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J

John G. Doench

Broad Institute

80H-index
730Paper Count
4.4WCitation Count
Published Papers 160
Publication Date
Methylation Mesa define functional regulatory elements for targeted gene activation
err2026-08-26
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errOAAI
errY. V. Liu; J. Suryatenggara; H. Wong; M. K. Jayasinghe; J. P. Tang; H. K. Tan; J. Kwon; Q. Zhou; J. Zhang; S. Moein; S. Ummarino; M. T. N. Le; J. G. Doench; T. Benoukraf; L. Chai; D. Hiwase; D. Thomas; A. Di Ruscio; D. G. Tenen; M. A. Bassal
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A transcriptional biosensor reveals mechanisms of α-ketoglutarate signaling to chromatin
errScience
IF45.8
err2026-07-16
err0
PREAI
errAlex C. Sternisha; Haocheng Li; Kumar Gajendra; Yi Xiao; Xin Zhao; Jeffrey I. Traylor; Lei Guo; Ji Hyung Jun; Morgan Fleishman; Tracey Shipman; Vinesh T. Puliyappadamba; Pranita Kaphle; Qing Ouyang; Michael Schmidt; Diana D. Shi; Milan R. Savani; Alexander C.-Y. Tsai; Joyce H. Lee; Ruth Gordillo; Javier Garcia-Bermudez; Yoon Jung Kim; Shih-Chia Tso; Chad A. Brautigam; Lauren G. Zacharias; Thomas P. Mathews; Lin Xu; John G. Doench; Vidyasagar Koduri; Kalil G. Abdullah; Michalis Agathocleous; Laura A. Banaszynski; Ralph J. DeBerardinis; Eric M. Morrow; Samuel K. McBrayer
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CRISPR base editor screening identifies spectrum of MEN1 mutations impacting menin inhibitors in clinical trials
err2026-05-09
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errOAAI
errWallace Bourgeois; Hannah E. Rice; Daniela V. Wenge; Florian Perner; Hong Yue; Brandon D. Regalado; George Wan; Jan C. Schroeder; Alba Sommerschield; Charlie Hatton; Shivendra Singh; Sweta Singh; Shipra Bijpuria; Brian M. McKeever; William H. Miller; Jordan F. Safer; Sumaiya Iqbal; Jennifer A. Perry; Eric S. Fischer; John G. Doench; Gerard M. McGeehan; Jevon A. Cutler; Scott A. Armstrong
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Genome-wide CRISPR interference screen identifies Clip2 as a novel regulator of osteocyte maturation and morphology
err2026-04-27
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errOAAI
errCourtney M. Mazur; Parthena E. Kotsalidis; Majd George; Tom Whalley; Tadatoshi Sato; John G. Doench; Lauren E. Surface; Marc N. Wein
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Sialylated CD43 forms a glyco-immune barrier that restrains antileukemic immunity
errScience
IF45.8
err2026-04-09
err0
PREAI
errJooho Chung; Mounica Vallurupalli; Sarah Noel; Gail Schor; Sofia Mrowka; Ilario Scapozza; Zelalem Demere; Sachin V. Kammula; Margaret Hu; Sarah Y. Kim; YuhJong Liu; Celeste Nobrega; Jonathan J. Perera; Ewa Wrona; Collins K. Cheruiyot; Yunkang Lin; David W. Wu; Maria Saberi; Aidan Cruickshank; Elliot C. Woods; Cun Lan Chuong; Filippo Birocchi; Ashwin V. Kammula; Omar I. Avila; Nelson Knudsen; Mustafa Kocak; John G. Doench; Dean Procter; Lindsey Thornton; Andrew M. Brunner; Eric Winer; Daniel J. DeAngelo; Jacqueline S. Garcia; Richard M. Stone; Russell W. Jenkins; Marcela V. Maus; Timothy A. Graubert; Kathleen B. Yates; Todd R. Golub; Robert T. Manguso
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Balancing off-target and on-target considerations for optimized CRISPR-Cas9 knockout library design
err2026-03-25
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errOAAI
errLaura M. Drepanos; Smriti Srikanth; Eleanor G. Kaplan; Spencer T. Shah; Berta Escude Velasco; Sarra Merzouk; John G. Doench
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Activity-based selection for enhanced base editor mutational scanning
err2025-10-14
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PREAI
errEleanor G. Kaplan; Ryan J. Steger; Spencer T. Shah; Laura M. Drepanos; Audrey L. Griffith; Ganna Reint; John G. Doench
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In vivo CRISPR screens identify modifiers of CAR T cell function in myeloma
errNature
IF48.5
err2025-09-24
err0
PREAI
errNelson H. Knudsen; Giulia Escobar; Felix Korell; Tamina Kienka; Celeste Nobrega; Seth Anderson; Andrew Y. Cheng; Maria Zschummel; Alexander Armstrong; Amanda Bouffard; Michael C. Kann; Sadie Goncalves; Hans W. Pope; Mitra Pezeshki; Alexander Rojas; Juliette S. M. T. Suermondt; Merle Phillips; Trisha R. Berger; Sangwoo Park; Diego Salas-Benito; Elijah P. Darnell; Filippo Birocchi; Mark B. Leick; Rebecca C. Larson; John G. Doench; Debattama Sen; Kathleen B. Yates; Robert T. Manguso; Marcela V. Maus
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Sialyl-T Antigen: A Novel Red Blood Cell Determinant for Plasmodium falciparum Invasion
err2025-08-29
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PREAI
errMahmoud Mikdar; Estela Shabani; Christof Grüring; Mudit Chaand; Usheer Kanjee; Jonathan M. Goldberg; Slim Azouzi; Jacob A. Tennessen; Brendan Elsworth; Cyrianne Keutcha; Natasha S. Barteneva; John G. Doench; Manoj T. Duraisingh
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Identification of Synthetic Lethal Vulnerabilities Between TRIM28 and NOTCH2 in Small Cell Lung Cancer Through CRISPR/Cas9 Screening
err2025-08-29
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PREAI
errDeli Hong; Ying Lyu; Keita Masuzawa; Zoe Devos; Shin Saito; Qi Liu; Yixiang Li; Zhaorong Li; Leslie Duplaquet; Eric H. Knelson; Tran Thai; John G. Doench; David A. Barbie; Michael Y. Tolystorukov; Jun Qi; Yejing Ge; Matthew G. Oser
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Cyclin A/B RxL Macrocyclic Inhibitors to Treat Cancers with High E2F Activity
err2025-08-29
err0
PREAI
errShilpa Singh; Catherine E. Gleason; Min Fang; Yasmin N. Laimon; Vishal Khivansara; Shanhai Xie; Yavuz T. Durmaz; Aniruddha Sarkar; Kenneth Ngo; Varunika Savla; Yixiang Li; Muhannad Abu-Remaileh; Xinyue Li; Bishma Tuladhar; Ranya Odeh; Frances Hamkins-Indik; Daphne He; Miles W. Membreno; Meisam Nosrati; Nathan N. Gushwa; Siegfried S.F. Leung; Breena Fraga-Walton; Luis Hernandez; Miguel P. Baldomero; Bryan M. Lent; David Spellmeyer; Joshua F. Luna; Dalena Hoang; Yuliana Gritsenko; Manesh Chand; Megan K. DeMart; Sammy Metobo; Chinmay Bhatt; Justin A. Shapiro; Kai Yang; Nathan J. Dupper; Andrew T. Bockus; John G. Doench; James B. Aggen; Li-Fen Liu; Bernard Levin; Evelyn W. Wang; Iolanda Vendrell; Roman Fischer; Benedikt Kessler; Prafulla C. Gokhale; Sabina Signoretti; Alexander Spektor; Constantine Kreatsoulas; Rajinder Singh; David J. Earp; Pablo D. Garcia; Deepak Nijhawan; Matthew G. Oser
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Loss of NOTCH2 creates a TRIM28-dependent vulnerability in small cell lung cancer
err2025-08-26
err0
PREAI
errDeli Hong; Ying Lyu; Richa Nayak; Justin S. Becker; Matthew A. Booker; Keita Masuzawa; Zoe Devos; Tianchu Wang; Shin Saito; Qi Liu; Yixiang Li; Zhaorong Li; Eric H. Knelson; Tran Thai; Leslie Duplaquet; Yasmin N. Laimon; Gabriel Roberti De Oliveira; Sabina Signoretti; John G. Doench; David A. Barbie; Michael Y. Tolystorukov; Jun Qi; Bradley E. Bernstein; Yejing Ge; Matthew G. Oser
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Targeting G1–S-checkpoint-compromised cancers with cyclin A/B RxL inhibitors
errNature
IF48.5
err2025-08-20
err0
errOAAI
errShilpa Singh; Catherine E. Gleason; Min Fang; Yasmin N. Laimon; Vishal Khivansara; Shanhai Xie; Yavuz T. Durmaz; Aniruddha Sarkar; Kenneth Ngo; Varunika Savla; Yixiang Li; Muhannad Abu-Remaileh; Xinyue Li; Marie-Anais Locquet; Bishma Tuladhar; Ranya Odeh; Frances Hamkins-Indik; Daphne He; Miles W. Membreno; Meisam Nosrati; Nathan N. Gushwa; Siegfried S. F. Leung; Breena Fraga-Walton; Luis Hernandez; Miguel P. Baldomero; Bryan M. Lent; David Spellmeyer; Joshua F. Luna; Dalena Hoang; Yuliana Gritsenko; Manesh Chand; Megan K. DeMart; Sammy Metobo; Chinmay Bhatt; Justin A. Shapiro; Kai Yang; Nathan J. Dupper; Andrew T. Bockus; Jinshu Fang; Ramesh Bambal; Peadar Cremin; John G. Doench; James B. Aggen; Li-Fen Liu; Bernard Levin; Evelyn W. Wang; Iolanda Vendrell; Roman Fischer; Benedikt Kessler; Prafulla C. Gokhale; Sabina Signoretti; Alexander Spektor; Constantine Kreatsoulas; Marie Evangelista; Rajinder Singh; David J. Earp; Deepak Nijhawan; Pablo D. Garcia; Matthew G. Oser
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A STUB1–CHIC2 complex inhibits CD8+ T cells to restrain tumor immunity
err2025-08-12
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PREAI
errMartin W. LaFleur; Lauren E. Milling; Priyamvada Prathima; Vivian Li; Ashlyn M. Lemmen; Ivy S. L. Streeter; Paul K. S. Heisig; Nicole M. Derosia; Elizabeth Riffo; Haonan Xu; Thao H. Nguyen; Aashiya Kolengaden; Samuel C. Markson; John G. Doench; Arlene H. Sharpe
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HKU5 bat merbecoviruses engage bat and mink ACE2 as entry receptors
err2025-07-24
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errOAAI
errMia Madel Alfajaro; Emma L. Keeler; Ning Li; Nicholas J. Catanzaro; I-Ting Teng; Zhe Zhao; Michael W. Grunst; Boyd Yount; Alexandra Schäfer; Danyi Wang; Arthur S. Kim; Aleksandra Synowiec; Mario A. Peña-Hernández; Samantha Zepeda; Ridwan Arinola; Ramandeep Kaur; Bridget L. Menasche; Jin Wei; Gabriel A. Russell; John Huck; Jaewon Song; Aaron Ring; Akiko Iwasaki; Rohit K. Jangra; Sanghyun Lee; David R. Martinez; Walther Mothes; Pradeep D. Uchil; John G. Doench; Alicen B. Spaulding; Ralph S. Baric; Leonid Serebryannyy; Yaroslav Tsybovsky; Tongqing Zhou; Daniel C. Douek; Craig B. Wilen
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A CRISPR Screen in Enucleated Red Blood Cells Identifies Critical Factors for Terminal Erythroid Differentiation
errBLOOD
IF23.1
err2024-11-05
err0
PREAI
errTetard, Marilou; Peterson, Nana A.; Lin, Tim; Doench, John G.; Egan, Elizabeth S.
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Discerning the Landscape of Menin Inhibitor Resistance
errBLOOD
IF23.1
err2024-11-05
err1
PREAI
errBourgeois, Wallace; Cutler, Jevon; Rice, Hannah E.; Regalado, Brandon; Wenge, Daniela, V; Perner, Florian; Doench, John G.; Mcgeehan, Jerry M.; Armstrong, Scott A.
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In Vivo CRISPR Screening Reveals CHD7 as a Positive Regulator of Short-lived Effector Cells
err2024-10-07
err0
PREAI
errLaFleur, Martin W.; D'Andrea, Jasmin M.; Patterson, Dillon G.; Streeter, Ivy S. L.; Coxe, Matthew A.; Osborn, Jossef F.; Milling, Lauren E.; Tjokrosurjo, Qin; Gillis, Jacob E.; Nguyen, Thao H.; Schwartz, Marc A.; Hacohen, Nir; Doench, John G.; Sharpe, Arlene H.
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Epigenetic tuning of PD-1 expression improves exhausted T cell function and viral control
err2024-09-17
err0
PREAI
errWeiss, Sarah A.; Huang, Amy Y.; Fung, Megan E.; Martinez, Daniela; Chen, Alex C. Y.; LaSalle, Thomas J.; Miller, Brian C.; Scharer, Christopher D.; Hegde, Mudra; Nguyen, Thao H.; Rowe, Jared H.; Osborn, Jossef F.; Patterson, Dillon G.; Sifnugel, Natalia; Mei-An Nolan, C.; Davidson, Richard A.; Schwartz, Marc A.; Bally, Alexander P. R.; Neeld, Dennis K.; LaFleur, Martin W.; Boss, Jeremy M.; Doench, John G.; Haining, W. Nicholas; Sharpe, Arlene H.; Sen, Debattama R.
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Host cell CRISPR genomics and modelling reveal shared metabolic vulnerabilities in the intracellular development of Plasmodium falciparum and related hemoparasites
err2024-07-21
err1
errOAAI
errMaurizio, Marina; Masid, Maria; Woods, Kerry; Caldelari, Reto; Doench, John G.; Naguleswaran, Arunasalam; Joly, Denis; Gonzalez-Fernandez, Martin; Zemp, Jonas; Borteele, Melanie; Hatzimanikatis, Vassily; Heussler, Volker; Rottenberg, Sven; Olias, Philipp
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