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T

Timothy Hla

Harvard University

108H-index
368Paper Count
4.3WCitation Count
Published Papers 175
Publication Date
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Apolipoprotein M: Structural Insights, Functional Roles and Therapeutic Approaches in Vascular Disease
errJournal of Biological Chemistry
IF3.9
err2026-02-28
err0
errOAAI
errTim F. Dorweiler; Timothy Hla
errShare
errSave
GlycoRNA complexed with heparan sulfate regulates VEGF-A signalling
errNature
IF48.5
err2026-01-28
err0
errOAAI
errPeiyuan Chai; Sina Kheiri; Andrew Kuo; Jessica Shah; Lauren Kageler; Ruiqi Ge; Jonathan Perr; Jennifer Porat; Charlotta G. Lebedenko; Joao M. L. Dias; Eliza Yankova; Sandeep K. Rai; Christopher P. Watkins; Petar Hristov; Konstantinos Tzelepis; Timothy Hla; Ritu Raman; Eliezer Calo; Jeffrey D. Esko; Ryan A. Flynn
errShare
errSave
Sphingosine kinase 1 is integral for elastin deficiency-induced arterial hypermuscularization
errNature Cardiovascular Research
IF10.8
err2026-01-05
err0
PREAI
errJunichi Saito; Jui M. Dave; Eunate Gallardo-Vara; Nandhini Sadagopan; Inamul Kabir; George Tellides; Robert K. Riemer; Zsolt Urban; Sarah Spiegel; Timothy Hla; Daniel M. Greif
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errSave
Inflamed endothelial cells express S1PR1 inhibitor CD69 to induce vascular leak
errJournal of Biological Chemistry
IF3.9
err2025-07-01
err0
errOAAI
errMichel V. Levesque; Andreane Cartier; Yueh-Chien Lin; Raj Kumar Sah; Hanming Zhang; Balkhrisa Chaube; Mantu Bhaumik; Jakob Körbelin; Yajaira Suárez; Carlos Fernández-Hernando; Timothy Hla
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errSave
ApoM-bound S1P acts via endothelial S1PR1 to suppress choroidal neovascularization and vascular leakage
errAngiogenesis
IF9.2
err2025-04-23
err0
errOAAI
errBongnam Jung; Hitomi Yagi; Andrew Kuo; Tim F. Dorweiler; Masanori Aikawa; Taku Kasai; Sasha A. Singh; Andrew J. Dannenberg; Zhongjie Fu; Colin Niaudet; Lois E. H. Smith; Timothy Hla
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errSave
Sphingosine Kinase 1 Is Integral For Elastin Deficiency-induced Arterial Hypermuscularization
errCIRCULATION
IF38.6
err2024-11-12
err0
PREAI
errSaito, Junichi; Dave, Jui; Kabir, Inamul; Gallardo-Vara, Eunate; Hla, Timothy; Greif, Daniel
errShare
errSave
RETRACTION: Lysophosphatidic acid stimulates the G-protein-coupled receptor EDG-1 as a low affinity agonist
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2024-08-01
err1
errOAAI
errLee, Menq-Jer; Thangada, Shobha; Liu, Catherine H.; Thompson, Brian D.; Hla, Timothy
errShare
errSave
The sphinx helps to answer the riddle of cardiac regeneration
errTRENDS IN ENDOCRINOLOGY AND METABOLISM
IF12.6
err2024-08-01
err0
PREAI
errJung, Jae Woo; Hla, Timothy; Arany, Zoltan
errShare
errSave
Regulation of cellular and systemic sphingolipid homeostasis
errNATURE REVIEWS MOLECULAR CELL BIOLOGY
IF90.2
err2024-06-18
err3
PREAI
errKuo, Andrew; Hla, Timothy
errShare
errSave
Endothelial cell sphingosine 1-phosphate receptor 1 restrains VE-cadherin cleavage and attenuates experimental inflammatory arthritis
errJCI INSIGHT
IF6.1
err2024-06-10
err2
errOAAI
errBurg, Nathalie; Malpass, Ryan; Alex, Linda; Tran, Miles; Englebrecht, Eric; Kuo, Andrew; Pannelini, Tania; Minett, Margaret; Athukorala, Kalana; Worgall, Tilla; Faust, Heather J.; Goodman, Susan; Mehta, Bella; Brenner, Michael; Vestweber, Dietmar; Wei, Kevin; Blobel, Carl; Hla, Timothy; Salmon, Jane E.
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errSave
The β-catenin C terminus links Wnt and sphingosine-1-phosphate signaling pathways to promote vascular remodeling and atherosclerosis
errSCIENCE ADVANCES
IF12.5
err2024-03-15
err1
errOAAI
errOliveira-Paula, Gustavo H.; Liu, Sophia; Maira, Alishba; Ressa, Gaia; Ferreira, Graziele C.; Quintar, Amado; Jayakumar, Smitha; Almonte, Vanessa; Parikh, Dippal; Valenta, Tomas; Basler, Konrad; Hla, Timothy; Riascos-Bernal, Dario F.; Sibinga, Nicholas E. S.
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errSave
Designer high-density lipoprotein particles enhance endothelial barrier function and suppress inflammation
errSCIENCE SIGNALING
IF6.6
err2024-02-20
err1
errOAAI
errLin, Yueh-Chien; Swendeman, Steven; Moreira, Irina S.; Ghosh, Avishek; Kuo, Andrew; Rosario-Ferreira, Nicia; Guo, Shihui; Culbertson, Alan; Levesque, Michel V.; Cartier, Andreane; Seno, Takahiro; Schmaier, Alec; Galvani, Sylvain; Inoue, Asuka; Parikh, Samir M.; FitzGerald, Garret A.; Zurakowski, David; Liao, Maofu; Flaumenhaft, Robert; Gumus, Zeynep H.; Hla, Timothy
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errSave
Augmentation of Endothelial S1PR1 Attenuates Postviral Pulmonary Fibrosis
errAMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
IF5.3
err2024-02-01
err4
PREAI
errBrazee, Patricia L.; Cartier, Andreane; Kuo, Andrew; Haring, Alexis M.; Nguyen, Trong; Hariri, Lida P.; Griffith, Jason W.; Hla, Timothy; Medoff, Benjamin D.; Knipe, Rachel S.
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errSave
Report from the 2023 workshop on endothelial permeability, edema and inflammation
errcardiovascular research
IF10.8
err2023-12-08
err0
PREAI
errVestweber, Dietmar; Claesson-Welsh, Lena; McDonald, Donald M.; Williams, Timothy; Schwartz, Martin A.; Scallan, Joshua; Gavins, Felicity N. E.; van Buul, Jaap; Gamble, Jennifer; Vadas, Matthew; Annex, Brian H.; Messe, Steven R.; Perretti, Mauro; Andre, Helder; Ferrara, Napoleone; Hla, Timothy; Nourshargh, Sussan; Simons, Michael
errShare
errSave
Beta-catenin C-terminus inhibition reduces vascular remodeling by precluding the expression of sphingosine-1-phosphate receptor-1
errJOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
IF3.8
err2023-06-01
err0
errOAAI
errde Paula, Gustavo Oliveira; Ressa, Gaia; Almonte, Vanessa; Parikh, Dippal; Valenta, Tomas; Basler, Konrad; Hla, Timothy; Riascos-Bernal, Dario; Sibinga, Nicholas
errShare
errSave
Beta-catenin C-terminus Signaling Drives Sphingosine-1phosphate Receptor-1 Expression in Smooth Muscle Cells to Promote Vascular Remodeling
errARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
IF7.4
err2023-05-01
err0
PREAI
errde Paula, Gustavo H. Oliveira; Ressa, Gaia; Jayakumar, Smitha; Almonte, Vanessa; Parikh, Dippal; Valenta, Tomas; Basler, Konrad; Hla, Timothy; Riascos-Bernal, Dario F.; Sibinga, Nicholas
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errSave
Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err217
errOAAI
errKohno, Masataka; Momoi, Michiko; Oo, Myat Lin; Paik, Ji-Hye; Lee, Yong-Moon; Venkataraman, Krishnan; Ai, Youxi; Ristimaki, Ari P.; Fyrst, Henrik; Sano, Hajime; Rosenberg, Daniel; Saba, Julie D.; Proia, Richard L.; Hla, Timothy
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errSave
Therapeutic activation of endothelial sphingosine-1-phosphate receptor 1 by chaperone-bound S1P suppresses proliferative retinal neovascularization
errEMBO MOLECULAR MEDICINE
IF8.3
err2023-03-13
err8
errOAAI
errNiaudet, Colin; Jung, Bongnam; Kuo, Andrew; Swendeman, Steven; Bull, Edward; Seno, Takahiro; Crocker, Reed; Fu, Zhongjie; Smith, Lois E. H.; Hla, Timothy
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errSave
Murine endothelial serine palmitoyltransferase 1 (SPTLC1) is required for vascular development and systemic sphingolipid homeostasis
errELIFE
IF0
err2022-10-05
err12
errOAAI
errKuo, Andrew; Checa, Antonio; Niaudet, Colin; Jung, Bongnam; Fu, Zhongjie; Wheelock, Craig E.; Singh, Sasha A.; Aikawa, Masanori; Smith, Lois E.; Proia, Richard L.; Hla, Timothy
errShare
errSave
DOCK4 Regulation of Rho GTPases Mediates Pulmonary Vascular Barrier Function
errARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
IF7.4
err2022-07-01
err4
errOAAI
errYazbeck, Pascal; Cullere, Xavier; Bennett, Paul; Yajnik, Vijay; Wang, Huan; Kawada, Kenji; Davis, Vanessa M.; Parikh, Asit; Kuo, Andrew; Mysore, Vijayashree; Hla, Timothy; Milstone, David S.; Mayadas, Tanya N.
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Research Directions

No research directions
Co-authors
Cooperation Journals
M
M Snyder
H-index: 210 · Papers: 3.3K
N
Napoleone Ferrara
H-index: 156 · Papers: 389
B
Bruce R. Blazar
H-index: 148 · Papers: 1.5K
A
A. John Camm
H-index: 147 · Papers: 1.5K
S
Scott L. Friedman
H-index: 144 · Papers: 709
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