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Unraveling complexity and leveraging opportunities in uncommon breast cancer subtypes Pareja, Fresia; Bhargava, Rohit; Borges, Virginia F.; Brogi, Edi; Canas Marques, Rita; Cardoso, Fatima; Desmedt, Christine; Harigopal, Malini; Lakhani, Sunil R.; Lee, Adrian; Leone, Jose Pablo; Linden, Hannah; Lord, Christopher J.; Marchio, Caterina; Merajver, Sofia D.; Rakha, Emad; Reis-Filho, Jorge S.; Richardson, Andrea; Sawyer, Elinor; Schedin, Pepper; Schwartz, Christopher J.; Tutt, Andrew; Ueno, Naoto T.; Vincent-Salomon, Anne; Weigelt, Britta; Wen, Y. Hannah; Schnitt, Stuart J.; Oesterreich, Steffi Share Save
Persistence of BRCA1 and RAD51C methylation after neoadjuvant chemotherapy in high risk TNBC Pettitt, S.; Proszek, P.; Torga, G.; Gulati, A.; Llop-Guevara, A.; Jank, P.; Felder, B.; Rodriguez, A.; Cooke, S.; Garcia-Murillas, I.; Ravindran, N.; Alaguthurai, T.; Jones, L.; Roxanis, Y.; Serra, V.; Denkert, C.; Loibl, S.; Haider, S.; Lord, C.; Tutt, A. Share Save
Targeting GPR89 as a novel therapeutic strategy for breast cancer Ferro, R.; Carroll, A.; Hickman, O.; Vlachogiannis, G.; Trendell, J.; Krastev, D.; Pettitt, S.; Amodeo, V.; Annunziato, S.; Jonkers, J.; Liv, N.; Pardo, M.; Roumeliotis, T. I.; Choudhary, J.; Natrajan, R.; Grigoriadis, A.; Madhusudhan, M. S.; Haider, S.; Lord, C. J.; Tutt, A. Share Save
PAK6 acts downstream of IQGAP3 to promote contractility in triple negative breast cancer cells Pipili, Aikaterini; Babteen, Nouf A.; Kuwair, Lujain; Jannet, Mahfuja Bulu; Quist, Jelmar; Ong, Karine K. V.; Pitaluga, Ryan; Grigoriadis, Anita G.; Tutt, Andrew; Wells, Claire M. Share Save
Anti-EGFR Antibody-Drug Conjugate Carrying an Inhibitor Targeting CDK Restricts Triple-Negative Breast Cancer Growth Cheung, Anthony; Chenoweth, Alicia M.; Johansson, Annelie; Laddach, Roman; Guppy, Naomi; Trendell, Jennifer; Esapa, Benjamina; Mavousian, Antranik; Navarro-Llinas, Blanca; Haider, Syed; Romero-Clavijo, Pablo; Hoffmann, Ricarda M.; Andriollo, Paolo; Rahman, Khondaker M.; Jackson, Paul; Tsoka, Sophia; Irshad, Sheeba; Roxanis, Ioannis; Grigoriadis, Anita; Thurston, David E.; Lord, Christopher J.; Tutt, Andrew N. J.; Karagiannis, Sophia N. Share Save
Functional assessment of RAD51 foci and replication fork dynamics in PARPi resistant BRCA1/2 mutated breast cancer Harvey-Jones, Elizabeth; Raghunandan, Maya; Robbez-Masson, Luisa; Alaguthurai, Thanussuyah; Llop-Guevara, Alba; Trendell, Jennifer; Rodriguez, Olga; Guzman, Marta; Weekes, Daniel; deRenty, Christelle; Knight, Eleanor; Marlow, Rebecca; Starling, Christopher; Liu, Ruifang; Ravindran, Nivedita; Roxanis, Ioannis; Lukashchuk, Natalia; Serra, Violeta; Pettitt, Stephen; Lord, Christopher; Tutt, Andrew N. J. Share Save
Longitudinal pro fi ling identi fi es co-occurring BRCA1/2 reversions, TP53BP1, RIF1 and PAXIP1 mutations in PARP inhibitor-resistant advanced breast cancer Harvey-Jones, E.; Raghunandan, M.; Robbez-Masson, L.; Magraner-Pardo, L.; Alaguthurai, T.; Yablonovitch, A.; Yen, J.; Xiao, H.; Brough, R.; Frankum, J.; Song, F.; Yeung, J.; Savy, T.; Gulati, A.; Alexander, J.; Kemp, H.; Starling, C.; Konde, A.; Marlow, R.; Cheang, M.; Proszek, P.; Hubank, M.; Cai, M.; Trendell, J.; Lu, R.; Liccardo, R.; Ravindran, N.; Llop-Guevara, A.; Rodriguez, O.; Balmana, J.; Lukashchuk, N.; Dorschner, M.; Drusbosky, L.; Roxanis, I.; Serra, V.; Haider, S.; Pettitt, S. J.; Lord, C. J.; Tutt, A. N. J. Share Save
Cancer-associated FBXW7 loss is synthetic lethal with pharmacological targeting of CDC7 Baxter, Joseph S.; Brough, Rachel; Krastev, Dragomir B.; Song, Feifei; Sridhar, Sandhya; Gulati, Aditi; Alexander, John; Roumeliotis, Theodoros I.; Kozik, Zuza; Choudhary, Jyoti S.; Haider, Syed; Pettitt, Stephen J.; Tutt, Andrew N. J.; Lord, Christopher J. Share Save
Integrated Multimodal Analyses of DNA Damage Response and Immune Markers as Predictors of Response in Metastatic Triple-Negative Breast Cancer in the TNT Trial (NCT00532727) Tovey, Holly; Sipos, Orsolya; Parker, Joel S.; Hoadley, Katherine A.; Quist, Jelmar; Kernaghan, Sarah; Kilburn, Lucy; Salgado, Roberto; Loi, Sherene; Kennedy, Richard D.; Roxanis, Ioannis; Gazinska, Patrycja; Pinder, Sarah E.; Bliss, Judith; Perou, Charles M.; Haider, Syed; Grigoriadis, Anita; Tutt, Andrew; Cheang, Maggie Chon U. Share Save
A HUWE1 defect causes PARP inhibitor resistance by modulating the BRCA1-increment 11q splice variant Pettitt, Stephen J.; Shao, Nan; Zatreanu, Diana; Frankum, Jessica; Bajrami, Ilirjana; Brough, Rachel; Krastev, Dragomir B.; Roumeliotis, Theodoros I.; Choudhary, Jyoti S.; Lorenz, Sonja; Rust, Alistair; de Bono, Johann S.; Yap, Timothy A.; Tutt, Andrew N. J.; Lord, Christopher J. Share Save
Serum-derived extracellular vesicles from breast cancer patients contribute to differential regulation of T-cell-mediated immune-escape mechanisms in breast cancer subtypes Graham, Rosalind; Gazinska, Patrycja; Zhang, Birong; Khiabany, Atousa; Sinha, Shubhankar; Alaguthurai, Thanussuyah; Flores-Borja, Fabian; Vicencio, Jose; Beuron, Fabienne; Roxanis, Ioannis; Matkowski, Rafal; Liam-Or, Revadee; Tutt, Andrew; Ng, Tony; Al-Jamal, Khuloud T.; Zhou, You; Irshad, Sheeba Share Save
Adjuvant olaparib in the subset of patients from Japan with BRCA1- or BRCA2-mutated high-risk early breast cancer from the phase 3 OlympiA trial (Apr, 10.1007/s12282-023-01451-8, 2023) Yamauchi, Hideko; Toi, Masakazu; Takayama, Shin; Nakamura, Seigo; Takano, Toshimi; Cui, Karen; Campbell, Christine; De Vos, Liesbet; Geyer, Charles; Tutt, Andrew Share Save
MND1 and PSMC3IP control PARP inhibitor sensitivity in mitotic cells Zelceski, Anabel; Francica, Paola; Lingg, Lea; Mutlu, Merve; Stok, Colin; Liptay, Martin; Alexander, John; Baxter, Joseph S.; Brough, Rachel; Gulati, Aditi; Haider, Syed; Raghunandan, Maya; Song, Feifei; Sridhar, Sandhya; Forment, Josep, V; O'Connor, Mark J.; Davies, Barry R.; van Vugt, Marcel A. T. M.; Krastev, Dragomir B.; Pettitt, Stephen J.; Tutt, Andrew N. J.; Rottenberg, Sven; Lord, Christopher J. Share Save
BRCA1 promoter methylation in sporadic breast cancer patients detected by liquid biopsy Yen, Jennifer; Chen, Sai; Jenkins, Colby; Overstreet, Brooke; Fu, Yu; Zhao, Jun; Jiang, Tingting; Drusbosky, Leylah; Pettitt, Stephen; Dorschner, Michael; Lawrence, Lauren; Chuang, Han-Yu; Tutt, Andrew Share Save
Longitudinal analysis of PARP inhibitor and platinum resistance in BRCA1/2m breast cancer using liquid biopsy Harvey-Jones, Elizabeth; Raghunandan, Maya; Robbez-Masson, Luisa; Thanussuyah, Alaguthurai; Liccardo, Roberta; Yablonovitch, Arielle; Cai, Mingyang; Drusbosky, Leylah; Dorschner, Michael; Pardo, Lorena Magraner; Marlow, Rebecca; Konde, Asha; Trendell, Jennifer; Alexander, John; Haider, Syed; Starling, Chris; Roxanis, Ioannis; Yen, Jennifer; Pettitt, Stephen J.; Lord, Christopher J.; Tutt, Andrew N. Share Save
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