Not logged in Remodelling of the immune landscape by IFNγ counteracts IFNγ-dependent tumour escape in mouse tumour models Lau, Vivian W. C.; Mead, Gracie J.; Varyova, Zofia; Mazet, Julie M.; Krishnan, Anagha; Roberts, Edward W.; Prota, Gennaro; Gileadi, Uzi; Midwood, Kim S.; Cerundolo, Vincenzo; Gerard, Audrey Share Save
Semaphorin 3A causes immune suppression by inducing cytoskeletal paralysis in tumour-specific CD8+ T cells (vol 15, 3448 , 2024) Barnkob, Mike B.; Michaels, Yale S.; Andre, Violaine; Macklin, Philip S.; Gileadi, Uzi; Valvo, Salvatore; Rei, Margarida; Kulicke, Corinna; Chen, Ji-Li; Jain, Vitul; Woodcock, Victoria K.; Colin-York, Huw; Hadjinicolaou, Andreas V.; Kong, Youxin; Mayya, Viveka; Mazet, Julie M.; Mead, Gracie-Jennah; Bull, Joshua A.; Rijal, Pramila; Pugh, Christopher W.; Townsend, Alain R.; Gerard, Audrey; Olsen, Lars R.; Fritzsche, Marco; Fulga, Tudor A.; Dustin, Michael L.; Jones, E. Yvonne; Cerundolo, Vincenzo Share Save
ATF4-SLC7A11-GSH axis mediates the acquisition of immunosuppressive properties by activated CD4+T cells in low arginine condition Zou, Ziqi; Cheng, Qian; Zhou, Jiajie; Guo, Chenyao; Hadjinicolaou, Andreas, V; Salio, Mariolina; Liang, Xinghua; Yang, Cuiyu; Du, Yue; Yao, Weiran; Wang, Dongrui; Cerundolo, Vincenzo; Wang, Qingqing; Xia, Meng Share Save
Lipoproteins act as vehicles for lipid antigen delivery and activation of invariant natural killer T cells Engelen, Suzanne E.; Ververs, Francesca A.; Markovska, Angela; Lagerholm, B. Christoffer; Kraaijenhof, Jordan M.; Yousif, Laura I. E.; Zurke, Yasemin-Xiomara; Gulersonmez, Can M. C.; Kooijman, Sander; Goddard, Michael; van Eijkeren, Robert J.; Jervis, Peter J.; Besra, Gurdyal S.; Haitjema, Saskia; Asselbergs, Folkert W.; Kalkhoven, Eric; Ploegh, Hidde L.; Boes, Marianne; Cerundolo, Vincenzo; Hovingh, G. K.; Salio, Mariolina; Stigter, Edwin C. A.; Rensen, Patrick C. N.; Monaco, Claudia; Schipper, Henk S. Share Save
MAIT cells activate dendritic cells to promote TFH cell differentiation and induce humoral immunity Pankhurst, Theresa E.; Buick, Kaitlin H.; Lange, Joshua L.; Marshall, Andrew J.; Button, Kaileen R.; Palmer, Olga R.; Farrand, Kathryn J.; Montgomerie, Isabelle; Bird, Thomas W.; Mason, Ngarangi C.; Kuang, Joanna; Compton, Benjamin J.; Comoletti, Davide; Salio, Mariolina; Cerundolo, Vincenzo; Quinones-Mateu, Miguel E.; Painter, Gavin F.; Hermans, Ian F.; Connor, Lisa M. Share Save
Recombinant single-cycle influenza virus with exchangeable pseudotypes allows repeated immunization to augment anti-tumour immunity with immune checkpoint inhibitors Kandasamy, Matheswaran; Gileadi, Uzi; Rijal, Pramila; Tan, Tiong Kit; Lee, Lian N.; Chen, Jili; Prota, Gennaro; Klenerman, Paul; Townsend, Alain; Cerundolo, Vincenzo; Kurosaki, Tomohiro Share Save
Decitabine increases neoantigen and cancer testis antigen expression to enhance T-cell-mediated toxicity against glioblastoma Ma, Ruichong; Rei, Margarida; Woodhouse, Isaac; Ferris, Katherine; Kirschner, Sophie; Chandran, Anandhakumar; Gileadi, Uzi; Chen, Ji-Li; Pereira Pinho, Mariana; Ariosa-Morejon, Yoanna; Kriaucionis, Skirmantas; Ternette, Nicola; Koohy, Hashem; Ansorge, Olaf; Ogg, Graham; Plaha, Puneet; Cerundolo, Vincenzo Share Save
The P5-type ATPase ATP13A1 modulates major histocompatibility complex I-related protein 1 (MR1)-mediated antigen presentation Kulicke, Corinna A.; De Zan, Erica; Hein, Zeynep; Gonzalez-Lopez, Claudia; Ghanwat, Swapnil; Veerapen, Natacha; Besra, Gurdyal S.; Klenerman, Paul; Christianson, John C.; Springer, Sebastian; Nijman, Sebastian M.; Cerundolo, Vincenzo; Salio, Mariolina Share Save
Generation and characterization of HLA-A2 transgenic mice expressing the human TCR 1G4 specific for the HLA-A2 restricted NY-ESO-1157-165 tumor-specific peptide Shenderov, Eugene; Kandasamy, Matheswaran; Gileadi, Uzi; Chen, Jili; Shepherd, Dawn; Gibbs, James; Prota, Gennaro; Silk, Jonathan D.; Yewdell, Jonathan W.; Cerundolo, Vincenzo Share Save
Chromatin accessibility governs the differential response of cancer and T cells to arginine starvation Crump, Nicholas T.; Hadjinicolaou, Andreas, V; Xia, Meng; Walsby-Tickle, John; Gileadi, Uzi; Chen, Ji-Li; Setshedi, Mashiko; Olsen, Lars R.; Lau, I-Jun; Godfrey, Laura; Quek, Lynn; Yu, Zhanru; Ballabio, Erica; Barnkob, Mike B.; Napolitani, Giorgio; Salio, Mariolina; Koohy, Hashem; Kessler, Benedikt M.; Taylor, Stephen; Vyas, Paresh; McCullagh, James S. O.; Milne, Thomas A.; Cerundolo, Vincenzo Share Save
HLA-E-restricted, Gag-specific CD8+ T cells can suppress HIV-1 infection, offering vaccine opportunities Yang, Hongbing; Rei, Margarida; Brackenridge, Simon; Brenna, Elena; Sun, Hong; Abdulhaqq, Shaheed; Liu, Michael K. P.; Ma, Weiwei; Kurupati, Prathiba; Xu, Xiaoning; Cerundolo, Vincenzo; Jenkins, Edward; Davis, Simon J.; Sacha, Jonah B.; Frueh, Klaus; Picker, Louis J.; Borrow, Persephone; Gillespie, Geraldine M.; McMichael, Andrew J. Share Save
PLGA Nanoparticles Co-encapsulating NY-ESO-1 Peptides and IMM60 Induce Robust CD8 and CD4 T Cell and B Cell Responses Dolen, Yusuf; Gileadi, Uzi; Chen, Ji-Li; Valente, Michael; Creemers, Jeroen H. A.; Van Dinther, Eric A. W.; van Riessen, N. Koen; Jager, Eliezer; Hruby, Martin; Cerundolo, Vincenzo; Diken, Mustafa; Figdor, Carl G.; de Vries, I. Jolanda M. Share Save
Hepcidin-Mediated Hypoferremia Disrupts Immune Responses to Vaccination and Infection Frost, Joe N.; Tan, Tiong Kit; Abbas, Munawar; Wideman, Sarah K.; Bonadonna, Michael; Stoffel, Nicole U.; Wray, Katherine; Kronsteiner, Barbara; Smits, Gaby; Campagna, Dean R.; Duarte, Tiago L.; Lopes, Jose M.; Shah, Akshay; Armitage, Andrew E.; Arezes, Joao; Lim, Pei Jin; Preston, Alexandra E.; Ahern, David; Teh, Megan; Naylor, Caitlin; Salio, Mariolina; Gileadi, Uzi; Andrews, Simon C.; Dunachie, Susanna J.; Zimmermann, Michael B.; van der Klis, Fiona R. M.; Cerundolo, Vincenzo; Bannard, Oliver; Draper, Simon J.; Townsend, Alain R. M.; Galy, Bruno; Fleming, Mark D.; Lewis, Marie C.; Drakesmith, Hal Share Save
Deletion of the deISGylating enzyme USP18 enhances tumour cell antigenicity and radiosensitivity Pinto-Fernandez, Adan; Salio, Mariolina; Partridge, Tom; Chen, Jianzhou; Vere, George; Greenwood, Helene; Olie, Cyriel Sebastiaan; Damianou, Andreas; Scott, Hannah Claire; Pegg, Henry Jack; Chiarenza, Alessandra; Diaz-Saez, Laura; Smith, Paul; Gonzalez-Lopez, Claudia; Patel, Bhavisha; Anderton, Emma; Jones, Neil; Hammonds, Tim R.; Huber, Kilian; Muschel, Ruth; Borrow, Persephone; Cerundolo, Vincenzo; Kessler, Benedikt M. Share Save
Structural and functional characterization of C0021158, a high-affinity monoclonal antibody that inhibits Arginase 2 function via a novel non-competitive mechanism of action Austin, Mark; Burschowsky, Daniel; Chan, Denice T. Y.; Jenkinson, Lesley; Haynes, Stuart; Diamandakis, Agata; Seewooruthun, Chitra; Addyman, Alexandra; Fiedler, Sebastian; Ryman, Stephanie; Whitehouse, Jessica; Slater, Louise H.; Hadjinicolaou, Andreas V.; Gileadi, Uzi; Gowans, Ellen; Shibata, Yoko; Barnard, Michelle; Kaserer, Teresa; Sharma, Pooja; Luheshi, Nadia M.; Wilkinson, Robert W.; Vaughan, Tristan J.; Holt, Sarah V.; Cerundolo, Vincenzo; Carr, Mark D.; Groves, Maria A. T. Share Save
USP18 modulates the ISGylome, immune signaling and sensitizes tumor cells to irradiation and CTL recognition Pinto-Fernandez, Adan; Greenwood, Helene; Salio, Mariolina; Chen, Jianzhou; Partridge, Thomas; Vere, George; Scott, Hannah C.; Damianou, Andreas; Borrow, Persephone; Muschel, Ruth; Cerundolo, Vincenzo; Kessler, Benedikt M. Share Save
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Cell identity and nucleo-mitochondrial genetic context modulate OXPHOS performance and determine somatic heteroplasmy dynamics Victoria Lechuga-Vieco, Ana; Latorre-Pellicer, Ana; Johnston, Iain G.; Prota, Gennaro; Gileadi, Uzi; Justo-Mendez, Raquel; Acin-Perez, Rebeca; Martinez-de-Mena, Raquel; Maria Fernandez-Toro, Jose; Jimenez-Blasco, Daniel; Mora, Alfonso; Nicolas-Avila, Jose A.; Santiago, Demetrio J.; Priori, Silvia G.; Pedro Bolanos, Juan; Sabio, Guadalupe; Miguel Criado, Luis; Ruiz-Cabello, Jesus; Cerundolo, Vincenzo; Jones, Nick S.; Antonio Enriquez, Jose Share Save
Impacts of combining anti-PD-L1 immunotherapy and radiotherapy on the tumour immune microenvironment in a murine prostate cancer model Philippou, Yiannis; Sjoberg, Hanna T.; Murphy, Emma; Alyacoubi, Said; Jones, Keaton I.; Gordon-Weeks, Alex N.; Phyu, Su; Parkes, Eileen E.; Gillies McKenna, W.; Lamb, Alastair D.; Gileadi, Uzi; Cerundolo, Vincenzo; Scheiblin, David A.; Lockett, Stephen J.; Wink, David A.; Mills, Ian G.; Hamdy, Freddie C.; Muschel, Ruth J.; Bryant, Richard J. Share Save
Extensive sequence and structural evolution of Arginase 2 inhibitory antibodies enabled by an unbiased approach to affinity maturation Chan, Denice T. Y.; Jenkinson, Lesley; Haynes, Stuart W.; Austin, Mark; Diamandakis, Agata; Burschowsky, Daniel; Seewooruthun, Chitra; Addyman, Alexandra; Fiedler, Sebastian; Ryman, Stephanie; Whitehouse, Jessica; Slater, Louise H.; Gowans, Ellen; Shibata, Yoko; Barnard, Michelle; Wilkinson, Robert W.; Vaughan, Tristan J.; Holt, Sarah, V; Cerundolo, Vincenzo; Carr, Mark D.; Groves, Maria A. T. Share Save
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