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D

Douglas C. Wallace

children's hospital of philadelphia

134H-index
605Paper Count
7.5WCitation Count
Published Papers 234
Publication Date
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MSeqDR PMD-VR: An Expert-Curated Virtual Registry of 11,000 Mitochondrial Disease Cases Established Through Literature Mining and Generative AI Augmentation
errGenes
IF2.8
err2026-07-01
err0
errOAAI
errLishuang Shen; Marie T. Lott; Elizabeth M. Mccormick; Colleen C. Muraresku; Kierstin Keller; Douglas C. Wallace; Zarazuela Zolkipli-Cunningham; Shamima Rahman; Marni J. Falk; Xiaowu Gai
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Mitochondrial cardiomyopathy: bridging molecular mechanisms and clinical frontiers
errNature Reviews Cardiology
IF44.2
err2026-06-18
err0
PREAI
errAtsuko Imai-Okazaki; Liming Pei; Douglas C. Wallace
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Author Correction: Partial restoration of mitochondrial dysfunction by AAV-Ant1 protects from dilated cardiomyopathy in Ant1-/- plus mtDNA mutant mice
errNature Communications
IF15.7
err2026-05-06
err0
errOAAI
errAlessia Angelin; Kierstin Keller; Peiran Lu; Joseph W. Guarnieri; Gabrielle A. Widjaja; Rasheed Sule; Kevin Janssen; Arnold Olali; Zimu Cen; Valeria Carosi; Maina Beauplan; Deborah G. Murdock; Prasanth Potluri; Liming Pei; Douglas C. Wallace
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Combined ketone body and glutamine supplementation restores aerobic energy production in AGC1-deficient neuronal progenitors
errCell Death & Disease
IF9.6
err2025-12-15
err0
errOAAI
errSimona Nicole Barile; Maria Chiara Magnifico; Eleonora Poeta; Felix Distelmaier; Luigi Viggiano; Nicola Balboni; Michele Protti; Sabrina Petralla; Antonella Pignataro; Giacomo Volpe; Monica De Luise; Massimo Bonora; Marica Antonicelli; Giorgia Babini; Francesca Massenzio; Vito Porcelli; Eleonora Lama; Roberto Arrigoni; Isabella Pisano; Veronica Addabbo; Anna Campana; Francesca Begnozzi; Stewart A. Anderson; Giuseppe Fiermonte; Federico Manuel Giorgi; Paolo Pinton; Ferdinando Palmieri; Giuseppe Gasparre; Laura Mercolini; Luigi Palmieri; Douglas C. Wallace; Julia Hentschel; Barbara Monti; Francesco Massimo Lasorsa
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Partial restoration of mitochondrial dysfunction by AAV-Ant1 protects from dilated cardiomyopathy in Ant1-/- plus mtDNA mutant mice
errNature Communications
IF15.7
err2025-12-15
err0
errOAAI
errAlessia Angelin; Kierstin Keller; Peiran Lu; Joseph W. Guarnieri; Gabrielle A. Widjaja; Rasheed Sule; Kevin Janssen; Arnold Olali; Zimu Cen; Valeria Carosi; Maina Beauplan; Deborah G. Murdock; Prasanth Potluri; Liming Pei; Douglas C. Wallace
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errSave
Optical Mapping in Black Genomes: Distinct LCR22 Structures and 22q11.2 Deletion Syndrome Mechanisms
errGenetics in Medicine
IF6.2
err2025-10-21
err0
PREAI
errSteven Pastor; Oanh Tran; Ryan Lapointe; Arnold Z. Olali; Douglas C. Wallace; Bernice Morrow; Elaine H. Zackai; Donna M. McDonald-McGinn; Beverly S. Emanuel
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Importance of De Novo Gene Evolution to Emerging Viral Threats: The ORF10 Strain-Restricted Orphan Gene of SARS-CoV-2 Promotes Pathogenesis
errMOLECULAR BIOLOGY AND EVOLUTION
IF5.3
err2025-10-01
err0
PREAI
errHaltom, Jeffrey A.; Trovao, Nidia S.; Guarnieri, Joseph W.; Pan, Vincent; Singh, Urminder; Tsoy, Sergey; O'Leary, Collin A.; Bram, Yaron; Widjaja, Gabrielle A.; Cen, Zimu; Meller, Robert; Baylin, Stephen B.; Moss, Walter N.; Nikolau, Basil J.; Enguita, Francisco J.; Wallace, Douglas C.; Beheshti, Afshin; Schwartz, Robert E.; Wurtele, Eve Syrkin
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Respiration defects limit serine synthesis required for lung cancer growth and survival
errNature Communications
IF15.7
err2025-08-15
err0
errOAAI
errEduardo Cararo Lopes; Fuqian Shi; Akshada Sawant; Maria Ibrahim; Maria Gomez-Jenkins; Zhixian Hu; Pranav Manchiraju; Vrushank Bhatt; Wenping Wang; Christian S. Hinrichs; Douglas C. Wallace; Xiaoyang Su; Joshua D. Rabinowitz; Chang S. Chan; Jessie Yanxiang Guo; Shridar Ganesan; Edmund C. Lattime; Eileen White
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errSave
Respiratory viral infections awaken metastatic breast cancer cells in lungs
errNature
IF48.5
err2025-07-30
err0
errOAAI
errShi B. Chia; Bryan J. Johnson; Junxiao Hu; Felipe Valença-Pereira; Marc Chadeau-Hyam; Fernando Guntoro; Hugh Montgomery; Meher P. Boorgula; Varsha Sreekanth; Andrew Goodspeed; Bennett Davenport; Marco De Dominici; Vadym Zaberezhnyy; Wolfgang E. Schleicher; Dexiang Gao; Andreia N. Cadar; Lucia Petriz-Otaño; Michael Papanicolaou; Afshin Beheshti; Stephen B. Baylin; Joseph W. Guarnieri; Douglas C. Wallace; James C. Costello; Jenna M. Bartley; Thomas E. Morrison; Roel Vermeulen; Julio A. Aguirre-Ghiso; Mercedes Rincon; James DeGregori
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Interpreting the clinical significance of multiple large-scale mitochondrial DNA deletions (MLSMD) in skeletal muscle tissue in the diagnostic evaluation of primary mitochondrial disease
errFRONTIERS IN PHARMACOLOGY
IF4.8
err2025-04-09
err0
errOAAI
errWang, Jing; Peterson, James T.; Santos, Joaquim Diego D.; Chan, Ada J. S.; Diaz-Miranda, Maria Alejandra; Rahaman, Imon; Flickinger, Jean; Goldstein, Amy; Bogush, Emily; Mccormick, Elizabeth M.; Muraresku, Colleen C.; Anderson, Vernon E.; Dulik, Matthew C.; Wallace, Douglas C.; Xiao, Rui; Falk, Marni J.; Viaene, Angela N.; Zolkipli-Cunningham, Zarazuela
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errSave
BUTYRATE MITIGATES KIDNEY AND LIVER MITOCHONDRIAL DYSFUNCTION IN A LIPOPOLYSACCHARIDE MOUSE MODEL
errCRITICAL CARE MEDICINE
IF6
err2025-01-30
err0
PREAI
errWeiss, Scott; Khan, Muznah; Farooqi, Sumera; Mitchell, Katherine; Chowdhury, Subir; Cabrera-Ayala, Marian; Huang, Jessica; Wallace, Douglas
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Mitochondrial DNA lineages determine tumor progression through T cell reactive oxygen signaling
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2025-01-03
err2
errOAAI
errYardeni, Tal; Olali, Arnold Z.; Chen, Hsiao-Wen; Wang, Liqing; Halton, Jeffrey A.; Zenab, Angi; Morrow, Ryan; Butic, Arrienne; Murdock, Deborah G.; Waymire, Katrina G.; Macgregor, Grant R.; Boursi, Ben; Beier, Ulf H.; Hancock, Wayne W.; Wallace, Douglas C.
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Effect of sodium butyrate on kidney and liver mitochondrial dysfunction in a lipopolysaccharide mouse model
errFASEB JOURNAL
IF4.2
err2024-12-06
err1
PREAI
errKhan, Muznah; Farooqi, Sumera; Mitchell, Katherine L.; Chowdhury, Subir Kumar Roy; Cabrera-Ayala, Marian; Huang, Jessica; Wallace, Douglas C.; Weiss, Scott L.
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Lethal COVID-19 associates with RAAS- induced inflammation for multiple organ damage including mediastinal lymph nodes
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2024-11-27
err0
errOAAI
errTopper, Michael J.; Guarnieri, Joseph W.; Haltom, Jeffrey A.; Chadburn, Amy; Cope, Henry; Frere, Justin; An, Julia; Borczuk, Alain; Sinha, Saloni; Kim, Jangkeun; Park, Jiwoon; Butler, Daniel; Meydan, Cem; Foox, Jonathan; Bram, Yaron; Richard, Stephanie A.; Epsi, Nusrat J.; Agan, Brian; Chenoweth, Josh G.; Simons, Mark P.; Tribble, David; Burgess, Timothy; Dalgard, Clifton; Heise, Mark T.; Moorman, Nathaniel J.; Baxter, Victoria K.; Madden, Emily A.; Taft-Benz, Sharon A.; Anderson, Elizabeth J.; Sanders, Wes A.; Dickmander, Rebekah J.; Beigel, Katherine; Widjaja, Gabrielle A.; Janssen, Kevin A.; Lie, Timothy; Murdock, Deborah G.; Angelin, Alessia; Albrecht, Yentli E. Soto; Olali, Arnold Z.; Cen, Zimu; Dybas, Joseph; Priebe, Waldemar; Emmett, Mark R.; Best, Sonja M.; Johnson, Maya Kelsey; Trovao, Nidia S.; Clark, Kevin B.; Zaksas, Victoria; Meller, Robert; Grabham, Peter; Schisler, Jonathan C.; Moraes-Vieira, Pedro M.; Pollett, Simon; Mason, Christopher E.; Wurtele, Eve Syrkin; Taylor, Deanne; Schwartz, Robert E.; Beheshti, Afshin; Wallace, Douglas C.; Baylin, Stephen B.
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sChemNET: a deep learning framework for predicting small molecules targeting microRNA function
errNATURE COMMUNICATIONS
IF15.7
err2024-10-23
err1
errOAAI
errGaleano, Diego; Imrat, Jeffrey; Haltom, Jeffrey; Andolino, Chaylen; Yousey, Aliza; Zaksas, Victoria; Das, Saswati; Baylin, Stephen B.; Wallace, Douglas C.; Slack, Frank J.; Enguita, Francisco J.; Wurtele, Eve Syrkin; Teegarden, Dorothy; Meller, Robert; Cifuentes, Daniel; Beheshti, Afshin
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Post-transcriptional methylation of mitochondrial-tRNA differentially contributes to mitochondrial pathology
errNATURE COMMUNICATIONS
IF15.7
err2024-10-18
err0
errOAAI
errMaharjan, Sunita; Gamper, Howard; Yamaki, Yuka; Christian, Thomas; Henley, Robert Y.; Li, Nan-Sheng; Suzuki, Takeo; Suzuki, Tsutomu; Piccirilli, Joseph A.; Wanunu, Meni; Seifert, Erin; Wallace, Douglas C.; Hou, Ya-Ming
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errSave
Ketone bodies resume mitochondrial respiration in neuronal progenitors from iPSCs of patients with AGC1 deficiency
errBIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
IF2.7
err2024-09-01
err0
PREAI
errLasorsa, Francesco M.; Barile, Simona N.; Magnifico, Maria C.; Distelmaier, Felix; Poeta, Eleonora; Viggiano, Luigi; Pignataro, Antonella; Antonicelli, Marica; Palmieri, Luigi; Petralla, Sabrina; Hentschel, Julia; Porcelli, Vito; Tioli, Gaia; Pisano, Isabella; Porcelli, Anna Maria; Fiermonte, Giuseppe; Palmieri, Ferdinando; Anderson, Stewart A.; Iommarini, Luisa; Wallace, Douglas C.; Monti, Barbara
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Low Magnetic Fields Stimulates Cardiac Mitochondrial Bioenergetics with a Bell-Shaped Response, Possibly Through the Radical Pair Mechanism
errBIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
IF2.7
err2024-09-01
err0
PREAI
errSheu, Shey-Shing; Beutner, Gisela; Yuh, Huoy-Jen; Goldenberg, Ilan; Wallace, Douglas C.; Porter, George A., Jr.; Moss, Arthur J.
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Spatially resolved multiomics on the neuronal effects induced by spaceflight in mice
errNATURE COMMUNICATIONS
IF15.7
err2024-06-11
err5
errOAAI
errMasarapu, Yuvarani; Cekanaviciute, Egle; Andrusivova, Zaneta; Westholm, Jakub O.; Bjorklund, Asa; Fallegger, Robin; Badia-i-Mompel, Pau; Boyko, Valery; Vasisht, Shubha; Saravia-Butler, Amanda; Gebre, Samrawit; Lazar, Eniko; Graziano, Marta; Frapard, Solene; Hinshaw, Robert G.; Bergmann, Olaf; Taylor, Deanne M.; Wallace, Douglas C.; Sylven, Christer; Meletis, Konstantinos; Saez-Rodriguez, Julio; Galazka, Jonathan M.; Costes, Sylvain V.; Giacomello, Stefania
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Space radiation damage rescued by inhibition of key spaceflight associated miRNAs
errNATURE COMMUNICATIONS
IF15.7
err2024-06-11
err3
errOAAI
errMcDonald, J. Tyson; Kim, JangKeun; Farmerie, Lily; Johnson, Meghan L.; Trovao, Nidia S.; Arif, Shehbeel; Siew, Keith; Tsoy, Sergey; Bram, Yaron; Park, Jiwoon; Overbey, Eliah; Ryon, Krista; Haltom, Jeffrey; Singh, Urminder; Enguita, Francisco J.; Zaksas, Victoria; Guarnieri, Joseph W.; Topper, Michael; Wallace, Douglas C.; Meydan, Cem; Baylin, Stephen; Meller, Robert; Muratani, Masafumi; Porterfield, D. Marshall; Kaufman, Brett; Mori, Marcelo A.; Walsh, Stephen B.; Sigaudo-Roussel, Dominique; Mebarek, Saida; Bottini, Massimo; Marquette, Christophe A.; Wurtele, Eve Syrkin; Schwartz, Robert E.; Galeano, Diego; Mason, Christopher E.; Grabham, Peter; Beheshti, Afshin
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Research Directions

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