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Paul A. Northcott

st jude childrens research hospital

106H-index
637Paper Count
6.7WCitation Count
Published Papers 208
Publication Date
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Divergent medulloblastoma chromatin states disclose KDM2B as a selective dependency
errNature Genetics
IF29
err2026-09-24
err0
errOAAI
errRan Tao; Serap Erkek-Ozhan; Beisi Xu; Yurika Matsui; Priya Mittal; Kyle S. Smith; Yiran Li; David Filipovic; Ruijie Xu; Qingsong Gao; Emily Darrow; Rahul Kumar; Nadhir Djekidel; Richa Bajpai; Jennifer Hadley; Melissa Batts; Sara A. Lewis; Taha Soliman; Colleen Reilly; Natarajan V. Bhanu; Leena Paul; Hong Lin; Brian Gudenas; Kim Lowe; Marc Zapatka; Laura Sieber; David T. W. Jones; Marcel Kool; Sebastian M. Waszak; Volker Hovestadt; Ivo Buchhalter; Marina Ryzhova; Andrey Korshunov; Peter Lichter; Lukas Chavez; Lena M. Kutscher; Benjamin A. Garcia; Shondra M. Pruett-Miller; Xin Zhou; Brent A. Orr; Giles W. Robinson; Gang Wu; Jan O. Korbel; Jamy C. Peng; Stefan M. Pfister; Paul A. Northcott
errShare
errSave
Cell autonomous regional differences in oligodendrocyte lineage development and responses to oncohistone H3.3 K27M
errNature Communications
IF15.7
err2026-08-26
err0
errOAAI
errJared M. Andrews; Kaitlin M. Budd; Chang-Hyuk Kwon; Jon D. Larson; Abbas Shirinifard; Lawryn H. Kasper; Chanrika C. Williams; Alfonso Lavado; Sharon King; Jorge Gutierrez; Daniel Stabley; Tong Lin; Sara A. Lewis; Paul A. Northcott; Arzu Onar-Thomas; Suzanne J. Baker
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errSave
Investigation of a global mouse methylome atlas reveals subtype-specific copy number alterations in pediatric cancer models
errNature Genetics
IF29
err2025-12-11
err0
errOAAI
errMelanie Schoof; Tuyu Zheng; Martin Sill; Roland Imle; Alessia Cais; Lea Altendorf; Alicia Fürst; Nina Hofmann; Kati Ernst; Dominik Vonficht; Kenneth Chun-Ho Chan; Tim Holland-Letz; Andreas Postlmayr; Ryo Shiraishi; Wanchen Wang; Alaide Morcavallo; Michael Spohn; Carolin Göbel; Judith Niesen; Levke-Sophie Peter; Franck Bourdeaut; Zhi-Yan Han; Yanxin Pei; Najiba Murad; Fredrik J. Swartling; Jessica Taylor; Monika Yadav; Garrett R. Gibson; Richard J. Gilbertson; Matthias Dottermusch; Rajanya Roy; Kornelius Kerl; Rainer Glass; Jiying Cheng; Martin A. Horstmann; Gerrit Wolters-Eisfeld; Haotian Zhao; Dominik Sturm; Viveka Nand Yadav; Louis Chesler; Simon Haas; William A. Weiss; Paul A. Northcott; Lena M. Kutscher; Ana Guerreiro Stucklin; Olivier Ayrault; Julia E. Neumann; Daisuke Kawauchi; David T. W. Jones; Kristian Pajtler; Ana Banito; Stefan M. Pfister; Ulrich Schüller; Marc Zuckermann
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errSave
DIVERGENT MEDULLOBLASTOMA CHROMATIN STATES DISCLOSE KDM2B AS A SELECTIVE DEPENDENCY
errNEURO-ONCOLOGY
IF13.4
err2025-11-01
err0
errOAAI
errTao, Ran; Erkek-Ozhan, Serap; Xu, Beisi; Matsui, Yurika; Mittal, Priya; Smith, Kyle; Li, Yiran; Gao, Qingsong; Darrow, Emily; Xu, Ruijie; Djekidel, Nadhir; Bajpai, Richa; Kumar, Rahul; Reilly, Colleen; Soliman, Taha; Hadley, Jennifer; Batts, Melissa; Bhanu, Natarajan; Gudenas, Brian; Paul, Leena; Lin, Hong; Lowe, Kim; Kutscher, Lena; Garcia, Benjamin; Pruett-Miller, Shondra; Zhou, Xin; Orr, Brent; Robinson, Giles; Wu, Gang; Korbel, Jan; Peng, Jamy; Pfister, Stefan; Northcott, Paul
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errSave
An integrated analysis of three medulloblastoma clinical trials refines risk-stratification approaches for reducing toxicity and improving survival
errNEURO-ONCOLOGY
IF13.4
err2025-11-01
err0
errOAAI
errSmith, Kyle S.; Dhanda, Sandeep K.; Billups, Catherine A.; Sioson, Edgar; Lu, Congyu; Peraza, Airen Zaldivar; Gangwani, Karishma; Li, Yimei; Li, Qian; Lin, Tong; Michalski, Jeff M.; Packer, Roger J.; Olson, James M.; Leary, Sarah E. S.; Fouladi, Maryam; Gajjar, Amar; Zhou, Xin; Onar-Thomas, Arzu; Northcott, Paul A.; Robinson, Giles W.
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errSave
Enhancing Medulloblastoma Classification: Integrating IHC and DNA Methylation Data from the SJMB12 Clinical Trial
errNEURO-ONCOLOGY
IF13.4
err2025-11-01
err0
errOAAI
errDhanda, Sandeep Kumar; Breuer, Alexander; Tran, Quynh T.; Smith, Kyle; Strother, Douglas; Fisher, Michael; Bendel, Anne; Hwang, Eugene; Zhao, Sibo; Gottardo, Nick; Hassall, Timothy; Elster, Jennifer; Perreault, Sebastien; Ramaswamy, Vijay; Partap, Sonia; Laughton, Stephen; Cohn, Richard; Chintagumpala, Murali; McCowage, Geoff; Sullivan, Michale; Sayour, Elias; Bowers, Daniel C.; Marks, Asher; Wright, Avery; Onar-Thomas, Arzu; Ellison, David; Northcott, Paul A.; Gajjar, Amar; Robinson, Giles W.; Orr, Brent A.
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errSave
AN ONCOGENIC PHOTORECEPTOR PROGRAM UNIFIES DISTINCT CENTRAL NERVOUS SYSTEM TUMORS
errNEURO-ONCOLOGY
IF13.4
err2025-11-01
err0
errOAAI
errGudenas, Brian; Ahmad, Shiekh; Englinger, Bernhard; Liu, Anthony; Zhao, Miao; Paul, Leena; Hadley, Jennifer; Lin, Hong; Li, Yiran; Batts, Melissa; Mittal, Priya; Wu, Stephanie; Lewis, Sara; Han, Katie; Soliman, Taha; Janke, Laure; Meredith, David; Pfaff, Elke; Gojo, Johannes; Cotter, Jennifer; Klimo, Paul; Boop, Frederick; Gajjar, Amar; Robinson, Giles; Rosen, Gabriela; Alexandrescu, Sanda; Jones, David; Orr, Brent; Swartling, Fredrik; Filbin, Mariella; Northcott, Paul
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errSave
IDENTIFYING NOVEL TUMORIGENIC MECHANISMS UNDERLYING GROUP 3/4 MEDULLOBLASTOMA USING HARMONIZED AND RHOMBIC LIP-ENRICHED CEREBELLAR ATLASES
errNEURO-ONCOLOGY
IF13.4
err2025-11-01
err0
errOAAI
errXu, Ruijie; Martin, Vincentius; Soliman, Taha; Bihannic, Laure; Wang, Lei; Haldipur, Parthiv; Smith, Kyle; Li, Yiran; Mittal, Priya; Lin, Hong; Alexandre, Paula; He, Guanyi; Millen, Kathleen; Northcott, Paul
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errSave
Molecular insights into response and resistance in children with relapsed/refractory brain tumors on ribociclib combination therapy: results from SJDAWN
errNEURO-ONCOLOGY
IF13.4
err2025-11-01
err0
errOAAI
errHan, Katie; Robinson, Giles W.; Smith, Kyle S.; Kostecka, Anna; Dhanda, Sandeep K.; Lin, Tong; Filipovic, David; Lin, Hong; Mikkelsen, Margit; Sabin, Noah D.; Onar-Thomas, Arzu; Roussel, Martine F.; Stewart, Clinton; Orr, Brent A.; Gajjar, Amar; Northcott, Paul A.
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errSave
Robust classification of pediatric brain tumors from cell-free DNA methylomes
errNEURO-ONCOLOGY
IF13.4
err2025-11-01
err0
errOAAI
errSmith, Kyle; Fischer, Tom; Han, Katie; Kostecka, Anna; Lin, Hong; Senfter, Daniel; Stepien, Natalia; Volz, Stefanie; Schwarz, Nathalie; Wedig, Tatjana; Madlener, Sibylle; Haberler, Christine; Dhanda, Sandeep; Upadhyaya, Santhosh; Schmook, Maria; De Bont, Judith; Haapasalo, Hannu; Dargvainiene, Justina; Leypoldt, Frank; Pfister, Stefan; Hulleman, Esther; Gajjar, Amar; Robinson, Giles; Haapasalo, Joonas; Nordfors, Kristiina; Gojo, Johannes; Maass, Kendra; Pajtler, Kristian; Northcott, Paul
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errSave
DISSECTING MYC-DRIVEN EPIGENETIC MECHANISMS THAT PROMOTE GROUP 3 MEDULLOBLASTOMA UTILIZING HUMANIZED IPSC MODELS
errNEURO-ONCOLOGY
IF13.4
err2025-11-01
err0
errOAAI
errQadeer, Zulekha; Hou, Elise; Siegel, Dara; Westelman, Samantha; Gudenas, Brian; Smith, Kyle; Ismail, Wazim Mohammed; Wang, Linyu; Beytagh, Mary Clare; Phua, Ronald; Hendrikse, Liam; Huang, Miller; Gaspar-Maia, Alexandre; Northcott, Paul; Taylor, Michael; Weiss, William
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errSave
CELL-FREE DNA ANALYSIS OF CSF SAMPLES ENABLES ASSESSMENT OF TREATMENT RESPONSE AND TRACKING OF CAR T-CELLS POST-LOCOREGIONAL DELIVERY IN PEDIATRIC BRAIN TUMOR PATIENTS
errNEURO-ONCOLOGY
IF13.4
err2025-11-01
err0
errOAAI
errKostecka, Anna; Smith, Kyle S.; Han, Katie; Martin, Vincentius; Lin, Hong; Langfitt, Deanna; Ward, Meghan B.; Walhart, Tara; Gottschalk, Stephen; Krenciute, Giedre; Derenzo, Christopher; Bertrand, Kelsey C.; Northcott, Paul A.
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errSave
Locoregional B7-H3 CAR-T cells for relapsed/refractory CNS tumors: preliminary clinical experience of the Loc3CAR trial
errNEURO-ONCOLOGY
IF13.4
err2025-11-01
err0
errOAAI
errBertrand, Kelsey; Hanzlik, Emily; Chiang, Jason; Pinto, Soniya; Selukar, Subodh; Kosteka, Anna; Smith, Kyle; Han, Katie; Ibanez, Jorge; Tlais, Dana; Orr, Brent; Langfitt, Deanna; Metais, Jean-Yves; Lockey, Timothy; Willis, Catherine; Fazio, Frank; Shanmugmam, Raghu; Tian, Liqing; Walhart, Tara; Wang, Yu; Allmon, Patricia; Perry, Scott; Schell, Sarah; Adams, Polly; Ward, Meghan; Meehl, Michaela; Akel, Salem; Poston, Leigh; Bag, Asim; Mack, Stephen; Klimo, Paul; Gajjar, Amar; Thomas, Paul; Crawford, Jeremy; Robinson, Giles; Park, Julie; Northcott, Paul; Gottschalk, Stephen; Krenciute, Giedre; Derenzo, Christopher
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errSave
Human pluripotent stem cell-derived cerebellar organoids as a robust platform for studying medulloblastoma pathogenesis
errNEURO-ONCOLOGY
IF13.4
err2025-11-01
err0
errOAAI
errWu, Stephanie; Xu, Rachel; Li, Yiran; Northcott, Paul
errShare
errSave
Genetic modeling of ELP1-associated Sonic hedgehog medulloblastoma identifies MDM2 as a selective therapeutic target
errNEURO-ONCOLOGY
IF13.4
err2025-11-01
err0
PREAI
errAhmad, Shiekh Tanveer; Li, Yiran; Garcia-Lopez, Jesus; Gudenas, Brian; Hadley, Jennifer; Paul, Leena; Wu, Stephanie; Refaat, Alaa; Kojic, Marija; Batts, Melissa; Soliman, Taha; Pitre, Aaron; Arnskotter, Frederik; Zindy, Frederique; Jones, Alun; Twarog, Nathaniel; Mayasundari, Anand; Bianski, Brandon; Tinkle, Christopher; Shirinifard, Abbas; Janke, Laura; Lu, Meifen; Lewis, Sara; Onar-Thomas, Arzu; Pfister, Stefan; Gajjar, Amar; Baker, Suzanne; Roussel, Martine; Rankovic, Zoran; Robinson, Giles; Orr, Brent; Wainwright, Brandon; Shelat, Anang; Waszak, Sebastian; Kutscher, Lena; Lin, Hong; Northcott, Paul
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errSave
Molecular characterization of the SJMB12 clinical trial for children and young adults with newly diagnosed medulloblastoma
errNEURO-ONCOLOGY
IF13.4
err2025-11-01
err0
PREAI
errFilipovic, David; Smith, Kyle; Dhanda, Sandeep; Strother, Doug; Fisher, Micheal J.; Bendel, Anne; Hwang, Eugene, I; Zhao, Sibo; Gottardo, Nicholas G.; Hassall, Timothy E. G.; Elster, Jennifer; Perreault, Sebastien; Ramaswamy, Vijay; Partap, Sonia; Laughton, Stephen; Cohn, Richard; Chintagumpala, Murali; Mccowage, Geoffrey; Sullivan, Michael; Sayour, Elias; Bowers, Daniel C.; Marks, Asher; Wright, Avery C.; Onar-Thomas, Arzu; Gajjar, Amar; Robinson, Giles W.; Northcott, Paul A.
errShare
errSave
INTEGRATED MULTI-OMIC PROFILING REVEALS PROTEOMIC HETEROGENEITY AND PATHWAY DYNAMICS IN MEDULLOBLASTOMA
errNEURO-ONCOLOGY
IF13.4
err2025-11-01
err0
errOAAI
errLi, Yiran; North, Kelsey; Lin, Hong; Wu, Stephine; Gudenas, Brian; Smith, Kyle; Yuan, Zuo-Fei; Soliman, Taha; Hadley, Jennifer; Batts, Melissa; Dhanda, Sandeep; Atkinson, Natasha; Mercer, Kimberly; High, Andy; Wang, Xusheng; Peng, Junmin; Roussel, Martine; Robinson, Giles; Orr, Brent; Northcott, Paul
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errSave
Author Correction: MOADE: a multimodal autoencoder for dissociating bulk multi-omics data
errGenome Biology
IF9.4
err2025-10-11
err0
errOAAI
errJiao Sun; Ayesha A. Malik; Tong Lin; Ayla Bratton; Yue Pan; Kyle Smith; Arzu Onar-Thomas; Giles W. Robinson; Wei Zhang; Paul A. Northcott; Qian Li
errShare
errSave
MOADE: a multimodal autoencoder for dissociating bulk multi-omics data
errGenome Biology
IF9.4
err2025-10-03
err0
errOAAI
errJiao Sun; Ayesha A. Malik; Tong Lin; Ayla Bratton; Yue Pan; Kyle Smith; Arzu Onar-Thomas; Giles W. Robinson; Wei Zhang; Paul A. Northcott; Qian Li
errShare
errSave
P10.04.A MYC-DRIVEN PEDIATRIC BRAIN TUMORS SHARE A COMMON PHOTORECEPTOR IDENTITY
errNeuro-Oncology
IF13.4
err2025-10-03
err0
errOAAI
errM Zhao; G Rosen; A Sundström; G Giraud; T K Olsen; B L Gudenas; P A Northcott; F J Swartling
errShare
errSave

Research Directions

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