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E

Evangelos D. Michelakis

university of alberta

76H-index
278Paper Count
2.3WCitation Count
Published Papers 136
Publication Date
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Discovery of a snail hibernation-inducer offering hibernation-like cardioprotection through metabolic rewiring and autophagy in mice
errNature Communications
IF15.7
err2026-06-10
err0
errOAAI
errJiyuan Piao; Yongneng Zhang; Yuan-Yuan Zhao; Patrick Hanington; Jacob Hambrook; Yongsheng Liu; John R. Ussher; Seyed Amirhossein Tabatabaei Dakhili; Gopinath Sutendra; Evangelos D. Michelakis
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Selective translation of ZNF281 as part of the integrated stress response system has therapeutic relevance for cardio-oncology
errScience Translational Medicine
IF14.6
err2026-04-15
err0
PREAI
errMaria Areli Lorenzana-Carrillo; Saymon Tejay; Guocheng Huang; Joseph Nanoa; Yuan-Yuan Zhao; Cory Wagg; Farah Eaton; Michelle Mendiola Pla; Dawn E. Bowles; Adam Kinnaird; Evangelos D. Michelakis; Seyed Amirhossein Tabatabaei Dakhili; John R. Ussher; Gopinath Sutendra
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Efficacy of anakinra in reducing progression to organ dysfunction in patients with pneumonia (INSPIRE): a randomised, double-blind, placebo-controlled, phase IIa trial
errThe Lancet Regional Health - Europe
IF0
err2025-12-29
err0
errOAAI
errGeorgios Tavoulareas; Olga Kontakou-Zoniou; Nikolaos Antonakos; Elisavet Tasouli; George Adamis; Nikolaos Kakavoulis; Evangelos Michelakis; Ilias Skopelitis; Konstantina Dakou; Christos Psarrakis; Panagiotis Koufargyris; Myrto Astriti; Styliani Sympardi; Evangelos J. Giamarellos-Bourboulis
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Cysteine Oxidation of a Redox Hub within Complex I can Facilitate Electron Transport Chain Supercomplex Formation
errJournal of Biological Chemistry
IF3.9
err2025-08-05
err0
errOAAI
errRuntai Chen; Seyed Amirhossein Tabatabaei Dakhili; Rokas Geruskis; Yuan Yuan Zhao; Steven Lockhart; Lusine Tonoyan; Arno Siraki; Guocheng Huang; Adam Kinnaird; Darren H. Freed; Shelley Minteer; Evangelos D. Michelakis; John R. Ussher; Gopinath Sutendra
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Tumour initiated purinergic signalling promotes cardiomyocyte RBFOX1 degradation and cardiotoxicity from DNA damaging anticancer agents
errNature Communications
IF15.7
err2025-07-25
err0
errOAAI
errSaymon Tejay; Maria Areli Lorenzana-Carrillo; Guocheng Huang; Seyed Amirhossein Tabatabaei Dakhili; Yuan -Yuan Zhao; Farah Eaton; Michelle Mendiola Pla; Dawn E. Bowles; Adam Kinnaird; D. Ian Paterson; Edith Pituskin; John R. Ussher; Evangelos D. Michelakis; Gopinath Sutendra
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Three-dimensional spatial localization and volume estimation of prostate tumors using 18F-PSMA-1007 PET/CT versus multiparametric MRI
errEUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
IF7.6
err2024-12-27
err0
errOAAI
errHuang, Guocheng; Albers, Patrick; Mookerji, Nikhile; Pfanner, Tyler; Hui, Amaris; Mittal, Rohan; Broomfield, Stacey; Dean, Lucas; St. Martin, Blair; Jacobsen, Niels-Erik; Evans, Howard; Gao, Yuan; Hung, Ryan; Abele, Jonathan; Dromparis, Peter; Lima, Joema Felipe; Bismar, Tarek A.; Michelakis, Evangelos; Sutendra, Gopinath; Wuest, Frank; Tu, Wendy; Adam, Benjamin A.; Fung, Christopher; Ghosh, Sunita; Tamm, Alexander; Kinnaird, Adam
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Myofibroblast transition and loss of UCP2 in a rat model and a human pulmonary hypertension cohort underline right ventricular decompensation: potential value of a loss -of-function UCP2 SNP
errCIRCULATION
IF38.6
err2024-11-12
err0
PREAI
errZhang, Yongneng; Haromy, Alois; Liu, Yongsheng; Zhao, Yuan Yuan; Bonnet, Sandra Breuils; Bonnet, Sebastien; Bowles, Dawn; Sutendra, Gopinath; Michelakis, Evangelos
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errSave
A novel small molecule synthesized based on a snail hibernation model induces hibernation in mouse fibroblasts and perfused hearts
errCIRCULATION
IF38.6
err2024-11-12
err0
PREAI
errPiao, Jiyuan; Zhang, Yongneng; Zhao, Yuan Yuan; Hannington, Patrick; Dakhili, Seyed Amirhossein Tabatabaei; Ussher, John; Sutendra, Gopinath; Michelakis, Evangelos
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errSave
TRIM35 Monoubiquitinates H2B in Cardiac Cells, Implications for Heart Failure
errCIRCULATION RESEARCH
IF16.2
err2024-07-05
err0
PREAI
errLorenzana-Carrillo, Maria Areli; Tejay, Saymon; Nanoa, Joseph; Huang, Guocheng; Liu, Yongsheng; Haromy, Alois; Zhao, Yuan Yuan; Pla, Michelle Mendiola; Bowles, Dawn E.; Kinnaird, Adam; Michelakis, Evangelos D.; Sutendra, Gopinath
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errSave
The Effects of Oxygen-Derived Free-Radical Scavengers During Normothermic Ex-Situ Heart Perfusion
errASAIO JOURNAL
IF2.3
err2024-03-08
err0
PREAI
errQi, Xiao; Hatami, Sanaz; Bozso, Sabin; Wang, Xiuhua; Saleme, Bruno; Nagendran, Jayan; Michelakis, Evangelos; Sutendra, Gopinath; Freed, Darren H.
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A Critical Contribution of Cardiac Myofibroblasts and a Predictive Role of UCP2 SNPs in the RV Decompensation in Pulmonary Hypertension
errCIRCULATION
IF38.6
err2023-11-07
err0
PREAI
errZhang, Yongneng; Carrillo, Maria A. Lorenzana; Tejay, Saymon; Haromy, Alois S.; Liu, Yongsheng; Zhao, Yuan Yuan; Sutendra, Gopinath; Michelakis, Evangelos D.
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errSave
Fasting increases susceptibility to acute myocardial ischaemia/reperfusion injury through a sirtuin-3 mediated increase in fatty acid oxidation
errSCIENTIFIC REPORTS
IF3.9
err2022-11-29
err4
errOAAI
errHall, Andrew R. R.; Karwi, Qutuba G. G.; Kumar, Sanjeev; Dongworth, Rachel; Aksentijevic, Dunja; Altamimi, Tariq R. R.; Fridianto, Kevin Timothy; Chinda, Kroekkiat; Hernandez-Resendiz, Sauri; Mahmood, Mohammad U. U.; Michelakis, Evangelos; Ramachandra, Chrishan J. J.; Ching, Jianhong; Vicencio, Jose M. M.; Shattock, Michael J. J.; Kovalik, Jean-Paul; Yellon, Derek M. M.; Lopaschuk, Gary; Hausenloy, Derek J. J.
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TRIM35-mediated degradation of nuclear PKM2 destabilizes GATA4/6 and induces P53 in cardiomyocytes to promote heart failure
errSCIENCE TRANSLATIONAL MEDICINE
IF14.6
err2022-11-02
err11
PREAI
errLorenzana-Carrillo, Maria Areli; Gopal, Keshav; Byrne, Nikole J.; Tejay, Saymon; Saleme, Bruno; Das, Subhash K.; Zhang, Yongneng; Haromy, Alois; Eaton, Farah; Pla, Michelle Mendiola; Bowles, Dawn E.; Dyck, Jason R. B.; Ussher, John R.; Michelakis, Evangelos D.; Sutendra, Gopinath
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Atrial Shunt Devices in Patients With Heart Failure and Preserved or Mildly Reduced Ejection Fraction and the Pulmonary Circulation: Promises and Concerns
errCIRCULATION
IF38.6
err2022-05-24
err2
errOAAI
errSaunders, Alexandra; Michelakis, Evangelos
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Changing cell fate in the wall of pulmonary arteries
errSCIENCE TRANSLATIONAL MEDICINE
IF14.6
err2022-05-04
err0
PREAI
errZhang, Yongneng; Michelakis, Evangelos D.
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errSave
Oral treprostinil improves pulmonary vascular compliance in pulmonary arterial hypertension
errRESPIRATORY MEDICINE
IF3.1
err2022-03-01
err11
errOAAI
errKhan, Akram; White, R. James; Meyer, Gisela; Zamudio, Tomas R. Pulido; Jerjes-Sanchez, Carlos; Johnson, Dana; Grover, Rob; Broderick, Meredith; Ousmanou, Aliou; Holdstock, Louis; Michelakis, Evangelos
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errSave
MFN2-driven mitochondria-to-nucleus tethering allows a non-canonical nuclear entry pathway of the mitochondrial pyruvate dehydrogenase complex
errMOLECULAR CELL
IF16.6
err2022-03-01
err27
errOAAI
errZervopoulos, Sotirios D.; Boukouris, Aristeidis E.; Saleme, Bruno; Haromy, Alois; Tejay, Saymon; Sutendra, Gopinath; Michelakis, Evangelos D.
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A reversible metabolic stress-sensitive regulation of CRMP2A orchestrates EMT/stemness and increases metastatic potential in cancer
errCELL REPORTS
IF6.9
err2022-03-01
err8
PREAI
errBoukouris, Aristeidis E.; Zhang, Yongneng; Saleme, Bruno; Kinnaird, Adam; Zhao, Yuan Yuan; Liu, Yongsheng; Zervopoulos, Sotirios D.; Das, Subhash K.; Mittal, Rohan D.; Haromy, Alois; Lorenzana-Carrillo, Maria Areli; Krysler, Amanda R.; Cromwell, Christopher R.; Hubbard, Basil P.; Sutendra, Gopinath; Michelakis, Evangelos D.
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SNPs for Genes Encoding the Mitochondrial Proteins Sirtuin3 and Uncoupling Protein 2 Are Associated With Disease Severity, Type 2 Diabetes, and Outcomes in Patients With Pulmonary Arterial Hypertension and This Is Recapitulated in a New Mouse Model Lacking Both Genes
errJOURNAL OF THE AMERICAN HEART ASSOCIATION
IF5.3
err2021-12-07
err9
errOAAI
errZhang, Yongneng; Zervopoulos, Sotirios D.; Boukouris, Aristeidis E.; Lorenzana-Carrillo, Maria Areli; Saleme, Bruno; Webster, Linda; Liu, Yongsheng; Haromy, Alois; Dakhili, Seyed Amirhossein Tabatabaei; Ussher, John R.; Sutendra, Gopinath; Michelakis, Evangelos D.
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A Phase-2 NIH-sponsored Randomized Clinical Trial of Rituximab in Scleroderma-associated Pulmonary Arterial Hypertension Did Not Reach Significance for Its Endpoints End of Story? Not So Fast!
errAMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
IF19.4
err2021-07-15
err8
errOAAI
errZhang, Yongneng; Michelakis, Evangelos D.
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Research Directions

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Co-authors
Cooperation Journals
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Werner Seeger
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William C. Sessa
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D
Derek M. Yellon
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