Deborah L. Croteau - Publications, H-index & Citations

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Deborah L. Croteau

NIH

62H-index

180Paper Count

1.9WCitation Count

Published Papers 127

Publication Date

Mitochondrial accumulation and lysosomal dysfunction result in mitochondrial plaques in Alzheimer’s disease

Nature Neuroscience

IF20

2026-07-29

PREAI

Xiuli Dan; Deborah L. Croteau; Wenlong Liu; Xixia Chu; Ross A. McDevitt; Paul D. Robbins; Vilhelm A. Bohr

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Spatial transcriptomics reveals an unexpected impact of tau and tau pathology on the expression of transthyretin

Frontiers in Aging Neuroscience

IF4.5

2025-10-31

OAAI

Deborah L. Croteau †; Jose Fernandez Navarro †; Thomas Comptdaer; Zaneta Andrusivova; Aleksandra Jurek; Eliette Bonnefoy; Luc Buée; Vilhelm A. Bohr; Joakim Lundeberg; Marie-Christine Galas

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Cockayne syndrome mice reflect human kidney disease and are defective in de novo NAD biosynthesis

CELL DEATH AND DIFFERENTIATION

IF15.4

2025-05-15

OAAI

Pekhale, Komal; Tiwari, Vinod; Hussain, Mansoor; Bridges, Christy C.; Croteau, Deborah L.; Levi, Moshe; Rosenberg, Avi Z.; Santo, Briana; Yang, Xiaoping; Kulikowicz, Tomasz; Wang, Xiaoxin X.; Lee, Jong-Hyuk; Bohr, Vilhelm A.

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RECQL4 requires PARP1 for recruitment to DNA damage, and PARG dePARylation facilitates its associated role in end joining

EXPERIMENTAL AND MOLECULAR MEDICINE

IF12.9

2025-01-28

OAAI

Hussain, Mansoor; Khadka, Prabhat; Pekhale, Komal; Kulikowicz, Tomasz; Gray, Samuel; May, Alfred; Croteau, Deborah L.

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Urolithin A and nicotinamide riboside differentially regulate innate immune defenses and metabolism in human microglial cells

FRONTIERS IN AGING NEUROSCIENCE

IF4.5

2024-11-27

OAAI

Madsen, Helena Borland; Navarro, Claudia; Gasparini, Emilie; Park, Jae-Hyeon; Li, Zhiquan; Croteau, Deborah L.; Bohr, Vilhelm A.

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Nicotinamide riboside modulates the reactive species interactome, bioenergetic status and proteomic landscape in a brain-region-specific manner

NEUROBIOLOGY OF DISEASE

IF5.6

2024-10-01

OAAI

Marmolejo-Garza, Alejandro; Chatre, Laurent; Croteau, Deborah L.; Herron-Bedoya, Alejandro; Luu, Minh Danh Anh; Bernay, Benoit; Pontin, Julien; Bohr, Vilhelm A.; Boddeke, Erik; Dolga, Amalia M.

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Loss of DNA glycosylases improves health and cognitive function in a C. elegans model of human tauopathy

NUCLEIC ACIDS RESEARCH

IF13.1

2024-08-16

OAAI

Tiwari, Vinod; Buvarp, Elisabeth; Borbolis, Fivos; Puligilla, Chandrakala; Croteau, Deborah L.; Palikaras, Konstantinos; Bohr, Vilhelm A.

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Urolithin A improves Alzheimer's disease cognition and restores mitophagy and lysosomal functions

ALZHEIMERS & DEMENTIA

IF11.1

2024-05-16

OAAI

Hou, Yujun; Chu, Xixia; Park, Jae-Hyeon; Zhu, Qing; Hussain, Mansoor; Li, Zhiquan; Madsen, Helena Borland; Yang, Beimeng; Wei, Yong; Wang, Yue; Fang, Evandro F.; Croteau, Deborah L.; Bohr, Vilhelm A.

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The cGAS-STING signaling pathway is modulated by urolithin A

MECHANISMS OF AGEING AND DEVELOPMENT

IF5.1

2024-02-01

OAAI

Madsen, H. B.; Park, J-h.; Chu, X.; Hou, Y.; Li, Z.; Rasmussen, L. J.; Croteau, D. L.; Bohr, V. A.; Akbari, M.

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The RNA-binding motif protein 14 regulates telomere integrity at the interface of TERRA and telomeric R-loops

NUCLEIC ACIDS RESEARCH

IF13.1

2023-11-01

OAAI

Wang, Yajun; Zhu, Wei; Jang, Yumi; Sommers, Joshua A.; Yi, Gong; Puligilla, Chandrakala; Croteau, Deborah L.; Yang, Yibin; Kai, Mihoko; Liu, Yie

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Long-term NAD plus supplementation prevents the progression of age-related hearing loss in mice

AGING CELL

IF7.1

2023-07-03

OAAI

Okur, Mustafa N.; Sahbaz, Burcin Duan; Kimura, Risako; Manor, Uri; Patel, Jaimin; Park, Jae-Hyeon; Andrade, Leo; Puligilla, Chandrakala; Croteau, Deborah L.; Bohr, Vilhelm A.

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Mitochondrial OGG1 expression reduces age-associated neuroinflammation by regulating cytosolic mitochondrial DNA

FREE RADICAL BIOLOGY AND MEDICINE

IF8.2

2023-07-01

OAAI

Hussain, Mansoor; Chu, Xixia; Sahbaz, Burcin Duan; Gray, Samuel; Pekhale, Komal; Park, Jae-Hyeon; Croteau, Deborah L.; Bohr, Vilhelm A.

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RecQ dysfunction contributes to social and depressive-like behavior and affects aldolase activity in mice

NEUROBIOLOGY OF DISEASE

IF5.6

2023-05-01

OAAI

Hou, Yujun; Park, Jae-Hyeon; Dan, Xiuli; Chu, Xixia; Yang, Beimeng; Hussain, Mansoor; Croteau, Deborah L.; Bohr, Vilhelm A.

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Differential and Concordant Roles for Poly(ADP-Ribose) Polymerase 1 and Poly(ADP-Ribose) in Regulating WRN and RECQL5 Activities

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-20

OAAI

Khadka, Prabhat; Hsu, Joseph K.; Veith, Sebastian; Tadokoro, Takashi; Shamanna, Raghavendra A.; Mangerich, Aswin; Croteau, Deborah L.; Bohr, Vilhelm A.

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DNA Polymerase Beta Participates in Mitochondrial DNA Repair

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-17

OAAI

Sykora, P.; Kanno, S.; Akbari, M.; Kulikowicz, T.; Baptiste, B. A.; Leandro, G. S.; Lu, H.; Tian, J.; May, A.; Becker, K. A.; Croteau, D. L.; Wilson, D. M., III; Sobol, R. W.; Yasui, A.; Bohr, V. A.

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Loss of smelling is an early marker of aging and is associated with inflammation and DNA damage in C57BL/6J mice

AGING CELL

IF7.1

2023-02-27

OAAI

Dan, Xiuli; Yang, Beimeng; McDevitt, Ross A.; Gray, Samuel; Chu, Xixia; Claybourne, Quia; Figueroa, David M.; Zhang, Yongqing; Croteau, Deborah L.; Bohr, Vilhelm A.

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Mitochondrial PARP1 regulates NAD+-dependent poly ADP-ribosylation of mitochondrial nucleoids

EXPERIMENTAL AND MOLECULAR MEDICINE

IF12.9

2022-12-06

OAAI

Lee, Jong-Hyuk; Hussain, Mansoor; Kim, Edward W.; Cheng, Shang-Jung; Leung, Anthony K. L.; Fakouri, Nima Borhan; Croteau, Deborah L.; Bohr, Vilhelm A.

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Nicotinamide adenine dinucleotide supplementation drives gut microbiota variation in Alzheimer's mouse model

FRONTIERS IN AGING NEUROSCIENCE

IF4.5

2022-09-15

OAAI

Chu, Xixia; Hou, Yujun; Meng, Qiong; Croteau, Deborah L.; Wei, Yong; De, Supriyo; Becker, Kevin G.; Bohr, Vilhelm A.

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A brain proteomic signature of incipient Alzheimer's disease in young APOE ε4 carriers identifies novel drug targets

SCIENCE ADVANCES

IF12.5

2021-11-12

OAAI

Roberts, Jackson A.; Varma, Vijay R.; An, Yang; Varma, Sudhir; Candia, Julian; Fantoni, Giovanna; Tiwari, Vinod; Anerillas, Carlos; Williamson, Andrew; Saito, Atsushi; Loeffler, Tina; Schilcher, Irene; Moaddel, Ruin; Khadeer, Mohammed; Lovett, Jacqueline; Tanaka, Toshiko; Pletnikova, Olga; Troncoso, Juan C.; Bennett, David A.; Albert, Marilyn S.; Yu, Kaiwen; Niu, Mingming; Haroutunian, Vahram; Zhang, Bin; Peng, Junmin; Croteau, Deborah L.; Resnick, Susan M.; Gorospe, Myriam; Bohr, Vilhelm A.; Ferrucci, Luigi; Thambisetty, Madhav

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CDK2 phosphorylation of Werner protein (WRN) contributes to WRN's DNA double-strand break repair pathway choice

AGING CELL

IF7.1

2021-10-06

OAAI

Lee, Jong-Hyuk; Shamanna, Raghavendra A.; Kulikowicz, Tomasz; Borhan Fakouri, Nima; Kim, Edward W.; Christiansen, Louise S.; Croteau, Deborah L.; Bohr, Vilhelm A.

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Research Directions