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D

Derek W. Cain

Duke University

32H-index
100Paper Count
6.2KCitation Count
Published Papers 43
Publication Date
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Env-antibody coevolution identifies B cell priming as the principal bottleneck to HIV V2 apex broadly neutralizing antibody development
errScience Immunology
IF16.3
err2026-02-13
err0
PREAI
errRumi Habib; Ryan S. Roark; Hui Li; Andrew Jesse Connell; Michael P. Hogarty; Kshitij Wagh; Shuyi Wang; Lorie Marchitto; Ashwin N. Skelly; John W. Carey; Kirsten J. Sowers; Kasirajan Ayyanathan; Samantha J. Plante; Frederic Bibollet-Ruche; Younghoon Park; Colby J. Agostino; Ajay Singh; Christian L. Martella; Emily Lewis; Juliette M. Rando; Neha Chohan; Jinery Lora; Wenge Ding; Mary S. Campion; Chengyan Zhao; Weimin Liu; Yingying Li; Xuduo Li; Bo Liang; Rohan Roy Chowdhury; Khaled Amereh; Elizabeth Van Itallie; Zizhang Sheng; Amrit R. Ghosh; Katharine J. Bar; Wilton B. Williams; Kevin Wiehe; Kevin O. Saunders; Robert J. Edwards; Derek W. Cain; Mark G. Lewis; Facundo D. Batista; Dennis R. Burton; Raiees Andrabi; Daniel W. Kulp; Barton F. Haynes; Bette Korber; Lawrence Shapiro; Peter D. Kwong; Beatrice H. Hahn; George M. Shaw
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errSave
A neutralizing human antibody induces movement of the HCoV-229E receptor binding domain
errCommunications Biology
IF5.1
err2025-12-31
err0
errOAAI
errMera F. Liccione; Trevor Scobey; Heather M. Froggatt; Camryn Pajon; Boyd L. Yount; Qi Yin; Taylor N. Spence; Emmanuel B. Walter; Kevin O. Saunders; Robert J. Edwards; Ralph S. Baric; Barton F. Haynes; Derek W. Cain; Timothy P. Sheahan; Daniel Wrapp
errShare
errSave
On the carrying capacity of the bone marrow survival niche in mice
errFrontiers in Immunology
IF5.9
err2025-11-20
err0
errOAAI
errKeisuke Tonouchi†; Chen-Hao Yeh†; Derek W. Cain; E. Ashley Moseman; Barton F. Haynes; Kshitij Wagh; Kevin Wiehe; Tomohiro Kurosaki; Garnett Kelsoe
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errSave
Vaccine induction of heterologous HIV-1-neutralizing antibody B cell lineages in humans
errCell
IF42.5
err2025-11-01
err0
errOAAI
errWilton B. Williams; S. Munir Alam; Gilad Ofek; Nathaniel Erdmann; David C. Montefiori; Michael S. Seaman; Kshitij Wagh; Bette Korber; Robert J. Edwards; Katayoun Mansouri; Amanda Eaton; Derek W. Cain; Mitchell Martin; JongIn Hwang; Aria Arus-Altuz; Xiaozhi Lu; Fangping Cai; Nolan Jamieson; Robert Parks; Maggie Barr; Andrew Foulger; Kara Anasti; Parth Patel; Salam Sammour; Ruth J. Parsons; Xiao Huang; Jared Lindenberger; Susan Fetics; Katarzyna Janowska; Aurelie Niyongabo; Benjamin M. Janus; Anagh Astavans; Christopher B. Fox; Ipsita Mohanty; Tyler Evangelous; Yue Chen; Madison Berry; Helene Kirshner; Elizabeth Van Itallie; Kevin O. Saunders; Kevin Wiehe; Kristen W. Cohen; M. Juliana McElrath; Lawrence Corey; Priyamvada Acharya; Stephen R. Walsh; Lindsey R. Baden; Barton F. Haynes
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errSave
Engineering immunogens that select for specific mutations in HIV broadly neutralizing antibodies
errNATURE COMMUNICATIONS
IF15.7
err2024-11-03
err0
errOAAI
errHenderson, Rory; Anasti, Kara; Manne, Kartik; Stalls, Victoria; Saunders, Carrie; Bililign, Yishak; Williams, Ashliegh; Bubphamala, Pimthada; Montani, Maya; Kachhap, Sangita; Li, Jingjing; Jaing, Chuancang; Newman, Amanda; Cain, Derek W.; Lu, Xiaozhi; Venkatayogi, Sravani; Berry, Madison; Wagh, Kshitij; Korber, Bette; Saunders, Kevin O.; Tian, Ming; Alt, Fred; Wiehe, Kevin; Acharya, Priyamvada; Alam, S. Munir; Haynes, Barton F.
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errSave
Comparison of the immunogenicity of mRNA-encoded and protein HIV-1 Env-ferritin nanoparticle designs
errJOURNAL OF VIROLOGY
IF3.8
err2024-09-17
err1
PREAI
errMu, Zekun; Whitley, Jill; Martik, Diana; Sutherland, Laura; Newman, Amanda; Barr, Maggie; Parks, Robert; Wiehe, Kevin; Cain, Derek W.; Hodges, Katrina Z.; Venkatayogi, Sravani; Lee, Esther M.; Smith, Lena; Mansouri, Katayoun; Edwards, Robert J.; Wang, Yunfei; Rountree, Wes; Alameh, Mohamad-Gabriel; Tam, Ying; Barbosa, Christopher; Tomai, Mark; Lewis, Mark G.; Santrai, Sampa; Maughan, Maureen; Tian, Ming; Alt, Frederick W.; Weissman, Drew; Saunders, Kevin O.; Haynes, Barton F.
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errSave
Conjugation of HIV-1 envelope to hepatitis B surface antigen alters vaccine responses in rhesus macaques
errNPJ VACCINES
IF6.5
err2023-11-24
err0
errOAAI
errNettere, Danielle; Unnithan, Shakthi; Rodgers, Nicole; Nohara, Junsuke; Cray, Paul; Berry, Madison; Jones, Caroline; Armand, Lawrence; Li, Shuk Hang; Berendam, Stella J.; Fouda, Genevieve G.; Cain, Derek W.; Spence, Taylor N.; Granek, Joshua A.; Davenport, Clemontina A.; Edwards, Robert J.; Wiehe, Kevin; Van Rompay, Koen K. A.; Moody, M. Anthony; Permar, Sallie R.; Pollara, Justin
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errSave
Neonatal SHIV infection in rhesus macaques elicited heterologous HIV-1-neutralizing antibodies
errCELL REPORTS
IF6.9
err2023-03-01
err4
errOAAI
errHora, Bhavna; Li, Hui; Shen, Xiaoying; Martin, Mitchell; Chen, Yue; Berry, Madison; Evangelous, Tyler; Macintyre, Andrew N.; Arus-Altuz, Aria; Wang, Shuyi; Singh, Ajay; Zhao, Chengyan; De Naeyer, Nicole; DeMarco, Todd; Kuykendall, Cindy; Gurley, Thaddeus; Saunders, Kevin O.; Denny, Thomas; Moody, M. Anthony; Misamore, John; Lewis, Mark G.; Wiehe, Kevin; Cain, Derek W.; Montefiori, David C.; Shaw, George M.; Williams, Wilton B.
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errSave
A Germline-Targeting Chimpanzee SIV Envelope Glycoprotein Elicits a New Class of V2-Apex Directed Cross-Neutralizing Antibodies
errMBIO
IF4.7
err2023-02-28
err4
errOAAI
errBibollet-Ruche, Frederic; Russell, Ronnie M. M.; Ding, Wenge; Liu, Weimin; Li, Yingying; Wagh, Kshitij; Wrapp, Daniel; Habib, Rumi; Skelly, Ashwin N. N.; Roark, Ryan S. S.; Sherrill-Mix, Scott; Wang, Shuyi; Rando, Juliette; Lindemuth, Emily; Cruickshank, Kendra; Park, Younghoon; Baum, Rachel; Carey, John W. W.; Connell, Andrew Jesse; Li, Hui; Giorgi, Elena E. E.; Song, Ge S. S.; Ding, Shilei; Finzi, Andres; Newman, Amanda; Hernandez, Giovanna E. E.; Machiele, Emily; Cain, Derek W. W.; Mansouri, Katayoun; Lewis, Mark G. G.; Montefiori, David C. C.; Wiehe, Kevin J. J.; Alam, S. Munir; Teng, I-Ting; Kwong, Peter D. D.; Andrabi, Raiees; Verkoczy, Laurent; Burton, Dennis R. R.; Korber, Bette T. T.; Saunders, Kevin O. O.; Haynes, Barton F. F.; Edwards, Robert J. J.; Shaw, George M. M.; Hahn, Beatrice H. H.
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errSave
Breadth of SARS-CoV-2 neutralization and protection induced by a nanoparticle vaccine
errNATURE COMMUNICATIONS
IF15.7
err2022-10-23
err36
errOAAI
errLi, Dapeng; Martinez, David R.; Schafer, Alexandra; Chen, Haiyan; Barr, Maggie; Sutherland, Laura L.; Lee, Esther; Parks, Robert; Mielke, Dieter; Edwards, Whitney; Newman, Amanda; Bock, Kevin W.; Minai, Mahnaz; Nagata, Bianca M.; Gagne, Matthew; Douek, Daniel; DeMarco, C. Todd; Denny, Thomas N.; Oguin, Thomas H., III; Brown, Alecia; Rountree, Wes; Wang, Yunfei; Mansouri, Katayoun; Edwards, Robert J.; Ferrari, Guido; Sempowski, Gregory D.; Eaton, Amanda; Tang, Juanjie; Cain, Derek W.; Santra, Sampa; Pardi, Norbert; Weissman, Drew; Tomai, Mark; Fox, Christopher; Moore, Ian N.; Andersen, Hanne; Lewis, Mark G.; Golding, Hana; Khurana, Surender; Seder, Robert; Baric, Ralph S.; Montefiori, David C.; Saunders, Kevin O.; Haynes, Barton F.
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errSave
Stabilized HIV-1 envelope immunization induces neutralizing antibodies to the CD4bs and protects macaques against mucosal infection
errSCIENCE TRANSLATIONAL MEDICINE
IF14.6
err2022-09-07
err18
errOAAI
errSaunders, Kevin O.; Edwards, Robert J.; Tilahun, Kedamawit; Manne, Kartik; Lu, Xiaozhi; Cain, Derek W.; Wiehe, Kevin; Williams, Wilton B.; Mansouri, Katayoun; Hernandez, Giovanna E.; Sutherland, Laura; Scearce, Richard; Parks, Robert; Barr, Maggie; DeMarco, Todd; Eater, Chloe M.; Eaton, Amanda; Morton, Georgeanna; Mildenberg, Benjamin; Wang, Yunfei; Rountree, R. Wes; Tomai, Mark A.; Fox, Christopher B.; Moody, M. Anthony; Alam, S. Munir; Santra, Sampa; Lewis, Mark G.; Denny, Thomas N.; Shaw, George M.; Montefiori, David C.; Acharya, Priyamvada; Haynes, Barton F.
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errSave
Immunogenicity of a germline-targeting nanoparticle in knock-in mice expressing human B cell receptors of the HIV gp41 neutralizing antibody, DH511
errJOURNAL OF IMMUNOLOGY
IF3.4
err2022-05-01
err0
PREAI
errCain, Derek Wilson; Tian, Ming; Schiffner, Torben; Rantalainen, Kimmo; Saunders, Kevin O.; Wiehe, Kevin; Watts, Brian; Ward, Andrew; Ofek, Gilad; Alt, Frederick W.; Haynes, Barton F.; Schief, William R.; Alam, S. Munir
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errSave
Mouse and human antibodies bind HLA-E-leader peptide complexes and enhance NK cell cytotoxicity
errCOMMUNICATIONS BIOLOGY
IF5.1
err2022-03-28
err15
errOAAI
errLi, Dapeng; Brackenridge, Simon; Walters, Lucy C.; Swanson, Olivia; Harlos, Karl; Rozbesky, Daniel; Cain, Derek W.; Wiehe, Kevin; Scearce, Richard M.; Barr, Maggie; Mu, Zekun; Parks, Robert; Quastel, Max; Edwards, Robert J.; Wang, Yunfei; Rountree, Wes; Saunders, Kevin O.; Ferrari, Guido; Borrow, Persephone; Jones, E. Yvonne; Alam, S. Munir; Azoitei, Mihai L.; Gillespie, Geraldine M.; McMichael, Andrew J.; Haynes, Barton F.
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errSave
mRNA-encoded HIV-1 Env trimer ferritin nanoparticles induce monoclonal antibodies that neutralize heterologous HIV-1 isolates in mice
errCELL REPORTS
IF6.9
err2022-03-01
err36
errOAAI
errMu, Zekun; Wiehe, Kevin; Saunders, Kevin O.; Henderson, Rory; Cain, Derek W.; Parks, Robert; Martik, Diana; Mansouri, Katayoun; Edwards, Robert J.; Newman, Amanda; Lu, Xiaozhi; Shi-Mao Xia; Eaton, Amanda; Bonsignori, Mattia; Montefiori, David; Han, Qifeng; Venkatayogi, Sravani; Evangelous, Tyler; Wang, Yunfei; Rountree, Wes; Korber, Bette; Wagh, Kshitij; Tam, Ying; Barbosa, Christopher; Alam, S. Munir; Williams, Wilton B.; Tian, Ming; Alt, Frederick W.; Pardi, Norbert; Weissman, Drew; Haynes, Barton F.
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errSave
Strategies for eliciting multiple lineages of broadly neutralizing antibodies to HIV by vaccination
errCURRENT OPINION IN VIROLOGY
IF5.1
err2021-12-01
err14
errOAAI
errMu, Zekun; Haynes, Barton F.; Cain, Derek W.
errShare
errSave
HIV envelope antigen valency on peptide nanofibers modulates antibody magnitude and binding breadth
errSCIENTIFIC REPORTS
IF3.9
err2021-07-14
err14
errOAAI
errFries, Chelsea N.; Chen, Jui-Lin; Dennis, Maria L.; Votaw, Nicole L.; Eudailey, Joshua; Watts, Brian E.; Hainline, Kelly M.; Cain, Derek W.; Barfield, Richard; Chan, Cliburn; Moody, M. Anthony; Haynes, Barton F.; Saunders, Kevin O.; Permar, Sallie R.; Fouda, Genevieve G.; Collier, Joel H.
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errSave
HIV mRNA Vaccines-Progress and Future Paths
errVACCINES
IF3.4
err2021-02-07
err49
errOAAI
errMu, Zekun; Haynes, Barton F.; Cain, Derek W.
errShare
errSave
After 62 years of regulating immunity, dexamethasone meets COVID-19
errNATURE REVIEWS IMMUNOLOGY
IF60.9
err2020-08-10
err91
errOAAI
errCain, Derek W.; Cidlowski, John A.
errShare
errSave
Murine Glucocorticoid Receptors Orchestrate B Cell Migration Selectively between Bone Marrow and Blood
errJOURNAL OF IMMUNOLOGY
IF3.4
err2020-08-01
err23
errOAAI
errCain, Derek W.; Bortner, Carl D.; Diaz-Jimenez, David; Petrillo, Maria G.; Gruver-Yates, Amanda; Cidlowski, John A.
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errSave
Conditional antibody expression to avoid central B cell deletion in humanized HIV-1 vaccine mouse models
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2020-03-24
err8
errOAAI
errTian, Ming; McGovern, Kelly; Cheng, Hwei-Ling; Waddicor, Peyton; Rieble, Lisa; Dao, Mai; Chen, Yiwei; Kimble, Michael T.; Cantor, Elizabeth; Manfredonia, Nicole; Judson, Rachael; Chapdelaine-Williams, Aimee; Cain, Derek W.; Haynes, Barton F.; Alt, Frederick W.
errShare
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Research Directions

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Co-authors
Cooperation Journals
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Dennis R. Burton
H-index: 172 · Papers: 800
F
Frederick W. Alt
H-index: 172 · Papers: 637
L
Lawrence Corey
H-index: 162 · Papers: 1.2K
R
Rafi Ahmed
H-index: 162 · Papers: 764
J
John R. Mascola
H-index: 152 · Papers: 777
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