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J

John M. Maris

children's hospital of philadelphia

115H-index
1.4KPaper Count
5.3WCitation Count
Published Papers 288
Publication Date
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The PLK4 inhibitor RP-1664 demonstrates potent efficacy in neuroblastoma preclinical models through a dual mechanism of sensitivity
errNature Communications
IF15.7
err2026-06-13
err0
errOAAI
errIsabel Soria-Bretones; Matias Casás-Selves; Minu Samanta; David Groff; Jayne Murray; Jamie I. Fletcher; Alvin Farrel; Steven Pastor; Khushbu Patel; Elliot Goodfellow; Li Li; Cathy Caron; Ariya Shiwram; Hyeyeon Kim; Danielle Henry; Nancy Laterreur; Julian Bowlan; Kateryna Krytska; Steven B. Neuhauser; Timothy M. Stearns; Jeffrey A. Schubert; Jinhua Wu; Lea F. Surrey; Daniel Martinez; Crystal Mak; Jennifer Brand; Caitlin Wesley; Klaartje Somers; Alejandro Álvarez-Quilón; Frédéric Vallée; Parham Nejad; Joseph D. Schonhoft; Joanna Li; Artur Veloso; Jordan T. F. Young; Marc L. Hyer; Stephen J. Morris; Yael P. Mossé; C. Gary Marshall; Michelle Haber; Michal Zimmermann; John M. Maris
errShare
errSave
HLA-Shuttle: A system for enhancing antigen presentation in immunologically cold tumors
errSCIENCE ADVANCES
IF12.5
err2026-01-01
err0
PREAI
errHwang, Daniel; Erdman, Molly C.; Adhikari, Santosh; Pantula, Ram; Epstein, Kaya; Li, Peiyao; Costabile, Francesca; Rotsides, Photis; Wang, Chloe S.; Sun, Shirley M.; Fazelinia, Hossein; Spruce, Lynn A.; Fugmann, Tim; Rrustemi, Trendelina; Soh, Wai Tuck; Farrel, Alvin; Want, Muzamil Y.; Facciabene, Andrea; Mir, Mustafa; Maris, John M.; Sgourakis, Nikolaos G.
errShare
errSave
Atomically accurate de novo design of antibodies with RFdiffusion
errNature
IF48.5
err2025-11-05
err0
errOAAI
errNathaniel R. Bennett; Joseph L. Watson; Robert J. Ragotte; Andrew J. Borst; DéJenaé L. See; Connor Weidle; Riti Biswas; Yutong Yu; Ellen L. Shrock; Russell Ault; Philip J. Y. Leung; Buwei Huang; Inna Goreshnik; John Tam; Kenneth D. Carr; Benedikt Singer; Cameron Criswell; Basile I. M. Wicky; Dionne Vafeados; Mariana Garcia Sanchez; Ho Min Kim; Susana Vázquez Torres; Sidney Chan; Shirley M. Sun; Timothy T. Spear; Yi Sun; Keelan O’Reilly; John M. Maris; Nikolaos G. Sgourakis; Roman A. Melnyk; Chang C. Liu; David Baker
errShare
errSave
Investigating the immunological effect of MYCN depletion in MYCN-amplified neuroblastoma
errJOURNAL OF IMMUNOLOGY
IF3.4
err2025-11-01
err0
PREAI
errTorres-Rodriguez, Kyabeth M.; Salvacion, Mykaela; Mycek, Emily; Betts, Michael; Wolpaw, Adam J.; Maris, John M.
errShare
errSave
The Open Pediatric Cancer Project
errGigaScience
IF3.9
err2025-09-02
err0
errOAAI
errZhuangzhuang Geng; Eric Wafula; Ryan J Corbett; Yuanchao Zhang; Run Jin; Krutika S Gaonkar; Sangeeta Shukla; Komal S Rathi; Dave Hill; Aditya Lahiri; Daniel P Miller; Alex Sickler; Kelsey Keith; Christopher Blackden; Antonia Chroni; Miguel A Brown; Adam A Kraya; Kaylyn L Clark; Brian R Rood; Adam C Resnick; Nicholas Van Kuren; John M Maris; Alvin Farrel; Mateusz P Koptyra; Gerri R Trooskin; Noel Coleman; Yuankun Zhu; Stephanie Stefankiewicz; Zied Abdullaev; Asif T Chinwalla; Mariarita Santi; Ammar S Naqvi; Jennifer L Mason; Carl J Koschmann; Xiaoyan Huang; Sharon J Diskin; Kenneth Aldape; Bailey K Farrow; Weiping Ma; Bo Zhang; Brian M Ennis; Sarah Tasian; Saksham Phul; Matthew R Lueder; Chuwei Zhong; Joseph M Dybas; Pei Wang; Deanne Taylor; Jo Lynne Rokita
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errSave
A humanized anaplastic lymphoma kinase (ALK)-directed antibody-drug conjugate with pyrrolobenzodiazepine payload demonstrates efficacy in ALK-expressing cancers
errNature Communications
IF15.7
err2025-08-15
err0
errOAAI
errAlberto D. Guerra; Smita Matkar; Christina Acholla; Colleen Casey; Grant Li; Martina Mazzeschi; Khushbu Patel; Kateryna Krytska; Chuan Chen; Skye Balyasny; Joshua Kalna; Paul Kamitsuka; Mark Gerelus; Grace Polkosnik; David Groff; Apratim Mukherje; Cynthia Adams; Gabriela Witek; Amber K. Hamilton; Daniel Martinez; Jennifer Pogoriler; Timothy T. Spear; Yimei Li; Piotr Jung; Diego Alvarado; Mattia Lauriola; John M. Maris; Adam J. Wolpaw; Kristopher R. Bosse; Dimiter Dimitrov; Mustafa Mir; Dontcho V. Jelev; Yael P. Mossé
errShare
errSave
The Non-Coding Regulatory Variant rs2863002 at chr11p11.2 Increases Neuroblastoma Risk by Affecting HSD17B12 Expression and Lipid Metabolism
errADVANCED SCIENCE
IF14.1
err2025-06-01
err0
errOAAI
errMaiorino, Teresa; Avitabile, Marianna; Aievola, Vincenzo; Montella, Annalaura; Lasorsa, Vito A.; Bonfiglio, Ferdinando; Cantalupo, Mariagrazia; Cantalupo, Sueva; Estinto, Gilda; Tirelli, Matilde; Morini, Martina; Ardito, Martina; Eva, Alessandra; Cerbone, Vincenza; Mauriello, Lucia; Caterino, Marianna; Ruoppolo, Margherita; Maris, John M.; Diskin, Sharon J.; Iolascon, Achille; Capasso, Mario
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errSave
Longitudinal single-cell multiomic atlas of high-risk neuroblastoma reveals chemotherapy-induced tumor microenvironment rewiring
errNATURE GENETICS
IF0
err2025-04-14
err0
errOAAI
errYu, Wenbao; Biyik-Sit, Rumeysa; Uzun, Yasin; Chen, Chia-Hui; Thadi, Anusha; Sussman, Jonathan H.; Pang, Minxing; Wu, Chi-Yun; Grossmann, Liron D.; Gao, Peng; Wu, David W.; Yousey, Aliza; Zhang, Mei; Turn, Christina S.; Zhang, Zhan; Bandyopadhyay, Shovik; Huang, Jeffrey; Patel, Tasleema; Chen, Changya; Martinez, Daniel; Surrey, Lea F.; Hogarty, Michael D.; Bernt, Kathrin; Zhang, Nancy R.; Maris, John M.; Tan, Kai
errShare
errSave
ImmunoTar-integrative prioritization of cell surface targets for cancer immunotherapy
errBIOINFORMATICS
IF5.4
err2025-02-11
err0
errOAAI
errShraim, Rawan; Mooney, Brian; Conkrite, Karina L.; Hamilton, Amber K.; Morin, Gregg B.; Sorensen, Poul H.; Maris, John M.; Diskin, Sharon J.; Sacan, Ahmet
errShare
errSave
Lessons learned from 20 years of preclinical testing in pediatric cancers
errPHARMACOLOGY & THERAPEUTICS
IF12.5
err2024-12-01
err0
PREAI
errSmith, Malcolm A.; Houghton, Peter J.; Lock, Richard B.; Maris, John M.; Gorlick, Richard; Kurmasheva, Raushan T.; Li, Xiao-Nan; Teicher, Beverly A.; Chuang, Jeffrey H.; Cruz, Filemon S. Dela; Dyer, Michael A.; Kung, Andrew L.; Lloyd, Michael W.; Mosse, Yael P.; Stearns, Timothy M.; Stewart, Elizabeth A.; Bult, Carol J.; Erickson, Stephen W.
errShare
errSave
Comparison of human pluripotent stem cell differentiation protocols to generate neuroblastoma tumors
errSCIENTIFIC REPORTS
IF3.9
err2024-10-04
err1
errOAAI
errCheng, Bo; Fang, Wanqi; Pastor, Steven; March, Alexander R.; Porras, Tania; Wu, Hong-Wei; Velez, Miriam; Parekh, Chintan; Maris, John M.; Asgharzadeh, Shahab; Huang, Miller
errShare
errSave
VCAN plus macrophages promote neuroblastoma cell growth, migration, and adrenergic to mesenchymal transition via the HB-EGF/ERBB signaling axis
errCANCER RESEARCH
IF16.6
err2024-09-05
err0
PREAI
errBiyik-Sit, Rumeysa; Yu, Wenbao; Chen, Chia-Hui; Thadi, Anusha; Pang, Minxing; Grossmann, Liron D.; Patel, Tasleema; Martinez, Daniel; Surrey, Lea F.; Hogarty, Michael D.; Bernt, Kathrin; Zhang, Nancy; Maris, John M.; Tan, Kai
errShare
errSave
Whole genome and reverse protein phase array landscapes of patient derived osteosarcoma xenograft models
errSCIENTIFIC REPORTS
IF3.9
err2024-08-27
err0
errOAAI
errWu, Chia-Chin; Huang, Licai; Zhang, Zhongting; Ju, Zhenlin; Song, Xingzhi; Kolb, E. Anders; Zhang, Wendong; Gill, Jonathan; Ha, Min; Smith, Malcolm A.; Houghton, Peter; Morton, Christopher L.; Kurmasheva, Raushan; Maris, John; Mosse, Yael; Lu, Yiling; Gorlick, Richard; Futreal, P. Andrew; Beird, Hannah C.
errShare
errSave
Identification and Characterization of Chemotherapy-Resistant High-Risk Neuroblastoma Persister Cells
errCANCER DISCOVERY
IF33.3
err2024-07-31
err1
errOAAI
errGrossmann, Liron D.; Chen, Chia-Hui; Uzun, Yasin; Thadi, Anusha; Wolpaw, Adam J.; Louault, Kevin; Goldstein, Yael; Surrey, Lea F.; Martinez, Daniel; Calafatti, Matteo; Gerelus, Mark; Gao, Peng; Lee, Lobin; Patel, Khushbu; Kaufman, Rebecca S.; Shani, Guy; Farrel, Alvin; Moshitch-Moshkovitz, Sharon; Grimaldi, Paris; Shapiro, Matthew; Kendsersky, Nathan M.; Lindsay, Jarrett M.; Casey, Colleen E.; Krytska, Kateryna; Scolaro, Laura; Tsang, Matthew; Groff, David; Matkar, Smita; Kalna, Josh R.; Mycek, Emily; Mcdevitt, Jayne; Runbeck, Erin; Patel, Tasleema; Bernt, Kathrin M.; Asgharzadeh, Shahab; Declerck, Yves A.; Mosse, Yael P.; Tan, Kai; Maris, John M.
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errSave
Preclinical development of a chimeric antigen receptor T cell therapy targeting FGFR4 in rhabdomyosarcoma (vol 5, 101586, 2024)
errCELL REPORTS MEDICINE
IF10.6
err2024-05-01
err0
errOAAI
errTian, Meijie; Wei, Jun S.; Shivaprasad, Nityashree; Highfill, Steven L.; Gryder, Berkley E.; Milewski, David; Brown, G. Tom; Moses, Larry; Song, Hannah; Wu, Jerry T.; Azorsa, Peter; Kumar, Jeetendra; Schneider, Dina; Chou, Hsien-Chao; Song, Young K.; Rahmy, Abdelrahman; Masih, Katherine E.; Kim, Yong Yean; Belyea, Brian; Linardic, Corinne M.; Dropulic, Boro; Sullivan, Peter M.; Sorensen, Poul H.; Dimitrov, Dimiter S.; Maris, John M.; Mackall, Crystal L.; Orentas, Rimas J.; Cheuk, Adam T.; Khan, Javed
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errSave
In vivo efficacy of anti-B7-H3 antibody-drug conjugate (ADC) ifinatamab deruxtecan (I-DXd; DS-7300): An update from the Pediatric Preclinical In Vivo Testing (PIVOT) Program
errCANCER RESEARCH
IF16.6
err2024-04-05
err1
PREAI
errGorlick, Richard; Gill, Jonathan; Zhang, Wendong; Mosse, Yael; Maris, John; Groff, David; Smith, Malcolm; Teicher, Beverly; Neuhauser, Steve; Stearns, Tim; Philip, Vivek; Jocoy, Emily; Chuang, Jeff; Bult, Carol J.; Hasegawa, Jun; Qian, Xiaozhong; Houghton, Peter; Kurmasheva, Raushan
errShare
errSave
The Virtual Child
errCANCER DISCOVERY
IF33.3
err2024-04-04
err1
errOAAI
errGilbertson, Richard J.; Behjati, Sam; Boettcher, Anna-Lisa; Bronner, Marianne E.; Burridge, Matthew; Clausing, Henrick; Clifford, Harry; Danaher, Tracey; Donovan, Laura K.; Drost, Jarno; Eggermont, Alexander M. M.; Emerson, Chris; Flores, Mona G.; Hamerlik, Petra; Jabado, Nada; Jones, Andrew; Kaessmann, Henrick; Kleinman, Claudia L.; Kool, Marcel; Kutscher, Lena M.; Lindberg, Gavin; Linnane, Emily; Marioni, John C.; Maris, John M.; Monje, Michelle; Macaskill, Alexandra; Niederer, Steven; Northcott, Paul A.; Peeters, Elizabeth; Plieger-van Solkema, Willemijn; Preussner, Liane; Rios, Anne C.; Rippe, Karsten; Sandford, Peter; Sgourakis, Nikolaos G.; Shlien, Adam; Smith, Pete; Straathof, Karin; Sullivan, Patrick J.; Suva, Mario L.; Taylor, Michael D.; Thompson, Emma; Vento-Tormo, Roser; Wainwright, Brandon J.; Wechsler-Reya, Robert J.; Westermann, Frank; Winslade, Shannon; Al-Lazikani, Bissan; Pfister, Stefan M.
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errSave
Targeting DLK1, a Notch ligand, with an antibody-drug conjugate in adrenocortical carcinoma
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errSun, Nai-Yun; Kumar, Suresh; Weiner, Amber; Kim, Yoo Sun; Mendoza, Arnulfo; Nguyen, Rosa; Okada, Reona; Pommier, Yves; Martinez, Dan; Pogoriler, Jennifer; Diskin, Sharon; Maris, John; Del Rivero, Jaydira; Roper, Nitin
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errSave
GPC2 directed CAR T cells are efficacious against fusion-positive and fusionnegative rhabdomyosarcomas
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errShraim, Rawan; Schuerch, Patrick M.; Giudice, Anna Maria; Conkrite, Karina L.; Weiner, Amber K.; Radaoui, Alexander B.; Mooney, Brian; Kurmasheva, Raushan T.; Houghton, Peter J.; Morin, Gregg B.; Mosse, Yael B.; Sorensen, Poul H.; Garcia, Benjamin A.; Sacan, Ahmet; Maris, John M.; Bosse, Kristopher R.; Diskin, Sharon J.
errShare
errSave
Next-generation immunocompetent and humanized neuroblastoma murine models for the discovery and validation of novel immunotherapies
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errSpear, Timothy T.; Posthill, Elisabeth; Groff, David; Giudice, Anna M.; Bosse, Kristopher R.; Ma, Leyuan; Schoenberger, Stephen P.; Maris, John M.
errShare
errSave

Research Directions

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