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K

Kenneth G. C. Smith

The Walter and Eliza Hall Institute of Medical Research

100H-index
487Paper Count
3.8WCitation Count
Published Papers 158
Publication Date
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Large-scale GWAS meta-analysis of serum antibody levels in healthy individuals reveals distinct genetic architectures
errGenes and Immunity
IF4.5
err2026-08-26
err0
errOAAI
errThomas W. Willis; Effrossyni Gkrania-Klotsas; Nicholas J. Wareham; Eoin F. McKinney; Paul A. Lyons; Kenneth G. C. Smith; Chris Wallace
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errSave
Multiomic analysis identifies glutaminolysis-dependent metabolic enhancement of immune memory utilised for vaccine development
errNature Communications
IF15.7
err2026-06-26
err0
errOAAI
errJ. M. Sowerby; P. Kotagiri; S. Clare; D. Griffiths; O. Knight; I. Cuthbertson; K. Harcourt; P. Pereyra Gerber; I. Pshenichnaya; C. Connor; A. Denton; G. A. Stoll; C. Matara; C. Keel; G. Manferrari; T. Birkle; P. Naydenova; H. Peck; P. A. Lyons; I. Barr; Y. Modis; G. Dougan; N. J. Matheson; K. G. C. Smith; E. F. McKinney
errShare
errSave
Avian-origin influenza A viruses tolerate elevated pyrexic temperatures in mammals
errScience
IF45.8
err2025-11-27
err0
PREAI
errMatthew L. Turnbull; Yingxue Wang; Simon Clare; Gauthier Lieber; Stephanie L. Williams; Marko Noerenberg; Akira J. T. Alexander; Sara Clohisey Hendry; Douglas G. Stewart; Joseph Hughes; Simon Swingler; Spyros Lytras; Emma L. Davies; Katherine Harcourt; Katherine Smollett; Rute M. Pinto; Hui-Min Lee; Eleanor R. Gaunt; Colin Loney; Johanna S. Jung; Paul A. Lyons; Darrell R. Kapczynski; Edward Hutchinson; Ana da Silva Filipe; Jeffery K. Taubenberger; Suzannah J. Rihn; J. Kenneth Baillie; Ervin Fodor; Alfredo Castello; Kenneth G. C. Smith; Paul Digard; Sam J. Wilson
errShare
errSave
Anti-tumor necrosis factor treatment from diagnosis is more effective and less costly than conventional step-up care for patients with active Crohn's disease: a cost-effectiveness analysis from the PROFILE trial
errJOURNAL OF CROHNS & COLITIS
IF8.7
err2025-09-01
err0
errOAAI
errNoor, Nurulamin M.; Davies, Neil; Tahir, Warda; Bond, Simon; Dowling, Francis; Patel, Kamal, V; Lyons, Paul A.; McKinney, Eoin F.; Smith, Kenneth G. C.; Lee, James C.; Buchanan, Vanessa; Parkes, Miles
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errSave
Assessment of PredictSURE IBD Assay in a Multinational Cohort of Patients With Inflammatory Bowel Disease
errUnited European Gastroenterology Journal
IF6.7
err2025-07-11
err0
errOAAI
errDahham Alsoud; Nurulamin M. Noor; Lea Ann Chen; Vivian Abadom; Simon H. C. Anderson; Lediona Ardolli; Jordan Axelrad; Peter Bossuyt; Kenneth Croitoru; Oriana M. Damas; Lily Deng; Parakkal Deepak; Juan De La Revilla Negro; Shanika de Silva; Marc Ferrante; Karen Hills; Peter M. Irving; James O. Lindsay; Dana J. Lukin; Paul A. Lyons; Eoin F. McKinney; Maria Oliva-Hemker; Caterina Oneto; Roohi Patel; Miles Parkes; Lieven Pouillon; João Sabino; Lawrence J. Saubermann; Jenny S. Sauk; Sarah Sheibani; Kenneth G. C. Smith; Keith S. Sultan; Tony C. Tham; Sare Verstockt; Raluca Vrabie; Melissa Weidner; Huimin Yu; Bram Verstockt; James C. Lee; Séverine Vermeire
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errSave
Disease-specific B cell clones are shared between patients with Crohn's disease
errNATURE COMMUNICATIONS
IF15.7
err2025-04-17
err0
errOAAI
errKotagiri, Prasanti; Rae, William M.; Bergamaschi, Laura; Pombal, Diana; Lee, Ji-Yeun; Noor, Nurulamin M.; Sojwal, Raoul S.; Rubin, Samuel J. S.; Unger, Lukas W.; Tolmeijer, Sofie H.; Manferrari, Giulia; Bashford-Rogers, Rachael J. M.; Bingham, David B.; Stift, Anton; Rogalla, Stephan; Gubatan, John; Lee, James C.; Smith, Kenneth G. C.; Mckinney, Eoin F.; Boyd, Scott D.; Lyons, Paul A.
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errSave
Cost-effectiveness analysis of anti-TNF treatment from diagnosis for patients with moderate and severe Crohn's disease: an analysis using data from the PROFILE trial
errJOURNAL OF CROHNS & COLITIS
IF8.7
err2025-01-22
err0
PREAI
errNoor, N.; Davies, N.; Tahir, W.; Bond, S.; Dowling, F.; Brezina, B.; Patel, K.; Lee, J.; Lyons, P.; Mckinney, E.; Smith, K.; Buchanan, V; Parkes, M.; PROFILE Study Grp
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errSave
Characterization of Genetic Landscape and Novel Inflammatory Biomarkers in Patients With Adult-Onset Still's Disease
errARTHRITIS & RHEUMATOLOGY
IF10.9
err2024-12-16
err0
errOAAI
errTopping, Joanne; Chang, Leon; Nadat, Fatima; Poulter, James A.; Ibbotson, Alice; Lara-Reyna, Samuel; Watson, Christopher M.; Carter, Clive; Pournara, Linda P.; Zernicke, Jan; Ross, Rebecca L.; Cargo, Catherine; Lyons, Paul A.; Smith, Kenneth G. C.; Del Galdo, Francesco; Rech, Juergen; Fautrel, Bruno; Feist, Eugen; Mcdermott, Michael F.; Savic, Sinisa; ImmunAID Consortium
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errSave
Intratumoral antigen signaling traps CD8+ T cells to confine exhaustion to the tumor site
errSCIENCE IMMUNOLOGY
IF16.3
err2024-05-24
err3
errOAAI
errTakahashi, Munetomo; So, Tsz Y.; Chamberlain-Evans, Vitalina; Hughes, Robert; Yam-Puc, Juan Carlos; Kania, Katarzyna; Ruhle, Michelle; Mann, Tiffeney; Schuijs, Martijn J.; Coupland, Paul; Naisbitt, Dean; Halim, Timotheus Y. F.; Lyons, Paul A.; Lio, Pietro; Roychoudhuri, Rahul; Okkenhaug, Klaus; Adams, David J.; Smith, Ken G. C.; Jodrell, Duncan I.; Chapman, Michael A.; Thaventhiran, James E. D.
errShare
errSave
A biomarker-stratified comparison of top-down versus accelerated step-up treatment strategies for patients with newly diagnosed Crohn's disease (PROFILE): a multicentre, open-label randomised controlled trial
errLANCET GASTROENTEROLOGY & HEPATOLOGY
IF38.6
err2024-05-01
err43
errOAAI
errNoor, Nurulamin M.; Lee, James C.; Bond, Simon; Dowling, Francis; Brezina, Biljana; Patel, Kamal, V; Ahmad, Tariq; Banim, Paul J.; Berrill, James W.; Cooney, Rachel; Negro, Juan De La Revilla; de Silva, Shanika; Din, Shahida; Durai, Dharmaraj; Gordon, John N.; Irving, Peter M.; Johnson, Matthew; Kent, Alexandra J.; Kok, Klaartje B.; Moran, Gordon W.; Mowat, Craig; Patel, Pritash; Probert, Chris S.; Raine, Tim; Saich, Rebecca; Seward, Abigail; Sharpstone, Dan; Smith, Melissa A.; Subramanian, Sreedhar; Upponi, Sara S.; Wiles, Alan; Williams, Horace R. T.; van den Brink, Gijs R.; Vermeire, Severine; Jairath, Vipul; D'Haens, Geert R.; McKinney, Eoin F.; Lyons, Paul A.; Lindsay, James; Kennedy, Nicholas A.; Smith, Kenneth G. C.; Parkes, Miles
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errSave
Recapitulating primary immunodeficiencies with expanded potential stem cells: Proof of concept with STAT1 gain of function
errJOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
IF11.2
err2024-04-01
err1
PREAI
errLiu, Xueyan; Chan, Vera S. F.; Smith, Kenneth G. C.; Ming, Chang; Or, Chung Sze; Tsui, Faria T. W.; Gao, Bo; Cook, Matthew C.; Liu, Pentao; Lau, Chak Sing; Li, Philip Hei
errShare
errSave
Iron dysregulation and inflammatory stress erythropoiesis associates with long-term outcome of COVID-19
errNATURE IMMUNOLOGY
IF27.6
err2024-03-01
err9
errOAAI
errHanson, Aimee L.; Mule, Matthew P.; Ruffieux, Helene; Mescia, Federica; Bergamaschi, Laura; Pelly, Victoria S.; Turner, Lorinda; Kotagiri, Prasanti; Gottgens, Berthold; Hess, Christoph; Gleadall, Nicholas; Bradley, John R.; Nathan, James A.; Lyons, Paul A.; Drakesmith, Hal; Smith, Kenneth G. C.
errShare
errSave
Loss of T follicular regulatory cell-derived IL-1R2 augments germinal center reactions via increased IL-1
errJCI INSIGHT
IF6.1
err2024-02-08
err3
errOAAI
errPyrillou, Katerina; Humphry, Melanie; Kitt, Lauren A.; Rodgers, Amanda; Nus, Meritxell; Bennett, Martin R.; Smith, Kenneth G. C.; Lyons, Paul A.; Mallat, Ziad; Clarke, Murray C. H.
errShare
errSave
Proinflammatory cytokines driving cardiotoxicity in COVID-19
errCARDIOVASCULAR RESEARCH
IF13.3
err2023-12-02
err3
errOAAI
errColzani, Maria; Bargehrshare, Johannes; Mescia, Federica; Williams, Eleanor C.; Knight-Schrijver, Vincent; Lee, Jonathan; Summers, Charlotte; Mohorianu, Irina; Smith, Kenneth G. C.; Lyons, Paul A.; Sinha, Sanjay
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errSave
Prevalence of CFTR variants in primary immunodeficiency patients with bronchiectasis is an important modifying cofactor
errJOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
IF11.2
err2023-07-01
err4
errOAAI
errLawless, Dylan; Allen, Hana Lango; Thaventhiran, James E. D.; Goddard, Sarah; Burren, Oliver S.; Robson, Evie; Peckham, Daniel; Smith, Kenneth G. C.; Savic, Sinisa
errShare
errSave
Article Proteomic analysis of circulating immune cells identifies cellular phenotypes associated with COVID-19 severity
errCELL REPORTS
IF6.9
err2023-06-01
err10
errOAAI
errPotts, Martin; Fletcher-Etherington, Alice; Nightingale, Katie; Mescia, Federica; Bergamaschi, Laura; Calero-Nieto, Fernando J.; Antrobus, Robin; Williamson, James; Parsons, Harriet; Huttlin, Edward L.; Kingston, Nathalie; Gottgens, Berthold; Bradley, John R.; Lehner, Paul J.; Matheson, Nicholas J.; Smith, Kenneth G. C.; Wills, Mark R.; Lyons, Paul A.; Weekes, Michael P.
errShare
errSave
Obesity Is Associated with Attenuated Tissue Immunity in COVID-19
errAMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
IF19.4
err2023-03-01
err8
errOAAI
errGuo, Shuang A.; Bowyer, Georgina S.; Ferdinand, John R.; Maes, Mailis; Tuong, Zewen K.; Gillman, Eleanor; Liao, Mingfeng; Lindeboom, Rik G. H.; Yoshida, Masahiro; Worlock, Kaylee; Gopee, Hudaa; Stephenson, Emily; Gao, Catherine A.; Lyons, Paul A.; Smith, Kenneth G. C.; Haniffa, Muzlifah; Meyer, Kerstin B.; Nikolic, Marko Z.; Zhang, Zheng; Wunderink, Richard G.; Misharin, Alexander, V; Dougan, Gordon; Navapurkar, Vilas; Teichmann, Sarah A.; Morris, Andrew Conway; Clatworthy, Menna R.
errShare
errSave
A patient-centric modeling framework captures recovery from SARS-CoV-2 infection
errNATURE IMMUNOLOGY
IF27.6
err2023-01-30
err24
errOAAI
errRuffieux, Helene; Hanson, Aimee L.; Lodge, Samantha; Lawler, Nathan G.; Whiley, Luke; Gray, Nicola; Nolan, Tui H.; Bergamaschi, Laura; Mescia, Federica; Turner, Lorinda; de Sa, Aloka; Pelly, Victoria S.; Kotagiri, Prasanti; Kingston, Nathalie R.; Bradley, John; Holmes, Elaine; Wist, Julien K.; Nicholson, Jeremy A.; Lyons, Paul; Smith, Kenneth G. C.; Richardson, Sylvia; Bantug, Glenn; Hess, Christoph
errShare
errSave
Sec22b is a critical and nonredundant regulator of plasma cell maintenance
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2023-01-03
err6
errOAAI
errBonaud, Amelie; Gargowitsch, Laetitia; Gilbert, Simon M.; Rajan, Elanchezhian; Canales-Herrerias, Pablo; Stockholm, Daniel; Rahman, Nabila F.; Collins, Mark O.; Taskiran, Hakan; Hill, Danika L.; Alloatti, Andres; Alouche, Nagham; Balor, Stephanie; Soldan, Vanessa; Gillet, Daniel; Barbier, Julien; Bachelerie, Francoise; Smith, Kenneth G. C.; Jellusova, Julia; Bruhns, Pierre; Amigorena, Sebastian; Balabanian, Karl; Linterman, Michelle A.; Peden, Andrew A.; Espeli, Marion
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EROS is a selective chaperone regulating the phagocyte NADPH oxidase and purinergic signalling
errELIFE
IF0
err2022-11-24
err7
errOAAI
errRandzavola, Lyra O.; Mortimer, Paige M.; Garside, Emma; Dufficy, Elizabeth R.; Schejtman, Andrea; Roumelioti, Georgia; Yu, Lu; Pardo, Mercedes; Spirohn, Kerstin; Tolley, Charlotte; Brandt, Cordelia; Harcourt, Katherine; Nichols, Esme; Nahorski, Mike; Woods, Geoff; Williamson, James C.; Suresh, Shreehari; Sowerby, John M.; Matsumoto, Misaki; Santos, Celio X. C.; Kiar, Cher Shen; Mukhopadhyay, Subhankar; Rae, William M.; Dougan, Gordon J.; Grainger, John; Lehner, Paul J.; Calderwood, Michael A.; Choudhary, Jyoti; Clare, Simon; Speak, Anneliese; Santilli, Giorgia; Bateman, Alex; Smith, Kenneth G. C.; Magnani, Francesca; Thomas, David C.
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errSave

Research Directions

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