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Structural mimicry of UM171 and neomorphic cancer mutants co-opts E3 ligase KBTBD4 for HDAC1/2 recruitment Chen, Zhuoyao; Chi, Gamma; Balo, Timea; Chen, Xiangrong; Montes, Beatriz Ralsi; Clifford, Steven C.; D'Angiolella, Vincenzo; Szabo, Timea; Kiss, Arpad; Novak, Tibor; Herner, Andras; Kotschy, Andras; Bullock, Alex N. Share Save
A CLINICALLY RELEVANT IN VIVO MODEL RECAPITULATES THE LATE EFFECTS OF RADIOTHERAPY IN CHILDHOOD MEDULLOBLASTOMA SURVIVORS Egnuni, T.; Castle, J.; Shaw, G.; Weller, D.; Fielder, E.; Singh, M.; Skinner, R.; von Zglinicki, T.; Clifford, S.; Miwa, S.; Hicks, D.; Short, S. C. Share Save
Molecular and clinical heterogeneity within MYC-family amplified medulloblastoma is associated with survival outcomes: A multicenter cohort study Schwalbe, Edward C.; Lindsey, Janet C.; Danilenko, Marina; Hill, Rebecca M.; Crosier, Stephen; Ryan, Sarra L.; Williamson, Daniel; Castle, Jemma; Hicks, Debbie; Kool, Marcel; Milde, Till; Korshunov, Andrey; Pfister, Stefan M.; Bailey, Simon; Clifford, Steven C. Share Save
MYC-dependent upregulation of the de novo serine and glycine synthesis pathway is a targetable metabolic vulnerability in group 3 medulloblastoma Adiamah, Magretta; Poole, Bethany; Lindsey, Janet C.; Kohe, Sarah; Morcavallo, Alaide; Burte, Florence; Hill, Rebecca M.; Blair, Helen; Thompson, Dean; Singh, Mankaran; Swartz, Shanel; Crosier, Stephen; Zhang, Tong; Maddocks, Oliver D. K.; Peet, Andrew; Chesler, Louis; Hickson, Ian; Maxwell, Ross J.; Clifford, Steven C. Share Save
MOLECULAR PATHOLOGY, TREATMENT AND PROGNOSIS OF INFANT SONIC HEDGEHOG MEDULLOBLASTOMA: A GLOBAL MULTI-COHORT STUDY Richardson, Stacey; Hicks, Debbie; Gough, Melissa; Castle, Jemma; Crosier, Stephen; Garcia-Ariza, Miguel; Martin-Guerrero, Idoia; LA Plasschaert, Sabine; Bourdeaut, Franck; Dufour, Christelle; Masliah-Planchon, Julien; Buttarelli, Francesca R.; Garre, Maria-Luisa; Biassoni, Veronica; Massimino, Maura; Kanemura, Yonehiro; Ramaswamy, Vijay; Gajjar, Amar; Northcott, Paul; Robinson, Giles; Korshunov, Andrey; Pfister, Stefan M.; Mynarek, Martin; Rutkowski, Stefan; Schwalbe, Edward C.; Bailey, Simon; Clifford, Steven C. Share Save
IN VIVO MODELLING RECAPITULATES RADIOTHERAPY DELIVERY AND LATE-EFFECT PROFILE FOR CHILDHOOD MEDULLOBLASTOMA Castle, Jemma; Shaw, Gary; Weller, Dominic; Fielder, Edward; Egnuni, Teklu; Singh, Mankaran; Skinner, Roderick; von Zglinicki, Thomas; Clifford, Steven C.; Short, Susan; Miwa, Satomi; Hicks, Debbie Share Save
SERINE/GLYCINE METABOLISM REPRESENTS A NOVEL TARGETABLE THERAPEUTIC VULNERABILITY IN MYC-AMPLIFIED MEDULLOBLASTOMA Adiamah, Magretta; Poole, Bethany; Lindsey, Janet C.; Swartz, Shanel; Morcavallo, Alaide; Gosling, Samantha Jepson; Singh, Mankaran; Blair, Helen J.; Kohe, Sarah; Zhang, Tong; Maddocks, Oliver; Peet, Andrew; Chesler, Louis; Hickson, Ian; Maxwell, Ross; Hill, Rebecca M.; Clifford, Steven C. Share Save
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NOVEL TRANSCRIPTS ASSOCIATE WITH SURVIVAL IN CHILDHOOD MEDULLOBLASTOMA Mateos, Marion K.; Williamson, Daniel; Danilenko, Marina; Goddard, Jack; Crosier, Stephen; Fletcher, Anya; Schwalbe, Edward; Hicks, Debbie; Bailey, Simon; Clifford, Steven C. Share Save
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SIOPE-MB6-THE RATIONALE FOR THE NEXT EUROPEAN STANDARD RISK MEDULLOBLASTOMA PHASE II/III TRIAL Mynarek, Martin; Doz, Francois; Clifford, Steve C.; Bailey, Simon; Rutkowski, Stefan; Padovani, Laeticia; Bouchoucha, Yassine; Partanen, Marita; Verity, Sarah; Sehested, Astrid; Puhr, Anita; Rossius, Anne; Chevignard, Mathilde; Dorfer, Christian; El Damaty, Ahmed; Beccaria, Kevin; Aquilina, Kristian; Hoving, Eelco W.; Schuhmann, Martin U.; Thomale, Ulrich W.; Milde, Till Share Save
HIGH-THROUGHPUT SMALL MOLECULE DRUG SCREENING, TRANSCRIPTOMICS AND INTEGRATIVE AI IDENTIFY TARGETABLE MYC-DEPENDENT THERAPEUTIC VULNERABILITIES IN HIGH-RISK MEDULLOBLASTOMA Llargues-Sistac, Gemma; Taylor, Louisa; Lindsey, Janet; Buttigieg, Marie Claire; Morcavallo, Alaide; Bowers, Chantelle; Che, Harvey; Kwok, Colin; Williamson, Daniel; Anderson, John; Donovan, Laura K.; Hill, Rebecca M.; Al-Lazikani, Bissan; Chesler, Louis; Clifford, Steven C. Share Save
TOWARDS CLINICAL IMPLEMENTATION OF LIQUID BIOPSY ANALYSIS FOR PAEDIATRIC BRAIN TUMOUR PATIENTS - A PAN-EUROPEAN EFFORT FOR STANDARDIZATION Simon, Nike; Maass, Kendra K.; Pokorna, Petra; Stepien, Natalia; Rettenmeier, Johanna; Saijonmaa, Oskar; Fischer, Tom T.; Senfter, Daniel; Madlener, Sibylle; Giraud, Geraldine; Tham, Emma; Scarpini, Cinzia G.; Murray, Matthew J.; Hulleman, Esther; Clifford, Steven C.; Pfister, Stefan M.; Pajtler, Kristian W.; Gojo, Johannes Share Save
In vivo modeling recapitulates radiotherapy delivery and late-effect profile for childhood medulloblastoma Castle, Jemma; Shaw, Gary; Weller, Dominic; Fielder, Edward; Egnuni, Teklu; Singh, Mankaran; Skinner, Roderick; von Zglinicki, Thomas; Clifford, Steven C.; Short, Susan C.; Miwa, Satomi; Hicks, Debbie Share Save
Risk factors for domain-specific neurocognitive outcome in pediatric survivors of a brain tumor in the posterior fossa-Results of the HIT 2000 trial Mynarek, Martin; Rossius, Anne; Guiard, Anika; Ottensmeier, Holger; von Hoff, Katja; Obrecht-Sturm, Denise; Bussenius, Lisa; Friedrich, Carsten; von Bueren, Andre O.; Gerber, Nicolas U.; Traunwieser, Thomas; Kortmann, Rolf-Dieter; Warmuth-Metz, Monika; Bison, Brigitte; Thomale, Ulrich-W; Krauss, Juergen; Pietsch, Torsten; Clifford, Steven C.; Pfister, Stefan M.; Sturm, Dominik; Sahm, Felix; Tischler, Tanja; Rutkowski, Stefan Share Save
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Metabolite profiles of medulloblastoma for rapid and non-invasive detection of molecular disease groups Kohe, Sarah; Bennett, Christopher; Burte, Florence; Adiamah, Magretta; Rose, Heather; Worthington, Lara; Scerif, Fatma; MacPherson, Lesley; Gill, Simrandip; Hicks, Debbie; Schwalbe, Edward C.; Crosier, Stephen; Storer, Lisa; Lourdusamy, Ambarasu; Mitra, Dipyan; Morgan, Paul S.; Dineen, Robert A.; Avula, Shivaram; Pizer, Barry; Wilson, Martin; Davies, Nigel; Tennant, Daniel; Bailey, Simon; Williamson, Daniel; Arvanitis, Theodoros N.; Grundy, Richard G.; Clifford, Steven C.; Peet, Andrew C. Share Save
Compartments in medulloblastoma with extensive nodularity are connected through differentiation along the granular precursor lineage Ghasemi, David R.; Okonechnikov, Konstantin; Rademacher, Anne; Tirier, Stephan; Maass, Kendra K.; Schumacher, Hanna; Joshi, Piyush; Gold, Maxwell P.; Sundheimer, Julia; Statz, Britta; Rifaioglu, Ahmet S.; Bauer, Katharina; Schumacher, Sabrina; Bortolomeazzi, Michele; Giangaspero, Felice; Ernst, Kati J.; Clifford, Steven C.; Saez-Rodriguez, Julio; Jones, David T. W.; Kawauchi, Daisuke; Fraenkel, Ernest; Mallm, Jan-Philipp; Rippe, Karsten; Korshunov, Andrey; Pfister, Stefan M.; Pajtler, Kristian W. Share Save
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