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J

John Silke

The Walter and Eliza Hall Institute of Medical Research

91H-index
369Paper Count
3.7WCitation Count
Published Papers 183
Publication Date
The benchmarking and application of tag-degraders in vivo to validate therapeutic targets
err2026-05-29
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errCharlene M. Magtoto; Stephen Mieruszynski; Hao Dong; Ashley P. Ng; Ladina Di Rago; Andrew J. Kueh; Martin Brzozowski; Christoph Grohmann; Joel R. Walker; Ngee Kiat Chua; Laura F. Dagley; Alessio Ciulli; Guillaume Lessene; Marco J. Herold; Joan K. Heath; John Silke; Rebecca Feltham
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The transmembrane domain structure of TNFR1 suppresses ligand-independent autoactivation but is not required for TNF-induced signaling
err2026-05-12
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PREAI
errPanxue Wang; Assaf Elazar; Jonathan Y. Weinstein; Nicholas J. Chandler; Sarel J. Fleishman; Melissa J. Call; Matthew E. Call; John Silke
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Expanding the toolbox to develop IAP-based degraders of TEAD transcription factors
err2026-01-19
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errNishma Gupta; Nicole Trainor; Mona Radwan; Stephanie Nguyen; Luke Duncan; Andrew X. Tang; Julia Beveridge; Natasha Silke; Jumana Yousef; Ceren Bilgilier; Johannes Wachter; Peter Greb; Zuzana Jandova; Ján Eliaš; Sara Kopf; Thomas Gerstberger; Peggy Stolt-Bergner; Nina Braun; Harald Weinstabl; Darryl B. McConnell; Federico Mauri; Isabelle S. Lucet; John Silke; Nicola E. A. Chessum; Michael J. Roy
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Enabling high-resolution diagnostic oral confocal laser endomicroscopy in mice
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IF4.3
err2025-07-01
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errCelentano, Antonio; Rickard, James A.; Low, Jun; Silke, Natasha; Mohammed, Ali Ibrahim; Moslemi, Elham; Ramani, Rishi S.; Franca, Paula Demetrio De Souza; Reiner, Thomas; McCullough, Michael J.; Yap, Tami; Silke, John; O'Reilly, Lorraine A.
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The RBR E3 ubiquitin ligase HOIL-1 can ubiquitinate diverse non-protein substrates in vitro
err2025-04-01
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errWang, Xiangyi S.; Jiou, Jenny; Cerra, Anthony; Cobbold, Simon A.; Jochem, Marco; Mak, Ka Hin Toby; Corcilius, Leo; Silke, John; Payne, Richard J.; Goddard-Borger, Ethan D.; Komander, David; Lechtenberg, Bernhard C.
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Convolutional neural networks for accurate real-time diagnosis of oral epithelial dysplasia and oral squamous cell carcinoma using high-resolution in vivo confocal microscopy
err2025-01-20
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errRamani, Rishi S.; Tan, Ivy; Bussau, Lindsay; O'Reilly, Lorraine A.; Silke, John; Angel, Christopher; Celentano, Antonio; Whitehead, Lachlan; Mccullough, Michael; Yap, Tami
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Complex IIa formation and ABC transporters determine sensitivity of OSCC to Smac mimetics
err2024-11-22
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errWang, Yuhan; Liu, Zijian; Si, Qian; Lu, Wanqiu; Song, Yuxian; Jin, Wanyong; Yang, Xihu; Li, Zihui; Hu, Xinyang; Ding, Liang; Jing, Yue; Weng, Pei; Yu, Qiuya; O'Reilly, Lorraine A.; Silke, John; Zhang, Xiaoxin; Hu, Qingang; Ni, Yanhong
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RIPK1 prevents TRADD-driven, but TNFR1 independent, apoptosis during development (vol 26, pg 877, 2019)
err2024-11-07
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errAnderton, Holly; Bandala-Sanchez, Esther; Simpson, Daniel S.; Rickard, James A.; Ng, Ashley P.; Di Rago, Ladina; Hall, Cathrine; Vince, James E.; Silke, John; Liccardi, Gianmaria; Feltham, Rebecca
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Intracellular zinc protects tumours from T cell-mediated cytotoxicity
err2024-09-11
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errLelliott, Emily J.; Naddaf, Jonathan; Ganio, Katherine; Michie, Jessica; Wang, Shelly; Liu, Lin; Silke, Natasha; Ahn, Antonio; Ramsbottom, Kelly M.; Brennan, Amelia J.; Freeman, Andrew J.; Goel, Shom; Vervoort, Stephin J.; Kearney, Conor J.; Beavis, Paul A.; Mcdevitt, Christopher A.; Silke, John; Oliaro, Jane
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An immunohistochemical atlas of necroptotic pathway expression
err2024-05-15
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errChiou, Shene; Al-Ani, Aysha H.; Pan, Yi; Patel, Komal M.; Kong, Isabella Y.; Whitehead, Lachlan W.; Light, Amanda; Young, Samuel N.; Barrios, Marilou; Sargeant, Callum; Rajasekhar, Pradeep; Zhu, Leah; Hempel, Anne; Lin, Ann; Rickard, James A.; Hall, Cathrine; Gangatirkar, Pradnya; Yip, Raymond K. H.; Cawthorne, Wayne; Jacobsen, Annette, V; Horne, Christopher R.; Martin, Katherine R.; Ioannidis, Lisa J.; Hansen, Diana S.; Day, Jessica; Wicks, Ian P.; Law, Charity; Ritchie, Matthew E.; Bowden, Rory; Hildebrand, Joanne M.; O'Reilly, Lorraine A.; Silke, John; Giulino-Roth, Lisa; Tsui, Ellen; Rogers, Kelly L.; Hawkins, Edwin D.; Christensen, Britt; Murphy, James M.; Samson, Andre L.
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Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency
err2024-04-12
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PREAI
errOda, Hirotsugu; Manthiram, Kalpana; Chavan, Pallavi Pimpale; Rieser, Eva; Veli, Oenay; Kaya, Oeykue; Rauch, Charles; Nakabo, Shuichiro; Kuehn, Hye Sun; Swart, Mariel; Wang, Yanli; Celik, Nisa Ilgim; Molitor, Anne; Ziaee, Vahid; Movahedi, Nasim; Shahrooei, Mohammad; Parvaneh, Nima; Alipour-Olyei, Nasrin; Carapito, Raphael; Xu, Qin; Preite, Silvia; Beck, David B.; Chae, Jae Jin; Nehrebecky, Michele; Ombrello, Amanda K.; Hoffmann, Patrycja; Romeo, Tina; Deuitch, Natalie T.; Matthiasardottir, Brynja; Mullikin, James; Komarow, Hirsh; Stoddard, Jennifer; Niemela, Julie; Dobbs, Kerry; Sweeney, Colin L.; Anderton, Holly; Lawlor, Kate E.; Yoshitomi, Hiroyuki; Yang, Dan; Boehm, Manfred; Davis, Jeremy; Mudd, Pamela; Randazzo, Davide; Tsai, Wanxia Li; Gadina, Massimo; Kaplan, Mariana J.; Toguchida, Junya; Mayer, Christian T.; Rosenzweig, Sergio D.; Notarangelo, Luigi D.; Iwai, Kazuhiro; Silke, John; Schwartzberg, Pamela L.; Boisson, Bertrand; Casanova, Jean-Laurent; Bahram, Seiamak; Rao, Anand Prahalad; Peltzer, Nieves; Walczak, Henning; Lalaoui, Najoua; Aksentijevich, Ivona; Kastner, Daniel L.
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RIPK1 and necroptosis role in premature ageing
err2024-03-27
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PREAI
errWang, Panxue; Silke, John
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RIPK3 cleavage is dispensable for necroptosis inhibition but restricts NLRP3 inflammasome activation
err2024-03-21
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errOAAI
errTran, Hong Tri; Kratina, Tobias; Coutansais, Auriane; Michalek, Dominika; Hogan, Benjamin M.; Lawlor, Kate E.; Vince, James E.; Silke, John; Lalaoui, Najoua
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Immunogenic cell death in cancer: targeting necroptosis to induce antitumour immunity
err2024-03-07
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PREAI
errMeier, Pascal; Legrand, Arnaud J.; Adam, Dieter; Silke, John
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Mind bomb 2 limits inflammatory dermatitis in Sharpin mutant mice independently of cell death
err2023-12-18
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errSimpson, Daniel S.; Anderton, Holly; Yousef, Jumana; Vaibhav, Vineet; Cobbold, Simon A.; Bandala-Sanchez, Esther; Kueh, Andrew J.; Dagley, Laura F.; Herold, Marco J.; Silke, John; Vince, James E.; Feltham, Rebecca
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cIAPs control RIPK1 kinase activity-dependent and -independent cell death and tissue inflammation
err2023-10-04
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errSchorn, Fabian; Werthenbach, J. Paul; Hoffmann, Mattes; Daoud, Mila; Stachelscheid, Johanna; Schiffmann, Lars M.; Hildebrandt, Ximena; Lyu, Su Ir; Peltzer, Nieves; Quaas, Alexander; Vucic, Domagoj; Silke, John; Pasparakis, Manolis; Kashkar, Hamid
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A common human MLKL polymorphism confers resistance to negative regulation by phosphorylation
err2023-09-28
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errGarnish, Sarah E.; Martin, Katherine R.; Kauppi, Maria; Jackson, Victoria E.; Ambrose, Rebecca; Eng, Vik Ven; Chiou, Shene; Meng, Yanxiang; Frank, Daniel; Crutchfield, Emma C. Tovey; Patel, Komal M.; Jacobsen, Annette V.; Atkin-Smith, Georgia K.; Di Rago, Ladina; Doerflinger, Marcel; Horne, Christopher R.; Hall, Cathrine; Young, Samuel N.; Cook, Matthew; Athanasopoulos, Vicki; Vinuesa, Carola G.; Lawlor, Kate E.; Wicks, Ian P.; Ebert, Gregor; Ng, Ashley P.; Slade, Charlotte A.; Pearson, Jaclyn S.; Samson, Andre L.; Silke, John; Murphy, James M.; Hildebrand, Joanne M.
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