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Single-cell AI-based detection and prognostic and predictive value of DNA mismatch repair deficiency in colorectal cancer Nowak, Marta; Jabbar, Faiz; Rodewald, Ann-Katrin; Gneo, Luciana; Tomasevic, Tijana; Harkin, Andrea; Iveson, Tim; Saunders, Mark; Kerr, Rachel; Oein, Karin; Maka, Noori; Hay, Jennifer; Edwards, Joanne; Tomlinson, Ian; Sansom, Owen; Kelly, Caroline; Pezzella, Francesco; Kerr, David; Easton, Alistair; Domingo, Enric; Koelzer, Viktor H.; Church, David N. Share Save
Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1 (vol 133, e168277, 2023) Beach, Callum; MacLean, David; Majorova, Dominika; Melemenidis, Stavros; Nambiar, Dhanya K.; Kim, Ryan K.; Valbuena, Gabriel N.; Guglietta, Silvia; Krieg, Carsten; Darvish-Damavandi, Mahnaz; Suwa, Tatsuya; Easton, Alistair; Hillson, Lily V. S.; McCulloch, Ashley K.; McMahon, Ross K.; Pennel, Kathryn; Edwards, Joanne; O'Cathail, Sean M.; Roxburgh, Campbell S.; Domingo, Enric; Moon, Eui Jung; Jiang, Dadi; Jiang, Yanyan; Zhang, Qingyang; Koong, Albert C.; Woodruff, Trent M.; Graves, Edward E.; Maughan, Tim; Buczacki, Simon J. A.; Stucki, Manuel; Le, Quynh-Thu; Leedham, Simon J.; Giaccia, Amato J.; Olcina, Monica M. Share Save
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Identi fi cation and validation of a machine learning model of complete response to radiation in rectal cancer reveals immune in fi ltrate and TGF P as key predictors Domingo, Enric; Rathee, Sanjay; Blake, Andrew; Samuel, Leslie; Murray, Graeme; Sebag-Montefiore, David; Gollins, Simon; West, Nicholas; Begum, Rubina; Richman, Susan; Quirke, Phil; Redmond, Keara; Chatzipli, Aikaterini; Barberis, Alessandro; Hassanieh, Sylvana; Mahmood, Umair; Youdell, Michael; McDermott, Ultan; Koelzer, Viktor; Leedham, Simon; Tomlinson, Ian; Dunne, Philip; Buffa, Francesca M.; Maughan, Timothy S. Share Save
Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer (Vol 56, pg 458, 2024) Malla, Sudhir B.; Byrne, Ryan M.; Lafarge, Maxime W.; Corry, Shania M.; Fisher, Natalie C.; Tsantoulis, Petros K.; Mills, Megan L.; Ridgway, Rachel A.; Lannagan, Tamsin R. M.; Najumudeen, Arafath K.; Gilroy, Kathryn L.; Amirkhah, Raheleh; Maguire, Sarah L.; Mulholland, Eoghan J.; Belnoue-Davis, Hayley L.; Grassi, Elena; Viviani, Marco; Rogan, Emily; Redmond, Keara L.; Sakhnevych, Svetlana; McCooey, Aoife J.; Bull, Courtney; Hoey, Emily; Sinevici, Nicoleta; Hall, Holly; Ahmaderaghi, Baharak; Domingo, Enric; Blake, Andrew; Richman, Susan D.; Isella, Claudio; Miller, Crispin; Bertotti, Andrea; Trusolino, Livio; Loughrey, Maurice B.; Kerr, Emma M.; Tejpar, Sabine; Maughan, Timothy S.; Lawler, Mark; Campbell, Andrew D.; Leedham, Simon J.; Koelzer, Viktor H.; Sansom, Owen J.; Dunne, Philip D. Share Save
Image-based consensus molecular subtyping in rectal cancer biopsies and response to neoadjuvant chemoradiotherapy Lafarge, Maxime W.; Domingo, Enric; Sirinukunwattana, Korsuk; Wood, Ruby; Samuel, Leslie; Murray, Graeme; Richman, Susan D.; Blake, Andrew; Sebag-Montefiore, David; Gollins, Simon; Klieser, Eckhard; Neureiter, Daniel; Huemer, Florian; Greil, Richard; Dunne, Philip; Quirke, Philip; Weiss, Lukas; Rittscher, Jens; Maughan, Tim; Koelzer, Viktor H. Share Save
Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer Malla, Sudhir B.; Byrne, Ryan M.; Lafarge, Maxime W.; Corry, Shania M.; Fisher, Natalie C.; Tsantoulis, Petros K.; Mills, Megan L.; Ridgway, Rachel A.; Lannagan, Tamsin R. M.; Najumudeen, Arafath K.; Gilroy, Kathryn L.; Amirkhah, Raheleh; Maguire, Sarah L.; Mulholland, Eoghan J.; Belnoue-Davis, Hayley L.; Grassi, Elena; Viviani, Marco; Rogan, Emily; Redmond, Keara L.; Sakhnevych, Svetlana; Mccooey, Aoife J.; Bull, Courtney; Hoey, Emily; Sinevici, Nicoleta; Hall, Holly; Ahmaderaghi, Baharak; Domingo, Enric; Blake, Andrew; Richman, Susan D.; Isella, Claudio; Miller, Crispin; Bertotti, Andrea; Trusolino, Livio; Loughrey, Maurice B.; Kerr, Emma M.; Tejpar, Sabine; Maughan, Timothy S.; Lawler, Mark; Campbell, Andrew D.; Leedham, Simon J.; Koelzer, Viktor H.; Sansom, Owen J.; Dunne, Philip D. Share Save
Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1 Beach, Callum; MacLean, David; Majorova, Dominika; Melemenidis, Stavros; Nambiar, Dhanya K.; Kim, Ryan K.; Valbuena, Gabriel N.; Guglietta, Silvia; Krieg, Carsten; Darvish-Damavandi, Mahnaz; Suwa, Tatsuya; Easton, Alistair; Hillson, Lily V. S.; McCulloch, Ashley K.; McMahon, Ross K.; Pennel, Kathryn; Edwards, Joanne; O'Cathail, Sean M.; Roxburgh, Campbell S.; Domingo, Enric; Moon, Eui Jung; Jiang, Dadi; Jiang, Yanyan; Zhang, Qingyang; Koong, Albert C.; Woodruff, Trent M.; Graves, Edward E.; Maughan, Tim; Buczacki, Simon J. A.; Stucki, Manuel; Le, Quynh-Thu; Leedham, Simon J.; Giaccia, Amato J.; Olcina, Monica M. Share Save
Multiparameter immunoprofiling reveals independent prognostic value of intraepithelial CD8 and intrastromal FoxP3 infiltrate in stage II/III colorectal cancer: Analysis of 3,409 cases from the SCOT and QUASAR2 trials Church, D. N.; Frei, A.; McGuigan, A.; Sinha, R.; Harkin, A.; Iveson, T. J.; Saunders, M. P.; Hay, J.; Edwards, J.; Sansom, O. J.; Kelly, C.; Kerr, R.; Kerr, D. J.; Domingo, E.; Koelzer, V. H. Share Save
Single cell AI-based detection of DNA mismatch repair deficiency in 1,988 colorectal cancers reveals prognostic and predictive value in the SCOT trial Jabbar, F.; Nowak, M.; Rodewald, A-K.; Gneo, L.; Tomasevic, T.; Harkin, A.; Iveson, T. J.; Saunders, M. P.; Kerr, R.; Oien, K. A.; Maka, N.; Hay, J.; Edwards, J.; Tomlinson, I.; Sansom, O. J.; Kelly, C.; Easton, A.; Domingo, E.; Koelzer, V. H.; Church, D. N. Share Save
Accounting for intensity variation in image analysis of large-scale multiplexed clinical trial datasets Frei, Anja L.; McGuigan, Anthony; Sinha, Ritik R. A. K.; Glaire, Mark A.; Jabbar, Faiz; Gneo, Luciana; Tomasevic, Tijana; Harkin, Andrea; Iveson, Tim J.; Saunders, Mark; Oein, Karin; Maka, Noori; Pezella, Francesco; Campo, Leticia; Hay, Jennifer; Edwards, Joanne; Sansom, Owen J.; Kelly, Caroline; Tomlinson, Ian; Kildal, Wanja; Kerr, Rachel S.; Kerr, David J.; Danielsen, Havard E.; Domingo, Enric; TransSCOT Consortium, David N.; Church, David N.; Koelzer, Viktor H. Share Save
A proliferative subtype of colorectal liver metastases exhibits hypersensitivity to cytotoxic chemotherapy Spurr, Liam F.; Martinez, Carlos A.; Katipally, Rohan R.; Iyer, Soumya C.; Pugh, Sian A.; Bridgewater, John A.; Primrose, John N.; Domingo, Enric; Maughan, Timothy S.; D'Angelica, Michael, I; Talamonti, Mark; Posner, Mitchell C.; Connell, Philip P.; Weichselbaum, Ralph R.; Pitroda, Sean P. Share Save
Complement downregulation promotes an inflammatory signature that renders colorectal cancer susceptible to immunotherapy Krieg, Carsten; Weber, Lukas M.; Fosso, Bruno; Marzano, Marinella; Hardiman, Gary; Olcina, Monica M.; Domingo, Enric; El Aidy, Sahar; Mallah, Khalil; Robinson, Mark D.; Guglietta, Silvia Share Save
Biological Misinterpretation of Transcriptional Signatures in Tumor Samples Can Unknowingly Undermine Mechanistic Understanding and Faithful Alignment with Preclinical Data Fisher, Natalie C.; Byrne, Ryan M.; Leslie, Holly; Wood, Colin; Legrini, Assya; Cameron, Andrew J.; Ahmaderaghi, Baharak; Corry, Shania M.; Malla, Sudhir B.; Amirkhah, Raheleh; McCooey, Aoife J.; Rogan, Emily; Redmond, Keara L.; Sakhnevych, Svetlana; Domingo, Enric; Jackson, James; Loughrey, Maurice B.; Leedham, Simon; Maughan, Tim; Lawler, Mark; Sansom, Owen J.; Lamrock, Felicity; Koelzer, Viktor H.; Jamieson, Nigel B.; Dunne, Philip D. Share Save
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Inhibition of WEE1 is effective in TP53 and RAS mutant metastatic colorectal cancer (mCRC): A randomised phase II trial (FOCUS4-C) comparing adavosertib (AZD1775) with active monitoring Seligmann, J.; Fisher, D. J.; Brown, L. C.; Adams, R.; Graham, J.; Quirke, P.; Richman, S.; Butler, R.; Domingo, E.; Blake, A.; Braun, M.; Collinson, F.; Jones, R.; Brown, E.; De Winton, E.; Humphies, T.; Kaplan, R.; Wilson, R.; Seymour, M.; Maughan, T. Share Save
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