stoynov
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The dynamic and heterogeneous composition of biomolecular condensates and its functional relevance
err2025-11-20
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PREAI
errChristopher Chin Sang; Sayantani Upadhyay; Michael L. Nosella; Julie D. Forman-Kay; Hyun O. Lee
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J-domain proteins cooperate with Hsp70 to drive multiphase separation of RNA-binding-deficient TDP-43
err2025-10-22
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errOAAI
errKian Hua Yeo; Jian Hua Kong; Qing Hao Ng; Mi-Jeong Yoon; Olivia Agatha; Eunyoung Chae; Hyun O. Lee; H.Shawn Je; Young-Jun Choe
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Small-molecule dissolution of stress granules by redox modulation benefits ALS models
err2025-05-14
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errUechi, Hiroyuki; Sridharan, Sindhuja; Nijssen, Jik; Bilstein, Jessica; Iglesias-Artola, Juan M.; Kishigami, Satoshi; Casablancas-Antras, Virginia; Poser, Ina; Martinez, Eduardo J.; Boczek, Edgar; Wagner, Michael; Tomschke, Nadine; Domingues, Antonio M. de Jesus; Pal, Arun; Doeleman, Thom; Kour, Sukhleen; Anderson, Eric Nathaniel; Stein, Frank; Lee, Hyun O.; Zhang, Xiaojie; Fritsch, Anatol W.; Jahnel, Marcus; Fuersch, Julius; Murthy, Anastasia C.; Alberti, Simon; Bickle, Marc; Fawzi, Nicolas L.; Nadler, Andre; David, Della C.; Pandey, Udai B.; Hermann, Andreas; Stengel, Florian; Davis, Benjamin G.; Baldwin, Andrew J.; Savitski, Mikhail M.; Hyman, Anthony A.; Wheeler, Richard J.
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ASiDentify (ASiD): a machine learning model to predict new autism spectrum disorder risk genes
err2025-03-01
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PREAI
errRynard, Katherine M.; Han, Kara; Wainberg, Michael; Calarco, John A.; Lee, Hyun O.; Lipshitz, Howard D.; Smibert, Craig A.; Tripathy, Shreejoy J.
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PARP1 condensates differentially partition DNA repair proteins and enhance DNA ligation
err2024-11-04
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PREAI
errSang, Christopher Chin; Moore, Gaelen; Tereshchenko, Maria; Zhang, Hongshan; Nosella, Michael L.; Dasovich, Morgan; Alderson, T. Reid; Leung, Anthony K. L.; Finkelstein, Ilya J.; Forman-Kay, Julie D.; Lee, Hyun O.
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A secreted bacterial protein protects bacteria from cationic antimicrobial peptides by entrapment in phase-separated droplets
err2024-04-02
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errOAAI
errOstan, Nicholas K. H.; Cole, Gregory B.; Wang, Flora Zhiqi; Reichheld, Sean E.; Moore, Gaelen; Pan, Chuxi; Yu, Ronghua; Lai, Christine Chieh-Lin; Sharpe, Simon; Lee, Hyun O.; Schryvers, Anthony B.; Moraes, Trevor F.
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Poly(ADP-ribosyl)ation enhances nucleosome dynamics and organizes DNA damage repair components within biomolecular condensates
err2024-02-01
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PREAI
errNosella, Michael L.; Kim, Tae Hun; Huang, Shuya Kate; Harkness, Robert W.; Goncalves, Monica; Pan, Alisia; Tereshchenko, Maria; Vahidi, Siavash; Rubinstein, John L.; Lee, Hyun O.; Forman-Kay, Julie D.; Kay, Lewis E.
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Depicting a cellular space occupied by condensates
err2023-09-01
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errLiu, Daniel; Riggi, Margot; Lee, Hyun O.; Currie, Simon L.; Goodsell, David S.; Iwasa, Janet H.; Rog, Ofer
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A central chaperone-like role for 14-3-3 proteins in human cells
err2023-03-01
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errSegal, Dmitri; Maier, Stefan; Mastromarco, Giovanni J.; Qian, Wesley Wei; Nabeel-Shah, Syed; Lee, Hyunmin; Moore, Gaelen; Lacoste, Jessica; Larsen, Brett; Lin, Zhen-Yuan; Selvabaskaran, Abeeshan; Liu, Karen; Smibert, Craig; Zhang, Zhaolei; Greenblatt, Jack; Peng, Jian; Lee, Hyun O.; Gingras, Anne-Claude; Taipale, Mikko
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FUS ALS neurons activate major stress pathways and reduce translation as an early protective mechanism against neurodegeneration
err2023-02-01
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errOAAI
errSzewczyk, Barbara; Guenther, Rene; Japtok, Julia; Frech, Moritz J.; Naumann, Marcel; Lee, Hyun O.; Hermann, Andreas
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O-Linked-N-Acetylglucosaminylation of the RNA-Binding Protein EWS N-Terminal Low Complexity Region Reduces Phase Separation and Enhances Condensate Dynamics
err2021-07-26
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PREAI
errNosella, Michael L.; Tereshchenko, Maria; Pritisanac, Iva; Chong, P. Andrew; Toretsky, Jeffrey A.; Lee, Hyun O.; Forman-Kay, Julie D.
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DNA repair by Rad52 liquid droplets
err2020-02-04
err106
errOAAI
errOshidari, Roxanne; Huang, Richard; Medghalchi, Maryam; Tse, Elizabeth Y. W.; Ashgriz, Nasser; Lee, Hyun O.; Wyatt, Haley; Mekhail, Karim
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Biomolecular condensates in neurodegeneration and cancer
errTRAFFIC
IF2.5
err2019-11-21
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errOAAI
errSpannl, Stephanie; Tereshchenko, Maria; Mastromarco, Giovanni J.; Ihn, Sean J.; Lee, Hyun O.
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Small heat shock proteins: multifaceted proteins with important implications for life
err2019-03-01
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errCarra, Serena; Alberti, Simon; Benesch, Justin L. P.; Boelens, Wilbert; Buchner, Johannes; Carver, John A.; Cecconi, Ciro; Ecroyd, Heath; Gusev, Nikolai; Hightower, Lawrence E.; Klevit, Rachel E.; Lee, Hyun O.; Liberek, Krzysztof; Lockwood, Brent; Poletti, Angelo; Timmerman, Vincent; Toth, Melinda E.; Vierling, Elizabeth; Wu, Tangchun; Tanguay, Robert M.
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Isogenic FUS-eGFP iPSC Reporter Lines Enable Quantification of FUS Stress Granule Pathology that Is Rescued by Drugs Inducing Autophagy
err2018-02-01
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errOAAI
errMarrone, Lara; Poser, Ina; Casci, Ian; Japtok, Julia; Reinhardt, Peter; Janosch, Antje; Andree, Cordula; Lee, Hyun O.; Moebius, Claudia; Koerner, Ellen; Reinhardt, Lydia; Cicardi, Maria Elena; Hackmann, Karl; Klink, Barbara; Poletti, Angelo; Alberti, Simon; Bickle, Marc; Hermann, Andreas; Pandey, Udai Bhan; Hyman, Anthony A.; Sterneckert, Jared L.
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