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R

Ralph A. DeFronzo

department of internal medicine

129H-index
672Paper Count
7.1WCitation Count
Published Papers 260
Publication Date
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Disease-modifying anti-diabetic drugs (DMADDs): bridging the SIMPLE approach to disease interception
errCardiovascular Diabetology
IF10.6
err2026-08-26
err0
errOAAI
errNizameddin Koca; Seyit Uyar; Yasin Şahintürk; Hamit Yıldız; Stefano Del Prato; RalphA. DeFronzo
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errSave
Differential Treatment Effects on β-Cell Function Using Model-Based Parameters in Type 2 Diabetes: Results From the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE)
errDIABETES CARE
IF16.6
err2025-02-25
err0
PREAI
errUtzschneider, Kristina M.; Tripputi, Mark; Butera, Nicole M.; Mari, Andrea; Rosin, Samuel P.; Banerji, Mary Ann; Bergenstal, Richard M.; Brown, Necole; Carlson, Anders L.; Defronzo, Ralph A.; Gramzinski, Michaela R.; Harindhanavudhi, Tasma; Kozedub, Alexandra; Sivitz, William I.; Steffes, Michael W.; Balasubramanyam, Ashok; Rasouli, Neda; GRADE Res Grp, J. P.
errShare
errSave
GLP-1 enhances β-cell response to protein ingestion and bariatric surgery amplifies it
errOBESITY
IF4.7
err2024-12-05
err0
PREAI
errRayas, Maria; Pezzica, Samantha; Honka, Henri; Carli, Fabrizia; Peterson, Richard; Defronzo, Ralph; Gastaldelli, Amalia; Salehi, Marzieh
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errSave
Effect of Hyperketonemia on Myocardial Function in Patients With Heart Failure and Type 2 Diabetes
errDIABETES
IF7.5
err2024-10-24
err0
PREAI
errSolis-Herrera, Carolina; Qin, Yuejuan; Honka, Henri; Cersosimo, Eugenio; Triplitt, Curtis; Neppala, Sivaram; Rajan, Jemena; Acosta, Francisca M.; Moody, Alexander J.; Iozzo, Patricio; Fox, Peter; Clarke, Geoffrey; Defronzo, Ralph A.
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errSave
Pre-Prediabetes: Insulin Resistance Is Associated With Cardiometabolic Risk in Nonobese Patients (STOP DIABETES)
errJOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
IF5.1
err2024-08-07
err0
errOAAI
errArmato, John; Defronzo, Ralph A.; Abdul-Ghani, Muhammad; Ruby, Ron
errShare
errSave
Novel Mechanism of Action Associated with SGLT2 Inhibition, Peripheral Energy Utilization, and CV Benefits in Subjects with Type 2 Diabetes Mellitus and HFrEF
errDIABETES
IF7.5
err2024-06-14
err0
PREAI
errQin, Yuejuan; Sanchez, Noah D.; Acosta, Francisca M.; Moody, Alexander; Neppala, Sivaram; Triplitt, Curtis L.; Clarke, Geoffrey D.; Cersosimo, Eugenio; Defronzo, Ralph A.; Solis-Herrera, Carolina
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errSave
Empagliflozin Enhances Hepatic Glucose Production and Reduces Total-Body Norepinephrine Turnover Rate-A Randomized Trial
errDIABETES
IF7.5
err2024-06-14
err0
PREAI
errAbdelgani, Siham; Baskoy, Gozde; Adams, John M., II; Khattab, Ahmed; Defronzo, Ralph A.; Abdul-Ghani, Muhammad
errShare
errSave
Mesenteric Visceral Lipectomy (MVL) Improves Glucose Tolerance in Patients with Type 2 Diabetes (T2D)
errDIABETES
IF7.5
err2024-06-14
err0
PREAI
errBaskoy, Gozde; Peterson, Richard M.; Kempenich, Jason W.; Triplitt, Curtis L.; Clarke, Geoffrey D.; Cersosimo, Eugenio; Andrew, Mark S.; Merovci, Aurora; Lavrynenko, Olga; Hansis-Diarte, Andrea A.; Solis-Herrera, Carolina; Chavez, Alberto; Salehi, Marzieh; Defronzo, Ralph A.
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errSave
Changes in Beta-Cell Function during Dapagliflozin Therapy in Combination with Exenatide in Type 2 Diabetes Patients (T2D)
errDIABETES
IF7.5
err2024-06-14
err0
PREAI
errDefronzo, Ralph A.; Baskoy, Gozde; Triplitt, Curtis L.; Cersosimo, Eugenio; Solis-Herrera, Carolina; Adams, John M., II; Hansis-Diarte, Andrea A.; Gastaldelli, Amalia; Chavez, Alberto
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errSave
Single-Nucleus Multiomics Profiling across 49 Individuals of Hispanic Ancestry Reveals Cell-Specific Skeletal Muscle Insulin-Responsive Gene Regulatory Signatures
errDIABETES
IF7.5
err2024-06-14
err0
PREAI
errLi, Benjamin; Varshney, Arushi; Tovar, Adelaide; Manickam, Nandini; Orchard, Peter; Defronzo, Ralph A.; Norton, Luke; Parker, Stephen
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errSave
Pioglitazone Amplifies the Decrease in HbA1c and Prevents the Increase in Plasma Ketone Caused by Dapagliflozin in Type 1 Diabetes Mellitus Patients
errDIABETES
IF7.5
err2024-06-14
err0
PREAI
errAbdul-Ghani, Muhammad; Baskoy, Gozde; Nakhleh, Afif; Abdelgani, Siham; Al-Mulla, Fahd; Abu-Farha, Mohamed; Alajmi, Fahad; Alessa, Thamer; Defronzo, Ralph A.; Shehadeh, Naim
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errSave
Empagliflozin Reduces Liver Fat in Diabetic and Nondiabetic Subjects
errMETABOLISM-CLINICAL AND EXPERIMENTAL
IF11.9
err2024-06-01
err0
errOAAI
errAbdelgani, Siham; Khattab, Ahmed; Adams, John; Baskoy, Gozde; Brown, Marissa; Clarke, Geoff; Larvenenko, Olga; DeFronzo, Ralph A.; Abdul-Ghani, Muhammad
errShare
errSave
Reduced Lipotoxicity Following Triple Therapy for 3 Years in New Onset T2DM
errMETABOLISM-CLINICAL AND EXPERIMENTAL
IF11.9
err2024-06-01
err0
PREAI
errLavynenko, Olga; Abdul-Ghani, Muhammad; DeFronzo, Ralph A.
errShare
errSave
Differential effect of endogenous glucagon-like peptide-1 on prandial glucose counterregulatory response to hypoglycaemia in humans with and without bariatric surgery
errDIABETES OBESITY & METABOLISM
IF5.7
err2024-04-01
err0
PREAI
errHonka, Henri; Gastaldelli, Amalia; Pezzica, Samantha; Peterson, Richard; Defronzo, Ralph; Salehi, Marzieh
errShare
errSave
Effect of Dapagliflozin on Renal and Hepatic Glucose Kinetics in T2D and NGT Subjects
errDIABETES
IF7.5
err2024-03-21
err0
errOAAI
errChen, Xi; Tripathy, Devjit; Chilton, Robert; Hansis-Diarte, Andrea; Salehi, Marzieh; Solis-Herrera, Carolina; Cersosimo, Eugenio; DeFronzo, Ralph A.
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errSave
SGLT2 inhibitors: cardiorenal metabolic drugs for the ages
errJOURNAL OF CLINICAL INVESTIGATION
IF13.6
err2024-03-01
err1
errOAAI
errDefronzo, Ralph A.
errShare
errSave
Empagliflozin Reduces Liver Fat in Individuals With and Without Diabetes
errDIABETES CARE
IF16.6
err2024-01-31
err2
errOAAI
errAbdelgani, Siham; Khattab, Ahmed; Adams, John; Baskoy, Gozde; Brown, Marissa; Clarke, Geoff; Larvenenko, Olga; DeFronzo, Ralph A.; Abdul-Ghani, Muhammad
errShare
errSave
Longitudinal Effects of Glucose-Lowering Medications on β-Cell Responses and Insulin Sensitivity in Type 2 Diabetes: The GRADE Randomized Clinical Trial
errDIABETES CARE
IF16.6
err2024-01-11
err6
errOAAI
errRasouli, Neda; Younes, Naji; Ghosh, Alokananda; Albu, Jeanine; Cohen, Robert M.; DeFronzo, Ralph A.; Diaz, Elsa; Kassem, Laure Sayyed; Luchsinger, Jose A.; McGill, Janet B.; Sivitz, William I.; Tamborlane, William V.; Utzschneider, Kristina M.; Kahn, Steven E.
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errSave
Impact of Insulin Sensitivity and β-Cell Function Over Time on Glycemic Outcomes in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE): Differential Treatment Effects of Dual Therapy
errDIABETES CARE
IF16.6
err2024-01-08
err1
errOAAI
errUtzschneider, Kristina M.; Younes, Naji; Butera, Nicole M.; Balasubramanyam, Ashok; Bergenstal, Richard M.; Barzilay, Joshua; DeSouza, Cyrus; DeFronzo, Ralph A.; Elasy, Tom; Krakoff, Jonathan; Kahn, Steven E.; Rasouli, Neda; Valencia, Willy M.; Sivitz, William I.
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errSave
Differential effect of gastric bypass versus sleeve gastrectomy on insulinotropic action of endogenous incretins
errOBESITY
IF4.7
err2023-10-19
err4
errOAAI
errSalehi, Marzieh; Peterson, Richard; Tripathy, Devjit; Pezzica, Samantha; Defronzo, Ralph; Gastaldelli, Amalia
errShare
errSave

Research Directions

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