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G

Gerald I. Shulman

Yale School of Medicine

183H-index
819Paper Count
14.1WCitation Count
Published Papers 427
Publication Date
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A controlled-release mitochondrial protonophore attenuates early- and late-stage atheroprogression in mice
errScience Translational Medicine
IF14.6
err2026-07-15
err0
PREAI
errBernardo Gindri dos Santos; Niki F. Brisnovali; Connor Haney; Myles Coven; Homa Linda Sebzevari; Lena Gaebel; Xinbo Zhang; Jonathan Sun; Alberto Canfrán-Duque; Noemi Rotllan; Ali Nasiri; Mario Kahn; Cameron S. McAlpine; Gerald I. Shulman; Leigh Goedeke
errShare
errSave
CIDEB and CGI-58 differentially regulate liver lipid-droplet cholesterol to modulate metabolic dysfunction-associated steatohepatitis severity
errCell Reports
IF6.9
err2026-06-03
err0
errOAAI
errIkki Sakuma; Rafael C. Gaspar; Henrique N. Morgan; Jie Zheng; Ali R. Nasiri; Sylvie Dufour; Mario Kahn; Mateus T. Guerra; Yuki Taki; Yusuke Kawashima; Dean Yimlamai; Mark Perelis; Daniel F. Vatner; Kitt Falk Petersen; Varman T. Samuel; Tomoaki Tanaka; Gerald I. Shulman
errShare
errSave
Insulin receptorT1160 phosphorylation mediates renal cortical insulin resistance but not excess gluconeogenesis from glycerol
errNature Communications
IF15.7
err2026-05-21
err0
errOAAI
errBrandon T. Hubbard; Yumin Ma; Rafael C. Gaspar; Traci E. LaMoia; Dongyan Zhang; Mario Kahn; Sylvie Dufour; Ali Nasiri; Gerald I. Shulman
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errSave
Western diet-induced MASH in PWK/PhJ mice identifies disruptions in amino acid and sphingolipid metabolism contributing to cardiac dysfunction
errNature Communications
IF15.7
err2026-05-20
err0
errOAAI
errSandra Rodríguez-López; Miguel Pérez-Rodríguez; Alaa Badreddine; Rafael Calais Gaspar; Henrique J. Novaes Morgan; Ikki Sakuma; Giacomo V. G. von Alvensleben; Alejandro Alonso-Calleja; Stacia P. A. Everts; Nicolas-Enzo Suter; Giorgia Benegiamo; Christine Goepfert; Simone de Brot; José Manuel Villalba; Gerald I. Shulman; Kristina Schoonjans; Johan Auwerx
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errSave
Distinct effects of ketogenic and non-ketogenic weight-loss diets on hepatic steatosis and mitochondrial metabolism in MASLD
errJournal of Hepatology
IF33
err2026-02-06
err0
errOAAI
errSami F. Qadri; Kimmo Porthan; Sylvie Dufour; Tiina E. Lehtimäki; Kitt Falk Petersen; Gerald I. Shulman; Hannele Yki-Järvinen; Panu K. Luukkonen
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errSave
A consensus guide to preclinical indirect calorimetry experiments
errNature Metabolism
IF20.8
err2025-09-24
err0
PREAI
errAlexander S. Banks; David B. Allison; Thierry Alquier; Ansarullah; Steven N. Austad; Johan Auwerx; Julio E. Ayala; Joseph A. Baur; Stefania Carobbio; Gary A. Churchill; Morten Dall; Rafael de Cabo; Jose Donato; Nathalia R. V. Dragano; Carol F. Elias; Anthony W. Ferrante; Brian N. Finck; Jose E. Galgani; Zachary Gerhart-Hines; Laurie J. Goodyear; Justin L. Grobe; Rana K. Gupta; Kirk M. Habegger; Sean M. Hartig; Andrea L. Hevener; Steven B. Heymsfield; Corey D. Holman; Martin Hrabě de Angelis; David E. James; Lawrence Kazak; Jae Bum Kim; Martin Klingenspor; Xingxing Kong; Sander Kooijman; Louise Lantier; K. C. Kent Lloyd; James C. Lo; Irfan J. Lodhi; Paul S. MacLean; Owen P. McGuinness; Gema Medina-Gómez; Raghavendra G. Mirmira; Christopher D. Morrison; Gregory J. Morton; Timo D. Müller; Yoshihiro Ogawa; David Pajuelo-Reguera; Matthew J. Potthoff; Nathan Qi; Marc L. Reitman; Patrick C. N. Rensen; Jan Rozman; Jennifer M. Rutkowsky; Kei Sakamoto; Philipp E. Scherer; Gary J. Schwartz; Radislav Sedlacek; Mohammed Selloum; Saame Raza Shaikh; Shuai Chen; Gerald I. Shulman; Vojtěch Škop; Alexander A. Soukas; John R. Speakman; Bruce M. Spiegelman; Gregory R. Steinberg; Katrin J. Svensson; John P. Thyfault; Tony Tiganis; Paul M. Titchenell; Nigel Turner; Licio A. Velloso; Antonio Vidal-Puig; Christopher S. Ward; Ashley S. Williams; Christian Wolfrum; Allison W. Xu; Ying Xu; Juleen R. Zierath
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errSave
Cideb knockdown in mice increases mitochondrial fat oxidation and reverses hepatic steatosis and insulin resistance by the plasma membrane sn-1,2-DAGs–PKCε–insulin receptor kinaseT1150 pathway
errDiabetologia
IF10.2
err2025-09-04
err0
PREAI
errJie Zheng; Rafael C. Gaspar; Ikki Sakuma; Brandon T. Hubbard; Dongyan Zhang; Ali Nasiri; Mario Kahn; Mark Perelis; Varman T. Samuel; Kitt F. Petersen; Gerald I. Shulman
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errSave
Liver lipid droplet cholesterol content is a key determinant of metabolic dysfunction-associated steatohepatitis
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2025-05-01
err0
errOAAI
errSakuma, Ikki; Gaspar, Rafael C.; Nasiri, Ali R.; Dufour, Sylvie; Kahn, Mario; Zheng, Jie; Lamoia, Traci E.; Guerra, Mateus T.; Taki, Yuki; Kawashima, Yusuke; Yimlamai, Dean; Perelis, Mark; Vatner, Daniel F.; Petersen, Kitt Falk; Huttasch, Maximilian; Knebel, Birgit; Kahl, Sabine; Roden, Michael; Samuel, Varman T.; Tanaka, Tomoaki; Shulman, Gerald I.
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errSave
Small molecules targeting selective PCK1 and PGC-1α lysine acetylation cause anti-diabetic action through increased lactate oxidation (vol 31, pg 1772, 2024)
errCELL CHEMICAL BIOLOGY
IF7.2
err2025-02-01
err0
PREAI
errMutlu, Beste; Sharabi, Kfir; Sohn, Jee Hyung; Yuan, Bo; Latorre-Muro, Pedro; Qin, Xin; Yook, Jin-Seon; Lin, Hua; Yu, Deyang; Camporez, Joao Paulo G.; Kajimura, Shingo; Shulman, Gerald I.; Hui, Sheng; Kamenecka, Theodore M.; Griffin, Patrick R.; Puigserver, Pere
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errSave
Renal Angptl4 is a key fibrogenic molecule in progressive diabetic kidney disease
errSCIENCE ADVANCES
IF12.5
err2024-12-06
err0
errOAAI
errSrivastava, Swayam Prakash; Zhou, Han; Shenoi, Rachel; Morris, Myshal; Lainez-Mas, Begona; Goedeke, Leigh; Rajendran, Barani Kumar; Setia, Ocean; Aryal, Binod; Kanasaki, Keizo; Koya, Daisuke; Inoki, Ken; Dardik, Alan; Bell, Thomas; Fernandez-Hernando, Carlos; Shulman, Gerald I.; Goodwin, Julie E.
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errSave
Glucagon promotes increased hepatic mitochondrial oxidation and pyruvate carboxylase flux in humans with fatty liver disease
errCELL METABOLISM
IF30.9
err2024-11-01
err2
PREAI
errPetersen, Kitt Falk; Dufour, Sylvie; Mehal, Wajahat Z.; Shulman, Gerald I.
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errSave
Ceramide synthesis inhibitors prevent lipid-induced insulin resistance through the DAG-PKCε-insulin receptorT1150 phosphorylation pathway
errCELL REPORTS
IF6.9
err2024-10-01
err1
errOAAI
errXu, Weiwei; Zhang, Dongyan; Ma, Yumin; Gaspar, Rafael C.; Kahn, Mario; Nasiri, Ali; Murray, Sue; Samuel, Varman T.; Shulman, Gerald I.
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errSave
Effect of Weight Loss on Skeletal Muscle Bioactive Lipids in People With Obesity and Type 2 Diabetes
errDIABETES
IF7.5
err2024-09-12
err1
PREAI
errPetersen, Max C.; Yoshino, Mihoko; Smith, Gordon I.; Gaspar, Rafael C.; Kahn, Mario; Samovski, Dmitri; Shulman, Gerald I.; Klein, Samuel
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errSave
O-GlcNAc modification in endothelial cells modulates adiposity via fat absorption from the intestine in mice
errHELIYON
IF3.6
err2024-07-01
err0
errOAAI
errOhgaku, Seiichiro; Ida, Shogo; Ohashi, Natsuko; Morino, Katsutaro; Ishikado, Atsushi; Yanagimachi, Tsuyoshi; Murata, Koichiro; Sato, Daisuke; Ugi, Satoshi; Nasiri, Ali; Shulman, Gerald I.; Maegawa, Hiroshi; Kume, Shinji; Fujita, Yukihiro
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errSave
CIDEB and CGI-58 Regulate Liver Lipid Droplet Size with Cholesterol Content, Linking to Inflammation and Fibrosis in Metabolic Dysfunction-Associated Steatohepatitis
errDIABETES
IF7.5
err2024-06-14
err0
PREAI
errSakuma, Ikki; Gaspar, Rafael C.; Nasiri, Ali; Kahn, Mario; Zheng, Jie; Guerra, Mateus; Yimlamai, Dean; Murray, Sue; Perelis, Mark; Barnes, William; Vatner, Daniel F.; Petersen, Kitt; Samuel, Varman; Shulman, Gerald I.
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errSave
Coenzyme A Synthase Knockdown Alleviates Metabolic Dysfunction-Associated Steatohepatitis via Decreasing Cholesterol in Liver Lipid Droplets
errDIABETES
IF7.5
err2024-06-14
err0
PREAI
errSakuma, Ikki; Gaspar, Rafael C.; Nasiri, Ali; Kahn, Mario; Guerra, Mateus; Yimlamai, Dean; Murray, Sue; Perelis, Mark; Barnes, William; Vatner, Daniel F.; Petersen, Kitt; Samuel, Varman; Shulman, Gerald I.
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errSave
Safety, PK, and Preliminary Efficacy of the Liver-Targeted Mitochondrial Protonophore TLC-6740-A Phase 1 Study
errDIABETES
IF7.5
err2024-06-14
err0
PREAI
errGane, Edward; Huss, Ryan S.; Sur, Jane; Murakami, Eisuke; Weng, Steve; Kirby, Brian J.; Shah, Amrik; Shulman, Gerald I.; Subramanian, Mani; Vijayakumar, Archana; Myers, Robert P.
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errSave
TLC-6740, a Liver-Targeted Mitochondrial Protonophore, Increases Energy Expenditure and Lipid Utilization in Obese Mice
errDIABETES
IF7.5
err2024-06-14
err1
PREAI
errSroda, Natalie; Vijayakumar, Archana; Murakami, Eisuke; Weng, Steve; Shulman, Gerald I.; Myers, Robert P.; Subramanian, Mani
errShare
errSave
Combinations of the Mitochondrial Protonophore TLC-6740 and/or the ACC2 Inhibitor TLC-3595 Provide Additive Glycemic Benefits to Semaglutide (SEMA) in db/db Mice
errDIABETES
IF7.5
err2024-06-14
err1
PREAI
errVijayakumar, Archana; Sroda, Natalie; Murakami, Eisuke; Weng, Steve; Myers, Robert P.; Subramanian, Mani; Shulman, Gerald I.
errShare
errSave
CIDEB Knockdown Promotes Increased Hepatic Mitochondrial Fat Oxidation and Reverses Hepatic Steatosis and Hepatic Insulin Resistance by the PKCe-Insulin Receptor Kinase Pathway
errDIABETES
IF7.5
err2024-06-14
err0
PREAI
errZheng, Jie; Nasiri, Ali; Gaspar, Rafael C.; Hubbard, Brandon T.; Sakuma, Ikki; Ma, Xiaoxian; Murray, Sue; Perelis, Mark; Barnes, William; Samuel, Varman; Petersen, Kitt; Shulman, Gerald I.
errShare
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Research Directions

No research directions
Co-authors
Cooperation Journals
L
Luigi Ferrucci
H-index: 237 · Papers: 2.6K
J
Jens J. Holst
H-index: 193 · Papers: 2.7K
B
Bruce M. Spiegelman
H-index: 186 · Papers: 471
J
Johan Auwerx
H-index: 183 · Papers: 913
D
Dennis S. Charney
H-index: 177 · Papers: 816
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