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J

Joseph L. Witztum

University of California

157H-index
605Paper Count
9.3WCitation Count
Published Papers 276
Publication Date
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Tissue tension fosters macrophage-driven lipid peroxidation-induced DNA damage
errCancer Cell
IF44.5
err2026-04-30
err0
PREAI
errMary-Kate Hayward; Jason J. Northey; Valentina Opazo-Mellado; Connor Stashko; Ori Maller; Alastair J. Ironside; Xuchu Que; Jonathon N. Lakins; E. Shelley Hwang; Joseph L. Witztum; Hugo Gonzalez; Valerie M. Weaver
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Oxidized phosphatidylcholines deposition drives chronic neurodegeneration in a mouse model of progressive multiple sclerosis via IL-1β signaling
errNature Neuroscience
IF20
err2025-12-01
err0
PREAI
errRuoqi Yu; Brian M. Lozinski; Ally Seifert; Khanh Ta; Stephanie Zandee; Deepak K. Kaushik; Jian Park; Wendy Klement; Sandra Larouche; Sotirios Tsimikas; Joseph L. Witztum; Dorian B. McGavern; Alexandre Prat; Yifei Dong
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Brief Communication: Strong Concordance of the North American Familial Chylomicronemia Syndrome Score with a Positive Genetic Diagnosis in Patients from the Balance Study
errJournal of Clinical Lipidology
IF4.6
err2025-07-23
err0
errOAAI
errAlan S. Brown; Philippe Moulin; Andrew Dibble; Veronica J. Alexander; Lu Li; Daniel Gaudet; Joseph L. Witztum; Sotirios Tsimikas; Robert A. Hegele
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Epigenetic silencing of interleukin-10 by host-derived oxidized phospholipids supports a lethal inflammatory response to infections
errImmunity
IF26.3
err2025-07-17
err0
PREAI
errMarco Di Gioia; Valentina Poli; Piao J. Tan; Roberto Spreafico; Anne Chu; Alex G. Cuenca; Zhongyang Wu; Mehdi Benamar; Laura Pandolfi; Federica Meloni; Fatemeh Askarian; Jason Hsiao; Elizaveata Borroum; Victor Nizet; Philip L.S.M. Gordts; Joseph L. Witztum; Talal A. Chatila; Janet Chou; Xu Zhou; James R. Springstead; Ivan Zanoni
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Familial chylomicronemia syndrome and treatments to target hepatic APOC3 mRNA (vol 403, 119114, 2025)
errATHEROSCLEROSIS
IF5.7
err2025-06-01
err0
PREAI
errBrinton, Eliot A.; Eckel, Robert H.; Gaudet, Daniel; Ballantyne, Christie M.; Baker, Brenda F.; Ginsberg, Henry N.; Witztum, Joseph L.
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The Role of Oxidized Phospholipids in Triggering Trained Immunity and Accelerating Atherosclerotic Plaque Inflammation during Cholesterol Cycling
errCIRCULATION
IF38.6
err2024-11-12
err0
PREAI
errLi, Zhixing; La Forest, Maxwell; Weinstock, Ada; Scolaro, Bianca; Fortounas, Konstantinos; Krautter, Franziska; Laskou, Maria; Obieta, Amaia; Espuig, Maria Nacher; Xu, Chenxi; Witztum, Joseph; Fisher, Edward
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The human milk oligosaccharide 3′sialyllactose reduces low-grade inflammation and atherosclerosis development in mice
errJCI INSIGHT
IF6.1
err2024-11-08
err0
errOAAI
errPessentheiner, Ariane R.; Spann, Nathanael J.; Autran, Chloe A.; Oh, Tae Gyu; Grunddal, Kaare, V; Coker, Joanna K. C.; Painter, Chelsea D.; Ramms, Bastian; Chiang, Austin W. T.; Wang, Chen-Vi; Hsiao, Jason; Wang, Viwen; Quach, Anthony; Booshehri, Laela M.; Hammond, Alexandra; Tognaccini, Chiara; Latasiewicz, Joanna; Willemsen, Lisa; Zengler, Karsten; Winther, Menno P. J. de; Hoffman, Hal M.; Philpott, Martin; Cribbs, Adam P.; Oppermann, Udo; Lewis, Nathan E.; Witztum, Joseph L.; Vu, Ruth; Atkins, Annette R.; Downes, Michael; Evans, Ron M.; Glass, Christopher K.; Bode, Lars; Gordts, Philip L. S. M.
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Time-Restricted Feeding Reduces Atherosclerosis in LDLR KO Mice but Not in ApoE Knockout Mice
errARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
IF7.4
err2024-09-01
err0
PREAI
errChaix, Amandine; Lin, Terry; Ramms, Bastian; Cutler, Roy G.; Le, Tiffani; Lopez, Catherine; Miu, Phuong; Pinto, Antonio F. M.; Saghatelian, Alan; Playford, Martin P.; Mehta, Nehal N.; Mattson, Mark P.; Gordts, Philip; Witztum, Joseph L.; Panda, Satchidananda
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Volanesorsen and triglyceride levels in familial chylomicronemia syndrome: Long-term efficacy and safety data from patients in an open-label extension trial (vol 17, pg 342, 2023)
errJOURNAL OF CLINICAL LIPIDOLOGY
IF4.6
err2024-05-01
err0
errOAAI
errWitztum, Joseph L.; Gaudet, Daniel; Arca, Marcello; Jones, Alan; Soran, Handrean; Gouni-Berthold, Ioanna; Stroes, Erik S. G.; Alexander, Veronica J.; Jones, Richard; Watts, Lynnetta; Xia, Shuting; Tsimikas, Sotirios
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Volanesorsen to Prevent Acute Pancreatitis in Hypertriglyceridemia
errNEW ENGLAND JOURNAL OF MEDICINE
IF78.5
err2024-02-01
err17
PREAI
errAlexander, Veronica J.; Karwatowska-Prokopczuk, Ewa; Prohaska, Thomas A.; Li, Lu; Geary, Richard S.; Gouni-Berthold, Ioanna; Oral, Elif A.; Hegele, Robert A.; Stroes, Erik S. G.; Witztum, Joseph L.; Tsimikas, Sotirios
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High immunoglobulin-M levels to oxidation-specific epitopes are associated with lower risk of acute myocardial infarction
errJOURNAL OF LIPID RESEARCH
IF4.1
err2023-06-01
err8
errOAAI
errTaleb, Adam; Willeit, Peter; Amir, Shahzada; Perkmann, Thomas; Kozma, Maria Ozsvar; Watzenboeck, Martin L.; Binder, Christoph J.; Witztum, Joseph L.; Tsimikas, Sotirios
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Volanesorsen and triglyceride levels in familial chylomicronemia syndrome: Long-term efficacy and safety data from patients in an open-label extension trial
errJOURNAL OF CLINICAL LIPIDOLOGY
IF4.6
err2023-05-01
err21
PREAI
errWitztum, Joseph L.; Gaudet, Daniel; Arca, Marcello; Jones, Alan; Soran, Handrean; Gouni-Berthold, Ioanna; Stroes, Erik S. G.; Alexander, Veronica J.; Jones, Richard; Watts, Lynnetta; Xia, Shuting; Tsimikas, Sotirios
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errSave
APOC3 inhibition with volanesorsen reduces hepatic steatosis in patients with severe hypertriglyceridemia
errJOURNAL OF CLINICAL LIPIDOLOGY
IF4.6
err2023-05-01
err26
errOAAI
errProhaska, Thomas A.; Alexander, Veronica J.; Karwatowska-Prokopczuk, Ewa; Tami, Joseph; Xia, Shuting; Witztum, Joseph L.; Tsimikas, Sotirios
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errSave
Apolipoprotein C3 induces inflammasome activation only in its delipidated form
errNATURE IMMUNOLOGY
IF27.6
err2023-02-13
err12
errOAAI
errHsu, Cheng-Chieh; Shao, Baohai; Kanter, Jenny E.; He, Yi; Vaisar, Tomas; Witztum, Joseph L.; Snell-Bergeon, Janet; McInnes, Gregory; Bruse, Shannon; Gottesman, Omri; Mullick, Adam E.; Bornfeldt, Karin E.
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Assessment of efficacy and safety of volanesorsen for treatment of metabolic complications in patients with familial partial lipodystrophy: Results of the BROADEN study
errJOURNAL OF CLINICAL LIPIDOLOGY
IF4.6
err2022-11-01
err38
PREAI
errOral, Elif A.; Garg, Abhimanyu; Tami, Joseph; Huang, Eric A.; O'Dea, Louis St. L.; Schmidt, Hartmut; Tiulpakov, Anatoly; Mertens, Ann; Alexander, Veronica J.; Watts, Lynnetta; Hurh, Eunju; Witztum, Joseph L.; Geary, Richard S.; Tsimikas, Sotirios
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The TBK1/IKKε inhibitor amlexanox improves dyslipidemia and prevents atherosclerosis
errJCI INSIGHT
IF6.1
err2022-09-08
err5
errOAAI
errZhao, Peng; Sun, Xiaoli; Liao, Zhongji; Yu, Hong; Li, Dan; Shen, Zeyang; Glass, Christopher K.; Witztum, Joseph L.; Saltiel, Alan R.
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Effect of olezarsen targeting APOC-III on lipoprotein size and particle number measured by NMR in patients with hypertriglyceridemia
errJOURNAL OF CLINICAL LIPIDOLOGY
IF4.6
err2022-09-01
err27
errOAAI
errKarwatowska-Prokopczuk, Ewa; Tardif, Jean-Claude; Gaudet, Daniel; Ballantyne, Christie M.; Shapiro, Michael D.; Moriarty, Patrick M.; Baum, Seth J.; St Amour, Eric; Alexander, Veronica J.; Xia, Shuting; Otvos, James D.; Witztum, Joseph L.; Tsimikas, Sotirios
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Development and validation of an isoform-independent monoclonal antibody-based ELISA for measurement of lipoprotein(a)
errJOURNAL OF LIPID RESEARCH
IF4.1
err2022-08-01
err20
errOAAI
errMarcovina, Santica M.; Navabi, Nazanin; Allen, Serena; Gonen, Ayelet; Witztum, Joseph L.; Tsimikas, Sotirios
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B-1b Cells Have Unique Functional Traits Compared to B-1a Cells at Homeostasis and in Aged Hyperlipidemic Mice With Atherosclerosis
errFRONTIERS IN IMMUNOLOGY
IF5.9
err2022-07-22
err7
errOAAI
errSrikakulapu, Prasad; Pattarabanjird, Tanyaporn; Upadhye, Aditi; Bontha, Sai Vineela; Osinski, Victoria; Marshall, Melissa A.; Garmey, James; Deroissart, Justine; Prohaska, Thomas A.; Witztum, Joseph L.; Binder, Christoph J.; Holodick, Nichol E.; Rothstein, Thomas L.; McNamara, Coleen A.
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Interventional hepatic apoC-III knockdown improves atherosclerotic plaque stability and remodeling by triglyceride lowering
errJCI INSIGHT
IF6.1
err2022-07-08
err10
errOAAI
errRamms, Bastian; Patel, Sohan; Sun, Xiaoli; Pessentheiner, Ariane R.; Ducasa, G. Michelle; Mullick, Adam E.; Lee, Richard G.; Crooke, Rosanne M.; Tsimikas, Sotirios; Witztum, Joseph L.; Gordts, Philip L. S. M.; Witztum, Joseph L.
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Research Directions

No research directions
Co-authors
Cooperation Journals
N
Nicholas J. Wareham
H-index: 233 · Papers: 2.2K
P
Peter Libby
H-index: 227 · Papers: 1.2K
P
Paul M. Ridker
H-index: 226 · Papers: 1.4K
V
Valentı́n Fuster
H-index: 219 · Papers: 2.2K
R
Ronald M. Evans
H-index: 211 · Papers: 924
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