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Targeting triple-negative breast cancers with the Smac-mimetic birinapant Lalaoui, Najoua; Merino, Delphine; Giner, Goknur; Vaillant, Francois; Chau, Diep; Liu, Lin; Kratina, Tobias; Pal, Bhupinder; Whittle, James R.; Etemadi, Nima; Berthelet, Jean; Grasel, Julius; Hall, Cathrine; Ritchie, Matthew E.; Ernst, Matthias; Smyth, Gordon K.; Vaux, David L.; Visvader, Jane E.; Lindeman, Geoffrey J.; Silke, John Share Save
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In the absence of apoptosis, myeloid cells arrest when deprived of growth factor, but remain viable by consuming extracellular glucose Dong, Li; Reljic, Boris; Cheung, Jen G.; Ng, Elizabeth S.; Lindqvist, Lisa M.; Elefanty, Andrew G.; Vaux, David L.; Tran, Hoanh Share Save
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Tumor necrosis factor (TNF) signaling, but not TWEAK (TNF-like weak inducer of apoptosis)-triggered cIAP1 (cellular inhibitor of apoptosis protein 1) degradation, requires cIAP1 RING dimerization and E2 binding (vol 285, pg 17525, 2010) Feltham, Rebecca L.; Moulin, Maryline; Vince, James E.; Mace, Peter D.; Wong, Wendy Wei-Lynn; Anderton, Holly; Day, Catherine L.; Vaux, David L.; Silke, John Share Save
XIAP Loss Triggers RIPK3-and Caspase-8-Driven IL-1β Activation and Cell Death as a Consequence of TLR-MyD88-Induced cIAP1-TRAF2 Degradation Lawlor, Kate E.; Feltham, Rebecca; Yabal, Monica; Conos, Stephanie A.; Chen, Kaiwen W.; Ziehe, Stephanie; Grass, Carina; Zhan, Yifan; Nguyen, Tan A.; Hall, Cathrine; Vince, Angelina J.; Chatfield, Simon M.; D'Silva, Damian B.; Pang, Kenneth C.; Schroder, Kate; Silke, John; Vaux, David L.; Jost, Philipp J.; Vince, James E. Share Save
Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner Conos, Stephanie A.; Chen, Kaiwen W.; De Nardo, Dominic; Hara, Hideki; Whitehead, Lachlan; Nunez, Gabriel; Masters, Seth L.; Murphy, James M.; Schroder, Kate; Vaux, David L.; Lawlor, Kate E.; Lindqvist, Lisa M.; Vince, James E. Share Save
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The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia Brumatti, Gabriela; Ma, Chunyan; Lalaoui, Najoua; Nguyen, Nhu-Y; Navarro, Mario; Tanzer, Maria C.; Richmond, Jennifer; Ghisi, Margherita; Salmon, Jessica M.; Silke, Natasha; Pomilio, Giovanna; Glaser, Stefan P.; de Valle, Elisha; Gugasyan, Raffi; Gurthridge, Mark A.; Condon, Stephen M.; Johnstone, Ricky W.; Lock, Richard; Salvesen, Guy; Wei, Andrew; Vaux, David L.; Ekert, Paul G.; Silke, John Share Save
Evolutionary divergence of the necroptosis effector MLKL Tanzer, M. C.; Matti, I.; Hildebrand, J. M.; Young, S. N.; Wardak, A.; Tripaydonis, A.; Petrie, E. J.; Mildenhall, A. L.; Vaux, D. L.; Vince, J. E.; Czabotar, P. E.; Silke, J.; Murphy, J. M. Share Save
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In TNF-stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and clAP1, which limits induction of non-canonical NF-κB and activation of caspase-8 (vol 286, pg 13282, 2011) Gentle, Ian E.; Wong, W. Wei-Lynn; Evans, Joseph M.; Bankovacki, Alexandra; Cook, Wendy D.; Khan, Nufail R.; Nachbur, Ulrich; Rickard, James; Anderton, Holly; Moulin, Maryline; Lluis, Josep Maria; Moujalled, Donia M.; Silke, John; Vaux, David L. Share Save
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