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High-resolution proteomic analysis of medulloblastoma clinical samples identifies MYC immunohistochemistry as a powerful outcome predictor outperforming genetic amplification detection Delaidelli, Alberto; Burwag, Fares; Suk, Yujin; Shyp, Taras; Kosteniuk, Suzanne; Dunham, Christopher; Cheng, Sylvia; Okonechnikov, Konstantin; Schrimpf, Daniel; Von Deimling, Andreas; Ellezam, Benjamin; Perreault, Sebastien; Singh, Sheila; Hawkins, Cynthia; Kool, Marcel; Pfister, Stefan; Steidl, Christian; Hughes, Christopher; Korshunov, Andrey; Sorensen, Poul Share Save
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A cycling, progenitor-like cell population at the base of atypical teratoid rhabdoid tumor subtype differentiation trajectories Blanco-Carmona, Enrique; Paassen, Irene; He, Jiayou; Demartino, Jeff; Bullesbach, Annette; Anderson, Nadia; Buhl, Juliane L.; Federico, Aniello; Mauermann, Monika; Brok, Mariel; Straathof, Karin; Behjati, Sam; Vibhakar, Rajeev; Donson, Andrew M.; Foreman, Nicholas K.; Shaw, Mckenzie; Fruhwald, Michael C.; Korshunov, Andrey; Hasselblatt, Martin; Thomas, Christian; Franke, Niels; Kranendonk, Mariette E. G.; Hoving, Eelco W.; Jaeger, Natalie; Johann, Pascal D.; Pfister, Stefan M.; Filbin, Mariella G.; Kool, Marcel; Drost, Jarno Share Save
Cellular hierarchies of embryonal tumors with multilayered rosettes are shaped by oncogenic microRNAs and receptor-ligand interactions Beck, Alexander; Gabler-Pamer, Lisa; Alencastro Veiga Cruzeiro, Gustavo; Lambo, Sander; Englinger, Bernhard; Shaw, McKenzie L.; Hack, Olivia A.; Liu, Ilon; Haase, Rebecca D.; de Biagi Jr, Carlos A. O.; Baumgartner, Alicia; Nascimento Silva, Andrezza Do; Klenner, Marbod; Freidel, Pia S.; Herms, Jochen; von Baumgarten, Louisa; Tonn, Joerg C.; Thon, Niklas; Bruckner, Katharina; Madlener, Sibylle; Mayr, Lisa; Senfter, Daniel; Peyrl, Andreas; Slavc, Irene; Loetsch, Daniela; Dorfer, Christian; Geyregger, Rene; Amberg, Nicole; Haberler, Christine; Mack, Norman; Schwalm, Benjamin; Pfister, Stefan M.; Korshunov, Andrey; Baird, Lissa C.; Yang, Edward; Chi, Susan N.; Alexandrescu, Sanda; Gojo, Johannes; Kool, Marcel; Hovestadt, Volker; Filbin, Mariella G. Share Save
Association of phosphorylation status of ERK and genetic MAPK alterations in pediatric tumors Selt, Florian; Sigaud, Romain; Korshunov, Andrey; Reuss, David; von Deimling, Andreas; Pajtler, Kristian W.; van Tilburg, Cornelis M.; Nesper-Brock, Martina; Jones, David T. W.; Pfister, Stefan M.; Witt, Olaf; Ecker, Jonas Share Save
IDH-mutant astrocytomas with primitive neuronal component have a distinct methylation profile and a higher risk of leptomeningeal spread Hinz, F; Friedel, D; Korshunov, A; Ippen, FM; Bogumil, H; Banan, R; Brandner, S; Hasselblatt, M; Boldt, HB; Dirse, V; Dohmen, H; Aronica, E; Brodhun, M; Broekman, MLD; Capper, D; Cherkezov, A; Deng, MY; van Dis, V; Felsberg, J; Frank, S; French, PJ; Gerlach, R; Göbel, K; Goold, E; Hench, J; Kantelhardt, S; Kohlhof-Meinecke, P; Krieg, S; Mawrin, C; Morrison, G; Mühlebner, A; Ozduman, K; Pfister, SM; Poliani, PL; Prinz, M; Reifenberger, G; Riemenschneider, MJ; Sankowski, R; Schrimpf, D; Sill, M; Snuderl, M; Verdijk, RM; Voisin, MR; Wesseling, P; Wick, W; Reuss, DE; von Deimling, A; Sahm, F; Maas, SLN; Suwala, AK Share Save
Spatio-temporal transcriptomics of chromothriptic SHH-medulloblastoma identifies multiple genetic clones that resist treatment and drive relapse Kats, Ilia; Simovic-Lorenz, Milena; Schreiber, Hannah Sophia; Sant, Pooja; Mallm, Jan-Philipp; Korber, Verena; Li, Albert; Velmurugan, Pravin; Heuer, Sophie; Kuees, Luisa; Devens, Frauke; Sill, Martin; Jugold, Manfred; Moustafa, Mahmoud; Abdollahi, Amir; Winkler, Frank; Korshunov, Andrey; Pfister, Stefan M.; Stegle, Oliver; Ernst, Aurelie Share Save
MOLECULAR SUBTYPES, CLINICAL CHARACTERISTICS, AND THERAPEUTIC IMPLICATIONS FOR CNS TUMORS WITH BCOR/BCORL1 FUSION/INTERNAL TANDEM DUPLICATION Gojo, Johannes; Federico, Aniello; Geisemeyer, Neal; Schmitt-Hoffner, Felix; Mauermann, Monika; Sill, Martin; Bruckner, Katharina; Korshunov, Andrey; Stichel, Damian; Capper, David; Tauziede-Espariat, Arnault; Varlet, Pascale; Aldape, Kenneth; Abdullaev, Zied; Donson, Andrew M.; Pahnke, Jens; Schueller, Ulrich; Galbraith, Kristyn; Snuderl, Matija; Alexandrescu, Sanda; Filbin, Mariella; Gramatzki, Dorothee; Urbanic-Purkart, Tadeja; Ziad, Fouzia; Toledano, Helen; Kerl, Kornelius; Hasselblatt, Martin; Papusha, Ludmila; Brandner, Sebastian; Lastowska, Maria; Miele, Evelina; v d Lugt, Jasper; Bunt, Jens; Kramm, Christof; Andre, Nicolas; Appay, Romain; Bouchoucha, Yassine; Hansford, Jordan; Zapotocky, Michal; Kranendonk, Mariette E.; Nobusawa, Sumihito; Solomon, David; Haberler, Christine; Jones, Barbara; Sturm, Dominik; Sahm, Felix; Jaeger, Natalie; Pfister, Stefan M.; v Hoff, Katja; Kool, Marcel Share Save
Molecular and clinical heterogeneity within MYC-family amplified medulloblastoma is associated with survival outcomes: A multicenter cohort study Schwalbe, Edward C.; Lindsey, Janet C.; Danilenko, Marina; Hill, Rebecca M.; Crosier, Stephen; Ryan, Sarra L.; Williamson, Daniel; Castle, Jemma; Hicks, Debbie; Kool, Marcel; Milde, Till; Korshunov, Andrey; Pfister, Stefan M.; Bailey, Simon; Clifford, Steven C. Share Save
Multiomic profiling of medulloblastoma reveals subtype-specific targetable alterations at the proteome and N-glycan level Godbole, Shweta; Voss, Hannah; Gocke, Antonia; Schlumbohm, Simon; Schumann, Yannis; Peng, Bojia; Mynarek, Martin; Rutkowski, Stefan; Dottermusch, Matthias; Dorostkar, Mario M.; Korshunov, Andrey; Mair, Thomas; Pfister, Stefan M.; Kwiatkowski, Marcel; Hotze, Madlen; Neumann, Philipp; Hartmann, Christian; Weis, Joachim; Liesche-Starnecker, Friederike; Guan, Yudong; Moritz, Manuela; Siebels, Bente; Struve, Nina; Schlueter, Hartmut; Schueller, Ulrich; Krisp, Christoph; Neumann, Julia E. Share Save
Identification of a putative molecular subtype of adult-type diffuse astrocytoma with recurrent MAPK pathway alterations Sievers, Philipp; Bielle, Franck; Goebel, Kirsten; Schrimpf, Daniel; Nichelli, Lucia; Mathon, Bertrand; Appay, Romain; Boldt, Henning B.; Dohmen, Hildegard; Selignow, Carmen; Acker, Till; Vicha, Ales; Martinetto, Horacio; Schweizer, Leonille; Schueller, Ulrich; Brandner, Sebastian; Wesseling, Pieter; Schmid, Simone; Capper, David; Abdullaev, Zied; Aldape, Kenneth; Korshunov, Andrey; Krieg, Sandro M.; Wick, Wolfgang; Pfister, Stefan M.; von Deimling, Andreas; Reuss, David E.; Jones, David T. W.; Sahm, Felix Share Save
MOLECULAR PATHOLOGY, TREATMENT AND PROGNOSIS OF INFANT SONIC HEDGEHOG MEDULLOBLASTOMA: A GLOBAL MULTI-COHORT STUDY Richardson, Stacey; Hicks, Debbie; Gough, Melissa; Castle, Jemma; Crosier, Stephen; Garcia-Ariza, Miguel; Martin-Guerrero, Idoia; LA Plasschaert, Sabine; Bourdeaut, Franck; Dufour, Christelle; Masliah-Planchon, Julien; Buttarelli, Francesca R.; Garre, Maria-Luisa; Biassoni, Veronica; Massimino, Maura; Kanemura, Yonehiro; Ramaswamy, Vijay; Gajjar, Amar; Northcott, Paul; Robinson, Giles; Korshunov, Andrey; Pfister, Stefan M.; Mynarek, Martin; Rutkowski, Stefan; Schwalbe, Edward C.; Bailey, Simon; Clifford, Steven C. Share Save
GENE REGULATORY NETWORK LANDSCAPE OF GROUP 3/4 MEDULLOBLASTOMA Joshi, Piyush; Stelzer, Tamina; Okonechnikov, Konstantin; Sarropoulos, Ioannis; Sepp, Mari; Pour-Jamnani, Mischan, V; Rademacher, Anne; Yamada-Saito, Tetsuya; Schneider, Celine; Schmidt, Julia; Schaefer, Philipp; Leiss, Kevin; Bortolomeazzi, Michele; Mallm, Jan-Philipp; da Silva, Patricia B. G.; Statz, Britta; Wittmann, Andrea; Schramm, Kathrin; Blattner-Johnson, Mirjam; Fiesel, Petra; Jones, Barbara; Milde, Till; Pajtler, Kristian; van Tilburg, Cornelis M.; Witt, Olaf; Rippe, Karsten; Korshunov, Andrey; Jones, David T. W.; Hovestadt, Volker; Northcott, Paul A.; Thongjuea, Supat; Jaeger, Natalie; Kaessmann, Henrik; Pfister, Stefan M.; Kutscher, Lena M. Share Save
MULTI-OMICS SEQUENCING OF ATYPICAL TERATOID RHABDOID TUMORS UNVEILS A SHARED GROUND-STATE POPULATION PROMOTING SUBGROUP-SPECIFIC DIFFERENTIATION TRAJECTORIES Carmona, Enrique Blanco; Paassen, Irene; He, Jiayou; Buellesbach, Annette; Buhl, Juliane L.; Federico, Aniello; Liu, Ilon; Young, Matthew; Kildisiute, Gerda; Behjati, Sam; Vibhakar, Rajeev; Donson, Andrew; Foreman, Nicholas; Hovestadt, Volker; Shaw, McKenzie; Chi, Susan N.; Fruehwald, Michael; Korshunov, Andrey; Hasselblatt, Martin; Hoving, Eelco W.; Jaeger, Natalie; Johann, Pascal D.; Pfister, Stefan M.; Filbin, Mariella; Drost, Jarno; Kool, Marcel Share Save
EVALUATING THERAPEUTIC APPROACHES IN EMBRYONAL TUMORS WITH PLAGL1 AND PLAGL2 AMPLIFICATION AND UNRAVELING MOLECULAR PARALLELS IN EPIGENETICALLY RELATED TUMORS WITH PLAG1-ALTERATIONS Keck, Michaela-Kristina; Tietze, Anna; Sievers, Philipp; Bison, Brigitte; Avula, Shivaram; Brandner, Sebastian; Cheesman, Edmund; Faure-Conter, Cecile; Fenouil, Tanguy; Figarella-Branger, Dominique; Gauchotte, Guillaume; Goebell, Einar; Gojo, Johannes; Haberler, Christine; Hakumaki, Juhana; Hayden, James T.; Jabado, Nada; Korhonen, Laura S.; Korshunov, Andrey; Koscielniak, Ewa; Kramm, Christof M.; Kranendonk, Mariette E. G.; Lavarino, Cinzia; Lequin, Maarten; Loiseau, Hugues; Ludlow, Louise E.; Maher, Ossama; Meyronet, David; Nyman, Per; Ora, Ingrid; Perwein, Thomas; Pesola, Jouni; Rauramaa, Tuomas; Reddingius, Roel; Samuel, David; Schouten-van Meeteren, Antoinette Y. N.; Schueller, Ulrich; Sexton-Oates, Alexandra; Solomon, David; Varlet, Pascale; Vasiljevic, Alexandre; von Kalle, Thekla; Wefers, Annika K.; Wesseling, Pieter; White, Christine; Zamecnik, Josef; Zapotocky, Michal; von Hoff, Katja; Jones, David T. W. Share Save
Clinically unfavorable transcriptome subtypes of non-WNT/non-SHH medulloblastomas are associated with a predominance in proliferating and progenitor-like cell subpopulations Okonechnikov, Konstantin; Schrimpf, Daniel; Koster, Jan; Sievers, Philipp; Milde, Till; Sahm, Felix; Jones, David T. W.; von Deimling, Andreas; Pfister, Stefan M.; Kool, Marcel; Korshunov, Andrey Share Save
Developmental basis of SHH medulloblastoma heterogeneity Gold, Maxwell P.; Ong, Winnie; Masteller, Andrew M.; Ghasemi, David R.; Galindo, Julie Anne; Park, Noel R.; Huynh, Nhan C.; Donde, Aneesh; Pister, Veronika; Saurez, Raul A.; Vladoiu, Maria C.; Hwang, Grace H.; Eisemann, Tanja; Donovan, Laura K.; Walker, Adam D.; Benetatos, Joseph; Dufour, Christelle; Garzia, Livia; Segal, Rosalind A.; Wechsler-Reya, Robert J.; Mesirov, Jill P.; Korshunov, Andrey; Pajtler, Kristian W.; Pomeroy, Scott L.; Ayrault, Olivier; Davidson, Shawn M.; Cotter, Jennifer A.; Taylor, Michael D.; Fraenkel, Ernest Share Save
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