Eric S. Lander - Publications, H-index & Citations

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Eric S. Lander

broad institute of mit and harvard

271H-index

898Paper Count

52.1WCitation Count

Published Papers 245

Publication Date

Quantitative changes in 3D contact predict changes in enhancer-promoter regulation upon cohesin depletion

Nature Communications

IF15.7

2026-09-29

OAAI

Philine Guckelberger; Benjamin R. Doughty; Suhas S. P. Rao; Glen Munson; Yingxuan Tan; Xiangmeng Shawn Cai; Charles P. Fulco; Joseph Nasser; Drew T. Bergman; Judhajeet Ray; Evelyn Jagoda; Andreas R. Gschwind; Maya U. Sheth; Chad J. Munger; Anthony S. Tan; Kristy S. Mualim; Saul Godinez Pulido; Namita Mitra; David Weisz; Muhammad Saad Shamim; Neva C. Durand; Ragini Mahajan; Ruqayya Khan; Lars M. Steinmetz; Masato T. Kanemaki; Eric S. Lander; Erez Lieberman Aiden; Jesse M. Engreitz

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Functional dissection of complex trait variants at single-nucleotide resolution

Nature

IF48.5

2026-02-25

OAAI

Layla Siraj; Rodrigo I. Castro; Hannah B. Dewey; Susan Kales; John C. Butts; Thanh Thanh L. Nguyen; Masahiro Kanai; Daniel Berenzy; Kousuke Mouri; Qingbo S. Wang; Petko P. Fiziev; Kristin Tsuo; Zachary R. McCaw; Sager J. Gosai; François Aguet; Ran Cui; Irfahan Kassam; Jeremy McRae; Christopher M. Vockley; Caleb A. Lareau; Sergey Abramov; Alexandr Boystov; Jeff Vierstra; Yukinori Okada; Alexander Gusev; Thouis R. Jones; Eric S. Lander; Pardis C. Sabeti; Hilary K. Finucane; Steven K. Reilly; Jacob C. Ulirsch; Ryan Tewhey

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Dissecting and quantifying pancreatic cancer plasticity using single-cell multiomics, lineage tracing and functional genomics reveals novel mediators of therapy resistance

CANCER RESEARCH

IF16.6

2024-04-05

PREAI

Mehta, Arnav; Bi, Lynn; Yeramosu, Deepika; Bogaev, Michael; Jankowiak, Martin; Collins, Abigail; Al'Khafaji, Aziz; Parikh, Milan; Babadi, Mehrtash; Evans, Kyle; Bloemendal, Alex; Kunnes, Russell; Schwartz, Marc; Munson, Glen; Donnard, Elisa; Jones, Thouis R.; Stanger, Ben Z.; Shendure, Jay; Weissman, Jonathan; Ting, David T.; Aguirre, Andrew; Hacohen, Nir; Pe'er, Dana; Lander, Eric S.

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The transcriptional and epigenetic regulation of epithelial-mesenchymal plasticity in patient-derived pancreatic cancer cell lines

CANCER RESEARCH

IF16.6

2024-03-22

PREAI

Yeramosu, Deepika; Bi, Lynn; Collins, Abigail; Bogaev, Mike; Jankowiak, Martin; Al'Khafaji, Aziz; Parikh, Milan; Babadi, Mehrtash; Bloemendal, Alex; Nagaraja, Surya; Jones, Ray; Shendure, Jay; Ting, David T.; Aguirre, Andrew; Hacohen, Nir; Pe'er, Dana; Lander, Eric S.; Mehta, Arnav

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Extremely sparse models of linkage disequilibrium in ancestrally diverse association studies

NATURE GENETICS

IF31.8

2023-08-28

OAAI

Nowbandegani, Pouria Salehi; Wohns, Anthony Wilder; Ballard, Jenna L.; Lander, Eric S.; Bloemendal, Alex; Neale, Benjamin M.; O'Connor, Luke J.

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Leveraging polygenic enrichments of gene features to predict genes underlying complex traits and diseases

NATURE GENETICS

IF31.8

2023-07-13

OAAI

Weeks, Elle M. M.; Ulirsch, Jacob C. C.; Cheng, Nathan Y. Y.; Trippe, Brian L. L.; Fine, Rebecca S. S.; Miao, Jenkai; Patwardhan, Tejal A. A.; Kanai, Masahiro; Nasser, Joseph; Fulco, Charles P. P.; Tashman, Katherine C. C.; Aguet, Francois; Li, Taibo; Ordovas-Montanes, Jose; Smillie, Christopher S. S.; Biton, Moshe; Shalek, Alex K. K.; Ananthakrishnan, Ashwin N. N.; Xavier, Ramnik J. J.; Regev, Aviv; Gupta, Rajat M. M.; Lage, Kasper; Ardlie, Kristin G. G.; Hirschhorn, Joel N. N.; Lander, Eric S. S.; Engreitz, Jesse M. M.; Finucane, Hilary K. K.

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Tumor mutational signatures in early-onset versus average-onset colorectal cancer

ANNALS OF ONCOLOGY

IF65.4

2023-06-01

PREAI

Lander, E.; Rivero-Hinojosa, S.; Aushev, V.; Liu, M.; Jurdi, A.; Eng, C.

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A platform for deep evolutionary profiling of cancer resistance

CANCER RESEARCH

IF16.6

2023-04-04

PREAI

Ravi, Arvind; Sontha, Sainikhil; Chowdhury, Maisha; Smigiel, Jacob; Rees, Matthew; Danysh, Brian; Roth, Jennifer; Parida, Laxmi; Lander, Eric; Getz, Gad

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Gene Sequencing Identifies Perturbation in Nitric Oxide Signaling as a Nonlipid Molecular Subtype of Coronary Artery Disease

CIRCULATION-GENOMIC AND PRECISION MEDICINE

IF5.5

2022-12-01

OAAI

Khera, Amit, V; Wang, Minxian; Chaffin, Mark; Emdin, Connor A.; Samani, Nilesh J.; Schunkert, Heribert; Watkins, Hugh; McPherson, Ruth; Erdmann, Jeanette; Elosua, Roberto; Boerwinkle, Eric; Ardissino, Diego; Butterworth, Adam S.; Di Angelantonio, Emanuele; Naheed, Aliya; Danesh, John; Chowdhury, Rajiv; Krumholz, Harlan M.; Sheu, Wayne H-H; Rich, Stephen S.; Rotter, Jerome, I; Chen, Yii-der Ida; Gabriel, Stacey; Lander, Eric S.; Saleheen, Danish; Kathiresan, Sekar

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Neurocognitive trajectory and proteomic signature of inherited risk for Alzheimer's disease

PLOS GENETICS

IF3.7

2022-09-01

OAAI

Paranjpe, Manish D.; Chaffin, Mark; Zahid, Sohail; Ritchie, Scott; Rotter, Jerome, I; Rich, Stephen S.; Gerszten, Robert; Guo, Xiuqing; Heckbert, Susan; Tracy, Russ; Danesh, John; Lander, Eric S.; Inouye, Michael; Kathiresan, Sekar; Butterworth, Adam S.; Khera, Amit, V

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A patient-driven clinicogenomic partnership for metastatic prostate cancer

CELL GENOMICS

IF9

2022-09-01

OAAI

Crowdis, Jett; Balch, Sara; Sterlin, Lauren; Thomas, Beena S.; Camp, Sabrina Y.; Dunphy, Michael; Anastasio, Elana; Shah, Shahrayz; Damon, Alyssa L.; Ramos, Rafael; Sosa, Delia M.; Small, Ilan K.; Tomson, Brett N.; Nguyen, Colleen M.; Mcgillicuddy, Mary; Chastain, Parker S.; He, Meng Xiao; Cheung, Alexander T. M.; Wankowicz, Stephanie; Tewari, Alok K.; Kim, Dewey; Aldubayan, Saud H.; Dowdye, Ayanah; Zola, Benjamin; Nowak, Joel; Manarite, Jan; Gunn, Idola Henry; Olson, Bryce; Lander, Eric S.; Painter, Corrie A.; Wagle, Nikhil; Van Allen, Eliezer M.

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Inferring gene regulation from stochastic transcriptional variation across single cells at steady state

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2022-08-15

OAAI

Gupta, Anika; Martin-Rufino, Jorge D.; Jones, Thouis R.; Subramanian, Vidya; Qiu, Xiaojie; Grody, Emanuelle, I; Bloemendal, Alex; Weng, Chen; Niu, Sheng-Yong; Min, Kyung Hoi; Mehta, Arnav; Zhang, Kaite; Siraj, Layla; Khafaji, Aziz Al'; Sankaran, Vijay G.; Raychaudhuri, Soumya; Cleary, Brian; Grossman, Sharon; Lander, Eric S.

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Cross-Sectional Assessment of SARS-CoV-2 Viral Load by Symptom Status in Massachusetts Congregate Living Facilities

JOURNAL OF INFECTIOUS DISEASES

IF4.5

2021-07-13

OAAI

Lennon, Niall J.; Bhattacharyya, Roby P.; Mina, Michael J.; Rehm, Heidi L.; Hung, Deborah T.; Smole, Sandra; Woolley, Ann; Lander, Eric S.; Gabriel, Stacey B.

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ARPA-H: Accelerating biomedical breakthroughs

SCIENCE

IF45.8

2021-07-09

PREAI

Collins, Francis S.; Schwetz, Tara A.; Tabak, Lawrence A.; Lander, Eric S.

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Compressed sensing for highly efficient imaging transcriptomics

NATURE BIOTECHNOLOGY

IF41.7

2021-04-15

OAAI

Cleary, Brian; Simonton, Brooke; Bezney, Jon; Murray, Evan; Alam, Shahul; Sinha, Anubhav; Habibi, Ehsan; Marshall, Jamie; Lander, Eric S.; Chen, Fei; Regev, Aviv

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A regulatory variant at 3q21.1 confers an increased pleiotropic risk for hyperglycemia and altered bone mineral density

CELL METABOLISM

IF30.9

2021-03-01

OAAI

Sinnott-Armstrong, Nasa; Sousa, Isabel S.; Laber, Samantha; Rendina-Ruedy, Elizabeth; Dankel, Simon E. Nitter; Ferreira, Teresa; Mellgren, Gunnar; Karasik, David; Rivas, Manuel; Pritchard, Jonathan; Guntur, Anyonya R.; Cox, Roger D.; Lindgren, Cecilia M.; Hauner, Hans; Sallari, Richard; Rosen, Clifford J.; Hsu, Yi-Hsiang; Lander, Eric S.; Kiel, Douglas P.; Claussnitzer, Melina

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Human Molecular Genetics and Genomics - Important Advances and Exciting Possibilities

NEW ENGLAND JOURNAL OF MEDICINE

IF78.5

2021-01-07

OAAI

Collins, Francis S.; Doudna, Jennifer A.; Lander, Eric S.; Rotimi, Charles N.

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HyPR-seq: Single-cell quantification of chosen RNAs via hybridization and sequencing of DNA probes

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2020-12-21

OAAI

Marshall, Jamie L.; Doughty, Benjamin R.; Subramanian, Vidya; Guckelberger, Philine; Wang, Qingbo; Chen, Linlin M.; Rodriques, Samuel G.; Zhang, Kaite; Fulco, Charles P.; Nasser, Joseph; Grinkevich, Elizabeth J.; Noel, Teia; Mangiameli, Sarah; Bergman, Drew T.; Greka, Anna; Lander, Eric S.; Chen, Fei; Engreitz, Jesse M.

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Delivery Mode Affects Stability of Early Infant Gut Microbiota

CELL REPORTS MEDICINE

IF10.6

2020-12-01

124

OAAI

Mitchell, Caroline M.; Mazzoni, Chiara; Hogstrom, Larson; Bryant, Allison; Bergerat, Agnes; Cher, Avital; Pochan, Shawna; Herman, Penelope; Carrigan, Maureen; Sharp, Karen; Huttenhower, Curtis; Lander, Eric S.; Vlamakis, Hera; Xavier, Ramnik J.; Yassour, Moran

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Polygenic background modifies penetrance of monogenic variants for tier 1 genomic conditions

NATURE COMMUNICATIONS

IF15.7

2020-08-20

257

OAAI

Fahed, Akl C.; Wang, Minxian; Homburger, Julian R.; Patel, Aniruddh P.; Bick, Alexander G.; Neben, Cynthia L.; Lai, Carmen; Brockman, Deanna; Philippakis, Anthony; Ellinor, Patrick T.; Cassa, Christopher A.; Lebo, Matthew; Ng, Kenney; Lander, Eric S.; Zhou, Alicia Y.; Kathiresan, Sekar; Khera, Amit V.

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Research Directions