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Head and Neck Cancers, Version 2.2025 Featured Updates to the NCCN Guidelines Colevas, A. Dimitrios; Cmelak, Anthony J.; Pfister, David G.; Spencer, Sharon; Adkins, Douglas; Birkeland, Andrew C.; Brizel, David M.; Busse, Paul M.; Caudell, Jimmy J.; Durm, Greg; Fakhry, Carole; Galloway, Thomas; Geiger, Jessica L.; Gillison, Maura L.; Glastonbury, Christine; Haddad, Robert I.; Hicks Jr, Wesley L.; Hitchcock, Ying J.; Jimeno, Antonio; Juloori, Aditya; Kase, Michael; Leizman, Debra; Maghami, Ellie; Mell, Loren K.; Mittal, Bharat B.; Pinto, Harlan A.; Price, Katharine; Rocco, James W.; Rodriguez, Cristina P.; Schwartz, David; Shah, Jatin P.; Sher, David; St John, Maie; Wang, He; Weinstein, Gregory; Worden, Francis; Bruce, Justine Yang; Yom, Sue S.; Zhen, Weining; Montgomery, Sarah; Darlow, Susan D. Share Save
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Low PD-L1 expression, MAP2K2 alterations, and enriched HPV gene signatures characterize brain metastases in head and neck squamous cell carcinoma Dennis, Michael J.; Pavlick, Dean C.; Kacew, Alec; Wotman, Michael; Macconaill, Laura E.; Jones, Stephanie M.; Pfaff, Kathleen L.; Rodig, Scott J.; Eacker, Stephen; Malig, Maika; Reister, Emily; Piccioni, David; Kesari, Santosh; Sehgal, Kartik; Haddad, Robert I.; Cohen, Ezra; Posner, Marshall R.; Deichaite, Ida; Hanna, Glenn J. Share Save
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A Phase I/II Trial of Sapanisertib in Advanced Anaplastic and Radioiodine Refractory Differentiated Thyroid Carcinoma Sehgal, Kartik; Serritella, Anthony; Liu, Mofei; Oneill, Anne; Nangia, Chaitali; Pappa, Theodora; Demeure, Michael J.; Worden, Francis P.; Haddad, Robert I.; Lorch, Jochen Share Save
Immunomethylomic profiles of long-term head and neck squamous cell carcinoma survivors on immune checkpoint inhibitors Lee, Min Kyung; Zhang, Ze; Sehgal, Kartik; Butler, Rondi; Stolrow, Hannah; Ramush, Geat; Shirai, Keisuke; Koestler, Devin C.; Salas, Lucas A.; Wiencke, John K.; Haddad, Robert; Kelsey, Karl T.; Christensen, Brock C. Share Save
IMvoke010: A phase III, double-blind randomized trial of atezolizumab (atezo) after definitive local therapy vs placebo in patients (pts) with high-risk locally advanced (LA) squamous cell carcinoma of the head and neck (SCCHN) Wong, Deborah J.; Fayette, Jerome; Teixeira, Maria; Prabhash, Kumar; Mesia, Ricard; Kawecki, Andrzej; Dechaphunkul, Arunee; Dinis, Jose; Guo, Ye; Masuda, Muneyuki; Hsieh, Ching-Yun; Ghi, Maria Grazia; Sette, Claudia Vaz de Melo; Jiang, Tao; Yan, Yibing; Kaul, Monika; Jagtiani, Ritika; Matheny, Christina; Cuchelkar, Vaikunth; Haddad, Robert Share Save
Xevinapant plus radiotherapy in resected, high-risk, cisplatin-ineligible LA SCCHN: the phase III XRay Vision study design Ferris, Robert L.; Mehanna, Hisham; Schoenfeld, Jonathan D.; Tahara, Makoto; Yom, Sue S.; Haddad, Robert; Koenig, Andre; Witzler, Pauline; Bajars, Marcis; Le Tourneau, Christophe Share Save
Biomarker benchmarking across ancestral populations Nassar, Amin; Adib, Elio; Abou Alaiwi, Sarah; El Zarif, Talal; Groha, Stefan; Akl, Elie W.; Nuzzo, Pier Vitale; Mouhieddine, Tarek H.; Perea-Chamblee, Tomin; Taraszka, Kodi; EI-Khoury, Habib; Labban, Muhieddine; Fong, Christopher; Arora, Kanika S.; Labaki, Chris; Xu, Wenxin; Sonpavde, Guru P.; Haddad, Robert I.; Mouw, Kent W.; Giannakis, Marios; Hodi, Stephen; Zaitlen, Noah; Schoenfeld, Adam; Schultz, Nikolaus; Berger, Michael F.; MacConaill, Laura E.; Ananda, Guruprasad; Kwiatkowski, David J.; Choueiri, Toni K.; Schrag, Deborah; Zhang, Jian-Carrot; Gusev, Alexander Share Save
INTERLINK-1: Phase III study of cetuximab (CTX) ± monalizumab (M) in participants (pts) with recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC) with disease progression on/after platinum chemotherapy (CT) and previously treated with an immune checkpoint inhibitor (ICI) Fayette, J.; Licitra, L. F. L.; Harrington, K. J.; Haddad, R.; Siu, L. L.; Liu, Y. C.; Tahara, M.; Machiels, J-P.; Rischin, D.; Seiwert, T.; Ferris, R.; Keilholz, U.; Psyrri, A.; Keam, B.; Bossi, P.; Metcalf, R.; Serrano, O.; Kaur, P.; Ruscica, D.; Cohen, R. B. Share Save
β-catenin/CBP activation of mTORC1 signaling promotes partial epithelial-mesenchymal states in head and neck cancer Reed, Eric R.; Jankowski, Stacy A.; Spinella, Anthony J.; Noonan, Vikki; Haddad, Robert; Nomoto, Kenichi; Matsui, Junji; Bais, Manish V.; Varelas, Xaralabos; Kukuruzinska, Maria A.; Monti, Stefano Share Save
Preexisting tumor-resident T cells with cytotoxic potential associate with response to neoadjuvant anti-PD-1 in head and neck cancer Oliveira, Giacomo; Egloff, Ann Marie; Afeyan, Alexander B.; Wolff, Jacquelyn O.; Zeng, Zexiang; Chernock, Rebecca D.; Zhou, Liye; Messier, Cameron; Lizotte, Patrick; Pfaff, Kathleen L.; Stromhaug, Kari; Penter, Livius; Haddad, Robert I.; Hanna, Glenn J.; Schoenfeld, Jonathan D.; Goguen, Laura A.; Annino, Donald J.; Jo, Vickie; Oppelt, Peter; Pipkorn, Patrik; Jackson, Ryan; Puram, Sidharth V.; Paniello, Randal C.; Rich, Jason T.; Webb, Jason; Zevallos, Jose P.; Mansour, Mena; Fu, Jingxin; Dunn, Gavin P.; Rodig, Scott J.; Ley, Jessica; Morris, Luc G. T.; Dunn, Lara; Paweletz, Cloud P.; Kallogjeri, Dorina; Piccirillo, Jay F.; Adkins, Douglas R.; Wu, Catherine J.; Uppaluri, Ravindra Share Save
Managing cisplatin-ineligible patients with resected, high-risk, locally advanced squamous cell carcinoma of the head and neck: Is there a standard of care? Haddad, Robert I.; Harrington, Kevin; Tahara, Makoto; Szturz, Petr; Le Tourneau, Christophe; Salmio, Satu; Bajars, Marcis; Lee, Nancy Y. Share Save
Screening for extranodal extension in HPV-associated oropharyngeal carcinoma: evaluation of a CT-based deep learning algorithm in patient data from a multicentre, randomised de-escalation trial Kann, Benjamin H.; Likitlersuang, Jirapat; Bontempi, Dennis; Ye, Zezhong; Aneja, Sanjay; Bakst, Richard; Kelly, Hillary R.; Juliano, Amy F.; Payabvash, Sam; Guenette, Jeffrey P.; Uppaluri, Ravindra; Margalit, Danielle N.; Schoenfeld, Jonathan D.; Tishler, Roy B.; Haddad, Robert; Aerts, Hugo J. W. L.; Garcia, Joaquin J.; Flamand, Yael; Subramaniam, Rathan M.; Burtness, Barbara A.; Ferris, Robert L. Share Save
Durvalumab with or without tremelimumab versus the EXTREME regimen as first-line treatment for recurrent or metastatic squamous cell carcinoma of the head and neck: KESTREL, a randomized, open-label, phase III study Psyrri, A.; Fayette, J.; Harrington, K.; Gillison, M.; Ahn, M. -J.; Takahashi, S.; Weiss, J.; Machiels, J. -P.; Baxi, S.; Vasilyev, A.; Karpenko, A.; Dvorkin, M.; Hsieh, C. -Y.; Thungappa, S. C.; Segura, P. P.; Vynnychenko, I.; Haddad, R.; Kasper, S.; Mauz, P. -S.; Baker, V.; He, P.; Evans, B.; Wildsmith, S.; Olsson, R. F.; Yovine, A.; Kurland, J. F.; Morsli, N.; Seiwert, T. Y. Share Save
Association of Pretreatment Circulating Tumor Tissue-Modified Viral HPV DNA With Clinicopathologic Factors in HPV-Positive Oropharyngeal Cancer Rettig, Eleni M.; Wang, Annette A.; Ngoc-Anh Tran; Carey, Evan; Dey, Tanujit; Schoenfeld, Jonathan D.; Sehgal, Kartik; Guenette, Jeffrey P.; Margalit, Danielle N.; Sethi, Rosh; Uppaluri, Ravindra; Tishler, Roy B.; Annino, Donald J.; Goguen, Laura A.; Jo, Vickie Y.; Haddad, Robert, I; Hanna, Glenn J. Share Save
A phase II study of nivolumab for high-risk oral leukoplakia Hanna, G. J.; Villa, A.; Shi, R.; O'Neill, A.; Liu, M.; Quinn, C. T.; Curtin, R. K.; Flynn, M.; Treister, N. S.; Sroussi, H. Y.; Vacharotayangul, P.; Goguen, L. A.; Annino, D. J.; Rettig, E. M.; Jo, V. Y.; Wong, K.; Uppaluri, R.; Haddad, R.; Woo, S-B. Share Save
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Oncology clinical trial disruption during the COVID-19 pandemic: a COVID-19 and cancer outcomes study Bakouny, Z.; Labaki, C.; Bhalla, S.; Schmidt, A. L.; Steinharter, J. A.; Cocco, J.; Tremblay, D. A.; Awad, M. M.; Kessler, A.; Haddad, R., I; Evans, M.; Busser, F.; Wotman, M.; Curran, C. R.; Zimmerman, B. S.; Bouchard, G.; Jun, T.; Nuzzo, P., V; Qin, Q.; Hirsch, L.; Feld, J.; Kelleher, K. M.; Seidman, D.; Huang, H.; Anderson-Keightly, H. M.; El Zarif, T.; Abou Alaiwi, S.; Champagne, C.; Rosenbloom, T. D.; Stewart, P. S.; Johnson, B. E.; Trinh, Q.; Tolaney, S. M.; Galsky, M. D.; Choueiri, T. K.; Doroshow, D. B. Share Save
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