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J

Jukka‐Pekka Mecklin

jyväskylä university

98H-index
522Paper Count
4.7WCitation Count
Published Papers 160
Publication Date
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Epithelial interferon-stimulated gene programs modulate chemotherapy sensitivity in colorectal cancer via EPSTI1
errOncogene
IF7.3
err2026-08-21
err0
errOAAI
errErdogan Pekcan Erkan; Emmi Hämäläinen; Julia Kolikova; Tiia Nikupaavola; Karishma Sajnani; Kornelia Kuc; Kalle Ojala; Meiju Kukkonen; Ismaïl Hermelo; Antti Kurttila; Selja Koskensalo; Timo Tarvainen; Alli Leppä; Ilona Keränen; Carola Haapamäki; Essi Karjalainen; Monika Carpelan-Holmström; Laura Renkonen-Sinisalo; Laura Koskenvuo; Pauli Puolakkainen; Jukka-Pekka Mecklin; Juha P. Väyrynen; Elina Virolainen; Matti Nykter; Lauri A. Aaltonen; Alfonso Urbanucci; Anna Lepistö; Ari Ristimäki; Toni T. Seppälä
errShare
errSave
Tumor-Infiltrating Basophils Are Associated With Improved Prognosis in Colorectal Cancer
errLaboratory Investigation
IF4.2
err2026-07-09
err0
PREAI
errOskari Rahkola; Henna Karjalainen; Ville K. Äijälä; Meeri Kastinen; Vilja V. Tapiainen; Hanna Elomaa; Onni Sirkiä; Vesa-Matti Pohjanen; Maarit Ahtiainen; Olli Helminen; Taneli T. Mattila; Outi Lindgren; Erkki-Ville Wirta; Jukka Rintala; Sanna Meriläinen; Juha Saarnio; Tero Rautio; Toni T. Seppälä; Jan Böhm; Jukka-Pekka Mecklin
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errSave
Non-truncating BMPR1A variants associated with familial colorectal cancer and adenomatous polyps
errBMC Cancer
IF3.4
err2026-02-01
err0
errOAAI
errTaina T. Nieminen; Outi Kuismin; Riitta Laine; Anna Lepistö; Laura Koskenvuo; Laura Renkonen-Sinisalo; Markus J. Mäkinen; Ari Ristimäki; Jukka-Pekka Mecklin; Päivi Peltomäki
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Urothelium marker UPK2 identifies aggressive colorectal cancers with distinct molecular and histological features
errBritish Journal of Cancer
IF6.8
err2025-12-11
err0
errOAAI
errVille K. Äijälä; Jouni Härkönen; Päivi Sirniö; Tuomo Mantere; Hanna Elomaa; Onni Sirkiä; Akseli Kehusmaa; Henna Karjalainen; Meeri Kastinen; Vilja V. Tapiainen; Maarit Ahtiainen; Olli Helminen; Erkki-Ville Wirta; Jukka Rintala; Sanna Meriläinen; Juha Saarnio; Tero Rautio; Toni T. Seppälä; Jan Böhm; Jukka-Pekka Mecklin; Anne Tuomisto; Markus J. Mäkinen; Juha P. Väyrynen
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errSave
PTEN status, tumor immune microenvironment, and survival in colorectal cancer
errVirchows Archiv
IF3.1
err2025-11-18
err0
errOAAI
errJoni Karjalainen; Onni Sirkiä; Päivi Sirniö; Hanna Elomaa; Henna Karjalainen; Ville K. Äijälä; Meeri Kastinen; Vilja V. Tapiainen; Vesa-Matti Pohjanen; Maarit Ahtiainen; Olli Helminen; Erkki-Ville Wirta; Taneli T. Mattila; Outi Lindgren; Jukka Rintala; Sanna Meriläinen; Juha Saarnio; Tero Rautio; Toni T. Seppälä; Jan Böhm; Jukka-Pekka Mecklin; Anne Tuomisto; Markus J. Mäkinen; Juha P. Väyrynen
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errSave
Constrained hypermutation and absence of TERT promoter mutations in Lynch syndrome-associated urothelial cancer
errCell Reports
IF6.9
err2025-10-03
err0
errOAAI
errJussi Nikkola; Lauri Ryyppö; Juuso Vuorinen; Lauri Moilanen; Maarit Ahtiainen; Kirsi Pylvänäinen; Hanna Selin; Tuomo Virtanen; Matti Nykter; Thea Veitonmäki; Jukka-Pekka Mecklin; Toni T. Seppälä; Matti Annala
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errSave
Integrative omics approaches to uncover liquid-based cancer-predicting biomarkers in Lynch syndrome
errInternational Journal of Cancer
IF4.7
err2025-08-26
err0
errOAAI
errMinta Kärkkäinen; Tero Sievänen; Tia-Marje Korhonen; Joonas Tuomikoski; Kirsi Pylvänäinen; Sami Äyrämö; Toni T. Seppälä; Jukka-Pekka Mecklin; Eija K. Laakkonen; Tiina Jokela
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errSave
Molecular analysis of the evolutionary history of endometrial and ovarian carcinoma in Lynch syndrome
errInternational Journal of Cancer
IF4.7
err2025-08-07
err0
errOAAI
errAnni K. Kauppinen; Alisa P. Olkinuora; Jukka-Pekka Mecklin; Päivi T. Peltomäki
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errSave
Characteristics and significance of γδ T cells in colorectal cancer
errOncoImmunology
IF6.3
err2025-07-28
err0
errOAAI
errHenna Karjalainen; Jouni Härkönen; Päivi Sirniö; Hanna Elomaa; Ville K. Äijälä; Meeri Kastinen; Vilja V. Tapiainen; Sara A. Väyrynen; Maarit Ahtiainen; Olli Helminen; Erkki-Ville Wirta; Jukka Rintala; Sanna Meriläinen; Juha Saarnio; Tero Rautio; Toni T. Seppälä; Jan Böhm; Jukka-Pekka Mecklin; Anne Tuomisto; Markus J. Mäkinen; Juha P. Väyrynen
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errSave
Integrating Tumor Intraepithelial CD8+ and Stromal FOXP3+ T-Cell Densities as an Enhanced Immune Prognostic Index in Colorectal Cancer
errLaboratory Investigation
IF4.2
err2025-07-17
err0
errOAAI
errAnne Tuomisto; Päivi Sirniö; Hanna Elomaa; Henna Karjalainen; Ville K. Äijälä; Meeri Kastinen; Vilja V. Tapiainen; Maarit Ahtiainen; Olli Helminen; Erkki-Ville Wirta; Jukka Rintala; Sanna Meriläinen; Juha Saarnio; Tero Rautio; Toni T. Seppälä; Jan Böhm; Jukka-Pekka Mecklin; Markus J. Mäkinen; Juha P. Väyrynen
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errSave
Associations of mucinous differentiation and mucin expression with immune cell infiltration and prognosis in colorectal adenocarcinoma
errBRITISH JOURNAL OF CANCER
IF6.8
err2025-02-18
err0
errOAAI
errElomaa, Hanna; Tarkiainen, Vilma; Aijala, Ville K.; Sirnio, Paivi; Ahtiainen, Maarit; Sirkia, Onni; Karjalainen, Henna; Kastinen, Meeri; Tapiainen, Vilja V.; Rintala, Jukka; Merilainen, Sanna; Saarnio, Juha; Rautio, Tero; Tuomisto, Anne; Helminen, Olli; Wirta, Erkki-Ville; Seppala, Toni T.; Bohm, Jan; Makinen, Markus J.; Mecklin, Jukka-Pekka; Vayrynen, Juha P.
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errSave
Lynch syndrome-associated and sporadic microsatellite unstable colorectal cancers: different patterns of clonal evolution yield highly similar tumours
errHUMAN MOLECULAR GENETICS
IF3.2
err2024-08-24
err0
errOAAI
errMartin, Samantha; Katainen, Riku; Taira, Aurora; Valimaki, Niko; Ristimaki, Ari; Seppala, Toni; Renkonen-Sinisalo, Laura; Lepisto, Anna; Tahkola, Kyosti; Mattila, Anne; Koskensalo, Selja; Mecklin, Jukka-Pekka; Rajamaki, Kristiina; Palin, Kimmo; Aaltonen, Lauri A.
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Mitotic abnormalities precede microsatellite instability in lynch syndrome-associated colorectal tumourigenesis
errEBIOMEDICINE
IF10.8
err2024-05-01
err0
errOAAI
errPussila, Marjaana; Laiho, Aleksi; Toronen, Petri; Bjorkbacka, Pauliina; Nykaenen, Sonja; Pylvaenaeinen, Kirsi; Holm, Liisa; Mecklin, Jukka-Pekka; Renkonen-Sinisalo, Laura; Lehtonen, Taru; Lepisto, Anna; Linden, Jere; Maki-Nevala, Satu; Peltomaki, Paivi; Nystrom, Minna
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errSave
High immune cell infiltration predicts improved survival in cholangiocarcinoma
errFRONTIERS IN ONCOLOGY
IF3.3
err2024-05-01
err3
errOAAI
errWirta, Erkki-Ville; Szeto, Sade; Koppatz, Hanna; Nordin, Arno; Makisalo, Heikki; Arola, Johanna; Siren, Jukka; Ahtiainen, Maarit; Bohm, Jan; Mecklin, Jukka-Pekka; Sallinen, Ville; Seppala, Toni T.
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Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes
errNATURE COMMUNICATIONS
IF15.7
err2024-04-26
err4
errOAAI
errChen, Zhishan; Guo, Xingyi; Tao, Ran; Huyghe, Jeroen R.; Law, Philip J.; Fernandez-Rozadilla, Ceres; Ping, Jie; Jia, Guochong; Long, Jirong; Li, Chao; Shen, Quanhu; Xie, Yuhan; Timofeeva, Maria N.; Thomas, Minta; Schmit, Stephanie L.; Diez-Obrero, Virginia; Devall, Matthew; Moratalla-Navarro, Ferran; Fernandez-Tajes, Juan; Palles, Claire; Sherwood, Kitty; Briggs, Sarah E. W.; Svinti, Victoria; Donnelly, Kevin; Farrington, Susan M.; Blackmur, James; Vaughan-Shaw, Peter G.; Shu, Xiao-Ou; Lu, Yingchang; Broderick, Peter; Studd, James; Harrison, Tabitha A.; Conti, David V.; Schumacher, Fredrick R.; Melas, Marilena; Rennert, Gad; Obon-Santacana, Mireia; Martin-Sanchez, Vicente; Oh, Jae Hwan; Kim, Jeongseon; Jee, Sun Ha; Jung, Keum Ji; Kweon, Sun-Seog; Shin, Min-Ho; Shin, Aesun; Ahn, Yoon-Ok; Kim, Dong-Hyun; Oze, Isao; Wen, Wanqing; Matsuo, Keitaro; Matsuda, Koichi; Tanikawa, Chizu; Ren, Zefang; Gao, Yu-Tang; Jia, Wei-Hua; Hopper, John L.; Jenkins, Mark A.; Win, Aung Ko; Pai, Rish K.; Figueiredo, Jane C.; Haile, Robert W.; Gallinger, Steven; Woods, Michael O.; Newcomb, Polly A.; Duggan, David; Cheadle, Jeremy P.; Kaplan, Richard; Kerr, Rachel; Kerr, David; Kirac, Iva; Bohm, Jan; Mecklin, Jukka-Pekka; Jousilahti, Pekka; Knekt, Paul; Aaltonen, Lauri A.; Rissanen, Harri; Pukkala, Eero; Eriksson, Johan G.; Cajuso, Tatiana; Hanninen, Ulrika; Kondelin, Johanna; Palin, Kimmo; Tanskanen, Tomas; Renkonen-Sinisalo, Laura; Mannisto, Satu; Albanes, Demetrius; Weinstein, Stephanie J.; Ruiz-Narvaez, Edward; Palmer, Julie R.; Buchanan, Daniel D.; Platz, Elizabeth A.; Visvanathan, Kala; Ulrich, Cornelia M.; Siegel, Erin; Brezina, Stefanie; Gsur, Andrea; Campbell, Peter T.; Chang-Claude, Jenny; Hoffmeister, Michael; Brenner, Hermann; Slattery, Martha L.; Potter, John D.; Tsilidis, Kostas K.; Schulze, Matthias B.; Gunter, Marc J.; Murphy, Neil; Castells, Antoni; Castellvi-Bel, Sergi; Moreira, Leticia; Arndt, Volker; Shcherbina, Anna; Bishop, D. Timothy; Giles, Graham G.; Southey, Melissa C.; Idos, Gregory E.; McDonnell, Kevin J.; Abu-Ful, Zomoroda; Greenson, Joel K.; Shulman, Katerina; Lejbkowicz, Flavio; Offit, Kenneth; Su, Yu-Ru; Steinfelder, Robert; Keku, Temitope O.; van Guelpen, Bethany; Hudson, Thomas J.; Hampel, Heather; Pearlman, Rachel; Berndt, Sonja I.; Hayes, Richard B.; Martinez, Marie Elena; Thomas, Sushma S.; Pharoah, Paul D. P.; Larsson, Susanna C.; Yen, Yun; Lenz, Heinz-Josef; White, Emily; Li, Li; Doheny, Kimberly F.; Pugh, Elizabeth; Shelford, Tameka; Chan, Andrew T.; Cruz-Correa, Marcia; Lindblom, Annika; Hunter, David J.; Joshi, Amit D.; Schafmayer, Clemens; Scacheri, Peter C.; Kundaje, Anshul; Schoen, Robert E.; Hampe, Jochen; Stadler, Zsofia K.; Vodicka, Pavel; Vodickova, Ludmila; Vymetalkova, Veronika; Edlund, Christopher K.; Gauderman, W. James; Shibata, David; Toland, Amanda; Markowitz, Sanford; Kim, Andre; Chanock, Stephen J.; van Duijnhoven, Franzel; Feskens, Edith J. M.; Sakoda, Lori C.; Gago-Dominguez, Manuela; Wolk, Alicja; Pardini, Barbara; FitzGerald, Liesel M.; Lee, Soo Chin; Ogino, Shuji; Bien, Stephanie A.; Kooperberg, Charles; Li, Christopher I.; Lin, Yi; Prentice, Ross; Qu, Conghui; Bezieau, Stephane; Yamaji, Taiki; Sawada, Norie; Iwasaki, Motoki; Le Marchand, Loic; Wu, Anna H.; Qu, Chenxu; McNeil, Caroline E.; Coetzee, Gerhard; Hayward, Caroline; Deary, Ian J.; Harris, Sarah E.; Theodoratou, Evropi; Reid, Stuart; Walker, Marion; Ooi, Li Yin; Lau, Ken S.; Zhao, Hongyu; Hsu, Li; Cai, Qiuyin; Dunlop, Malcolm G.; Gruber, Stephen B.; Houlston, Richard S.; Moreno, Victor; Casey, Graham; Peters, Ulrike; Tomlinson, Ian; Zheng, Wei
errShare
errSave
Novel insights into tumorigenesis revealed by molecular analysis of Lynch syndrome cases with multiple colorectal tumors
errFRONTIERS IN ONCOLOGY
IF3.3
err2024-04-25
err0
errOAAI
errOlkinuora, Alisa; Maki-Nevala, Satu; Ukwattage, Sanjeevi; Ristimaki, Ari; Ahtiainen, Maarit; Mecklin, Jukka-Pekka; Peltomaki, Paivi
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errSave
Quantitative Multiplexed Analysis of Indoleamine 2,3-Dioxygenase (IDO) and Arginase-1 (ARG1) Expression and Myeloid Cell Infiltration in Colorectal Cancer
errMODERN PATHOLOGY
IF5.5
err2024-04-01
err3
errOAAI
errElomaa, Hanna; Harkonen, Jouni; Vayrynen, Sara A.; Ahtiainen, Maarit; Ogino, Shuji; Nowak, Jonathan A.; Lau, Mai Chan; Helminen, Olli; Wirta, Erkki-Ville; Seppala, Toni T.; Bohm, Jan; Mecklin, Jukka-Pekka; Kuopio, Teijo; Vayrynen, Juha P.
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errSave
Circulating metabolome landscape in Lynch syndrome
errCANCER & METABOLISM
IF5.3
err2024-02-05
err1
errOAAI
errJokela, Tiina A.; Karppinen, Jari E.; Karkkainen, Minta; Mecklin, Jukka-Pekka; Walker, Simon; Seppala, Toni T.; Laakkonen, Eija K.
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errSave
Identification of DHX40 as a candidate susceptibility gene for colorectal and hematological neoplasia
errLEUKEMIA
IF13.4
err2023-09-11
err1
errOAAI
errOlkinuora, Alisa; Nieminen, Taina T.; Douglas, Suvi; Kauppinen, Anni; Kontro, Mika; Vaananen, Juho; Kankainen, Matti; Ristimaki, Ari; Makinen, Markus; Lahermo, Paivi; Heckman, Caroline; Saarela, Janna; Salonen, Milla; Lepisto, Anna; Jarvinen, Heikki; Mecklin, Jukka-Pekka; Kilpivaara, Outi; Wartiovaara-Kautto, Ulla; Porkka, Kimmo; Peltomaki, Paeivi
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errSave
The prognostic role of tumor budding and tumor-stroma ratio in pulmonary metastasis of colorectal carcinoma
errEJSO
IF2.9
err2023-07-01
err7
errOAAI
errKarjula, Topias; Kemi, Niko; Niskakangas, Anne; Mustonen, Olli; Puro, Iiris; Pohjanen, Vesa-Matti; Kuopio, Teijo; Elomaa, Hanna; Ahtiainen, Maarit; Mecklin, Jukka-Pekka; Seppala, Toni T.; Wirta, Erkki-Ville; Sihvo, Eero; Vayrynen, Juha P.; Yannopoulos, Fredrik; Helminen, Olli
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Research Directions

No research directions
Co-authors
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