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M

Manolis Pasparakis

University of Cologne

98H-index
306Paper Count
4.4WCitation Count
Published Papers 172
Publication Date
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Cytotoxic CD4+ T cells induce age-associated myelopoiesis through CCL5–CCR5 signaling
errNature Aging
IF19.4
err2026-08-26
err0
errOAAI
errEnrique Gabandé-Rodríguez; Gonzalo Soto-Heredero; Elisa Carrasco; Carlos Anerillas; José Ignacio Escrig-Larena; Jorge Martínez-Cano; Sandra Delgado-Pulido; Isaac Francos-Quijorna; Gabriela Desdín-Micó; Tatiana Smirnova; Manuel M. Gómez de las Heras; Álvaro Fernández-Almeida; Alice Leandri; Andrea Cugurra; Eva María Blanco; Elia Winand-Osete; Pablo Ramírez-Ruiz de Erenchun; Virginia Zorita; Camilla Bean; Valentin Basset; Françoise Solly; Amanda Garrido; Rafael de Cabo; Santos Mañes; Manolis Pasparakis; Matteo Iannacone; César Cobaleda; Olaia Naveiras; Myriam Gorospe; María Mittelbrunn
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errSave
The anti-tumour activity of TNF in melanoma is determined by cFLIP
errCell Death & Disease
IF9.6
err2026-08-01
err0
errOAAI
errJohanna Stachelscheid; Cäcilia Kaul; Katrin Gerstenberg; J. Paul Werthenbach; Fabian Schorn; Joy Steinkamp; Paola Zigrino; Manolis Pasparakis; Lars M. Schiffmann; Hamid Kashkar
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errSave
Oncogenic KRAS-driven type I interferon signalling primes pancreatic cancer for necroptosis
errNature Communications
IF15.7
err2026-06-15
err0
errOAAI
errSofya Tishina; Alina Dahlhaus; Marta Manik; Lejla Mulalic; Janine Murr; Michael Kotliar; Hassan Rakhsh-Khorshid; Myrto Kostopoulou; Florian Hocher; Jenny Stroh; Julia Beck; Riley M. Williams; Gülce G. Balta; Fanyu Liu; Ali T. Abdallah; Christina M. Bebber; Moritz Reese; Jonathan K. M. Lim; Alexander Quaas; Johannes Brägelmann; Manolis Pasparakis; Filippo Beleggia; Siddharth Balachandran; Anna Trauzold; Gianmaria Liccardi; Igor Astsaturov; Maximilian Reichert; Ariadne Androulidaki; Silvia von Karstedt
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errSave
Loss of MLKL impairs abdominal aortic aneurysm development by attenuating smooth muscle cell necroptosis
errCell Death & Disease
IF9.6
err2026-02-11
err0
errOAAI
errHarshal Nemade; Dennis Mehrkens; Hannah Sophia Lottermoser; Zeynep Ece Yilmaz; Julian Mader; Patrik Schelemei; Felix Ruben Picard; Simon Geißen; Gülsah Fülgen Schwab; Friedrich Felix Hoyer; Henning Guthoff; Alexander Hof; Felix Sebastian Nettersheim; Agapios Sachinidis; Norbert Gerdes; Gerhard Sengle; Holger Winkels; Stefan Baldus; Manolis Pasparakis; Martin Mollenhauer; Matti Adam
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errSave
DNA-protein cross-links promote cGAS-STING–driven premature aging and embryonic lethality
errScience
IF45.8
err2026-01-29
err0
PREAI
errInes Tomaskovic; Cristian Prieto-Garcia; Maria Boskovic; Mateo Glumac; Tsung-Lin Tsai; Thorsten Mosler; Rubina Kazi; Rajeshwari Rathore; Jorge Andrade; Marina Hoffmann; Giulio Giuliani; Anne-Claire Jacomin; Raquel S. Pereira; Elias Knop; Laurens Wachsmuth; Petra Beli; Koraljka Husnjak; Manolis Pasparakis; Andrea Ablasser; Daniela S. Krause; Michael Potente; Stamatis Papathanasiou; Janos Terzic; Ivan Dikic
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errSave
Lack of caspase 8 directs neuronal progenitor-like reprogramming and small cell lung cancer progression
errNature Communications
IF15.7
err2025-12-18
err0
errOAAI
errAriadne Androulidaki; Fanyu Liu; Christina M. Bebber; Ilmars Kisis; Vignesh Sakthivelu; Pascal Hunold; Lioba Koerner; Alina Dahlhaus; Fatma Isil Yapici; Christina Grimm; Alicja Pacholewska; Sofya Tishina; Franka Doskotz; Lucia A. Torres Fernández; Jenny Stroh; Ali T. Abdallah; Julia Beck; Lejla Mulalic; Anna Schmitt; Holger Grüll; Thorsten Persigehl; Alexander Quaas; Martin Peifer; Johannes Brägelmann; H. Christian Reinhardt; Pascal Nieper; Robert Hänsel-Hertsch; Roman K. Thomas; Julie George; Michal R. Schweiger; Manolis Pasparakis; Filippo Beleggia; Silvia von Karstedt
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Kinase-independent functions of RIPK1 regulate hepatocyte survival and liver carcinogenesis (vol 127, pg 2662, 2017)
errJOURNAL OF CLINICAL INVESTIGATION
IF13.6
err2025-12-01
err1
PREAI
errVan, Trieu-My; Polykratis, Apostolos; Straub, Beate Katharina; Kondylis, Vangelis; Papadopoulou, Nikoletta; Pasparakis, Manolis
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492 Apoptosis, the silent cell death - Challenging the dogma
errJournal of Investigative Dermatology
IF5.7
err2025-11-24
err0
PREAI
errL Injarabian; B Roeck; A Majoul; K Kelepouras; G Liccardi; S Willenborg; M Pasparakis; H Kashkar; A Garcia Saez; SA Eming
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errSave
Author Correction: TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2
errNature
IF48.5
err2025-11-06
err0
errOAAI
errManolis Pasparakis; Gilles Courtois; Martin Hafner; Marc Schmidt-Supprian; Arianna Nenci; Atiye Toksoy; Monika Krampert; Matthias Goebeler; Reinhard Gillitzer; Alain Israel; Thomas Krieg; Klaus Rajewsky; Ingo Haase
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RIPK1 autophosphorylation at S161 mediates cell death and inflammation
errJOURNAL OF EXPERIMENTAL MEDICINE
IF10.6
err2025-09-25
err1
PREAI
errKoerner, Lioba; Li, Xiaoming; Silnov, Eveline; Laurien, Lucie; Pasparakis, Manolis
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errSave
Low Caspase 8 Expression Promotes Neuronal Progenitor Mimicry and Small Cell Lung Cancer Metastasis
errJournal of Thoracic Oncology
IF20.8
err2025-08-29
err0
PREAI
errAriadne Androulidaki; Fanyu Liu; Christina M. Bebber; Ilmars Kisis; Vignesh Sakthivelu; Pascal Hunold; Lioba Koerner; Alina Dahlhaus; Fatma Isil Yapici; Christina Grimm; Alicja Pacholewska; Sofya Tishina; Franka Doskotz; Lucia A. Torres Fernández; Ali T. Abdallah; Julia Beck; Lejla Mulalic; Anna Schmitt; Holger Grüll; Thorsten Persigehl; Alexander Quaas; Johannes Brägelmann; H. Christian Reinhardt; Pascal Nieper; Robert Hänsel-Hertsch; Roman K. Thomas; Julie George; Michal R. Schweiger; Manolis Pasparakis; Filippo Beleggia; Silvia von Karstedt
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errSave
Unfolded protein response transcription factor XBP1 suppresses necroptosis-induced colitis by reinforcing the mucus barrier
errImmunity
IF26.3
err2025-08-26
err0
errOAAI
errGöksu Gökberk Kaya; Robin Schwarzer; Marius Dannappel; Katerina Vlantis; Ulrike Göbel; Vangelis Kondylis; Sergei A. Nedospasov; Manolis Pasparakis
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errSave
Dessicating stress triggers and exacerbates experimental ocular Graft-versus-host-disease
errOCULAR SURFACE
IF5.6
err2025-07-01
err0
PREAI
errUta Gehlsen; Martina Maass; Daniela Stary; Svenja Wagener-Ryczek; Gwen Musial; Manolis Pasparakis; Cintia S. de Paiva; Michael E. Stern; Philipp Steven
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errSave
Endothelial CCR2 Signaling Induced by Colon Carcinoma Cells Enables Extravasation via the JAK2-Stat5 and p38MAPK Pathway (vol 22, pg 91, 2012)
errCANCER CELL
IF44.5
err2025-05-01
err0
PREAI
errWolf, Monika Julia; Hoos, Alexandra; Bauer, Judith; Boettcher, Steffen; Knust, Markus; Weber, Achim; Simonavicius, Nicole; Schneider, Christoph; Lang, Matthias; Stuerzl, Michael; Croner, Roland S.; Konrad, Andreas; Manz, Markus G.; Moch, Holger; Aguzzi, Adriano; van Loo, Geert; Pasparakis, Manolis; Prinz, Marco; Borsig, Lubor; Heikenwalder, Mathias
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errSave
MLKL activity requires a splicing-regulated, druggable intramolecular interaction
errMOLECULAR CELL
IF16.6
err2025-04-01
err0
errOAAI
errRos, Uris; Martinez-Osorio, Veronica; Valiente, Pedro A.; Abdelwahab, Yasmin; Gojkovic, Milos; Shalaby, Raed; Zanna, Silvia; Saggau, Julia; Wachsmuth, Laurens; Nemade, Harshal N.; Zoeller, Jonathan; Lottermoser, Hannah; Chen, Yu-Guang; Ibrahim, Mohamed; Kelepouras, Konstantinos; Vasilikos, Lazaros; Bedoya, Paula; Espiritu, Rafael A.; Mueller, Stefan; Altmannova, Veronika; Tieleman, D. Peter; Weir, John; Langer, Julian; Adam, Matti; Walczak, Henning; Wong, W. Wei-Lynn; Liccardi, Gianmaria; Mollenhauer, Martin; Pasparakis, Manolis; Peltzer, Nieves; Garcia-Saez, Ana J.
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errSave
Hematopoietic PI3KS deficiency aggravates murine atherosclerosis through impairment of Tregs
errJCI INSIGHT
IF6.1
err2024-11-22
err0
errOAAI
errZierden, Mario; Berghausen, Eva Maria; Gnatzy-Feik, Leoni; Millarg, Christopher; Picard, Felix Simon Ruben; Kiljan, Martha; Geissen, Simon; Polykratis, Apostolos; Zimmermann, Lea; Nies, Richard Julius; Pasparakis, Manolis; Baldus, Stephan; Valasarajan, Chanil; Pullamsetti, Soni Savai; Winkels, Holger; Vantler, Marius; Rosenkranz, Stephan
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errSave
Incontinentia pigmenti underlies thymic dysplasia, autoantibodies to type I IFNs, and viral diseases
errJOURNAL OF EXPERIMENTAL MEDICINE
IF10.6
err2024-10-01
err1
errOAAI
errRosain, Jeremie; Le Voyer, Tom; Liu, Xian; Gervais, Adrian; Polivka, Laura; Cederholm, Axel; Berteloot, Laureline; Parent, Audrey V.; Pescatore, Alessandra; Spinosa, Ezia; Minic, Snezana; Kiszewski, Ana Elisa; Tsumura, Miyuki; Thibault, Chloe; Azcoiti, Maria Esnaola; Martinovic, Jelena; Philippot, Quentin; Khan, Taushif; Marchal, Astrid; Charmeteau-De Muylder, Benedicte; Bizien, Lucy; Deswarte, Caroline; Hadjem, Lillia; Fauvarque, Marie-Odile; Dorgham, Karim; Eriksson, Daniel; Falcone, Emilia Liana; Puel, Mathilde; Uenal, Sinem; Geraldo, Amyrath; Le Floc'h, Corentin; Li, Hailun; Rheault, Sylvie; Muti, Christine; Bobrie-Moyrand, Claire; Welfringer-Morin, Anne; Fuleihan, Ramsay L.; Levy, Romain; Roelens, Marie; Gao, Liwei; Materna, Marie; Pellegrini, Silvia; Piemonti, Lorenzo; Catherinot, Emilie; Goffard, Jean-Christophe; Fekkar, Arnaud; Sacko-Sow, Aissata; Soudee, Camille; Boucherit, Soraya; Neehus, Anna-Lena; Has, Cristina; Huebner, Stefanie; Blanchard-Rohner, Geraldine; Amador-Borrero, Blanca; Utsumi, Takanori; Taniguchi, Maki; Tani, Hiroo; Izawa, Kazushi; Yasumi, Takahiro; Kanai, Sotaro; Migaud, Melanie; Aubart, Melodie; Lambert, Nathalie; Gorochov, Guy; Picard, Capucine; Soudais, Claire; L'Honneur, Anne-Sophie; Rozenberg, Flore; Milner, Joshua D.; Zhang, Shen-Ying; Vabres, Pierre; Trpinac, Dusan; Marr, Nico; Boddaert, Nathalie; Desguerre, Isabelle; Pasparakis, Manolis; Miller, Corey N.; Poziomczyk, Claudia S.; Abel, Laurent; Okada, Satoshi; Jouanguy, Emmanuelle; Cheynier, Remi; Zhang, Qian; Cobat, Aurelie; Beziat, Vivien; Boisson, Bertrand; Steffann, Julie; Fusco, Francesca; Ursini, Matilde Valeria; Hadj-Rabia, Smail; Bodemer, Christine; Bustamante, Jacinta; Luche, Herve; Puel, Anne; Courtois, Gilles; Bastard, Paul; Landegren, Nils; Anderson, Mark S.; Casanova, Jean-Laurent
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A shorter splicing isoform antagonizes ZBP1 to modulate cell death and inflammatory responses
errEMBO JOURNAL
IF8.3
err2024-09-19
err0
errOAAI
errNagata, Masahiro; Schafer, Yasmin Carvalho; Wachsmuth, Laurens; Pasparakis, Manolis
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errSave
RIPK1 is dispensable for cell death regulation in β-cells during hyperglycemia
errMOLECULAR METABOLISM
IF6.6
err2024-09-01
err2
errOAAI
errVeli, Onay; Kaya, Oyku; Varanda, Ana Beatriz; Hildebrandt, Ximena; Xiao, Peng; Estornes, Yann; Poggenberg, Matea; Wang, Yuan; Pasparakis, Manolis; Bertrand, Mathieu J. M.; Walczak, Henning; Annibaldi, Alessandro; Cardozo, Alessandra K.; Peltzer, Nieves
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The RIPK1 death domain restrains ZBP1-and TRIF-mediated cell death and inflammation
errIMMUNITY
IF26.3
err2024-07-01
err4
errOAAI
errImai, Takashi; Lin, Juan; Kaya, Goeksu Goekberk; Ju, Eunjin; Kondylis, Vangelis; Kelepouras, Konstantinos; Liccardi, Gianmaria; Kim, Chun; Pasparakis, Manolis
errShare
errSave

Research Directions

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Co-authors
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