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D

David T. Scadden

massachusetts general hospital

124H-index
666Paper Count
6.7WCitation Count
Published Papers 201
Publication Date
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Cancer risk and cause-specific mortality among people with thymoma in the United States
errJournal of Thoracic Oncology
IF20.8
err2026-07-27
err0
PREAI
errJun Tao; Patrick J. Loehrer; Angelina Cho; Choonsik Lee; Lindsay M. Morton; Kameron A. Kooshesh; Karin Gustafsson; David T. Scadden; Eric A. Engels
errShare
errSave
Shifting IRES versus Cap-initiated translation during homeostatic stem cell differentiation and stress
errScience Advances
IF12.5
err2026-05-22
err0
errOAAI
errMichael C. Mazzola; Ting Zhao; Anna Kiem; Trine A. Kristiansen; Karin Gustafsson; Lai Ping Wong; Emily Scott-Solomon; Marissa D. Fahlberg; Christina Mayerhofer; Ernst Mayerhofer; Sarah Forward; Emane Rose Assita; Giulia Schiroli; Maris Handley; Youmna Kfoury; Tsuyoshi Fukushima; Dan Li; Samuel Keyes; Azeem Sharda; Jelena Milosevic; Hiroki Kato; Pavel Ivanov; David B. Sykes; Sheldon J. J. Kwok; Ruslan I. Sadreyev; Vijay G. Sankaran; Ya-Chieh Hsu; David T. Scadden
errShare
errSave
Iron overload damages mitochondria and induces metabolic rewiring of hematopoietic stem cells towards glycolysis
errBlood
IF23.1
err2026-03-26
err0
errOAAI
errSilvia Sighinolfi; Laura Cassina; Maria Rosa Lidonnici; Stefano Beretta; Davide Stefanoni; Mariangela Storto; Christina Mayerhofer; Trine A Kristiansen; David T Scadden; Ivan Merelli; Alessandra Boletta; Annamaria Aprile; Giuliana Ferrari
errShare
errSave
Studying clonal heterogeneity of acute myeloid leukemia under nutrient and chemotherapy stress
errBlood Advances
IF7.1
err2025-12-06
err0
errOAAI
errChristina Mayerhofer; Eve Crompton; Ernst Mayerhofer; Trine Kristiansen; Tsuyoshi Fukushima; Sam Keyes; Azeem Sharda; Dan Li; Carmen Da Silva; Deumaya Shrestha; Anna Kiem; Tobias Feuchtinger; David T. Scadden; Peter G. Miller
errShare
errSave
Mesenchymal thymic niche cells enable regeneration of the adult thymus and T cell immunity
errNature Biotechnology
IF41.7
err2025-10-30
err0
PREAI
errKarin Gustafsson; Sergey Isaev; Kamdin Mirsanaye; Johanna Hofmann; Kameron A. Kooshesh; Ninib Baryawno; Anna Kiem; Nicolas Severe; Ting Zhao; Elizabeth W. Scadden; Joel A. Spencer; Christian Burns; Kumaran Akilan; Nikolaos Barkas; Hayalneh Gessessew; Konstantinos D. Kokkaliaris; Charles P. Lin; Peter V. Kharchenko; David T. Scadden
errShare
errSave
OGFOD1 enables AML chemo- and nutrient stress resistance by regulating protein synthesis
errCell Metabolism
IF30.9
err2025-09-16
err0
PREAI
errChristina Mayerhofer; Dan Li; Trine Kristiansen; Ernst Mayerhofer; Azeem Sharda; Giulia Schiroli; Karin Gustafsson; Lingli He; Michael Mazzola; Sam Keyes; Anna Kiem; Eve Crompton; Yanxin Xu; Sovannarith Korm; Zhixun Dou; Charles Vidoudez; Peter G. Miller; Nick van Gastel; Timothy A. Graubert; David T. Scadden
errShare
errSave
Derepressing nuclear pyruvate dehydrogenase induces therapeutic cancer cell reprogramming
errCell Metabolism
IF30.9
err2025-06-11
err0
PREAI
errTing Zhao; Lingli He; Lai Ping Wong; Shenglin Mei; Jun Xia; Yanxin Xu; Jonathan G. Van Vranken; Michael Mazzola; Lei Chen; Catherine Rhee; Tiancheng Fang; Tsuyoshi Fukushima; Leanne C. Sayles; Matthew Diaz; J. Alex B. Gibbons; Raul Mostoslavsky; Steven P. Gygi; Zhixun Dou; David B. Sykes; Ruslan I. Sadreyev; E. Alejandro Sweet-Cordero; David T. Scadden
errShare
errSave
Adult thymectomy is associated with increased mortality risk from cancer but not cardiovascular disease
errBlood Advances
IF7.1
err2025-06-09
err0
errOAAI
errKameron A. Kooshesh; Brody H. Foy; Richard A. Baylis; Karin Gustafsson; Daniel A. Zlotoff; Tomas G. Neilan; David T. Scadden
errShare
errSave
Niche-generated taurine is leukemic fuel
errCell Research
IF25.9
err2025-06-09
err0
PREAI
errChristina Mayerhofer; David T. Scadden
errShare
errSave
Integration of clinical outcomes and molecular features in extramedullary disease in multiple myeloma
errBLOOD CANCER JOURNAL
IF11.6
err2024-12-23
err0
errOAAI
errNakamoto-Matsubara, Rie; Nardi, Valentina; Horick, Nora; Fukushima, Tsuyoshi; Han, Ryan S.; Shome, Rajib; Ochi, Kiyosumi; Panaroni, Cristina; Fulzele, Keertik; Rexha, Farah; Branagan, Andrew R.; Cirstea, Diana; Yee, Andrew J.; Scadden, David T.; Raje, Noopur S.
errShare
errSave
AML Stem Cell Clearance By Inhibiting Selenoprotein Biosynthesis That Causes Cgas-Sting Activation and Ferroptosis
errBLOOD
IF23.1
err2024-11-05
err0
PREAI
errHe, Lingli; Zhao, Ting; Leong, Wei Zhong; Sharda, Azeem; Mayerhofer, Christina; Mei, Shenglin; Bonilla, Gracia M.; Menendez-Gonzalez, Juan Bautista; Gustafsson, Karin; Fukushima, Tsuyoshi; Kristiansen, Trine A.; Lee, Ji-Won; Xu, Yanxin; Budnik, Bogdan; Sadreyev, Ruslan; Dou, Zhixun; Sykes, David B.; Scadden, David
errShare
errSave
Modulating mRNA Translation Fidelity As a Novel Mechanism for AML Chemoresistance
errBLOOD
IF23.1
err2024-11-05
err0
PREAI
errMayerhofer, Christina; Li, Dan; Kristiansen, Trine A.; Mayerhofer, Ernst; Sharda, Azeem; He, Lingli; Mazzola, Michael; Schiroli, Giulia; Gustafsson, Karin; Keyes, Sam; Kiem, Anna; Crompton, Eve; Xu, Yanxin; Dou, Zhixun; Vidoudez, Charles; Miller, Peter G.; Van Gastel, Nick; Scadden, David
errShare
errSave
Cancer Versus Cardiac Mortality Risk with Adult Thymectomy
errBLOOD
IF23.1
err2024-11-05
err0
PREAI
errKooshesh, Kameron Allen; Foy, Brody; Baylis, Richard; Gustafsson, Karin; Zlotoff, Daniel; Neilan, Tomas; Scadden, David
errShare
errSave
Cell of origin epigenetic priming determines susceptibility to Tet2 mutation
errNATURE COMMUNICATIONS
IF15.7
err2024-05-21
err1
errOAAI
errSchiroli, Giulia; Kartha, Vinay; Duarte, Fabiana M.; Kristiansen, Trine A.; Mayerhofer, Christina; Shrestha, Rojesh; Earl, Andrew; Hu, Yan; Tay, Tristan; Rhee, Catherine; Buenrostro, Jason D.; Scadden, David T.
errShare
errSave
Cyclophilin A supports translation of intrinsically disordered proteins and affects haematopoietic stem cell ageing
errNATURE CELL BIOLOGY
IF19.1
err2024-03-29
err4
errOAAI
errManeix, Laure; Iakova, Polina; Lee, Charles G.; Moree, Shannon E.; Lu, Xuan; Datar, Gandhar K.; Hill, Cedric T.; Spooner, Eric; King, Jordon C. K.; Sykes, David B.; Saez, Borja; Di Stefano, Bruno; Chen, Xi; Krause, Daniela S.; Sahin, Ergun; Tsai, Francis T. F.; Goodell, Margaret A.; Berk, Bradford C.; Scadden, David T.; Catic, Andre
errShare
errSave
A mitochondrial NADPH-cholesterol axis regulates extracellular vesicle biogenesis to support hematopoietic stem cell fate
errCELL STEM CELL
IF20.4
err2024-03-01
err7
errOAAI
errBonora, Massimo; Morganti, Claudia; van Gastel, Nick; Ito, Kyoko; Calura, Enrica; Zanolla, Ilaria; Ferroni, Letizia; Zhang, Yang; Jung, Yookyung; Sales, Gabriele; Martini, Paolo; Nakamura, Takahisa; Lasorsa, Francesco Massimo; Finkel, Toren; Lin, Charles P.; Zavan, Barbara; Pinton, Paolo; Georgakoudi, Irene; Romualdi, Chiara; Scadden, David T.; Ito, Keisuke
errShare
errSave
Bone marrow adipocytes fuel emergency hematopoiesis after myocardial infarction
errcardiovascular research
IF10.8
err2023-12-05
err4
errOAAI
errZhang, Shuang; Paccalet, Alexandre; Rohde, David; Cremer, Sebastian; Hulsmans, Maarten; Lee, I-Hsiu; Mentkowski, Kyle; Grune, Jana; Schloss, Maximilian J.; Honold, Lisa; Iwamoto, Yoshiko; Zheng, Yi; Bredella, Miriam A.; Buckless, Colleen; Ghoshhajra, Brian; Thondapu, Vikas; van der Laan, Anja M.; Piek, Jan J.; Niessen, Hans W. M.; Pallante, Fabio; Carnevale, Raimondo; Perrotta, Sara; Carnevale, Daniela; Iborra-Egea, Oriol; Munoz-Guijosa, Christian; Galvez-Monton, Carolina; Bayes-Genis, Antoni; Vidoudez, Charles; Trauger, Sunia A.; Scadden, David T.; Swirski, Filip K.; Moskowitz, Michael A.; Naxerova, Kamila; Nahrendorf, Matthias
errShare
errSave
Clearing and replacing tissue-resident myeloid cells with an anti-CD45 antibody-drug conjugate
errBLOOD ADVANCES
IF7.1
err2023-11-17
err3
errOAAI
errGustafsson, Karin; Rhee, Catherine; Frodermann, Vanessa; Scadden, Elizabeth W.; Li, Dan; Iwamoto, Yoshiko; Palchaudhuri, Rahul; Hyzy, Sharon L.; Boitano, Anthony E.; Nahrendorf, Matthias; Scadden, David T.
errShare
errSave
The bone marrow stroma in human myelodysplastic syndrome reveals alterations that regulate disease progression
errBLOOD ADVANCES
IF7.1
err2023-10-31
err2
errOAAI
errKfoury, Youmna S.; Ji, Fei; Jain, Esha; Mazzola, Michael; Schiroli, Giulia; Papazian, Ani; Mercier, Francois; Sykes, David B.; Kiem, Anna; Randolph, Mark; Calvi, Laura M.; Abdel-Wahab, Omar; Sadreyev, Ruslan I.; Scadden, David T.
errShare
errSave
Adult Prg4+progenitors repair long-term articular cartilage wounds in vivo
errJCI INSIGHT
IF6.1
err2023-09-08
err4
errOAAI
errMassengale, Mei; Massengale, Justin L.; Benson, Catherine R.; Barywano, Ninib; Oki, Toshihiko; Steinhauser, Matthew L.; Wang, Alissa; Balani, Deepak; Oh, Luke S.; Randolph, Mark A.; Gill, Thomas J., III; Kronenberg, Henry M.; Scadden, David T.
errShare
errSave

Research Directions

No research directions
Co-authors
Cooperation Journals
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Peter Libby
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Paul M. Ridker
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Rakesh K. Jain
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Ralph Weissleder
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Kenneth C. Anderson
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