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J

James P. Pirruccello

Broad Institute of MIT and Harvard

43H-index
188Paper Count
1.5WCitation Count
Published Papers 92
Publication Date
Genetically Mediated Differences in LDL Cholesterol and Risk of Venous Thromboembolism
err2026-08-28
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PREAI
errYang Sui; Shinwan Kany; Shaan Khurshid; Kelvin Supriami; Joel T. Rämö; Sean J. Jurgens; Nobuyuki Enzan; Seung Hoan Choi; Zhi Yu; Linke Li; Buu Truong; Xingyu Chen; Min Seo Kim; Injeong Shim; Raphael Twerenbold; James P. Pirruccello; Pradeep Natarajan; Patrick T. Ellinor; Akl C. Fahed
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Multitrait analyses identify genetic variants associated with aortic valve function and aortic stenosis risk
err2025-12-19
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errOAAI
errShinwan Kany; Joel T. Rämö; Cody Hou; Sean J. Jurgens; Shaan Khurshid; Victor Nauffal; Jonathan W. Cunningham; Emily S. Lau; Satoshi Koyama; Jennifer E. Ho; Jeffrey E. Olgin; Sammy Elmariah; Aarno Palotie; Mark E. Lindsay; Patrick T. Ellinor; James P. Pirruccello
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Estimating Ascending Aortic Diameter From the Electrocardiogram
errJACC
IF0
err2025-12-10
err0
PREAI
errZachariah S. Demarais; Jeffrey E. Olgin; James P. Pirruccello
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An African ancestry-specific nonsense variant in CD36 is associated with a higher risk of dilated cardiomyopathy
err2025-10-31
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errOAAI
errJennifer E. Huffman; Liam Gaziano; Zeina R. Al Sayed; Renae L. Judy; Laura M. Raffield; Kiran J. Biddinger; Brian Charest; Anant Chopra; David Gagnon; Xiuqing Guo; Vera Koledova; Michael G. Levin; Yuan-I Min; James P. Pirruccello; Nosheen Reza; Richard Ruan; Shefali Setia Verma; Bharath Ambale Venkatesh; Anurag Verma; Jie Yao; John Jeffrey Carr; Juan P. Casas; Kelly Cho; Joao A. C. Lima; Wendy S. Post; Daniel J. Rader; Marylyn D. Ritchie; Amil Shah; Kent D. Taylor; James G. Terry; Stephen S. Rich; Christopher J. O’Donnell; Lawrence S. Phillips; Kathryn L. Lunetta; Jerome I. Rotter; Peter W. F. Wilson; J. Michael Gaziano; Scott M. Damrauer; Yan V. Sun; Patrick T. Ellinor; Jacob Joseph; Krishna G. Aragam
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Mendelian Randomization Suggests a Causal Link Between Glycemic Traits and Thoracic Aortic Structures and Diseases
err2025-10-31
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errOAAI
errTselmen Daria; Kruthika Iyer; Hasan Alkhairo; Pik Fang Kho; Ken Suzuki; Konstantinos Hatzikotoulas; Lorraine Southam; Henry J. Taylor; Xianyong Yin; Ravi Mandla; Alicia Huerta-Chagoya; William N. Rayner; Michael G. Levin; Scott M. Damrauer; Philip S. Tsao; James R. Priest; Derek Klarin; James Pirruccello; Justin B. Echouffo Tcheugui; Catherine Tcheandjieu
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Pathogenic Cardiomyopathy-Associated Gene Variants and Prognosis in Atrial Fibrillation
errJACC
IF0
err2025-09-01
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PREAI
errSean J. Jurgens; Giorgio E.M. Melloni; Shinwan Kany; Larissa Fabritz; Joel T. Rämö; Andreas Goette; Frederick K. Kamanu; David D. Berg; Christina Magnussen; Seung Hoan Choi; Marc P. Bonaca; Robert P. Giugliano; Benjamin M. Scirica; Stephen D. Wiviott; Deepak L. Bhatt; Philippe Gabriel Steg; Itamar Raz; Eugene Braunwald; James P. Pirruccello; Marc S. Sabatine; Nicholas A. Marston; Paulus Kirchhof; Patrick T. Ellinor; Christian T. Ruff
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Moving Beyond the Model
errJACC
IF0
err2025-09-01
err0
PREAI
errSneha S. Jain; Bobak J. Mortazavi; Seng Chan You; Xiaoxi Yao; Carolyn S.P. Lam; Pierre Elias; Timothy J. Poterucha; Robert Avram; Geoffrey H. Tison; James Pirruccello; Chenxi Huang; Jenna Wiens; Lee Schwamm; Xiaoyang Ruan; Jessilyn Dunn; Yuan Luo; Erica S. Spatz; Harlan M. Krumholz
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Electrocardiogram-Based Artificial Intelligence to Identify Coronary Artery Disease
err2025-09-01
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errOAAI
errKany, Shinwan; Friedman, Samuel F.; Al-Alusi, Mostafa; Khurshid, Shaan; Ramo, Joel T.; Pipilas, Daniel; Pirruccello, James P.; Reeder, Christopher; Philippakis, Anthony A.; Ho, Jennifer E.; Maddah, Mahnaz; Ellinor, Patrick T.; Fahed, Akl C.
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Improved multiancestry fine-mapping identifies cis-regulatory variants underlying molecular traits and disease risk
err2025-07-21
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PREAI
errZeyun Lu; Xinran Wang; Matthew Carr; Artem Kim; Steven Gazal; Pejman Mohammadi; Lang Wu; James Pirruccello; Linda Kachuri; Alexander Gusev; Nicholas Mancuso
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New Threshold for Defining Mild Aortic Stenosis Derived From Velocity-Encoded MRI in 60,000 Individuals
err2025-04-01
err1
PREAI
errKany, Shinwan; Ramo, Joel T.; Playford, David; Strange, Geoff; Hou, Cody; Jurgens, Sean J.; Nauffal, Victor; Cunningham, Jonathan W.; Lau, Emily S.; Butte, Atul J.; Ho, Jennifer E.; Olgin, Jeffrey E.; Elmariah, Sammy; Lindsay, Mark E.; Chan, Yih-Kai; Stewart, Simon; Ellinor, Patrick T.; Pirruccello, James P.
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A deep learning digital biomarker to detect hypertension and stratify cardiovascular risk from the electrocardiogram
err2025-02-22
err0
errOAAI
errAl-Alusi, Mostafa A.; Friedman, Samuel F.; Kany, Shinwan; Raemoe, Joel T.; Pipilas, Daniel; Singh, Pulkit; Reeder, Christopher; Khurshid, Shaan; Pirruccello, James P.; Ho, Jennifer E.
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Rare Genetic Variants in LDLR, APOB, and PCSK9 Are Associated With Aortic Stenosis
err2024-11-26
err0
PREAI
errRamo, Joel T.; Jurgens, Sean J.; Kany, Shinwan; Choi, Seung Hoan; Wang, Xin; Smirnov, Andrey N.; Friedman, Samuel F.; Maddah, Mahnaz; Khurshid, Shaan; Ellinor, Patrick T.; Pirruccello, James P.
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Multi-trait analysis identifies 307 genomic loci for thoracic aortic diameter and disease
err2024-11-12
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PREAI
errZamirpour, Siavash; Depaolo, John; Brundage, James; Damrauer, Scott; Pirruccello, James
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The Role of Socioeconomic Status in the Association Between Cardiovascular Polygenic Risk Score and Cardiovascular Events
err2024-11-12
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PREAI
errBhaskar, Saigeetha; Pirruccello, James; Hoffmann, Thomas; Beatty, Alexis
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Epidemiologic and genetic associations between proteomic markers and thoracic aortic diameter
err2024-11-12
err0
PREAI
errWells, Alexander; Brundage, James; Zamirpour, Siavash; Pirruccello, James
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Electrocardiogram-based artificial intelligence to identify prevalent coronary artery disease
err2024-10-28
err0
PREAI
errKany, S.; Friedman, S. F.; Al-Alusi, M.; Khurshid, S.; Raemoe, J. T.; Pipilas, D.; Pirruccello, J. P.; Reeder, C.; Phillippakis, A. A.; Ho, J. E.; Maddah, M.; Ellinor, P. T.; Fahed, A. C.
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Exome sequencing in over 63,000 patients in TIMI trials uncovers pathogenic cardiomyopathy variant carriers with high risk for heart failure and cardiovascular death
err2024-10-28
err0
PREAI
errKany, S.; Melloni, G. E. M.; Jurgens, S. J.; Berg, D.; Bonaca, M.; Giugliano, R. P.; Wiviott, S. D.; Bhatt, D. L.; Steg, P. G.; Raz, I; Pirruccello, J. P.; Sabatine, M. S.; Ruff, C. T.; Ellinor, P. T.; Marston, N. A.
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Pathogenic cardiomyopathy gene variants inform prognosis in atrial fibrillation: results from exome sequencing in over 17,000 patients in TIMI trials
err2024-10-28
err0
PREAI
errJurgens, S.; Melloni, G. E. M.; Kany, S.; Berg, D. D.; Bonaca, M. P.; Giugliano, R. P.; Wiviott, S. D.; Bhatt, D. L.; Steg, P. G.; Raz, I; Pirruccello, J. P.; Sabatine, M. S.; Marston, N. A.; Ellinor, P. T.; Ruff, C. T.
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