Arlene H. Sharpe - Publications, H-index & Citations

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Arlene H. Sharpe

robert h. lurie comprehensive cancer center

154H-index

737Paper Count

11.0WCitation Count

Published Papers 300

Publication Date

Stability and progressive differentiation of TFR cells are intrinsically and extrinsically controlled by TFH programs

Nature Immunology

IF27.6

2026-01-13

OAAI

Jeong-Mi Lee; Paulo Lisboa Raeder; Ridwan B. Rashid; Hengcheng Zhang; Cody S. Nelson; Sierra G. Richardson; Kelly P. Burke; Pragya Chandrakar; Manuel A. Podestà; Maya G. Gempler; Cole Batty; Dejun Kong; Samuel J. Gavzy; Marina W. Shirkey; Cyrus Yang; Jonathan S. Bromberg; Marcia C. Haigis; Wayne A. Marasco; Arlene H. Sharpe; Peter T. Sage

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PD-1, BTLA and TIGIT as therapeutic targets for rheumatic disease

Nature Reviews Rheumatology

IF32.7

2025-12-02

PREAI

Juhi R. Kuchroo; Naomi Goldman; Arlene H. Sharpe

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Overcoming microbiome-dependent resistance to cancer immunotherapy

JOURNAL OF IMMUNOLOGY

IF3.4

2025-11-01

PREAI

Park, Joon Seok; Gazzaniga, Francesca S.; Wu, Meng; Luthens, Amalia K.; Gillis, Jacob; Zheng, Wen; LaFleur, Martin W.; Johnson, Sarah B.; Morad, Golnaz; Park, Elizabeth M.; Zhou, Yifan; Watowich, Stephanie S.; Wargo, Jennifer A.; Freeman, Gordon J.; Kasper, Dennis L.; Sharpe, Arlene H.

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A STUB1–CHIC2 complex inhibits CD8+ T cells to restrain tumor immunity

Nature Immunology

IF27.6

2025-08-12

PREAI

Martin W. LaFleur; Lauren E. Milling; Priyamvada Prathima; Vivian Li; Ashlyn M. Lemmen; Ivy S. L. Streeter; Paul K. S. Heisig; Nicole M. Derosia; Elizabeth Riffo; Haonan Xu; Thao H. Nguyen; Aashiya Kolengaden; Samuel C. Markson; John G. Doench; Arlene H. Sharpe

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B-cell-specific checkpoint molecules that regulate anti-tumour immunity (vol 619, pg 348, 2023)

NATURE

IF48.5

2025-03-17

PREAI

Bod, Lloyd; Kye, Yoon-Chul; Shi, Jingwen; Triglia, Elena Torlai; Schnell, Alexandra; Fessler, Johannes; Ostrowski, Stephen M.; Von-Franque, Max Y.; Kuchroo, Juhi R.; Barilla, Rocky M.; Zaghouani, Sarah; Christian, Elena; Delorey, Toni Marie; Mohib, Kanishka; Xiao, Sheng; Slingerland, Nadine; Giuliano, Christopher J.; Ashenberg, Orr; Li, Zhaorong; Rothstein, David M.; Fisher, David E.; Rozenblatt-Rosen, Orit; Sharpe, Arlene H.; Quintana, Francisco J.; Apetoh, Lionel; Regev, Aviv; Kuchroo, Vijay K.

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Targeting RGMb interactions: Discovery and preclinical characterization of potent anti-RGMb antibodies blocking multiple ligand bindings

MABS

IF7.3

2024-11-26

OAAI

Meira, Maria; Frey, Aurore; Chekkat, Neila; Rybczynska, Magda; Sellam, Zaki; Park, Joon Seok; Gazzaniga, Francesca Smylie; Parmentier, Alexia; Le Gall, Marianne; Freeman, Gordon James; Kasper, Dennis Lee; Sharpe, Arlene Helen; Rambeaux, Eric; Shamshiev, Abdijapar

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In Vivo CRISPR Screening Reveals CHD7 as a Positive Regulator of Short-lived Effector Cells

JOURNAL OF IMMUNOLOGY

IF3.4

2024-10-07

PREAI

LaFleur, Martin W.; D'Andrea, Jasmin M.; Patterson, Dillon G.; Streeter, Ivy S. L.; Coxe, Matthew A.; Osborn, Jossef F.; Milling, Lauren E.; Tjokrosurjo, Qin; Gillis, Jacob E.; Nguyen, Thao H.; Schwartz, Marc A.; Hacohen, Nir; Doench, John G.; Sharpe, Arlene H.

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Epigenetic tuning of PD-1 expression improves exhausted T cell function and viral control

NATURE IMMUNOLOGY

IF27.6

2024-09-17

PREAI

Weiss, Sarah A.; Huang, Amy Y.; Fung, Megan E.; Martinez, Daniela; Chen, Alex C. Y.; LaSalle, Thomas J.; Miller, Brian C.; Scharer, Christopher D.; Hegde, Mudra; Nguyen, Thao H.; Rowe, Jared H.; Osborn, Jossef F.; Patterson, Dillon G.; Sifnugel, Natalia; Mei-An Nolan, C.; Davidson, Richard A.; Schwartz, Marc A.; Bally, Alexander P. R.; Neeld, Dennis K.; LaFleur, Martin W.; Boss, Jeremy M.; Doench, John G.; Haining, W. Nicholas; Sharpe, Arlene H.; Sen, Debattama R.

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Deciphering the effects of age on T cell immunity and immunotherapy

CANCER RESEARCH

IF16.6

2024-03-22

PREAI

Han, SeongJun; Georgiev, Peter; Schneider, Jaime; Huang, Amy; Nugmanova, Zhanel; Nguyen, Thao H.; Yao, Conghui; Johnson, Sheila; Joshi, Shakchhi; Dhiman, Ishita; Drijvers, Jefte M.; Fung, Megan; Rowe, Jared H.; Miller, Brian C.; Freeman, Gordon J.; Ringel, Alison E.; Haigis, Marcia C.; Sharpe, Arlene H.

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Editorial Expression of Concern: The threshold pattern of calcineurin-dependent gene expression is altered by loss of the endogenous inhibitor calcipressin

NATURE IMMUNOLOGY

IF27.6

2024-03-11

OAAI

Ryeom, Sandra; Greenwald, Rebecca. J.; Sharpe, Arlene. H.; Mckeon, Frank

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Framework for in vivo T cell screens

JOURNAL OF EXPERIMENTAL MEDICINE

IF10.6

2024-02-27

OAAI

Milling, Lauren E.; Markson, Samuel C.; Tjokrosurjo, Qin; Derosia, Nicole M.; Streeter, Ivy S. L.; Hickok, Grant H.; Lemmen, Ashlyn M.; Nguyen, Thao H.; Prathima, Priyamvada; Fithian, William; Schwartz, Marc A.; Hacohen, Nir; Doench, John G.; Lafleur, Martin W.; Sharpe, Arlene H.

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The B7:CD28 family and friends Unraveling coinhibitory interactions

IMMUNITY

IF26.3

2024-02-01

OAAI

Burke, Kelly P.; Chaudhri, Apoorvi; Freeman, Gordon J.; Sharpe, Arlene H.

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Regulatory T cells in skin mediate immune privilege of the hair follicle stem cell niche

SCIENCE IMMUNOLOGY

IF16.3

2024-01-12

OAAI

Cohen, Jarish N.; Gouirand, Victoire; Macon, Courtney E.; Lowe, Margaret M.; Boothby, Ian C.; Moreau, Joshua M.; Gratz, Iris K.; Stoecklinger, Angelika; Weaver, Casey T.; Sharpe, Arlene H.; Ricardo-Gonzalez, Roberto R.; Rosenblum, Michael D.

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Regulatory T cells in dominant immunologic tolerance

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IF11.2

2024-01-01

PREAI

Georgiev, Peter; Benamar, Mehdi; Han, SeongJun; Haigis, Marcia C.; Sharpe, Arlene H.; Chatila, Talal A.

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Antigen presentation deficiency, mesenchymal differentiation, and resistance to immunotherapy in the murine syngeneic CT2A tumor model

FRONTIERS IN IMMUNOLOGY

IF5.9

2023-12-28

OAAI

Iorgulescu, J. Bryan; Ruthen, Neil; Ahn, Ryuhjin; Panagioti, Eleni; Gokhale, Prafulla C.; Neagu, Martha; Speranza, Maria C.; Eschle, Benjamin K.; Soroko, Kara M.; Piranlioglu, Raziye; Datta, Meenal; Krishnan, Shanmugarajan; Yates, Kathleen B.; Baker, Gregory J.; Jain, Rakesh K.; Suva, Mario L.; Neuberg, Donna; White, Forest M.; Chiocca, E. Antonio; Freeman, Gordon J.; Sharpe, Arlene H.; Wu, Catherine J.; Reardon, David A.

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X-CHIME enables combinatorial, inducible, lineage-specific and sequential knockout of genes in the immune system

NATURE IMMUNOLOGY

IF27.6

2023-11-27

OAAI

Lafleur, Martin W.; Lemmen, Ashlyn M.; Streeter, Ivy S. L.; Nguyen, Thao H.; Milling, Lauren E.; Derosia, Nicole M.; Hoffman, Zachary M.; Gillis, Jacob E.; Tjokrosurjo, Qin; Markson, Samuel C.; Huang, Amy Y.; Anekal, Praju V.; Montero Llopis, Paula; Haining, W. Nicholas; Doench, John G.; Sharpe, Arlene H.

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Formate Supplementation Enhances Antitumor CD8+ T-cell Fitness and Efficacy of PD-1 Blockade

CANCER DISCOVERY

IF33.3

2023-09-20

OAAI

Rowe, Jared H.; Elia, Ilaria; Shahid, Osmaan; Gaudiano, Emily F.; Sifnugel, Natalia E.; Johnson, Sheila; Reynolds, Amy G.; Fung, Megan E.; Joshi, Shakchhi; LaFleur, Martin W.; Park, Joon Seok; Pauken, Kristen E.; Rabinowitz, Joshua D.; Freeman, Gordon J.; Haigis, Marcia C.; Sharpe, Arlene H.

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Microbiota-dependent regulation of costimulatory and coinhibitory pathways via innate immune sensors and implications for immunotherapy

EXPERIMENTAL AND MOLECULAR MEDICINE

IF12.9

2023-09-11

OAAI

Park, Joon Seok; Gazzaniga, Francesca S.; Kasper, Dennis L.; Sharpe, Arlene H.

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Metabolic modulation of mitochondrial mass during CD4+T cell activation

CELL CHEMICAL BIOLOGY

IF7.2

2023-09-01

OAAI

Kurmi, Kiran; Liang, Dan; van de Ven, Robert; Georgiev, Peter; Gassaway, Brandon Mark; Han, Seongjun; Notarangelo, Giulia; Harris, Isaac S.; Yao, Cong-Hui; Park, Joon Seok; Hu, Song-Hua; Peng, Jingyu; Drijvers, Jefte M.; Boswell, Sarah; Sokolov, Artem; Dougan, Stephanie K.; Sorger, Peter K.; Gygi, Steven P.; Sharpe, Arlene H.; Haigis, Marcia C.

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Single-cell profiling reveals unique features of diabetogenic T cells in anti-PD-1-induced type 1 diabetes mice

JOURNAL OF EXPERIMENTAL MEDICINE

IF10.6

2023-07-11

OAAI

Collier, Jenna L.; Pauken, Kristen E.; Lee, Catherine A. A.; Patterson, Dillon G.; Markson, Samuel C.; Conway, Thomas S.; Fung, Megan E.; France, Joshua A.; Mucciarone, Kyla N.; Lian, Christine G.; Murphy, George F.; Sharpe, Arlene H.

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Research Directions